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P01568

- IFN21_HUMAN

UniProt

P01568 - IFN21_HUMAN

Protein

Interferon alpha-21

Gene

IFNA21

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 147 (01 Oct 2014)
      Sequence version 2 (16 Apr 2002)
      Previous versions | rss
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    Functioni

    Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.1 Publication

    GO - Molecular functioni

    1. cytokine activity Source: RefGenome
    2. cytokine receptor binding Source: ProtInc
    3. type I interferon receptor binding Source: RefGenome

    GO - Biological processi

    1. adaptive immune response Source: RefGenome
    2. B cell differentiation Source: RefGenome
    3. B cell proliferation Source: RefGenome
    4. blood coagulation Source: Reactome
    5. cytokine-mediated signaling pathway Source: RefGenome
    6. defense response to virus Source: UniProtKB-KW
    7. humoral immune response Source: RefGenome
    8. innate immune response Source: RefGenome
    9. natural killer cell activation involved in immune response Source: RefGenome
    10. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: RefGenome
    11. regulation of MHC class I biosynthetic process Source: RefGenome
    12. regulation of type I interferon-mediated signaling pathway Source: Reactome
    13. response to exogenous dsRNA Source: RefGenome
    14. T cell activation involved in immune response Source: RefGenome
    15. type I interferon signaling pathway Source: Reactome

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Antiviral defense

    Enzyme and pathway databases

    ReactomeiREACT_24938. TRAF6 mediated IRF7 activation.
    REACT_24970. Factors involved in megakaryocyte development and platelet production.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_25216. Regulation of IFNA signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interferon alpha-21
    Short name:
    IFN-alpha-21
    Alternative name(s):
    Interferon alpha-F
    Short name:
    LeIF F
    Gene namesi
    Name:IFNA21
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:5424. IFNA21.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: RefGenome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29663.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 23232 PublicationsAdd
    BLAST
    Chaini24 – 189166Interferon alpha-21PRO_0000016370Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi24 ↔ 122By similarity
    Disulfide bondi52 ↔ 162By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP01568.
    PRIDEiP01568.

    Expressioni

    Gene expression databases

    ArrayExpressiP01568.
    BgeeiP01568.
    CleanExiHS_IFNA21.
    GenevestigatoriP01568.

    Organism-specific databases

    HPAiHPA047557.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000369574.

    Structurei

    3D structure databases

    ProteinModelPortaliP01568.
    SMRiP01568. Positions 24-189.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alpha/beta interferon family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG119628.
    HOGENOMiHOG000230500.
    HOVERGENiHBG052086.
    InParanoidiP01568.
    KOiK05414.
    OMAiMTQQIFN.
    OrthoDBiEOG7M98HV.
    PhylomeDBiP01568.
    TreeFamiTF336177.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000471. Interferon_alpha/beta/delta.
    [Graphical view]
    PANTHERiPTHR11691. PTHR11691. 1 hit.
    PfamiPF00143. Interferon. 1 hit.
    [Graphical view]
    PRINTSiPR00266. INTERFERONAB.
    SMARTiSM00076. IFabd. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01568-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALSFSLLMA VLVLSYKSIC SLGCDLPQTH SLGNRRALIL LAQMGRISPF    50
    SCLKDRHDFG FPQEEFDGNQ FQKAQAISVL HEMIQQTFNL FSTKDSSATW 100
    EQSLLEKFST ELNQQLNDLE ACVIQEVGVE ETPLMNVDSI LAVKKYFQRI 150
    TLYLTEKKYS PCAWEVVRAE IMRSFSLSKI FQERLRRKE 189
    Length:189
    Mass (Da):21,741
    Last modified:April 16, 2002 - v2
    Checksum:iF0B6C9C392905802
    GO

    Sequence cautioni

    The sequence AAA36041.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti60 – 601G → E AA sequence (PubMed:1634550)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti119 – 1191L → M.1 Publication
    Corresponds to variant rs1053885 [ dbSNP | Ensembl ].
    VAR_055325
    Natural varianti179 – 1791K → E.
    Corresponds to variant rs3750478 [ dbSNP | Ensembl ].
    VAR_049638

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V00540 mRNA. Translation: CAA23801.1.
    M12350 mRNA. Translation: AAA52718.1.
    X00145 mRNA. Translation: CAA24980.1.
    M28586 mRNA. Translation: AAA36041.1. Different initiation.
    AL390882 Genomic DNA. Translation: CAH70157.1.
    CH471071 Genomic DNA. Translation: EAW58623.1.
    BC069329 mRNA. Translation: AAH69329.1.
    BC069372 mRNA. Translation: AAH69372.1.
    BC069408 mRNA. Translation: AAH69408.1.
    BC096699 mRNA. Translation: AAH96699.1.
    BC101638 mRNA. Translation: AAI01639.1.
    BC101640 mRNA. Translation: AAI01641.1.
    CCDSiCCDS6497.1.
    PIRiA01832. IVHUF.
    D42753.
    E25843.
    I56313.
    I84464.
    RefSeqiNP_002166.2. NM_002175.2.
    UniGeneiHs.113211.

