ID   IFNA7_HUMAN             Reviewed;         189 AA.
AC   P01567; Q14607; Q5VV14;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   24-JAN-2024, entry version 192.
DE   RecName: Full=Interferon alpha-7;
DE            Short=IFN-alpha-7;
DE   AltName: Full=Interferon alpha-J;
DE            Short=LeIF J;
DE   AltName: Full=Interferon alpha-J1;
DE            Short=IFN-alpha-J1;
DE   Flags: Precursor;
GN   Name=IFNA7;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6181262; DOI=10.1016/0022-2836(82)90261-3;
RA   Ullrich A., Gray A., Goeddel D.V., Dull T.J.;
RT   "Nucleotide sequence of a portion of human chromosome 9 containing a
RT   leukocyte interferon gene cluster.";
RL   J. Mol. Biol. 156:467-486(1982).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=4057246; DOI=10.1016/0022-2836(85)90401-2;
RA   Henco K., Brosius J., Fujisawa A., Fujisawa J., Haynes J.R., Hochstadt J.,
RA   Kovacic T., Pasek M., Schamboeck A., Schmid J., Todokoro K., Waelchli M.,
RA   Nagata S., Weissmann C.;
RT   "Structural relationship of human interferon alpha genes and pseudogenes.";
RL   J. Mol. Biol. 185:227-260(1985).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2995168;
RA   Cohen S., Velan B., Grosfeld H., Shalita Z., Leitner M., Shafferman A.;
RT   "Cloning, expression and biological activity of a new variant of human
RT   interferon alpha identified in virus induced lymphoblastoid cells.";
RL   Dev. Biol. Stand. 60:111-122(1985).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   PROTEIN SEQUENCE OF 24-57.
RX   PubMed=9425112; DOI=10.1042/bj3290295;
RA   Nyman T.A., Toeloe H., Parkkinen J., Kalkkinen N.;
RT   "Identification of nine interferon-alpha subtypes produced by Sendai virus-
RT   induced human peripheral blood leucocytes.";
RL   Biochem. J. 329:295-302(1998).
RN   [8]
RP   ABSENCE OF POLYMORPHISM.
RX   PubMed=8910771; DOI=10.1089/jir.1996.16.853;
RA   Hussain M., Gill D.S., Liao M.-J.;
RT   "Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in
RT   the genome of a large human population.";
RL   J. Interferon Cytokine Res. 16:853-859(1996).
CC   -!- FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities.
CC       Interferon stimulates the production of two enzymes: a protein kinase
CC       and an oligoadenylate synthetase.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}.
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DR   EMBL; V00531; CAA23792.1; -; Genomic_DNA.
DR   EMBL; X02960; CAA26706.1; -; Genomic_DNA.
DR   EMBL; M34913; AAA36039.1; -; mRNA.
DR   EMBL; AL512606; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471071; EAW58620.1; -; Genomic_DNA.
DR   EMBL; BC074991; AAH74991.1; -; mRNA.
DR   EMBL; BC074992; AAH74992.1; -; mRNA.
DR   EMBL; BC113994; AAI13995.1; -; mRNA.
DR   EMBL; BC114000; AAI14001.1; -; mRNA.
DR   CCDS; CCDS34995.1; -.
DR   PIR; A01831; IVHUA0.
DR   PIR; F25843; F25843.
DR   PIR; I53102; I53102.
DR   RefSeq; NP_066401.2; NM_021057.2.
DR   AlphaFoldDB; P01567; -.
DR   SMR; P01567; -.
DR   BioGRID; 109667; 10.
DR   ComplexPortal; CPX-5997; Interferon alpha receptor-ligand complex, IFNA7 variant.
DR   IntAct; P01567; 1.
DR   STRING; 9606.ENSP00000239347; -.
DR   ChEMBL; CHEMBL3856161; -.
DR   iPTMnet; P01567; -.
DR   PhosphoSitePlus; P01567; -.
DR   BioMuta; IFNA7; -.
DR   DMDM; 124442; -.
DR   MassIVE; P01567; -.
DR   PaxDb; 9606-ENSP00000239347; -.
DR   PeptideAtlas; P01567; -.
DR   ABCD; P01567; 3 sequenced antibodies.
DR   Antibodypedia; 24856; 115 antibodies from 21 providers.
DR   DNASU; 3444; -.
DR   Ensembl; ENST00000239347.3; ENSP00000239347.3; ENSG00000214042.1.
