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P01562

- IFNA1_HUMAN

UniProt

P01562 - IFNA1_HUMAN

Protein

Interferon alpha-1/13

Gene

IFNA1

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 154 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.1 Publication

    GO - Molecular functioni

    1. cytokine activity Source: RefGenome
    2. type I interferon receptor binding Source: RefGenome

    GO - Biological processi

    1. adaptive immune response Source: RefGenome
    2. B cell differentiation Source: RefGenome
    3. B cell proliferation Source: RefGenome
    4. blood coagulation Source: Reactome
    5. cytokine-mediated signaling pathway Source: RefGenome
    6. defense response to virus Source: UniProtKB-KW
    7. humoral immune response Source: RefGenome
    8. innate immune response Source: RefGenome
    9. natural killer cell activation involved in immune response Source: RefGenome
    10. positive regulation of peptidyl-serine phosphorylation of STAT protein Source: RefGenome
    11. regulation of MHC class I biosynthetic process Source: RefGenome
    12. regulation of type I interferon-mediated signaling pathway Source: Reactome
    13. response to exogenous dsRNA Source: RefGenome
    14. T cell activation involved in immune response Source: RefGenome
    15. type I interferon signaling pathway Source: Reactome

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Antiviral defense

    Enzyme and pathway databases

    ReactomeiREACT_24938. TRAF6 mediated IRF7 activation.
    REACT_24970. Factors involved in megakaryocyte development and platelet production.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_25216. Regulation of IFNA signaling.
    SignaLinkiP01562.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interferon alpha-1/13
    Short name:
    IFN-alpha-1/13
    Alternative name(s):
    Interferon alpha-D
    Short name:
    LeIF D
    Gene namesi
    Name:IFNA1
    AND
    Name:IFNA13
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:5417. IFNA1.
    HGNC:5419. IFNA13.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: RefGenome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29658.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 23232 PublicationsAdd
    BLAST
    Chaini24 – 189166Interferon alpha-1/13PRO_0000016359Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi24 ↔ 122By similarity
    Disulfide bondi52 ↔ 1621 Publication

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP01562.
    PRIDEiP01562.

    PTM databases

    PhosphoSiteiP01562.

    Expressioni

    Gene expression databases

    BgeeiP01562.
    CleanExiHS_IFNA1.
    HS_IFNA13.
    GenevestigatoriP01562.

    Organism-specific databases

    HPAiHPA047557.

    Interactioni

    Protein-protein interaction databases

    BioGridi109662. 1 interaction.
    DIPiDIP-6020N.
    STRINGi9606.ENSP00000276927.

    Structurei

    Secondary structure

    1
    189
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi35 – 439
    Helixi49 – 513
    Turni53 – 553
    Helixi63 – 664
    Helixi77 – 9115
    Helixi94 – 996
    Helixi102 – 12221
    Helixi137 – 15620
    Turni157 – 1593
    Helixi161 – 17818

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3UX9X-ray2.80A/C24-189[»]
    ProteinModelPortaliP01562.
    SMRiP01562. Positions 32-179.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alpha/beta interferon family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG40434.
    HOVERGENiHBG052086.
    InParanoidiP01562.
    KOiK05414.
    OMAiSELEVCL.
    OrthoDBiEOG7M98HV.
    PhylomeDBiP01562.
    TreeFamiTF336177.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000471. Interferon_alpha/beta/delta.
    [Graphical view]
    PANTHERiPTHR11691. PTHR11691. 1 hit.
    PfamiPF00143. Interferon. 1 hit.
    [Graphical view]
    PRINTSiPR00266. INTERFERONAB.
    SMARTiSM00076. IFabd. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01562-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASPFALLMV LVVLSCKSSC SLGCDLPETH SLDNRRTLML LAQMSRISPS    50
    SCLMDRHDFG FPQEEFDGNQ FQKAPAISVL HELIQQIFNL FTTKDSSAAW 100
    DEDLLDKFCT ELYQQLNDLE ACVMQEERVG ETPLMNADSI LAVKKYFRRI 150
    TLYLTEKKYS PCAWEVVRAE IMRSLSLSTN LQERLRRKE 189
    Length:189
    Mass (Da):21,725
    Last modified:July 21, 1986 - v1
    Checksum:iF32F9CB969606B69
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti116 – 1161L → P in AAL35223. 1 PublicationCurated
    Sequence conflicti172 – 1721M → V in AAL35223. 1 PublicationCurated

