ID IFNA1_HUMAN Reviewed; 189 AA. AC P01562; D4Q9M8; Q14605; Q2M1L8; Q52LB8; Q5VYQ2; Q7M4Q1; Q8WZ68; Q9UMJ3; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 21-JUL-1986, sequence version 1. DT 27-MAR-2024, entry version 216. DE RecName: Full=Interferon alpha-1/13; DE Short=IFN-alpha-1/13; DE AltName: Full=Interferon alpha-D; DE Short=LeIF D; DE Flags: Precursor; GN Name=IFNA1; GN and GN Name=IFNA13; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6157600; DOI=10.1016/0378-1119(80)90137-7; RA Mantei N., Schwarzstein M., Streuli M., Panem S., Nagata S., Weissmann C.; RT "The nucleotide sequence of a cloned human leukocyte interferon cDNA."; RL Gene 10:1-10(1980). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6157095; DOI=10.1038/285547a0; RA Taniguchi T., Mantei N., Schwarzstein M., Nagata S., Muramatsu M., RA Weissmann C.; RT "Human leukocyte and fibroblast interferons are structurally related."; RL Nature 285:547-549(1980). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6163083; DOI=10.1038/290020a0; RA Goeddel D.V., Leung D.W., Dull T.J., Gross M., Lawn R.M., McCandliss R., RA Seeburg P.H., Ullrich A., Yelverton E., Gray P.W.; RT "The structure of eight distinct cloned human leukocyte interferon cDNAs."; RL Nature 290:20-26(1981). RN [4] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6479148; DOI=10.1002/j.1460-2075.1984.tb02050.x; RA Todokoro K., Kioussis D., Weissmann C.; RT "Two non-allelic human interferon alpha genes with identical coding RT regions."; RL EMBO J. 3:1809-1812(1984). RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=4057246; DOI=10.1016/0022-2836(85)90401-2; RA Henco K., Brosius J., Fujisawa A., Fujisawa J., Haynes J.R., Hochstadt J., RA Kovacic T., Pasek M., Schamboeck A., Schmid J., Todokoro K., Waelchli M., RA Nagata S., Weissmann C.; RT "Structural relationship of human interferon alpha genes and pseudogenes."; RL J. Mol. Biol. 185:227-260(1985). RN [6] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=2985969; DOI=10.1128/mcb.5.4.768-779.1985; RA Capon D.J., Shepard H.M., Goeddel D.V.; RT "Two distinct families of human and bovine interferon-alpha genes are RT coordinately expressed and encode functional polypeptides."; RL Mol. Cell. Biol. 5:768-779(1985). RN [7] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=20857263; DOI=10.1007/s00795-010-0492-5; RA Kimura T., Hashimoto I., Nishizawa M., Ito S., Yamada H.; RT "Novel cis-active structures in the coding region mediate CRM1-dependent RT nuclear export of IFN-alpha 1 mRNA."; RL Med. Mol. Morphol. 43:145-157(2010). RN [8] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT ALA-10. RA Rostoks N.; RL Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases. RN [9] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ALA-10; VAL-137 AND RP GLY-163. RG NIEHS SNPs program; RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases. RN [10] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164053; DOI=10.1038/nature02465; RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., RA Dunham I.; RT "DNA sequence and analysis of human chromosome 9."; RL Nature 429:369-374(2004). RN [11] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [12] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-10. RC TISSUE=Cerebellum; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [13] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-189. RX PubMed=6310510; DOI=10.1093/nar/11.16.5661; RA Weber H., Weissmann C.; RT "Formation of genes coding for hybrid proteins by recombination between RT related, cloned genes in E. coli."; RL Nucleic Acids Res. 11:5661-5669(1983). RN [14] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-189. RC TISSUE=Leukocyte; RA Chen H.H., Yu X.B.; RL Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases. RN [15] RP PROTEIN SEQUENCE OF 24-59, AND FUNCTION. RX PubMed=1634550; DOI=10.1016/s0021-9258(18)42167-9; RA Zoon K.C., Miller D., Bekisz J., zur Nedden D., Enterline J.C., RA Nguyen N.Y., Hu R.-Q.; RT "Purification and characterization of multiple components of human RT lymphoblastoid interferon-alpha."; RL J. Biol. Chem. 267:15210-15216(1992). RN [16] RP PROTEIN SEQUENCE OF 24-58. RX PubMed=9425112; DOI=10.1042/bj3290295; RA Nyman T.A., Toeloe H., Parkkinen J., Kalkkinen N.; RT "Identification of nine interferon-alpha subtypes produced by Sendai virus- RT induced human peripheral blood leucocytes."; RL Biochem. J. 329:295-302(1998). RN [17] RP POLYMORPHISM. RX PubMed=11032395; DOI=10.1089/10799900050151021; RA Hussain M., Ni D., Gill D., Liao M.-J.; RT "IFN-alpha-1a gene is the major variant in the North American population."; RL J. Interferon Cytokine Res. 20:763-768(2000). RN [18] RP X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 24-189 IN COMPLEX WITH ANTIBODY, RP AND DISULFIDE BOND. RX PubMed=22307521; DOI=10.1007/s00109-012-0866-3; RA Ouyang S., Gong B., Li J.Z., Zhao L.X., Wu W., Zhang F.S., Sun L., RA Wang S.J., Pan M., Li C., Liang W., Shaw N., Zheng J., Zhao G.P., Wang Y., RA Liu Z.J., Liang M.; RT "Structural insights into a human anti-IFN antibody exerting therapeutic RT potential for systemic lupus erythematosus."; RL J. Mol. Med. 90:837-846(2012). CC -!- FUNCTION: Produced by macrophages, IFN-alpha have antiviral activities. CC Interferon stimulates the production of two enzymes: a protein kinase CC and an oligoadenylate synthetase. {ECO:0000269|PubMed:1634550}. CC -!- INTERACTION: CC P01562; Q9UHD9: UBQLN2; NbExp=3; IntAct=EBI-11478589, EBI-947187; CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- POLYMORPHISM: Two forms exist; alpha-1a (shown here) and alpha-1b CC (PubMed:11032395). {ECO:0000269|PubMed:11032395}. CC -!- MISCELLANEOUS: Interferons alpha-1 and alpha-13 have identical protein CC sequences. CC -!- SIMILARITY: Belongs to the alpha/beta interferon family. {ECO:0000305}. CC -!- WEB RESOURCE: Name=NIEHS-SNPs; CC URL="http://egp.gs.washington.edu/data/ifna1/"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; V00537; CAA23798.1; -; mRNA. DR EMBL; J00210; AAB59403.1; -; Genomic_DNA. DR EMBL; V00538; CAA23799.1; -; mRNA. DR EMBL; X00803; CAA25381.1; -; Genomic_DNA. DR EMBL; X75934; CAA53538.1; -; Genomic_DNA. DR EMBL; AB445100; BAI99735.1; -; Genomic_DNA. DR EMBL; DQ185447; ABA03167.1; -; Genomic_DNA. DR EMBL; AL353732; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471071; EAW58609.1; -; Genomic_DNA. DR EMBL; BC069427; AAH69427.1; -; mRNA. DR EMBL; BC074928; AAH74928.1; -; mRNA. DR