Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interferon alpha-7

Gene

IFNA7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

GO - Molecular functioni

  1. cytokine activity Source: GO_Central
  2. type I interferon receptor binding Source: GO_Central

GO - Biological processi

  1. adaptive immune response Source: GO_Central
  2. B cell differentiation Source: GO_Central
  3. B cell proliferation Source: GO_Central
  4. blood coagulation Source: Reactome
  5. cell-cell signaling Source: ProtInc
  6. cytokine-mediated signaling pathway Source: GO_Central
  7. defense response to virus Source: UniProtKB-KW
  8. humoral immune response Source: GO_Central
  9. innate immune response Source: GO_Central
  10. natural killer cell activation involved in immune response Source: GO_Central
  11. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: GO_Central
  12. regulation of MHC class I biosynthetic process Source: GO_Central
  13. regulation of type I interferon-mediated signaling pathway Source: Reactome
  14. response to exogenous dsRNA Source: GO_Central
  15. response to virus Source: ProtInc
  16. T cell activation involved in immune response Source: GO_Central
  17. type I interferon signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense

Enzyme and pathway databases

ReactomeiREACT_24938. TRAF6 mediated IRF7 activation.
REACT_24970. Factors involved in megakaryocyte development and platelet production.
REACT_25162. Interferon alpha/beta signaling.
REACT_25216. Regulation of IFNA signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-7
Short name:
IFN-alpha-7
Alternative name(s):
Interferon alpha-J
Short name:
LeIF J
Interferon alpha-J1
Short name:
IFN-alpha-J1
Gene namesi
Name:IFNA7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:5428. IFNA7.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29667.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23231 PublicationAdd
BLAST
Chaini24 – 189166Interferon alpha-7PRO_0000016364Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 122By similarity
Disulfide bondi52 ↔ 162By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP01567.

PTM databases

PhosphoSiteiP01567.

Expressioni

Gene expression databases

BgeeiP01567.
CleanExiHS_IFNA7.
GenevestigatoriP01567.

Organism-specific databases

HPAiHPA047557.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000239347.

Structurei

3D structure databases

ProteinModelPortaliP01567.
SMRiP01567. Positions 24-189.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00760000119150.
HOGENOMiHOG000230500.
HOVERGENiHBG052086.
InParanoidiP01567.
KOiK05414.
OMAiAATWDES.
OrthoDBiEOG7M98HV.
PhylomeDBiP01567.
TreeFamiTF336177.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01567-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARSFSLLMV VLVLSYKSIC SLGCDLPQTH SLRNRRALIL LAQMGRISPF
60 70 80 90 100
SCLKDRHEFR FPEEEFDGHQ FQKTQAISVL HEMIQQTFNL FSTEDSSAAW
110 120 130 140 150
EQSLLEKFST ELYQQLNDLE ACVIQEVGVE ETPLMNEDFI LAVRKYFQRI
160 170 180
TLYLMEKKYS PCAWEVVRAE IMRSFSFSTN LKKGLRRKD
Length:189
Mass (Da):22,107
Last modified:July 20, 1986 - v1
Checksum:i9DF6F5C81E339A42
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 101V → A in AAA36039 (PubMed:2995168).Curated
Sequence conflicti155 – 1551M → T in AAA36039 (PubMed:2995168).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00531 Genomic DNA. Translation: CAA23792.1.
X02960 Genomic DNA. Translation: CAA26706.1.
M34913 mRNA. Translation: AAA36039.1.
AL512606 Genomic DNA. Translation: CAH71190.1.
CH471071 Genomic DNA. Translation: EAW58620.1.
BC074991 mRNA. Translation: AAH74991.1.
BC074992 mRNA. Translation: AAH74992.1.
BC113994 mRNA. Translation: AAI13995.1.
BC114000 mRNA. Translation: AAI14001.1.
CCDSiCCDS34995.1.
PIRiA01831. IVHUA0.
F25843.
I53102.
RefSeqiNP_066401.2. NM_021057.2.
UniGeneiHs.282274.

Genome annotation databases

EnsembliENST00000239347; ENSP00000239347; ENSG00000214042.
GeneIDi3444.
KEGGihsa:3444.
UCSCiuc003zop.1. human.

Polymorphism databases

DMDMi124442.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00531 Genomic DNA. Translation: CAA23792.1.
X02960 Genomic DNA. Translation: CAA26706.1.
M34913 mRNA. Translation: AAA36039.1.
AL512606 Genomic DNA. Translation: CAH71190.1.
CH471071 Genomic DNA. Translation: EAW58620.1.
BC074991 mRNA. Translation: AAH74991.1.
BC074992 mRNA. Translation: AAH74992.1.
BC113994 mRNA. Translation: AAI13995.1.
BC114000 mRNA. Translation: AAI14001.1.
CCDSiCCDS34995.1.
PIRiA01831. IVHUA0.
F25843.
I53102.
RefSeqiNP_066401.2. NM_021057.2.
UniGeneiHs.282274.

3D structure databases

ProteinModelPortaliP01567.
SMRiP01567. Positions 24-189.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000239347.

PTM databases

PhosphoSiteiP01567.

Polymorphism databases

DMDMi124442.

Proteomic databases

PRIDEiP01567.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000239347; ENSP00000239347; ENSG00000214042.
GeneIDi3444.
KEGGihsa:3444.
UCSCiuc003zop.1. human.

Organism-specific databases

CTDi3444.
GeneCardsiGC09M021251.
HGNCiHGNC:5428. IFNA7.
HPAiHPA047557.
MIMi147567. gene.
neXtProtiNX_P01567.
PharmGKBiPA29667.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119150.
HOGENOMiHOG000230500.
HOVERGENiHBG052086.
InParanoidiP01567.
KOiK05414.
OMAiAATWDES.
OrthoDBiEOG7M98HV.
PhylomeDBiP01567.
TreeFamiTF336177.

Enzyme and pathway databases

ReactomeiREACT_24938. TRAF6 mediated IRF7 activation.
REACT_24970. Factors involved in megakaryocyte development and platelet production.
REACT_25162. Interferon alpha/beta signaling.
REACT_25216. Regulation of IFNA signaling.

Miscellaneous databases

GeneWikiiIFNA7.
GenomeRNAii3444.
NextBioi13572.
PROiP01567.
SOURCEiSearch...

Gene expression databases

BgeeiP01567.
CleanExiHS_IFNA7.
GenevestigatoriP01567.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of a portion of human chromosome 9 containing a leukocyte interferon gene cluster."
    Ullrich A., Gray A., Goeddel D.V., Dull T.J.
    J. Mol. Biol. 156:467-486(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Cloning, expression and biological activity of a new variant of human interferon alpha identified in virus induced lymphoblastoid cells."
    Cohen S., Velan B., Grosfeld H., Shalita Z., Leitner M., Shafferman A.
    Dev. Biol. Stand. 60:111-122(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  7. "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes."
    Nyman T.A., Toeloe H., Parkkinen J., Kalkkinen N.
    Biochem. J. 329:295-302(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-57.
  8. "Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in the genome of a large human population."
    Hussain M., Gill D.S., Liao M.-J.
    J. Interferon Cytokine Res. 16:853-859(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: ABSENCE OF POLYMORPHISM.

Entry informationi

Entry nameiIFNA7_HUMAN
AccessioniPrimary (citable) accession number: P01567
Secondary accession number(s): Q14607, Q5VV14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 20, 1986
Last sequence update: July 20, 1986
Last modified: February 3, 2015
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.