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Protein

Interferon alpha-2

Gene

IFNA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Produced by macrophages, IFN-alpha have antiviral activities.

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • type I interferon receptor binding Source: ProtInc

GO - Biological processi

  • apoptotic process Source: ProtInc
  • B cell differentiation Source: GO_Central
  • B cell proliferation Source: GO_Central
  • blood coagulation Source: Reactome
  • cell-cell signaling Source: ProtInc
  • cell surface receptor signaling pathway Source: ProtInc
  • cytokine-mediated signaling pathway Source: GO_Central
  • defense response to virus Source: BHF-UCL
  • humoral immune response Source: GO_Central
  • inflammatory response Source: ProtInc
  • innate immune response Source: GO_Central
  • natural killer cell activation involved in immune response Source: GO_Central
  • negative regulation of gene expression Source: UniProtKB
  • negative regulation of interleukin-13 secretion Source: UniProtKB
  • negative regulation of interleukin-5 secretion Source: UniProtKB
  • negative regulation of T cell differentiation Source: UniProtKB
  • negative regulation of T-helper 2 cell cytokine production Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of viral entry into host cell Source: BHF-UCL
  • positive regulation of peptidyl-serine phosphorylation of STAT protein Source: GO_Central
  • positive regulation of phosphorylation Source: AgBase
  • positive regulation of transcription, DNA-templated Source: AgBase
  • positive regulation of tyrosine phosphorylation of STAT protein Source: BHF-UCL
  • regulation of type I interferon-mediated signaling pathway Source: Reactome
  • response to exogenous dsRNA Source: GO_Central
  • T cell activation involved in immune response Source: GO_Central
  • type I interferon signaling pathway Source: Reactome

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense

Enzyme and pathway databases

ReactomeiR-HSA-909733 Interferon alpha/beta signaling
R-HSA-912694 Regulation of IFNA signaling
R-HSA-933541 TRAF6 mediated IRF7 activation
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
SIGNORiP01563

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-2
Short name:
IFN-alpha-2
Alternative name(s):
Interferon alpha-A
Short name:
LeIF A
Gene namesi
Name:IFNA2
Synonyms:IFNA2A, IFNA2B, IFNA2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000188379.6
HGNCiHGNC:5423 IFNA2
MIMi147562 gene
neXtProtiNX_P01563

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Pharmaceutical usei

Available under the names Roferon-A (Roche) or Intron-A (Schering-Plough). Used as an anticancer drug for its antiproliferative activity.

Organism-specific databases

DisGeNETi3440
PharmGKBiPA29662

Protein family/group databases

Allergomei9876 Hom s IFN alpha

Polymorphism and mutation databases

BioMutaiIFNA2
DMDMi124449

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 232 PublicationsAdd BLAST23
ChainiPRO_000001636024 – 188Interferon alpha-2Add BLAST165

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 1211 Publication
Disulfide bondi52 ↔ 1611 Publication
GlycosylationiCAR_000049129O-linked (GalNAc...) threonine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP01563
PeptideAtlasiP01563
PRIDEiP01563

PTM databases

GlyConnecti289
290
iPTMnetiP01563
PhosphoSitePlusiP01563
UniCarbKBiP01563

Expressioni

Gene expression databases

BgeeiENSG00000188379
CleanExiHS_IFNA2
GenevisibleiP01563 HS

Organism-specific databases

HPAiHPA047557

Interactioni

Subunit structurei

Interacts with IFNAR2.2 Publications

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • type I interferon receptor binding Source: ProtInc

Protein-protein interaction databases

BioGridi1096638 interactors.
DIPiDIP-481N
IntActiP01563 1 interactor.
STRINGi9606.ENSP00000369554

