P01568 (IFN21_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interferon alpha-21
Short name=IFN-alpha-21

Alternative name(s):
Interferon alpha-F
Short name=LeIF F

Gene names

Name:

IFNA21

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	189 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Ref.8
Subcellular location	Secreted.
Sequence similarities	Belongs to the alpha/beta interferon family.
Sequence caution	The sequence AAA36041.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Antiviral defense
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	blood coagulation Traceable author statement. Source: Reactome defense response to virus Inferred from electronic annotation. Source: UniProtKB-KW regulation of type I interferon-mediated signaling pathway Traceable author statement. Source: Reactome type I interferon-mediated signaling pathway Traceable author statement. Source: Reactome
Cellular_component	extracellular region Traceable author statement. Source: Reactome extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	cytokine receptor binding Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Ref.8 Ref.9
	Chain	24 – 189	166	Interferon alpha-21		PRO_0000016370
Amino acid modifications
	Disulfide bond	24 ↔ 122		By similarity
	Disulfide bond	52 ↔ 162		By similarity
Natural variations
	Natural variant	119	1	L → M. Ref.1 Corresponds to variant rs1053885 [ dbSNP | Ensembl ].		VAR_055325
	Natural variant	179	1	K → E. Corresponds to variant rs3750478 [ dbSNP | Ensembl ].		VAR_049638
Experimental info
	Sequence conflict	60	1	G → E AA sequence Ref.8

Sequences

	Sequence		Length	Mass (Da)
	P01568 [UniParc]. Last modified April 16, 2002. Version 2. Checksum: F0B6C9C392905802	FASTA	189	21,741
	10 20 30 40 50 60 MALSFSLLMA VLVLSYKSIC SLGCDLPQTH SLGNRRALIL LAQMGRISPF SCLKDRHDFG 70 80 90 100 110 120 FPQEEFDGNQ FQKAQAISVL HEMIQQTFNL FSTKDSSATW EQSLLEKFST ELNQQLNDLE 130 140 150 160 170 180 ACVIQEVGVE ETPLMNVDSI LAVKKYFQRI TLYLTEKKYS PCAWEVVRAE IMRSFSLSKI FQERLRRKE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The structure of eight distinct cloned human leukocyte interferon cDNAs." Goeddel D.V., Leung D.W., Dull T.J., Gross M., Lawn R.M., McCandliss R., Seeburg P.H., Ullrich A., Yelverton E., Gray P.W. Nature 290:20-26(1981) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT MET-119.
[2]	"A new type of leukocytic interferon." Gren E.Y., Berzin V.M., Tsimanis A.Y., Apsalon U.R., Vishnevskii Y.I., Yansone I.V., Dishler A.V., Pudova N.V., Smorodintsev A.A., Iovlev V.I., Stepanov A.N., Feldmane G.Y., Meldrais Y.A., Lozha V.P., Kavsan V.M., Efimov V.A., Sverdlov E.D. Dokl. Biochem. 269:91-95(1983) Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Novel human leukocyte interferon subtype and structural comparison of alpha interferon genes." Gren E., Berzin V.M., Jansone I., Tsimanis A., Vishnevsky Y., Apsalons U. J. Interferon Res. 4:609-617(1984) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]	"Anomalous behavior of human leukocyte interferon subtypes on polyacrylamide gel electrophoresis in the presence of dodecyl sulfate." Ohara O., Teraoka H. FEBS Lett. 211:78-82(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-189. Tissue: Lymphoblast.
[8]	"Purification and characterization of multiple components of human lymphoblastoid interferon-alpha." Zoon K.C., Miller D., Bekisz J., zur Nedden D., Enterline J.C., Nguyen N.Y., Hu R.-Q. J. Biol. Chem. 267:15210-15216(1992) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 24-62, FUNCTION.
[9]	"Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes." Nyman T.A., Toeloe H., Parkkinen J., Kalkkinen N. Biochem. J. 329:295-302(1998) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 24-58.
[10]	"Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in the genome of a large human population." Hussain M., Gill D.S., Liao M.-J. J. Interferon Cytokine Res. 16:853-859(1996) [PubMed] [Europe PMC] [Abstract] Cited for: ABSENCE OF POLYMORPHISM.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	V00540 mRNA. Translation: CAA23801.1. M12350 mRNA. Translation: AAA52718.1. X00145 mRNA. Translation: CAA24980.1. M28586 mRNA. Translation: AAA36041.1. Different initiation. AL390882 Genomic DNA. Translation: CAH70157.1. CH471071 Genomic DNA. Translation: EAW58623.1. BC069329 mRNA. Translation: AAH69329.1. BC069372 mRNA. Translation: AAH69372.1. BC069408 mRNA. Translation: AAH69408.1. BC096699 mRNA. Translation: AAH96699.1. BC101638 mRNA. Translation: AAI01639.1. BC101640 mRNA. Translation: AAI01641.1.
IPI	IPI00307189.
PIR	IVHUF. A01832. D42753. E25843. I56313. I84464.
RefSeq	NP_002166.2. NM_002175.2.
UniGene	Hs.113211.
3D structure databases
ProteinModelPortal	P01568.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000369574.
Polymorphism databases
DMDM	20178289.
Proteomic databases
PaxDb	P01568.
Protocols and materials databases
DNASU	3452.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000380225; ENSP00000369574; ENSG00000137080.
GeneID	3452.
KEGG	hsa:3452.
UCSC	uc003zom.2. human.
Organism-specific databases
CTD	3452.
GeneCards	GC09M021165.
HGNC	HGNC:5424. IFNA21.
HPA	HPA047557.
MIM	147584. gene.
neXtProt	NX_P01568.
PharmGKB	PA29663.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG119628.
HOGENOM	HOG000230500.
HOVERGEN	HBG052086.
InParanoid	P01568.
KO	K05414.
OMA	MTQQIFN.
OrthoDB	EOG4DV5P6.
PhylomeDB	P01568.
Enzyme and pathway databases
Pathway_Interaction_DB	cd8tcrdownstreampathway. Downstream signaling in naive CD8+ T cells.
Reactome	REACT_604. Hemostasis. REACT_6900. Immune System.
Gene expression databases
ArrayExpress	P01568.
Bgee	P01568.
CleanEx	HS_IFNA21.
Genevestigator	P01568.
GermOnline	ENSG00000137080. Homo sapiens.
Family and domain databases
Gene3D	1.20.1250.10. 1 hit.
InterPro	IPR009079. 4_helix_cytokine-like_core. IPR012351. 4_helix_cytokine_core. IPR015589. Interferon_alpha. IPR000471. Interferon_alpha/beta/delta. [Graphical view]
PANTHER	PTHR11691. PTHR11691. 1 hit. PTHR11691:SF9. PTHR11691:SF9. 1 hit.
Pfam	PF00143. Interferon. 1 hit. [Graphical view]
PRINTS	PR00266. INTERFERONAB.
SMART	SM00076. IFabd. 1 hit. [Graphical view]
SUPFAM	SSF47266. 4_helix_cytokine. 1 hit.
PROSITE	PS00252. INTERFERON_A_B_D. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	3452.
NextBio	13600.
SOURCE	Search...

Entry information

Entry name

IFN21_HUMAN

Accession

Primary (citable) accession number: P01568
Secondary accession number(s): Q14608, Q5VWD1, Q7M4Q4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	April 16, 2002
Last modified:	May 1, 2013
This is version 134 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.