ID   IFN10_HUMAN             Reviewed;         189 AA.
AC   P01566; Q5VV13;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   24-JAN-2024, entry version 191.
DE   RecName: Full=Interferon alpha-10;
DE            Short=IFN-alpha-10;
DE   AltName: Full=Interferon alpha-6L;
DE   AltName: Full=Interferon alpha-C;
DE            Short=LeIF C;
DE   Flags: Precursor;
GN   Name=IFNA10;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=6163083; DOI=10.1038/290020a0;
RA   Goeddel D.V., Leung D.W., Dull T.J., Gross M., Lawn R.M., McCandliss R.,
RA   Seeburg P.H., Ullrich A., Yelverton E., Gray P.W.;
RT   "The structure of eight distinct cloned human leukocyte interferon cDNAs.";
RL   Nature 290:20-26(1981).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2526839; DOI=10.1089/jir.1989.9.407;
RA   Bartholomew C., Windass J.D.;
RT   "Identification of a functional allele of a human interferon-alpha gene
RT   previously characterized as a pseudogene.";
RL   J. Interferon Res. 9:407-417(1989).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   PROTEIN SEQUENCE OF 24-53.
RX   PubMed=9425112; DOI=10.1042/bj3290295;
RA   Nyman T.A., Toeloe H., Parkkinen J., Kalkkinen N.;
RT   "Identification of nine interferon-alpha subtypes produced by Sendai virus-
RT   induced human peripheral blood leucocytes.";
RL   Biochem. J. 329:295-302(1998).
CC   -!- FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities.
CC       Interferon stimulates the production of two enzymes: a protein kinase
CC       and an oligoadenylate synthetase.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}.
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DR   EMBL; V00551; CAA23812.1; -; mRNA.
DR   EMBL; AL512606; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471071; EAW58619.1; -; Genomic_DNA.
DR   EMBL; BC069409; AAH69409.1; -; mRNA.
DR   EMBL; BC103972; AAI03973.1; -; mRNA.
DR   EMBL; BC103973; AAI03974.1; -; mRNA.
DR   CCDS; CCDS6499.1; -.
DR   PIR; A60937; IVHUA5.
DR   RefSeq; NP_002162.1; NM_002171.2.
DR   AlphaFoldDB; P01566; -.
DR   SMR; P01566; -.
DR   BioGRID; 109669; 6.
DR   ComplexPortal; CPX-6002; Interferon alpha receptor-ligand complex, IFNA10 variant.
DR   IntAct; P01566; 4.
DR   STRING; 9606.ENSP00000369566; -.
DR   ChEMBL; CHEMBL3856161; -.
DR   BioMuta; IFNA10; -.
DR   DMDM; 124453; -.
DR   jPOST; P01566; -.
DR   MassIVE; P01566; -.
DR   PaxDb; 9606-ENSP00000369566; -.
DR   PeptideAtlas; P01566; -.
DR   ABCD; P01566; 5 sequenced antibodies.
DR   Antibodypedia; 24857; 212 antibodies from 20 providers.
DR   DNASU; 3446; -.
DR   Ensembl; ENST00000357374.2; ENSP00000369566.1; ENSG00000186803.3.
DR   GeneID; 3446; -.
DR   KEGG; hsa:3446; -.
DR   MANE-Select; ENST00000357374.2; ENSP00000369566.1; NM_002171.2; NP_002162.1.
DR   UCSC; uc003zoq.1; human.
DR   AGR; HGNC:5418; -.
DR   CTD; 3446; -.
DR   DisGeNET; 3446; -.
DR   GeneCards; IFNA10; -.
DR   HGNC; HGNC:5418; IFNA10.
DR   HPA; ENSG00000186803; Not detected.
DR   MIM; 147577; gene.
DR   neXtProt; NX_P01566; -.
DR   OpenTargets; ENSG00000186803; -.
DR   PharmGKB; PA29657; -.
DR   VEuPathDB; HostDB:ENSG00000186803; -.
DR   eggNOG; ENOG502SQAC; Eukaryota.
DR   GeneTree; ENSGT01000000214430; -.
DR   HOGENOM; CLU_109427_0_0_1; -.
DR   InParanoid; P01566; -.
DR   OMA; RKYSPCA; -.
DR   OrthoDB; 5358931at2759; -.
DR   PhylomeDB; P01566; -.
DR   TreeFam; TF336177; -.
DR   PathwayCommons; P01566; -.
DR   Reactome; R-HSA-909733; Interferon alpha/beta signaling.
DR   Reactome; R-HSA-912694; Regulation of IFNA/IFNB signaling.
DR   Reactome; R-HSA-933541; TRAF6 mediated IRF7 activation.
DR   Reactome; R-HSA-9705671; SARS-CoV-2 activates/modulates innate and adaptive immune responses.
DR   Reactome; R-HSA-983231; Factors involved in megakaryocyte development and platelet production.
DR   SignaLink; P01566; -.
DR   SIGNOR; P01566; -.
DR   BioGRID-ORCS; 3446; 10 hits in 1031 CRISPR screens.
DR   GeneWiki; IFNA10; -.
DR   GenomeRNAi; 3446; -.
DR   Pharos; P01566; Tbio.
DR   PRO; PR:P01566; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; P01566; Protein.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR   GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central.
DR   GO; GO:0002250; P:adaptive immune response; IBA:GO_Central.
DR   GO; GO:0030183; P:B cell differentiation; IBA:GO_Central.
DR   GO; GO:0042100; P:B cell proliferation; IBA:GO_Central.
DR   GO; GO:0098586; P:cellular response to virus; NAS:ComplexPortal.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0006959; P:humoral immune response; IBA:GO_Central.
DR   GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central.
DR   GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central.
DR   GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central.
DR   GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central.
DR   GO; GO:0060337; P:type I interferon-mediated signaling pathway; NAS:ComplexPortal.
DR   CDD; cd00095; IFab; 1.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR000471; Interferon_alpha/beta/delta.
DR   PANTHER; PTHR11691:SF66; INTERFERON ALPHA-10-RELATED; 1.
DR   PANTHER; PTHR11691; TYPE I INTERFERON; 1.
DR   Pfam; PF00143; Interferon; 1.
DR   PRINTS; PR00266; INTERFERONAB.
DR   SMART; SM00076; IFabd; 1.
DR   SUPFAM; SSF47266; 4-helical cytokines; 1.
DR   PROSITE; PS00252; INTERFERON_A_B_D; 1.
DR   Genevisible; P01566; HS.
PE   1: Evidence at protein level;
KW   Antiviral defense; Cytokine; Direct protein sequencing; Disulfide bond;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000269|PubMed:9425112"
FT   CHAIN           24..189
FT                   /note="Interferon alpha-10"
FT                   /id="PRO_0000016366"
FT   DISULFID        24..122
FT                   /evidence="ECO:0000250"
FT   DISULFID        52..162
FT                   /evidence="ECO:0000250"
FT   VARIANT         42
FT                   /note="G -> A (in dbSNP:rs2230853)"
FT                   /id="VAR_029227"
SQ   SEQUENCE   189 AA;  21835 MW;  CEC680996FDA706B CRC64;
     MALSFSLLMA VLVLSYKSIC SLGCDLPQTH SLGNRRALIL LGQMGRISPF SCLKDRHDFR
     IPQEEFDGNQ FQKAQAISVL HEMIQQTFNL FSTEDSSAAW EQSLLEKFST ELYQQLNDLE
     ACVIQEVGVE ETPLMNEDSI LAVRKYFQRI TLYLIERKYS PCAWEVVRAE IMRSLSFSTN
     LQKRLRRKD
//