Structurei

Secondary structure

1188
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi27 – 30Combined sources4
Helixi32 – 44Combined sources13
Helixi50 – 55Combined sources6
Helixi63 – 65Combined sources3
Beta strandi66 – 70Combined sources5
Turni72 – 74Combined sources3
Helixi76 – 89Combined sources14
Helixi93 – 98Combined sources6
Helixi101 – 120Combined sources20
Beta strandi126 – 129Combined sources4
Turni132 – 135Combined sources4
Helixi138 – 155Combined sources18
Turni156 – 158Combined sources3
Helixi160 – 177Combined sources18
Beta strandi180 – 182Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ITFNMR-A24-188[»]
1RH2X-ray2.90A/B/C/D/E/F24-188[»]
2HIEmodel-A24-188[»]
2HYMNMR-B24-188[»]
2KZ1NMR-A24-188[»]
2LAGNMR-A24-188[»]
2LMSNMR-A24-188[»]
3S9DX-ray2.00A/C24-188[»]
3SE3X-ray4.00B24-188[»]
4YPGX-ray3.00C/D24-182[»]
4Z5RX-ray3.00D/E/F/G/H/I/N/X24-188[»]
ProteinModelPortaliP01563
SMRiP01563
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01563

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J735 Eukaryota
ENOG410ZH91 LUCA
HOGENOMiHOG000230500
HOVERGENiHBG052086
InParanoidiP01563
KOiK05414
OrthoDBiEOG091G0MJ6
PhylomeDBiP01563
TreeFamiTF336177

Family and domain databases

CDDicd00095 IFab, 1 hit
InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000471 Interferon_alpha/beta/delta
PANTHERiPTHR11691 PTHR11691, 1 hit
PfamiView protein in Pfam
PF00143 Interferon, 1 hit
PRINTSiPR00266 INTERFERONAB
SMARTiView protein in SMART
SM00076 IFabd, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00252 INTERFERON_A_B_D, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01563-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALTFALLVA LLVLSCKSSC SVGCDLPQTH SLGSRRTLML LAQMRKISLF
60 70 80 90 100
SCLKDRHDFG FPQEEFGNQF QKAETIPVLH EMIQQIFNLF STKDSSAAWD
110 120 130 140 150
ETLLDKFYTE LYQQLNDLEA CVIQGVGVTE TPLMKEDSIL AVRKYFQRIT
160 170 180
LYLKEKKYSP CAWEVVRAEI MRSFSLSTNL QESLRSKE
Length:188
Mass (Da):21,550
Last modified:July 21, 1986 - v1
Checksum:i101DD21D394CBF97
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti85Q → L in AEX60803 (PubMed:23875128).Curated1
Sequence conflicti93K → M in AEX60802 (PubMed:23875128).Curated1

Polymorphismi

Three forms exist; alpha-2a (shown here), alpha-2b and alpha-2c (PubMed:7627809).1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0559726A → D. Corresponds to variant dbSNP:rs35971916Ensembl.1
Natural variantiVAR_00401246K → R in alpha-2B and alpha-2C. 1 PublicationCorresponds to variant dbSNP:rs1061959Ensembl.1
Natural variantiVAR_01300157H → R in alpha-2C. 1
Natural variantiVAR_036329177S → L in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00207 Genomic DNA Translation: AAB59402.1
V00544 mRNA Translation: CAA23805.1
V00548 mRNA Translation: CAA23809.1
V00549 mRNA Translation: CAA23810.1
Y11834 Genomic DNA Translation: CAA72532.1
JN591568 mRNA Translation: AEX60802.1
JN591569 mRNA Translation: AEX60803.1
JN591570 mRNA Translation: AEX60804.1
JN848522 mRNA Translation: AET86951.1
CR541921 mRNA Translation: CAG46719.1
CH471071 Genomic DNA Translation: EAW58611.1
BC074936 mRNA Translation: AAH74936.1
BC074937 mRNA Translation: AAH74937.1
BC104163 mRNA Translation: AAI04164.1
BC104164 mRNA Translation: AAI04165.1
M54886 mRNA Translation: AAA59181.1
M29883 Genomic DNA Translation: AAA52715.1
CCDSiCCDS6506.1
PIRiA93234 IVHUA2
I78570
RefSeqiNP_000596.2, NM_000605.3
UniGeneiHs.211575

Genome annotation databases

EnsembliENST00000380206; ENSP00000369554; ENSG00000188379
GeneIDi3440
KEGGihsa:3440
UCSCiuc003zpb.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIFNA2_HUMAN
AccessioniPrimary (citable) accession number: P01563
Secondary accession number(s): H2DF54
, H2DF55, P01564, Q14606, Q6DJX8, Q96KI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 25, 2018
This is version 177 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome