ID IFNA1_HUMAN Reviewed; 189 AA. AC P01562; D4Q9M8; Q14605; Q2M1L8; Q52LB8; Q5VYQ2; Q7M4Q1; Q8WZ68; AC Q9UMJ3; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 21-JUL-1986, sequence version 1. DT 14-DEC-2011, entry version 127. DE RecName: Full=Interferon alpha-1/13; DE Short=IFN-alpha-1/13; DE AltName: Full=Interferon alpha-D; DE Short=LeIF D; DE Flags: Precursor; GN Name=IFNA1; GN and GN Name=IFNA13; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=81005094; PubMed=6157600; DOI=10.1016/0378-1119(80)90137-7; RA Mantei N., Schwarzstein M., Streuli M., Panem S., Nagata S., RA Weissmann C.; RT "The nucleotide sequence of a cloned human leukocyte interferon RT cDNA."; RL Gene 10:1-10(1980). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=80254543; PubMed=6157095; DOI=10.1038/285547a0; RA Taniguchi T., Mantei N., Schwarzstein M., Nagata S., Muramatsu M., RA Weissmann C.; RT "Human leukocyte and fibroblast interferons are structurally RT related."; RL Nature 285:547-549(1980). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=81148795; PubMed=6163083; DOI=10.1038/290020a0; RA Goeddel D.V., Leung D.W., Dull T.J., Gross M., Lawn R.M., RA McCandliss R., Seeburg P.H., Ullrich A., Yelverton E., Gray P.W.; RT "The structure of eight distinct cloned human leukocyte interferon RT cDNAs."; RL Nature 290:20-26(1981). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85003592; PubMed=6479148; RA Todokoro K., Kioussis D., Weissmann C.; RT "Two non-allelic human interferon alpha genes with identical coding RT regions."; RL EMBO J. 3:1809-1812(1984). RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=86037205; PubMed=4057246; DOI=10.1016/0022-2836(85)90401-2; RA Henco K., Brosius J., Fujisawa A., Fujisawa J., Haynes J.R., RA Hochstadt J., Kovacic T., Pasek M., Schamboeck A., Schmid J., RA Todokoro K., Waelchli M., Nagata S., Weissmann C.; RT "Structural relationship of human interferon alpha genes and RT pseudogenes."; RL J. Mol. Biol. 185:227-260(1985). RN [6] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=85187974; PubMed=2985969; RA Capon D.J., Shepard H.M., Goeddel D.V.; RT "Two distinct families of human and bovine interferon-alpha genes are RT coordinately expressed and encode functional polypeptides."; RL Mol. Cell. Biol. 5:768-779(1985). RN [7] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=20857263; DOI=10.1007/s00795-010-0492-5; RA Kimura T., Hashimoto I., Nishizawa M., Ito S., Yamada H.; RT "Novel cis-active structures in the coding region mediate CRM1- RT dependent nuclear export of IFN-alpha 1 mRNA."; RL Med. Mol. Morphol. 43:145-157(2010). RN [8] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ALA-10. RA Rostoks N.; RL Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases. RN [9] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ALA-10; VAL-137 AND RP GLY-163. RG NIEHS SNPs program; RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases. RN [10] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164053; DOI=10.1038/nature02465; RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., RA Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., RA Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., RA Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R., RA Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., RA Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., RA Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., RA Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., RA Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., RA Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., RA Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., RA Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., RA Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., RA McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., RA Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., RA Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., RA Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., RA Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., RA Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., RA Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., RA Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., RA Rogers J., Dunham I.; RT "DNA sequence and analysis of human chromosome 9."; RL Nature 429:369-374(2004). RN [11] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [12] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-10. RC TISSUE=Cerebellum; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [13] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-189. RX MEDLINE=83299241; PubMed=6310510; DOI=10.1093/nar/11.16.5661; RA Weber H., Weissmann C.; RT "Formation of genes coding for hybrid proteins by recombination RT between related, cloned genes in E. coli."; RL Nucleic Acids Res. 11:5661-5669(1983). RN [14] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-189. RC TISSUE=Leukocyte; RA Chen H.H., Yu X.B.; RL Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases. RN [15] RP PROTEIN SEQUENCE OF 24-59, AND FUNCTION. RX MEDLINE=92340576; PubMed=1634550; RA Zoon K.C., Miller D., Bekisz J., zur Nedden D., Enterline J.C., RA Nguyen N.Y., Hu R.-Q.; RT "Purification and characterization of multiple components of human RT lymphoblastoid interferon-alpha."; RL J. Biol. Chem. 267:15210-15216(1992). RN [16] RP PROTEIN SEQUENCE OF 24-58. RX MEDLINE=98087498; PubMed=9425112; RA Nyman T.A., Toeloe H., Parkkinen J., Kalkkinen N.; RT "Identification of nine interferon-alpha subtypes produced by Sendai RT virus-induced human peripheral blood leucocytes."; RL Biochem. J. 329:295-302(1998). RN [17] RP POLYMORPHISM. RX MEDLINE=20485144; PubMed=11032395; DOI=10.1089/10799900050151021; RA Hussain M., Ni D., Gill D., Liao M.-J.; RT "IFN-alpha-1a gene is the major variant in the North American RT population."; RL J. Interferon Cytokine Res. 20:763-768(2000). RN [18] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-151, AND MASS RP SPECTROMETRY. RC TISSUE=Embryonic kidney; RX PubMed=19413330; DOI=10.1021/ac9004309; RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., RA Mohammed S.; RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in RT a refined SCX-based approach."; RL Anal. Chem. 81:4493-4501(2009). CC -!- FUNCTION: Produced by macrophages, IFN-alpha have antiviral CC activities. Interferon stimulates the production of two enzymes: a CC protein kinase and an oligoadenylate synthetase. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- POLYMORPHISM: Two forms exist; alpha-1a (shown here) and alpha-1b. CC -!- MISCELLANEOUS: Interferons alpha-1 and alpha-13 have identical CC protein sequences. CC -!- SIMILARITY: Belongs to the alpha/beta interferon family. CC -!- WEB RESOURCE: Name=NIEHS-SNPs; CC URL="http://egp.gs.washington.edu/data/ifna1/"; CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; V00537; CAA23798.1; -; mRNA. DR EMBL; J00210; AAB59403.1; -; Genomic_DNA. DR EMBL; V00538; CAA23799.1; -; mRNA. DR EMBL; X00803; CAA25381.1; -; Genomic_DNA. DR EMBL; X75934; CAA53538.1; -; Genomic_DNA. DR EMBL; AB445100; BAI99735.1; -; Genomic_DNA. DR EMBL; DQ185447; ABA03167.1; -; Genomic_DNA. DR EMBL; AL353732; CAH72904.1; -; Genomic_DNA. DR EMBL; AL353732; CAH72911.1; -; Genomic_DNA. DR EMBL; CH471071; EAW58609.1; -; Genomic_DNA. DR EMBL; BC069427; AAH69427.1; -; mRNA. DR