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P01562 (IFNA1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 152. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interferon alpha-1/13

Short name=IFN-alpha-1/13
Alternative name(s):
Interferon alpha-D
Short name=LeIF D
Gene names
Name:IFNA1
AND
Name:IFNA13
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length189 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Ref.15

Subcellular location

Secreted.

Polymorphism

Two forms exist; alpha-1a (shown here) and alpha-1b.

Miscellaneous

Interferons alpha-1 and alpha-13 have identical protein sequences.

Sequence similarities

Belongs to the alpha/beta interferon family.

Ontologies

Keywords
   Biological processAntiviral defense
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processB cell differentiation

Inferred from Biological aspect of Ancestor. Source: RefGenome

B cell proliferation

Inferred from Biological aspect of Ancestor. Source: RefGenome

T cell activation involved in immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

adaptive immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

blood coagulation

Traceable author statement. Source: Reactome

cytokine-mediated signaling pathway

Inferred from Biological aspect of Ancestor. Source: RefGenome

defense response to virus

Inferred from electronic annotation. Source: UniProtKB-KW

humoral immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

innate immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

natural killer cell activation involved in immune response

Inferred from Biological aspect of Ancestor. Source: RefGenome

positive regulation of peptidyl-serine phosphorylation of STAT protein

Inferred from Biological aspect of Ancestor. Source: RefGenome

regulation of MHC class I biosynthetic process

Inferred from Biological aspect of Ancestor. Source: RefGenome

regulation of type I interferon-mediated signaling pathway

Traceable author statement. Source: Reactome

response to exogenous dsRNA

Inferred from Biological aspect of Ancestor. Source: RefGenome

type I interferon signaling pathway

Traceable author statement. Source: Reactome

   Cellular_componentextracellular region

Traceable author statement. Source: Reactome

extracellular space

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functioncytokine activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

type I interferon receptor binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Ref.15 Ref.16
Chain24 – 189166Interferon alpha-1/13
PRO_0000016359

Amino acid modifications

Disulfide bond24 ↔ 122 By similarity
Disulfide bond52 ↔ 162 Ref.18

Natural variations

Natural variant101V → A. Ref.8 Ref.9 Ref.12
Corresponds to variant rs1758567 [ dbSNP | Ensembl ].
VAR_024508
Natural variant1371A → V in alpha-1B. Ref.9
Corresponds to variant rs2230050 [ dbSNP | Ensembl ].
VAR_013000
Natural variant1631A → G. Ref.9
Corresponds to variant rs33965070 [ dbSNP | Ensembl ].
VAR_025173

Experimental info

Sequence conflict1161L → P in AAL35223. Ref.14
Sequence conflict1721M → V in AAL35223. Ref.14

Secondary structure

.................... 189
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P01562 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: F32F9CB969606B69

FASTA18921,725
        10         20         30         40         50         60 
MASPFALLMV LVVLSCKSSC SLGCDLPETH SLDNRRTLML LAQMSRISPS SCLMDRHDFG 

        70         80         90        100        110        120 
FPQEEFDGNQ FQKAPAISVL HELIQQIFNL FTTKDSSAAW DEDLLDKFCT ELYQQLNDLE 

       130        140        150        160        170        180 
ACVMQEERVG ETPLMNADSI LAVKKYFRRI TLYLTEKKYS PCAWEVVRAE IMRSLSLSTN 