    Polymorphismi

    Two forms exist; alpha-1a (shown here) and alpha-1b.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti10 – 101V → A.3 Publications
    Corresponds to variant rs1758567 [ dbSNP | Ensembl ].
    VAR_024508
    Natural varianti137 – 1371A → V in alpha-1B. 1 Publication
    Corresponds to variant rs2230050 [ dbSNP | Ensembl ].
    VAR_013000
    Natural varianti163 – 1631A → G.1 Publication
    Corresponds to variant rs33965070 [ dbSNP | Ensembl ].
    VAR_025173

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V00537 mRNA. Translation: CAA23798.1.
    J00210 Genomic DNA. Translation: AAB59403.1.
    V00538 mRNA. Translation: CAA23799.1.
    X00803 Genomic DNA. Translation: CAA25381.1.
    X75934 Genomic DNA. Translation: CAA53538.1.
    AB445100 Genomic DNA. Translation: BAI99735.1.
    DQ185447 Genomic DNA. Translation: ABA03167.1.
    AL353732 Genomic DNA. Translation: CAH72904.1.
    AL353732 Genomic DNA. Translation: CAH72911.1.
    CH471071 Genomic DNA. Translation: EAW58609.1.
    BC069427 mRNA. Translation: AAH69427.1.
    BC074928 mRNA. Translation: AAH74928.1.
    BC074929 mRNA. Translation: AAH74929.1.
    BC093988 mRNA. Translation: AAH93988.1.
    BC112002 mRNA. Translation: AAI12003.1.
    BC112300 mRNA. Translation: AAI12301.1.
    BC112302 mRNA. Translation: AAI12303.1.
    M29884 Genomic DNA. Translation: AAA52714.1.
    AF439447 Genomic DNA. Translation: AAL35223.1.
    CCDSiCCDS6508.1.
    PIRiC23285. IVHUA1.
    F42753.
    H42753.
    RefSeqiNP_008831.3. NM_006900.3.
    NP_076918.1. NM_024013.2.
    UniGeneiHs.37026.
    Hs.533471.

    Genome annotation databases

    EnsembliENST00000276927; ENSP00000276927; ENSG00000197919.
    GeneIDi3439.
    3447.
    KEGGihsa:3439.
    hsa:3447.
    UCSCiuc003zpd.2. human.

    Polymorphism databases

    DMDMi124455.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V00537 mRNA. Translation: CAA23798.1 .
    J00210 Genomic DNA. Translation: AAB59403.1 .
    V00538 mRNA. Translation: CAA23799.1 .
    X00803 Genomic DNA. Translation: CAA25381.1 .
    X75934 Genomic DNA. Translation: CAA53538.1 .
    AB445100 Genomic DNA. Translation: BAI99735.1 .
    DQ185447 Genomic DNA. Translation: ABA03167.1 .
    AL353732 Genomic DNA. Translation: CAH72904.1 .
    AL353732 Genomic DNA. Translation: CAH72911.1 .
    CH471071 Genomic DNA. Translation: EAW58609.1 .
    BC069427 mRNA. Translation: AAH69427.1 .
    BC074928 mRNA. Translation: AAH74928.1 .
    BC074929 mRNA. Translation: AAH74929.1 .
    BC093988 mRNA. Translation: AAH93988.1 .
    BC112002 mRNA. Translation: AAI12003.1 .
    BC112300 mRNA. Translation: AAI12301.1 .
    BC112302 mRNA. Translation: AAI12303.1 .
    M29884 Genomic DNA. Translation: AAA52714.1 .
    AF439447 Genomic DNA. Translation: AAL35223.1 .
    CCDSi CCDS6508.1.
    PIRi C23285. IVHUA1.
    F42753.
    H42753.
    RefSeqi NP_008831.3. NM_006900.3.
    NP_076918.1. NM_024013.2.
    UniGenei Hs.37026.
    Hs.533471.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3UX9 X-ray 2.80 A/C 24-189 [» ]
    ProteinModelPortali P01562.
    SMRi P01562. Positions 32-179.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109662. 1 interaction.
    DIPi DIP-6020N.
    STRINGi 9606.ENSP00000276927.

    PTM databases

    PhosphoSitei P01562.

    Polymorphism databases

    DMDMi 124455.

    Proteomic databases

    PaxDbi P01562.
    PRIDEi P01562.

    Protocols and materials databases

    DNASUi 3439.
    3447.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000276927 ; ENSP00000276927 ; ENSG00000197919 .
    GeneIDi 3439.
    3447.
    KEGGi hsa:3439.
    hsa:3447.
    UCSCi uc003zpd.2. human.

