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Protein

Interferon alpha-21

Gene

IFNA21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.1 Publication

GO - Molecular functioni

  1. cytokine activity Source: GO_Central
  2. cytokine receptor binding Source: ProtInc
  3. type I interferon receptor binding Source: GO_Central

GO - Biological processi

  1. adaptive immune response Source: GO_Central
  2. B cell differentiation Source: GO_Central
  3. B cell proliferation Source: GO_Central
  4. blood coagulation Source: Reactome
  5. cytokine-mediated signaling pathway Source: GO_Central
  6. defense response to virus Source: UniProtKB-KW
  7. humoral immune response Source: GO_Central
  8. innate immune response Source: GO_Central
  9. natural killer cell activation involved in immune response Source: GO_Central
  10. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: GO_Central
  11. regulation of MHC class I biosynthetic process Source: GO_Central
  12. regulation of type I interferon-mediated signaling pathway Source: Reactome
  13. response to exogenous dsRNA Source: GO_Central
  14. T cell activation involved in immune response Source: GO_Central
  15. type I interferon signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense

Enzyme and pathway databases

ReactomeiREACT_24938. TRAF6 mediated IRF7 activation.
REACT_24970. Factors involved in megakaryocyte development and platelet production.
REACT_25162. Interferon alpha/beta signaling.
REACT_25216. Regulation of IFNA signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-21
Short name:
IFN-alpha-21
Alternative name(s):
Interferon alpha-F
Short name:
LeIF F
Gene namesi
Name:IFNA21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:5424. IFNA21.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29663.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23232 PublicationsAdd
BLAST
Chaini24 – 189166Interferon alpha-21PRO_0000016370Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 122By similarity
Disulfide bondi52 ↔ 162By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP01568.
PRIDEiP01568.

Expressioni

Gene expression databases

BgeeiP01568.
CleanExiHS_IFNA21.
ExpressionAtlasiP01568. baseline.
GenevestigatoriP01568.

Organism-specific databases

HPAiHPA047557.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000369574.

Structurei

3D structure databases

ProteinModelPortaliP01568.
SMRiP01568. Positions 24-189.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG119628.
GeneTreeiENSGT00760000119150.
HOGENOMiHOG000230500.
HOVERGENiHBG052086.
InParanoidiP01568.
KOiK05414.
OMAiMTQQIFN.
OrthoDBiEOG7M98HV.
PhylomeDBiP01568.
TreeFamiTF336177.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01568-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSFSLLMA VLVLSYKSIC SLGCDLPQTH SLGNRRALIL LAQMGRISPF
60 70 80 90 100
SCLKDRHDFG FPQEEFDGNQ FQKAQAISVL HEMIQQTFNL FSTKDSSATW
110 120 130 140 150
EQSLLEKFST ELNQQLNDLE ACVIQEVGVE ETPLMNVDSI LAVKKYFQRI
160 170 180
TLYLTEKKYS PCAWEVVRAE IMRSFSLSKI FQERLRRKE
Length:189
Mass (Da):21,741
Last modified:April 16, 2002 - v2
Checksum:iF0B6C9C392905802
GO

Sequence cautioni

The sequence AAA36041.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti60 – 601G → E AA sequence (PubMed:1634550).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti119 – 1191L → M.1 Publication
Corresponds to variant rs1053885 [ dbSNP | Ensembl ].
VAR_055325
Natural varianti179 – 1791K → E.
Corresponds to variant rs3750478 [ dbSNP | Ensembl ].
VAR_049638

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00540 mRNA. Translation: CAA23801.1.
M12350 mRNA. Translation: AAA52718.1.
X00145 mRNA. Translation: CAA24980.1.
M28586 mRNA. Translation: AAA36041.1. Different initiation.
AL390882 Genomic DNA. Translation: CAH70157.1.
CH471071 Genomic DNA. Translation: EAW58623.1.
BC069329 mRNA. Translation: AAH69329.1.
BC069372 mRNA. Translation: AAH69372.1.
BC069408 mRNA. Translation: AAH69408.1.
BC096699 mRNA. Translation: AAH96699.1.
BC101638 mRNA. Translation: AAI01639.1.
BC101640 mRNA. Translation: AAI01641.1.
CCDSiCCDS6497.1.
PIRiA01832. IVHUF.
D42753.
E25843.
I56313.
I84464.
RefSeqiNP_002166.2. NM_002175.2.
UniGeneiHs.113211.