LQERLRRKE 

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of a cloned human leukocyte interferon cDNA."
Mantei N., Schwarzstein M., Streuli M., Panem S., Nagata S., Weissmann C.
Gene 10:1-10(1980) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Human leukocyte and fibroblast interferons are structurally related."
Taniguchi T., Mantei N., Schwarzstein M., Nagata S., Muramatsu M., Weissmann C.
Nature 285:547-549(1980) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The structure of eight distinct cloned human leukocyte interferon cDNAs."
Goeddel D.V., Leung D.W., Dull T.J., Gross M., Lawn R.M., McCandliss R., Seeburg P.H., Ullrich A., Yelverton E., Gray P.W.
Nature 290:20-26(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Two non-allelic human interferon alpha genes with identical coding regions."
Todokoro K., Kioussis D., Weissmann C.
EMBO J. 3:1809-1812(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"Structural relationship of human interferon alpha genes and pseudogenes."
Henco K., Brosius J., Fujisawa A., Fujisawa J., Haynes J.R., Hochstadt J., Kovacic T., Pasek M., Schamboeck A., Schmid J., Todokoro K., Waelchli M., Nagata S., Weissmann C.
J. Mol. Biol. 185:227-260(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]"Two distinct families of human and bovine interferon-alpha genes are coordinately expressed and encode functional polypeptides."
Capon D.J., Shepard H.M., Goeddel D.V.
Mol. Cell. Biol. 5:768-779(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[7]"Novel cis-active structures in the coding region mediate CRM1-dependent nuclear export of IFN-alpha 1 mRNA."
Kimura T., Hashimoto I., Nishizawa M., Ito S., Yamada H.
Med. Mol. Morphol. 43:145-157(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[8]Rostoks N.
Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-10.
[9]NIEHS SNPs program
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-10; VAL-137 AND GLY-163.
[10]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[11]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[12]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-10.
Tissue: Cerebellum.
[13]"Formation of genes coding for hybrid proteins by recombination between related, cloned genes in E. coli."
Weber H., Weissmann C.
Nucleic Acids Res. 11:5661-5669(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-189.
[14]Chen H.H., Yu X.B.
Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-189.
Tissue: Leukocyte.
[15]"Purification and characterization of multiple components of human lymphoblastoid interferon-alpha."
Zoon K.C., Miller D., Bekisz J., zur Nedden D., Enterline J.C., Nguyen N.Y., Hu R.-Q.
J. Biol. Chem. 267:15210-15216(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 24-59, FUNCTION.
[16]"Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes."
Nyman T.A., Toeloe H., Parkkinen J., Kalkkinen N.
Biochem. J. 329:295-302(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 24-58.
[17]"IFN-alpha-1a gene is the major variant in the North American population."
Hussain M., Ni D., Gill D., Liao M.-J.
J. Interferon Cytokine Res. 20:763-768(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: POLYMORPHISM.
[18]"Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus."
Ouyang S., Gong B., Li J.Z., Zhao L.X., Wu W., Zhang F.S., Sun L., Wang S.J., Pan M., Li C., Liang W., Shaw N., Zheng J., Zhao G.P., Wang Y., Liu Z.J., Liang M.
J. Mol. Med. 90:837-846(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 24-189 IN COMPLEX WITH ANTIBODY, DISULFIDE BOND.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
V00537 mRNA. Translation: CAA23798.1.
J00210 Genomic DNA. Translation: AAB59403.1.
V00538 mRNA. Translation: CAA23799.1.
X00803 Genomic DNA. Translation: CAA25381.1.
X75934 Genomic DNA. Translation: CAA53538.1.
AB445100 Genomic DNA. Translation: BAI99735.1.
DQ185447 Genomic DNA. Translation: ABA03167.1.
AL353732 Genomic DNA. Translation: CAH72904.1.
AL353732 Genomic DNA. Translation: CAH72911.1.
CH471071 Genomic DNA. Translation: EAW58609.1.
BC069427 mRNA. Translation: AAH69427.1.
BC074928 mRNA. Translation: AAH74928.1.
BC074929 mRNA. Translation: AAH74929.1.
BC093988 mRNA. Translation: AAH93988.1.
BC112002 mRNA. Translation: AAI12003.1.
BC112300 mRNA. Translation: AAI12301.1.
BC112302 mRNA. Translation: AAI12303.1.
M29884 Genomic DNA. Translation: AAA52714.1.
AF439447 Genomic DNA. Translation: AAL35223.1.
CCDSCCDS6508.1.
PIRIVHUA1. C23285.
F42753.
H42753.
RefSeqNP_008831.3. NM_006900.3.
NP_076918.1. NM_024013.2.
UniGeneHs.37026.
Hs.533471.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3UX9X-ray2.80A/C24-189[»]
ProteinModelPortalP01562.
SMRP01562. Positions 32-179.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109662. 1 interaction.
DIPDIP-6020N.
STRING9606.ENSP00000276927.

PTM databases

PhosphoSiteP01562.

Polymorphism databases

DMDM124455.

Proteomic databases

PaxDbP01562.
PRIDEP01562.

Protocols and materials databases

DNASU3439.
3447.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000276927; ENSP00000276927; ENSG00000197919.
GeneID3439.
3447.
KEGGhsa:3439.
hsa:3447.
UCSCuc003zpd.2. human.

Organism-specific databases

CTD3439.
3447.
GeneCardsGC09M021357.
GC09P021430.
HGNCHGNC:5417. IFNA1.
HGNC:5419. IFNA13.
HPAHPA047557.
MIM147578. gene.
147660. gene.
neXtProtNX_P01562.
PharmGKBPA29658.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG40434.
HOVERGENHBG052086.
InParanoidP01562.
KOK05414.
OMASELEVCL.
OrthoDBEOG7M98HV.
PhylomeDBP01562.
TreeFamTF336177.

Enzyme and pathway databases

ReactomeREACT_604. Hemostasis.
REACT_6900. Immune System.
SignaLinkP01562.

Gene expression databases

BgeeP01562.
CleanExHS_IFNA1.
HS_IFNA13.
GenevestigatorP01562.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERPTHR11691. PTHR11691. 1 hit.
PfamPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSPR00266. INTERFERONAB.
SMARTSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMSSF47266. SSF47266. 1 hit.
PROSITEPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiIFNA13.
Interferon,_alpha_1.
NextBio13552.
PROP01562.
SOURCESearch...

Entry information

Entry nameIFNA1_HUMAN
AccessionPrimary (citable) accession number: P01562
Secondary accession number(s): D4Q9M8 expand/collapse secondary AC list , Q14605, Q2M1L8, Q52LB8, Q5VYQ2, Q7M4Q1, Q8WZ68, Q9UMJ3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: July 9, 2014
This is version 152 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM