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P01562

- IFNA1_HUMAN

UniProt

P01562 - IFNA1_HUMAN

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Protein

Interferon alpha-1/13

Gene

IFNA1

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.1 Publication

GO - Molecular functioni

  1. cytokine activity Source: RefGenome
  2. type I interferon receptor binding Source: RefGenome

GO - Biological processi

  1. adaptive immune response Source: RefGenome
  2. B cell differentiation Source: RefGenome
  3. B cell proliferation Source: RefGenome
  4. blood coagulation Source: Reactome
  5. cytokine-mediated signaling pathway Source: RefGenome
  6. defense response to virus Source: UniProtKB-KW
  7. humoral immune response Source: RefGenome
  8. innate immune response Source: RefGenome
  9. natural killer cell activation involved in immune response Source: RefGenome
  10. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: RefGenome
  11. regulation of MHC class I biosynthetic process Source: RefGenome
  12. regulation of type I interferon-mediated signaling pathway Source: Reactome
  13. response to exogenous dsRNA Source: RefGenome
  14. T cell activation involved in immune response Source: RefGenome
  15. type I interferon signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense

Enzyme and pathway databases

ReactomeiREACT_24938. TRAF6 mediated IRF7 activation.
REACT_24970. Factors involved in megakaryocyte development and platelet production.
REACT_25162. Interferon alpha/beta signaling.
REACT_25216. Regulation of IFNA signaling.
SignaLinkiP01562.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-1/13
Short name:
IFN-alpha-1/13
Alternative name(s):
Interferon alpha-D
Short name:
LeIF D
Gene namesi
Name:IFNA1
AND
Name:IFNA13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:5417. IFNA1.
HGNC:5419. IFNA13.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29658.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23232 PublicationsAdd
BLAST
Chaini24 – 189166Interferon alpha-1/13PRO_0000016359Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 122By similarity
Disulfide bondi52 ↔ 1621 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP01562.
PaxDbiP01562.
PRIDEiP01562.

PTM databases

PhosphoSiteiP01562.

Expressioni

Gene expression databases

BgeeiP01562.
CleanExiHS_IFNA1.
HS_IFNA13.
ExpressionAtlasiP01562. baseline and differential.
GenevestigatoriP01562.

Organism-specific databases

HPAiHPA047557.

Interactioni

Protein-protein interaction databases

BioGridi109662. 1 interaction.
109670. 2 interactions.
DIPiDIP-6020N.
STRINGi9606.ENSP00000276927.

Structurei

Secondary structure

1
189
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi35 – 439
Helixi49 – 513
Turni53 – 553
Helixi63 – 664
Helixi77 – 9115
Helixi94 – 996
Helixi102 – 12221
Helixi137 – 15620
Turni157 – 1593
Helixi161 – 17818

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3UX9X-ray2.80A/C24-189[»]
ProteinModelPortaliP01562.
SMRiP01562. Positions 32-179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40434.
GeneTreeiENSGT00760000119150.
HOVERGENiHBG052086.
InParanoidiP01562.
KOiK05414.
OMAiSELEVCL.
OrthoDBiEOG7M98HV.
PhylomeDBiP01562.
TreeFamiTF336177.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01562-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASPFALLMV LVVLSCKSSC SLGCDLPETH SLDNRRTLML LAQMSRISPS
60 70 80 90 100
SCLMDRHDFG FPQEEFDGNQ FQKAPAISVL HELIQQIFNL FTTKDSSAAW
110 120 130 140 150
DEDLLDKFCT ELYQQLNDLE ACVMQEERVG ETPLMNADSI LAVKKYFRRI
160 170 180
TLYLTEKKYS PCAWEVVRAE IMRSLSLSTN LQERLRRKE
Length:189
Mass (Da):21,725
Last modified:July 21, 1986 - v1
Checksum:iF32F9CB969606B69
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti116 – 1161L → P in AAL35223. 1 PublicationCurated
Sequence conflicti172 – 1721M → V in AAL35223. 1 PublicationCurated

Polymorphismi

Two forms exist; alpha-1a (shown here) and alpha-1b.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101V → A.3 Publications
Corresponds to variant rs1758567 [ dbSNP | Ensembl ].
VAR_024508
Natural varianti137 – 1371A → V in alpha-1B. 1 Publication
Corresponds to variant rs2230050 [ dbSNP | Ensembl ].
VAR_013000
Natural varianti163 – 1631A → G.1 Publication
Corresponds to variant rs33965070 [ dbSNP | Ensembl ].
VAR_025173

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V00537 mRNA. Translation: CAA23798.1.
J00210 Genomic DNA. Translation: AAB59403.1.
V00538 mRNA. Translation: CAA23799.1.
X00803 Genomic DNA. Translation: CAA25381.1.
X75934 Genomic DNA. Translation: CAA53538.1.
AB445100 Genomic DNA. Translation: BAI99735.1.
DQ185447 Genomic DNA. Translation: ABA03167.1.
AL353732 Genomic DNA. Translation: CAH72904.1.
AL353732 Genomic DNA. Translation: CAH72911.1.
CH471071 Genomic DNA. Translation: EAW58609.1.
BC069427 mRNA. Translation: AAH69427.1.
BC074928 mRNA. Translation: AAH74928.1.
BC074929 mRNA. Translation: AAH74929.1.
BC093988 mRNA. Translation: AAH93988.1.
BC112002 mRNA. Translation: AAI12003.1.
BC112300 mRNA. Translation: AAI12301.1.
BC112302 mRNA. Translation: AAI12303.1.
M29884 Genomic DNA. Translation: AAA52714.1.
AF439447 Genomic DNA. Translation: AAL35223.1.
CCDSiCCDS6508.1.
PIRiC23285. IVHUA1.
F42753.
H42753.
RefSeqiNP_008831.3. NM_006900.3.
NP_076918.1. NM_024013.2.
UniGeneiHs.37026.
Hs.533471.

Genome annotation databases

EnsembliENST00000276927; ENSP00000276927; ENSG00000197919.
ENST00000449498; ENSP00000394494; ENSG00000233816.
GeneIDi3439.
3447.
KEGGihsa:3439.
hsa:3447.
UCSCiuc003zpd.2. human.

Polymorphism databases

DMDMi124455.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
V00537 mRNA. Translation: CAA23798.1 .
J00210 Genomic DNA. Translation: AAB59403.1 .
V00538 mRNA. Translation: CAA23799.1 .
X00803 Genomic DNA. Translation: CAA25381.1 .
X75934 Genomic DNA. Translation: CAA53538.1 .
AB445100 Genomic DNA. Translation: BAI99735.1 .
DQ185447 Genomic DNA. Translation: ABA03167.1 .
AL353732 Genomic DNA. Translation: CAH72904.1 .
AL353732 Genomic DNA. Translation: CAH72911.1 .
CH471071 Genomic DNA. Translation: EAW58609.1 .
BC069427 mRNA. Translation: AAH69427.1 .
BC074928 mRNA. Translation: AAH74928.1 .
BC074929 mRNA. Translation: AAH74929.1 .
BC093988 mRNA. Translation: AAH93988.1 .
BC112002 mRNA. Translation: AAI12003.1 .
BC112300 mRNA. Translation: AAI12301.1 .
BC112302 mRNA. Translation: AAI12303.1 .
M29884 Genomic DNA. Translation: AAA52714.1 .
AF439447 Genomic DNA. Translation: AAL35223.1 .
CCDSi CCDS6508.1.
PIRi C23285. IVHUA1.
F42753.
H42753.
RefSeqi NP_008831.3. NM_006900.3.
NP_076918.1. NM_024013.2.
UniGenei Hs.37026.
Hs.533471.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3UX9 X-ray 2.80 A/C 24-189 [» ]
ProteinModelPortali P01562.
SMRi P01562. Positions 32-179.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109662. 1 interaction.
109670. 2 interactions.
DIPi DIP-6020N.
STRINGi 9606.ENSP00000276927.

PTM databases

PhosphoSitei P01562.

Polymorphism databases

DMDMi 124455.

Proteomic databases

MaxQBi P01562.
PaxDbi P01562.
PRIDEi P01562.

Protocols and materials databases

DNASUi 3439.
3447.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000276927 ; ENSP00000276927 ; ENSG00000197919 .
ENST00000449498 ; ENSP00000394494 ; ENSG00000233816 .
GeneIDi 3439.
3447.
KEGGi hsa:3439.
hsa:3447.
UCSCi uc003zpd.2. human.

Organism-specific databases

CTDi 3439.
3447.
GeneCardsi GC09M021357.
GC09P021430.
HGNCi HGNC:5417. IFNA1.
HGNC:5419. IFNA13.
HPAi HPA047557.
MIMi 147578. gene.
147660. gene.
neXtProti NX_P01562.
PharmGKBi PA29658.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40434.
GeneTreei ENSGT00760000119150.
HOVERGENi HBG052086.
InParanoidi P01562.
KOi K05414.
OMAi SELEVCL.
OrthoDBi EOG7M98HV.
PhylomeDBi P01562.
TreeFami TF336177.

Enzyme and pathway databases

Reactomei REACT_24938. TRAF6 mediated IRF7 activation.
REACT_24970. Factors involved in megakaryocyte development and platelet production.
REACT_25162. Interferon alpha/beta signaling.
REACT_25216. Regulation of IFNA signaling.
SignaLinki P01562.

Miscellaneous databases

GeneWikii IFNA13.
Interferon,_alpha_1.
NextBioi 13552.
PROi P01562.
SOURCEi Search...

Gene expression databases

Bgeei P01562.
CleanExi HS_IFNA1.
HS_IFNA13.
ExpressionAtlasi P01562. baseline and differential.
Genevestigatori P01562.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view ]
PANTHERi PTHR11691. PTHR11691. 1 hit.
Pfami PF00143. Interferon. 1 hit.
[Graphical view ]
PRINTSi PR00266. INTERFERONAB.
SMARTi SM00076. IFabd. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
PROSITEi PS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of a cloned human leukocyte interferon cDNA."
    Mantei N., Schwarzstein M., Streuli M., Panem S., Nagata S., Weissmann C.
    Gene 10:1-10(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Human leukocyte and fibroblast interferons are structurally related."
    Taniguchi T., Mantei N., Schwarzstein M., Nagata S., Muramatsu M., Weissmann C.
    Nature 285:547-549(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The structure of eight distinct cloned human leukocyte interferon cDNAs."
    Goeddel D.V., Leung D.W., Dull T.J., Gross M., Lawn R.M., McCandliss R., Seeburg P.H., Ullrich A., Yelverton E., Gray P.W.
    Nature 290:20-26(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "Two non-allelic human interferon alpha genes with identical coding regions."
    Todokoro K., Kioussis D., Weissmann C.
    EMBO J. 3:1809-1812(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "Two distinct families of human and bovine interferon-alpha genes are coordinately expressed and encode functional polypeptides."
    Capon D.J., Shepard H.M., Goeddel D.V.
    Mol. Cell. Biol. 5:768-779(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  7. "Novel cis-active structures in the coding region mediate CRM1-dependent nuclear export of IFN-alpha 1 mRNA."
    Kimura T., Hashimoto I., Nishizawa M., Ito S., Yamada H.
    Med. Mol. Morphol. 43:145-157(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  8. Rostoks N.
    Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-10.
  9. NIEHS SNPs program
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-10; VAL-137 AND GLY-163.
  10. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  12. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-10.
    Tissue: Cerebellum.
  13. "Formation of genes coding for hybrid proteins by recombination between related, cloned genes in E. coli."
    Weber H., Weissmann C.
    Nucleic Acids Res. 11:5661-5669(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-189.
  14. Chen H.H., Yu X.B.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-189.
    Tissue: Leukocyte.
  15. "Purification and characterization of multiple components of human lymphoblastoid interferon-alpha."
    Zoon K.C., Miller D., Bekisz J., zur Nedden D., Enterline J.C., Nguyen N.Y., Hu R.-Q.
    J. Biol. Chem. 267:15210-15216(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-59, FUNCTION.
  16. "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes."
    Nyman T.A., Toeloe H., Parkkinen J., Kalkkinen N.
    Biochem. J. 329:295-302(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-58.
  17. "IFN-alpha-1a gene is the major variant in the North American population."
    Hussain M., Ni D., Gill D., Liao M.-J.
    J. Interferon Cytokine Res. 20:763-768(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: POLYMORPHISM.
  18. "Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus."
    Ouyang S., Gong B., Li J.Z., Zhao L.X., Wu W., Zhang F.S., Sun L., Wang S.J., Pan M., Li C., Liang W., Shaw N., Zheng J., Zhao G.P., Wang Y., Liu Z.J., Liang M.
    J. Mol. Med. 90:837-846(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 24-189 IN COMPLEX WITH ANTIBODY, DISULFIDE BOND.

Entry informationi

Entry nameiIFNA1_HUMAN
AccessioniPrimary (citable) accession number: P01562
Secondary accession number(s): D4Q9M8
, Q14605, Q2M1L8, Q52LB8, Q5VYQ2, Q7M4Q1, Q8WZ68, Q9UMJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 29, 2014
This is version 155 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Interferons alpha-1 and alpha-13 have identical protein sequences.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3