    Organism-specific databases

    CTDi 3439.
    3447.
    GeneCardsi GC09M021357.
    GC09P021430.
    HGNCi HGNC:5417. IFNA1.
    HGNC:5419. IFNA13.
    HPAi HPA047557.
    MIMi 147578. gene.
    147660. gene.
    neXtProti NX_P01562.
    PharmGKBi PA29658.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40434.
    HOVERGENi HBG052086.
    InParanoidi P01562.
    KOi K05414.
    OMAi SELEVCL.
    OrthoDBi EOG7M98HV.
    PhylomeDBi P01562.
    TreeFami TF336177.

    Enzyme and pathway databases

    Reactomei REACT_24938. TRAF6 mediated IRF7 activation.
    REACT_24970. Factors involved in megakaryocyte development and platelet production.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_25216. Regulation of IFNA signaling.
    SignaLinki P01562.

    Miscellaneous databases

    GeneWikii IFNA13.
    Interferon,_alpha_1.
    NextBioi 13552.
    PROi P01562.
    SOURCEi Search...

    Gene expression databases

    Bgeei P01562.
    CleanExi HS_IFNA1.
    HS_IFNA13.
    Genevestigatori P01562.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR000471. Interferon_alpha/beta/delta.
    [Graphical view ]
    PANTHERi PTHR11691. PTHR11691. 1 hit.
    Pfami PF00143. Interferon. 1 hit.
    [Graphical view ]
    PRINTSi PR00266. INTERFERONAB.
    SMARTi SM00076. IFabd. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00252. INTERFERON_A_B_D. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of a cloned human leukocyte interferon cDNA."
      Mantei N., Schwarzstein M., Streuli M., Panem S., Nagata S., Weissmann C.
      Gene 10:1-10(1980) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Human leukocyte and fibroblast interferons are structurally related."
      Taniguchi T., Mantei N., Schwarzstein M., Nagata S., Muramatsu M., Weissmann C.
      Nature 285:547-549(1980) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The structure of eight distinct cloned human leukocyte interferon cDNAs."
      Goeddel D.V., Leung D.W., Dull T.J., Gross M., Lawn R.M., McCandliss R., Seeburg P.H., Ullrich A., Yelverton E., Gray P.W.
      Nature 290:20-26(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Two non-allelic human interferon alpha genes with identical coding regions."
      Todokoro K., Kioussis D., Weissmann C.
      EMBO J. 3:1809-1812(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. "Two distinct families of human and bovine interferon-alpha genes are coordinately expressed and encode functional polypeptides."
      Capon D.J., Shepard H.M., Goeddel D.V.
      Mol. Cell. Biol. 5:768-779(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    7. "Novel cis-active structures in the coding region mediate CRM1-dependent nuclear export of IFN-alpha 1 mRNA."
      Kimura T., Hashimoto I., Nishizawa M., Ito S., Yamada H.
      Med. Mol. Morphol. 43:145-157(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    8. Rostoks N.
      Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-10.
    9. NIEHS SNPs program
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-10; VAL-137 AND GLY-163.
    10. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    12. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-10.
      Tissue: Cerebellum.
    13. "Formation of genes coding for hybrid proteins by recombination between related, cloned genes in E. coli."
      Weber H., Weissmann C.
      Nucleic Acids Res. 11:5661-5669(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-189.
    14. Chen H.H., Yu X.B.
      Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-189.
      Tissue: Leukocyte.
    15. "Purification and characterization of multiple components of human lymphoblastoid interferon-alpha."
      Zoon K.C., Miller D., Bekisz J., zur Nedden D., Enterline J.C., Nguyen N.Y., Hu R.-Q.
      J. Biol. Chem. 267:15210-15216(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 24-59, FUNCTION.
    16. "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes."
      Nyman T.A., Toeloe H., Parkkinen J., Kalkkinen N.
      Biochem. J. 329:295-302(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 24-58.
    17. "IFN-alpha-1a gene is the major variant in the North American population."
      Hussain M., Ni D., Gill D., Liao M.-J.
      J. Interferon Cytokine Res. 20:763-768(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: POLYMORPHISM.
    18. "Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus."
      Ouyang S., Gong B., Li J.Z., Zhao L.X., Wu W., Zhang F.S., Sun L., Wang S.J., Pan M., Li C., Liang W., Shaw N., Zheng J., Zhao G.P., Wang Y., Liu Z.J., Liang M.
      J. Mol. Med. 90:837-846(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 24-189 IN COMPLEX WITH ANTIBODY, DISULFIDE BOND.

    Entry informationi

    Entry nameiIFNA1_HUMAN
    AccessioniPrimary (citable) accession number: P01562
    Secondary accession number(s): D4Q9M8
    , Q14605, Q2M1L8, Q52LB8, Q5VYQ2, Q7M4Q1, Q8WZ68, Q9UMJ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 154 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Interferons alpha-1 and alpha-13 have identical protein sequences.

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3