Genome annotation databases

EnsembliENST00000380225; ENSP00000369574; ENSG00000137080.
GeneIDi3452.
KEGGihsa:3452.
UCSCiuc003zom.2. human.

Polymorphism databases

DMDMi20178289.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00540 mRNA. Translation: CAA23801.1.
M12350 mRNA. Translation: AAA52718.1.
X00145 mRNA. Translation: CAA24980.1.
M28586 mRNA. Translation: AAA36041.1. Different initiation.
AL390882 Genomic DNA. Translation: CAH70157.1.
CH471071 Genomic DNA. Translation: EAW58623.1.
BC069329 mRNA. Translation: AAH69329.1.
BC069372 mRNA. Translation: AAH69372.1.
BC069408 mRNA. Translation: AAH69408.1.
BC096699 mRNA. Translation: AAH96699.1.
BC101638 mRNA. Translation: AAI01639.1.
BC101640 mRNA. Translation: AAI01641.1.
CCDSiCCDS6497.1.
PIRiA01832. IVHUF.
D42753.
E25843.
I56313.
I84464.
RefSeqiNP_002166.2. NM_002175.2.
UniGeneiHs.113211.

3D structure databases

ProteinModelPortaliP01568.
SMRiP01568. Positions 24-189.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000369574.

Polymorphism databases

DMDMi20178289.

Proteomic databases

PaxDbiP01568.
PRIDEiP01568.

Protocols and materials databases

DNASUi3452.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380225; ENSP00000369574; ENSG00000137080.
GeneIDi3452.
KEGGihsa:3452.
UCSCiuc003zom.2. human.

Organism-specific databases

CTDi3452.
GeneCardsiGC09M021165.
HGNCiHGNC:5424. IFNA21.
HPAiHPA047557.
MIMi147584. gene.
neXtProtiNX_P01568.
PharmGKBiPA29663.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG119628.
GeneTreeiENSGT00760000119150.
HOGENOMiHOG000230500.
HOVERGENiHBG052086.
InParanoidiP01568.
KOiK05414.
OMAiMTQQIFN.
OrthoDBiEOG7M98HV.
PhylomeDBiP01568.
TreeFamiTF336177.

Enzyme and pathway databases

ReactomeiREACT_24938. TRAF6 mediated IRF7 activation.
REACT_24970. Factors involved in megakaryocyte development and platelet production.
REACT_25162. Interferon alpha/beta signaling.
REACT_25216. Regulation of IFNA signaling.

Miscellaneous databases

GeneWikiiIFNA21.
GenomeRNAii3452.
NextBioi13600.
PROiP01568.
SOURCEiSearch...

Gene expression databases

BgeeiP01568.
CleanExiHS_IFNA21.
ExpressionAtlasiP01568. baseline.
GenevestigatoriP01568.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The structure of eight distinct cloned human leukocyte interferon cDNAs."
    Goeddel D.V., Leung D.W., Dull T.J., Gross M., Lawn R.M., McCandliss R., Seeburg P.H., Ullrich A., Yelverton E., Gray P.W.
    Nature 290:20-26(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT MET-119.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Novel human leukocyte interferon subtype and structural comparison of alpha interferon genes."
    Gren E., Berzin V.M., Jansone I., Tsimanis A., Vishnevsky Y., Apsalons U.
    J. Interferon Res. 4:609-617(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "Anomalous behavior of human leukocyte interferon subtypes on polyacrylamide gel electrophoresis in the presence of dodecyl sulfate."
    Ohara O., Teraoka H.
    FEBS Lett. 211:78-82(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-189.
    Tissue: Lymphoblast.
  8. "Purification and characterization of multiple components of human lymphoblastoid interferon-alpha."
    Zoon K.C., Miller D., Bekisz J., zur Nedden D., Enterline J.C., Nguyen N.Y., Hu R.-Q.
    J. Biol. Chem. 267:15210-15216(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-62, FUNCTION.
  9. "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes."
    Nyman T.A., Toeloe H., Parkkinen J., Kalkkinen N.
    Biochem. J. 329:295-302(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-58.
  10. "Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in the genome of a large human population."
    Hussain M., Gill D.S., Liao M.-J.
    J. Interferon Cytokine Res. 16:853-859(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: ABSENCE OF POLYMORPHISM.

Entry informationi

Entry nameiIFN21_HUMAN
AccessioniPrimary (citable) accession number: P01568
Secondary accession number(s): Q14608, Q5VWD1, Q7M4Q4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 16, 2002
Last modified: March 4, 2015
This is version 151 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.