EMBL; BC074929; AAH74929.1; -; mRNA. DR EMBL; BC093988; AAH93988.1; -; mRNA. DR EMBL; BC112002; AAI12003.1; -; mRNA. DR EMBL; BC112300; AAI12301.1; -; mRNA. DR EMBL; BC112302; AAI12303.1; -; mRNA. DR EMBL; M29884; AAA52714.1; -; Genomic_DNA. DR EMBL; AF439447; AAL35223.1; -; Genomic_DNA. DR CCDS; CCDS6508.1; -. DR PIR; C23285; IVHUA1. DR PIR; F42753; F42753. DR PIR; H42753; H42753. DR RefSeq; NP_008831.3; NM_006900.3. DR RefSeq; NP_076918.1; NM_024013.2. DR PDB; 3UX9; X-ray; 2.80 A; A/C=24-189. DR PDBsum; 3UX9; -. DR AlphaFoldDB; P01562; -. DR SMR; P01562; -. DR BioGRID; 109662; 12. DR BioGRID; 109670; 10. DR ComplexPortal; CPX-5996; Interferon alpha receptor-ligand complex, IFNA1 variant. DR DIP; DIP-6020N; -. DR IntAct; P01562; 13. DR MINT; P01562; -. DR STRING; 9606.ENSP00000276927; -. DR ChEMBL; CHEMBL3713007; -. DR iPTMnet; P01562; -. DR PhosphoSitePlus; P01562; -. DR BioMuta; IFNA1; -. DR DMDM; 124455; -. DR MassIVE; P01562; -. DR MaxQB; P01562; -. DR PaxDb; 9606-ENSP00000276927; -. DR PeptideAtlas; P01562; -. DR ABCD; P01562; 7 sequenced antibodies. DR Antibodypedia; 10448; 961 antibodies from 36 providers. DR Antibodypedia; 24875; 56 antibodies from 13 providers. DR DNASU; 3439; -. DR Ensembl; ENST00000276927.3; ENSP00000276927.1; ENSG00000197919.6. DR Ensembl; ENST00000449498.2; ENSP00000394494.2; ENSG00000233816.4. DR GeneID; 3439; -. DR GeneID; 3447; -. DR KEGG; hsa:3439; -. DR KEGG; hsa:3447; -. DR MANE-Select; ENST00000276927.3; ENSP00000276927.1; NM_024013.3; NP_076918.1. DR UCSC; uc003zpd.2; human. DR AGR; HGNC:5417; -. DR AGR; HGNC:5419; -. DR CTD; 3439; -. DR CTD; 3447; -. DR DisGeNET; 3439; -. DR DisGeNET; 3447; -. DR GeneCards; IFNA1; -. DR GeneCards; IFNA13; -. DR HGNC; HGNC:5417; IFNA1. DR HGNC; HGNC:5419; IFNA13. DR HPA; ENSG00000197919; Not detected. DR HPA; ENSG00000233816; Not detected. DR MIM; 147578; gene. DR MIM; 147660; gene. DR neXtProt; NX_P01562; -. DR OpenTargets; ENSG00000197919; -. DR PharmGKB; PA29658; -. DR VEuPathDB; HostDB:ENSG00000197919; -. DR VEuPathDB; HostDB:ENSG00000233816; -. DR eggNOG; ENOG502SQAC; Eukaryota. DR GeneTree; ENSGT01000000214430; -. DR HOGENOM; CLU_109427_0_0_1; -. DR InParanoid; P01562; -. DR OMA; DLPETHN; -. DR OrthoDB; 5358931at2759; -. DR PhylomeDB; P01562; -. DR TreeFam; TF336177; -. DR PathwayCommons; P01562; -. DR Reactome; R-HSA-909733; Interferon alpha/beta signaling. DR Reactome; R-HSA-912694; Regulation of IFNA/IFNB signaling. DR Reactome; R-HSA-933541; TRAF6 mediated IRF7 activation. DR Reactome; R-HSA-9705671; SARS-CoV-2 activates/modulates innate and adaptive immune responses. DR Reactome; R-HSA-983231; Factors involved in megakaryocyte development and platelet production. DR SignaLink; P01562; -. DR SIGNOR; P01562; -. DR BioGRID-ORCS; 3439; 38 hits in 988 CRISPR screens. DR BioGRID-ORCS; 3447; 24 hits in 1010 CRISPR screens. DR GeneWiki; IFNA13; -. DR GeneWiki; Interferon,_alpha_1; -. DR Pharos; P01562; Tbio. DR PRO; PR:P01562; -. DR Proteomes; UP000005640; Chromosome 9. DR RNAct; P01562; Protein. DR Bgee; ENSG00000197919; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 22 other cell types or tissues. DR ExpressionAtlas; P01562; baseline and differential. DR GO; GO:0005576; C:extracellular region; TAS:Reactome. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central. DR GO; GO:0005132; F:type I interferon receptor binding; IBA:GO_Central. DR GO; GO:0002250; P:adaptive immune response; IBA:GO_Central. DR GO; GO:0030183; P:B cell differentiation; IBA:GO_Central. DR GO; GO:0042100; P:B cell proliferation; IBA:GO_Central. DR GO; GO:0098586; P:cellular response to virus; NAS:ComplexPortal. DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central. DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW. DR GO; GO:0006959; P:humoral immune response; IBA:GO_Central. DR GO; GO:0002323; P:natural killer cell activation involved in immune response; IBA:GO_Central. DR GO; GO:0033141; P:positive regulation of peptidyl-serine phosphorylation of STAT protein; IBA:GO_Central. DR GO; GO:0043330; P:response to exogenous dsRNA; IBA:GO_Central. DR GO; GO:0002286; P:T cell activation involved in immune response; IBA:GO_Central. DR GO; GO:0060337; P:type I interferon-mediated signaling pathway; NAS:ComplexPortal. DR CDD; cd00095; IFab; 1. DR Gene3D; 1.20.1250.10; -; 1. DR InterPro; IPR009079; 4_helix_cytokine-like_core. DR InterPro; IPR000471; Interferon_alpha/beta/delta. DR PANTHER; PTHR11691:SF64; INTERFERON ALPHA-1_13; 1. DR PANTHER; PTHR11691; TYPE I INTERFERON; 1. DR Pfam; PF00143; Interferon; 1. DR PRINTS; PR00266; INTERFERONAB. DR SMART; SM00076; IFabd; 1. DR SUPFAM; SSF47266; 4-helical cytokines; 1. DR PROSITE; PS00252; INTERFERON_A_B_D; 1. DR Genevisible; P01562; HS. PE 1: Evidence at protein level; KW 3D-structure; Antiviral defense; Cytokine; Direct protein sequencing; KW Disulfide bond; Reference proteome; Secreted; Signal. FT SIGNAL 1..23 FT /evidence="ECO:0000269|PubMed:1634550, FT ECO:0000269|PubMed:9425112" FT CHAIN 24..189 FT /note="Interferon alpha-1/13" FT /id="PRO_0000016359" FT DISULFID 24..122 FT /evidence="ECO:0000250" FT DISULFID 52..162 FT /evidence="ECO:0000269|PubMed:22307521" FT VARIANT 10 FT /note="V -> A (in dbSNP:rs1758567)" FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.8, FT ECO:0000269|Ref.9" FT /id="VAR_024508" FT VARIANT 137 FT /note="A -> V (in alpha-1B; dbSNP:rs2230050)" FT /evidence="ECO:0000269|Ref.9" FT /id="VAR_013000" FT VARIANT 163 FT /note="A -> G (in dbSNP:rs28383794)" FT /evidence="ECO:0000269|Ref.9" FT /id="VAR_025173" FT CONFLICT 116 FT /note="L -> P (in Ref. 14; AAL35223)" FT /evidence="ECO:0000305" FT CONFLICT 172 FT /note="M -> V (in Ref. 14; AAL35223)" FT /evidence="ECO:0000305" FT HELIX 35..43 FT /evidence="ECO:0007829|PDB:3UX9" FT HELIX 49..51 FT /evidence="ECO:0007829|PDB:3UX9" FT TURN 53..55 FT /evidence="ECO:0007829|PDB:3UX9" FT HELIX 63..66 FT /evidence="ECO:0007829|PDB:3UX9" FT HELIX 77..91 FT /evidence="ECO:0007829|PDB:3UX9" FT HELIX 94..99 FT /evidence="ECO:0007829|PDB:3UX9" FT HELIX 102..122 FT /evidence="ECO:0007829|PDB:3UX9" FT HELIX 137..156 FT /evidence="ECO:0007829|PDB:3UX9" FT TURN 157..159 FT /evidence="ECO:0007829|PDB:3UX9" FT HELIX 161..178 FT /evidence="ECO:0007829|PDB:3UX9" SQ SEQUENCE 189 AA; 21725 MW; F32F9CB969606B69 CRC64; MASPFALLMV LVVLSCKSSC SLGCDLPETH SLDNRRTLML LAQMSRISPS SCLMDRHDFG FPQEEFDGNQ FQKAPAISVL HELIQQIFNL FTTKDSSAAW DEDLLDKFCT ELYQQLNDLE ACVMQEERVG ETPLMNADSI LAVKKYFRRI TLYLTEKKYS PCAWEVVRAE IMRSLSLSTN LQERLRRKE //