    Genome annotation databases

    EnsembliENST00000380225; ENSP00000369574; ENSG00000137080.
    GeneIDi3452.
    KEGGihsa:3452.
    UCSCiuc003zom.2. human.

    Polymorphism databases

    DMDMi20178289.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V00540 mRNA. Translation: CAA23801.1 .
    M12350 mRNA. Translation: AAA52718.1 .
    X00145 mRNA. Translation: CAA24980.1 .
    M28586 mRNA. Translation: AAA36041.1 . Different initiation.
    AL390882 Genomic DNA. Translation: CAH70157.1 .
    CH471071 Genomic DNA. Translation: EAW58623.1 .
    BC069329 mRNA. Translation: AAH69329.1 .
    BC069372 mRNA. Translation: AAH69372.1 .
    BC069408 mRNA. Translation: AAH69408.1 .
    BC096699 mRNA. Translation: AAH96699.1 .
    BC101638 mRNA. Translation: AAI01639.1 .
    BC101640 mRNA. Translation: AAI01641.1 .
    CCDSi CCDS6497.1.
    PIRi A01832. IVHUF.
    D42753.
    E25843.
    I56313.
    I84464.
    RefSeqi NP_002166.2. NM_002175.2.
    UniGenei Hs.113211.

    3D structure databases

    ProteinModelPortali P01568.
    SMRi P01568. Positions 24-189.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000369574.

    Polymorphism databases

    DMDMi 20178289.

    Proteomic databases

    PaxDbi P01568.
    PRIDEi P01568.

    Protocols and materials databases

    DNASUi 3452.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000380225 ; ENSP00000369574 ; ENSG00000137080 .
    GeneIDi 3452.
    KEGGi hsa:3452.
    UCSCi uc003zom.2. human.

    Organism-specific databases

    CTDi 3452.
    GeneCardsi GC09M021165.
    HGNCi HGNC:5424. IFNA21.
    HPAi HPA047557.
    MIMi 147584. gene.
    neXtProti NX_P01568.
    PharmGKBi PA29663.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG119628.
    HOGENOMi HOG000230500.
    HOVERGENi HBG052086.
    InParanoidi P01568.
    KOi K05414.
    OMAi MTQQIFN.
    OrthoDBi EOG7M98HV.
    PhylomeDBi P01568.
    TreeFami TF336177.

    Enzyme and pathway databases

    Reactomei REACT_24938. TRAF6 mediated IRF7 activation.
    REACT_24970. Factors involved in megakaryocyte development and platelet production.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_25216. Regulation of IFNA signaling.

    Miscellaneous databases

    GeneWikii IFNA21.
    GenomeRNAii 3452.
    NextBioi 13600.
    PROi P01568.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P01568.
    Bgeei P01568.
    CleanExi HS_IFNA21.
    Genevestigatori P01568.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000471. Interferon_alpha/beta/delta.
    [Graphical view ]
    PANTHERi PTHR11691. PTHR11691. 1 hit.
    Pfami PF00143. Interferon. 1 hit.
    [Graphical view ]
    PRINTSi PR00266. INTERFERONAB.
    SMARTi SM00076. IFabd. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00252. INTERFERON_A_B_D. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The structure of eight distinct cloned human leukocyte interferon cDNAs."
      Goeddel D.V., Leung D.W., Dull T.J., Gross M., Lawn R.M., McCandliss R., Seeburg P.H., Ullrich A., Yelverton E., Gray P.W.
      Nature 290:20-26(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT MET-119.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Novel human leukocyte interferon subtype and structural comparison of alpha interferon genes."
      Gren E., Berzin V.M., Jansone I., Tsimanis A., Vishnevsky Y., Apsalons U.
      J. Interferon Res. 4:609-617(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. "Anomalous behavior of human leukocyte interferon subtypes on polyacrylamide gel electrophoresis in the presence of dodecyl sulfate."
      Ohara O., Teraoka H.
      FEBS Lett. 211:78-82(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-189.
      Tissue: Lymphoblast.
    8. "Purification and characterization of multiple components of human lymphoblastoid interferon-alpha."
      Zoon K.C., Miller D., Bekisz J., zur Nedden D., Enterline J.C., Nguyen N.Y., Hu R.-Q.
      J. Biol. Chem. 267:15210-15216(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 24-62, FUNCTION.
    9. "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes."
      Nyman T.A., Toeloe H., Parkkinen J., Kalkkinen N.
      Biochem. J. 329:295-302(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 24-58.
    10. "Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in the genome of a large human population."
      Hussain M., Gill D.S., Liao M.-J.
      J. Interferon Cytokine Res. 16:853-859(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: ABSENCE OF POLYMORPHISM.

    Entry informationi

    Entry nameiIFN21_HUMAN
    AccessioniPrimary (citable) accession number: P01568
    Secondary accession number(s): Q14608, Q5VWD1, Q7M4Q4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: April 16, 2002
    Last modified: October 1, 2014
    This is version 147 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3