DR   GeneID; 3444; -.
DR   KEGG; hsa:3444; -.
DR   MANE-Select; ENST00000239347.3; ENSP00000239347.3; NM_021057.2; NP_066401.2.
DR   UCSC; uc003zop.1; human.
DR   AGR; HGNC:5428; -.
DR   CTD; 3444; -.
DR   DisGeNET; 3444; -.
DR   GeneCards; IFNA7; -.
DR   HGNC; HGNC:5428; IFNA7.
DR   HPA; ENSG00000214042; Not detected.
DR   MIM; 147567; gene.
DR   neXtProt; NX_P01567; -.
DR   OpenTargets; ENSG00000214042; -.
DR   PharmGKB; PA29667; -.
DR   VEuPathDB; HostDB:ENSG00000214042; -.
DR   eggNOG; ENOG502SQAC; Eukaryota.
DR   GeneTree; ENSGT01000000214430; -.
DR   HOGENOM; CLU_109427_0_0_1; -.
DR   InParanoid; P01567; -.
DR   OMA; RFPREEM; -.
DR   OrthoDB; 5358931at2759; -.
DR   PhylomeDB; P01567; -.
DR   TreeFam; TF336177; -.
DR   PathwayCommons; P01567; -.
DR   Reactome; R-HSA-909733; Interferon alpha/beta signaling.
DR   Reactome; R-HSA-912694; Regulation of IFNA/IFNB signaling.
DR   Reactome; R-HSA-933541; TRAF6 mediated IRF7 activation.
DR   Reactome; R-HSA-9705671; SARS-CoV-2 activates/modulates innate and adaptive immune responses.
DR   Reactome; R-HSA-983231; Factors involved in megakaryocyte development and platelet production.
DR   SignaLink; P01567; -.
DR   BioGRID-ORCS; 3444; 9 hits in 1069 CRISPR screens.
DR   GeneWiki; IFNA7; -.
DR   GenomeRNAi; 3444; -.
DR   Pharos; P01567; Tbio.
DR   PRO; PR:P01567; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; P01567; Protein.
DR   Bgee; ENSG00000214042; Expressed in pancreatic ductal cell and 4 other cell types or tissues.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central.
DR   GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR   GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
DR   GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
DR   GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
DR   GO; GO:0098586; P:cellular response to virus; NAS:ComplexPortal.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR   GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
DR   GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central.
DR   GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR   GO; GO:0009615; P:response to virus; TAS:ProtInc.
DR   GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
DR   GO; GO:0060337; P:type I interferon-mediated signaling pathway; NAS:ComplexPortal.
DR   CDD; cd00095; IFab; 1.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000471; Interferon_alpha/beta/delta.
DR   PANTHER; PTHR11691:SF69; INTERFERON ALPHA-7; 1.
DR   PANTHER; PTHR11691; TYPE I INTERFERON; 1.
DR   Pfam; PF00143; Interferon; 1.
DR   PRINTS; PR00266; INTERFERONAB.
DR   SMART; SM00076; IFabd; 1.
DR   SUPFAM; SSF47266; 4-helical cytokines; 1.
DR   PROSITE; PS00252; INTERFERON_A_B_D; 1.
DR   Genevisible; P01567; HS.
PE   1: Evidence at protein level;
KW   Antiviral defense; Cytokine; Direct protein sequencing; Disulfide bond;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000269|PubMed:9425112"
FT   CHAIN           24..189
FT                   /note="Interferon alpha-7"
FT                   /id="PRO_0000016364"
FT   DISULFID        24..122
FT                   /evidence="ECO:0000250"
FT   DISULFID        52..162
FT                   /evidence="ECO:0000250"
FT   CONFLICT        10
FT                   /note="V -> A (in Ref. 3; AAA36039)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        155
FT                   /note="M -> T (in Ref. 3; AAA36039)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   189 AA;  22107 MW;  9DF6F5C81E339A42 CRC64;
     MARSFSLLMV VLVLSYKSIC SLGCDLPQTH SLRNRRALIL LAQMGRISPF SCLKDRHEFR
     FPEEEFDGHQ FQKTQAISVL HEMIQQTFNL FSTEDSSAAW EQSLLEKFST ELYQQLNDLE
     ACVIQEVGVE ETPLMNEDFI LAVRKYFQRI TLYLMEKKYS PCAWEVVRAE IMRSFSFSTN
     LKKGLRRKD
//