EMBL; BC074928; AAH74928.1; -; mRNA. DR EMBL; BC074929; AAH74929.1; -; mRNA. DR EMBL; BC093988; AAH93988.1; -; mRNA. DR EMBL; BC112002; AAI12003.1; -; mRNA. DR EMBL; BC112300; AAI12301.1; -; mRNA. DR EMBL; BC112302; AAI12303.1; -; mRNA. DR EMBL; M29884; AAA52714.1; -; Genomic_DNA. DR EMBL; AF439447; AAL35223.1; -; Genomic_DNA. DR IPI; IPI00003072; -. DR PIR; C23285; IVHUA1. DR PIR; F42753; F42753. DR PIR; H42753; H42753. DR RefSeq; NP_008831.3; NM_006900.3. DR RefSeq; NP_076918.1; NM_024013.2. DR UniGene; Hs.37026; -. DR UniGene; Hs.533471; -. DR ProteinModelPortal; P01562; -. DR SMR; P01562; 24-189. DR DIP; DIP-6020N; -. DR STRING; P01562; -. DR PhosphoSite; P01562; -. DR DMDM; 124455; -. DR PRIDE; P01562; -. DR Ensembl; ENST00000276927; ENSP00000276927; ENSG00000197919. DR GeneID; 3439; -. DR GeneID; 3447; -. DR KEGG; hsa:3439; -. DR KEGG; hsa:3447; -. DR UCSC; uc003zpa.1; human. DR CTD; 3439; -. DR CTD; 3447; -. DR GeneCards; GC09M021357; -. DR GeneCards; GC09P021430; -. DR H-InvDB; HIX0034868; -. DR HGNC; HGNC:5417; IFNA1. DR HGNC; HGNC:5419; IFNA13. DR MIM; 147578; gene. DR MIM; 147660; gene. DR neXtProt; NX_P01562; -. DR PharmGKB; PA29658; -. DR eggNOG; prNOG19618; -. DR GeneTree; ENSGT00590000082966; -. DR HOVERGEN; HBG052086; -. DR InParanoid; P01562; -. DR OMA; DNRRTMM; -. DR OrthoDB; EOG4SF973; -. DR PhylomeDB; P01562; -. DR Pathway_Interaction_DB; cd8tcrdownstreampathway; Downstream signaling in naive CD8+ T cells. DR Reactome; REACT_604; Hemostasis. DR Reactome; REACT_6900; Immune System. DR NextBio; 13552; -. DR ArrayExpress; P01562; -. DR CleanEx; HS_IFNA1; -. DR CleanEx; HS_IFNA13; -. DR Genevestigator; P01562; -. DR GermOnline; ENSG00000197919; Homo sapiens. DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW. DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW. DR GO; GO:0005132; F:interferon-alpha/beta receptor binding; TAS:ProtInc. DR GO; GO:0007596; P:blood coagulation; TAS:Reactome. DR GO; GO:0060338; P:regulation of type I interferon-mediated signaling pathway; TAS:Reactome. DR GO; GO:0009615; P:response to virus; IEA:UniProtKB-KW. DR GO; GO:0060337; P:type I interferon-mediated signaling pathway; TAS:Reactome. DR InterPro; IPR009079; 4_helix_cytokine-like_core. DR InterPro; IPR012351; 4_helix_cytokine_core. DR InterPro; IPR015589; Interferon_alpha. DR InterPro; IPR000471; Interferon_alpha/beta/delta. DR Gene3D; G3DSA:1.20.1250.10; 4_helix_cytokine_core; 1. DR KO; K05414; -. DR PANTHER; PTHR11691:SF9; IFNa; 1. DR PANTHER; PTHR11691; Interferon_abd; 1. DR Pfam; PF00143; Interferon; 1. DR PRINTS; PR00266; INTERFERONAB. DR SMART; SM00076; IFabd; 1. DR SUPFAM; SSF47266; 4_helix_cytokine; 1. DR PROSITE; PS00252; INTERFERON_A_B_D; 1. PE 1: Evidence at protein level; KW Antiviral defense; Complete proteome; Cytokine; KW Direct protein sequencing; Disulfide bond; Phosphoprotein; KW Polymorphism; Reference proteome; Secreted; Signal. FT SIGNAL 1 23 FT CHAIN 24 189 Interferon alpha-1/13. FT /FTId=PRO_0000016359. FT MOD_RES 151 151 Phosphothreonine. FT DISULFID 24 122 By similarity. FT DISULFID 52 162 By similarity. FT VARIANT 10 10 V -> A (in dbSNP:rs1758567). FT /FTId=VAR_024508. FT VARIANT 137 137 A -> V (in alpha-1B; dbSNP:rs2230050). FT /FTId=VAR_013000. FT VARIANT 163 163 A -> G (in dbSNP:rs33965070). FT /FTId=VAR_025173. FT CONFLICT 116 116 L -> P (in Ref. 14; AAL35223). FT CONFLICT 172 172 M -> V (in Ref. 14; AAL35223). SQ SEQUENCE 189 AA; 21725 MW; F32F9CB969606B69 CRC64; MASPFALLMV LVVLSCKSSC SLGCDLPETH SLDNRRTLML LAQMSRISPS SCLMDRHDFG FPQEEFDGNQ FQKAPAISVL HELIQQIFNL FTTKDSSAAW DEDLLDKFCT ELYQQLNDLE ACVMQEERVG ETPLMNADSI LAVKKYFRRI TLYLTEKKYS PCAWEVVRAE IMRSLSLSTN LQERLRRKE //