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Protein

Interferon alpha-10

Gene

IFNA10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense

Enzyme and pathway databases

ReactomeiR-HSA-909733 Interferon alpha/beta signaling
R-HSA-912694 Regulation of IFNA signaling
R-HSA-933541 TRAF6 mediated IRF7 activation
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
SIGNORiP01566

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-10
Short name:
IFN-alpha-10
Alternative name(s):
Interferon alpha-6L
Interferon alpha-C
Short name:
LeIF C
Gene namesi
Name:IFNA10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000186803.3
HGNCiHGNC:5418 IFNA10
MIMi147577 gene
neXtProtiNX_P01566

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3446
OpenTargetsiENSG00000186803
PharmGKBiPA29657

Polymorphism and mutation databases

BioMutaiIFNA10
DMDMi124453

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000001636624 – 189Interferon alpha-10Add BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 122By similarity
Disulfide bondi52 ↔ 162By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP01566
PeptideAtlasiP01566
PRIDEiP01566
ProteomicsDBi51382

Expressioni

Gene expression databases

BgeeiENSG00000186803
CleanExiHS_IFNA10
GenevisibleiP01566 HS

Organism-specific databases

HPAiHPA047557

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109669, 3 interactors
STRINGi9606.ENSP00000369566

Structurei

3D structure databases

ProteinModelPortaliP01566
SMRiP01566
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J735 Eukaryota
ENOG410ZH91 LUCA
GeneTreeiENSGT00760000119150
HOGENOMiHOG000230500
HOVERGENiHBG052086
InParanoidiP01566
KOiK05414
OMAiHDFAFPQ
OrthoDBiEOG091G0PSY
PhylomeDBiP01566
TreeFamiTF336177

Family and domain databases

CDDicd00095 IFab, 1 hit
InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000471 Interferon_alpha/beta/delta
PANTHERiPTHR11691 PTHR11691, 1 hit
PfamiView protein in Pfam
PF00143 Interferon, 1 hit
PRINTSiPR00266 INTERFERONAB
SMARTiView protein in SMART
SM00076 IFabd, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00252 INTERFERON_A_B_D, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01566-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSFSLLMA VLVLSYKSIC SLGCDLPQTH SLGNRRALIL LGQMGRISPF
60 70 80 90 100
SCLKDRHDFR IPQEEFDGNQ FQKAQAISVL HEMIQQTFNL FSTEDSSAAW
110 120 130 140 150
EQSLLEKFST ELYQQLNDLE ACVIQEVGVE ETPLMNEDSI LAVRKYFQRI
160 170 180
TLYLIERKYS PCAWEVVRAE IMRSLSFSTN LQKRLRRKD
Length:189
Mass (Da):21,835
Last modified:July 21, 1986 - v1
Checksum:iCEC680996FDA706B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02922742G → A. Corresponds to variant dbSNP:rs2230853Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00551 mRNA Translation: CAA23812.1
AL512606 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58619.1
BC069409 mRNA Translation: AAH69409.1
BC103972 mRNA Translation: AAI03973.1
BC103973 mRNA Translation: AAI03974.1
CCDSiCCDS6499.1
PIRiA60937 IVHUA5
RefSeqiNP_002162.1, NM_002171.2
UniGeneiHs.282275

Genome annotation databases

EnsembliENST00000357374; ENSP00000369566; ENSG00000186803
GeneIDi3446
KEGGihsa:3446
UCSCiuc003zoq.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIFN10_HUMAN
AccessioniPrimary (citable) accession number: P01566
Secondary accession number(s): Q5VV13
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: June 20, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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