P01563H2DF54H2DF55P01564Q14606Q6DJX8Q96KI6IFNA2_HUMANInterferon alpha-2IFN-alpha-2Interferon alpha-ALeIF AIFNA2IFNA2AIFNA2BIFNA2CHomo sapiensHumanEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomoHuman leukocyte interferon produced by E. coli is biologically active.NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ALLELES ALPHA-2A AND ALPHA-2B)SUBCELLULAR LOCATIONFUNCTIONThe structure of eight distinct cloned human leukocyte interferon cDNAs.NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ALLELES ALPHA-2A AND ALPHA-2B)DNA sequence of a major human leukocyte interferon gene.NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ALLELE ALPHA-2B)Cloning of human leukocyte interferon cDNA and a strategy for its production in E. coli.NUCLEOTIDE SEQUENCE [MRNA] (ALLELES ALPHA-2A AND ALPHA-2B)A defective retroviral vector encoding human interferon alpha 2 can transduce human leukemic cell lines.NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE ALPHA-2B)Heterologous expression, immunochemical and computational analysis of recombinant human interferon alpha 2b.NUCLEOTIDE SEQUENCE [MRNA] (ALLELE ALPHA-2B)NUCLEOTIDE SEQUENCE [MRNA] (ALLELE ALPHA-2B)Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE ALPHA-2B)DNA sequence and analysis of human chromosome 9.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE ALPHA-2B)At least three human type alpha interferons: structure of alpha 2.NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 7-188 (ALLELE ALPHA-2B)Formation of genes coding for hybrid proteins by recombination between related, cloned genes in E. coli.NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-188A family of structural genes for human lymphoblastoid (leukocyte-type) interferon.PROTEIN SEQUENCE OF 24-112 AND 136-188Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes.PROTEIN SEQUENCE OF 24-58Assignment of the disulphide bonds of leukocyte interferon.DISULFIDE BONDSNatural human interferon-alpha 2 is O-glycosylated.GLYCOSYLATION AT THR-129ALLELES ALPHA-2B AND ALPHA-2CInterferon-alpha 2 variants in the human genome.POLYMORPHISMA homology model of human interferon alpha-2.3D-STRUCTURE MODELINGZinc mediated dimer of human interferon-alpha 2b revealed by X-ray crystallography.X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS)The three-dimensional high resolution structure of human interferon alpha-2a determined by heteronuclear NMR spectroscopy in solution.STRUCTURE BY NMRDetermination of the human type I interferon receptor binding site on human interferon-alpha2 by cross saturation and an NMR-based model of the complex.STRUCTURE BY NMR OF 24-188 IN COMPLEX WITH IFNAR2SUBUNITDISULFIDE BONDSIntermolecular interactions in a 44 kDa interferon-receptor complex detected by asymmetric reverse-protonation and two-dimensional NOESY.STRUCTURE BY NMR OF 24-188 IN COMPLEX WITH IFNAR2SUBUNITDISULFIDE BONDSThe consensus coding sequences of human breast and colorectal cancers.VARIANT [LARGE SCALE ANALYSIS] LEU-177Produced by macrophages, IFN-alpha have antiviral activities.Interacts with IFNAR2.P01563P48551false2P01563Q9NPL8false3SecretedThree alleles exist; alpha-2A, alpha-2B (shown here) and alpha-2C (PubMed:7627809). Allele alpha-2B is the predominant allele while allele alpha-2A is less predominant and alpha-2C only a minor allelic variant.Available under the names Roferon-A (Roche) or Intron-A (Schering-Plough). Used as an anticancer drug for its antiproliferative activity.Belongs to the alpha/beta interferon family.3D-structureAntiviral defenseCytokineDirect protein sequencingDisulfide bondGlycoproteinPharmaceuticalReference proteomeSecretedSignalADRKHRSLQLKMMALTFALLVALLVLSCKSSCSVGCDLPQTHSLGSRRTLMLLAQMRRISLFSCLKDRHDFGFPQEEFGNQFQKAETIPVLHEMIQQIFNLFSTKDSSAAWDETLLDKFYTELYQQLNDLEACVIQGVGVTETPLMKEDSILAVRKYFQRITLYLKEKKYSPCAWEVVRAEIMRSFSLSTNLQESLRSKE
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