Reviewed, UniProtKB/Swiss-Prot P01562 (IFNA1_HUMAN)

Names and origin

Protein names

Recommended name:
    Interferon alpha-1/13
Alternative name(s):
    Interferon alpha-D
      Short name(s)=LeIF D

Gene names

Name:	IFNA1
AND
Name:	IFNA13

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	189 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
Subcellular location	Secreted.
Polymorphism	Two forms exist; alpha-1a (shown here) and alpha-1b.
Miscellaneous	Interferons alpha-1 and alpha-13 have identical protein sequences.
Sequence similarities	Belongs to the alpha/beta interferon family.

Ontologies

Keywords
Biological process	Antiviral defense
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Cytokine
Technical term	Direct protein sequencing
Gene Ontology (GO)
Molecular function	interferon-alpha/beta receptor binding Ref.5 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Signal peptide	1 – 23	23
	Chain	24 – 189	166	Interferon alpha-1/13
Amino acid modifications
	Disulfide bond	24 ↔ 122		By similarity
	Disulfide bond	52 ↔ 162		By similarity
Natural variations
	Natural variant	10	1	V → A: dbSNP rs1758567.
	Natural variant	137	1	A → V in alpha-1B. dbSNP rs2230050.
	Natural variant	163	1	A → G
Experimental info
	Sequence conflict	116	1	L → P in AAL35223. Ref.12
	Sequence conflict	172	1	M → V in AAL35223. Ref.12

Sequences

	Sequence		Length	Mass (Da)
	P01562-1 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: F32F9CB969606B69	FASTA	189	21,725
	10 20 30 40 50 60 MASPFALLMV LVVLSCKSSC SLGCDLPETH SLDNRRTLML LAQMSRISPS SCLMDRHDFG 70 80 90 100 110 120 FPQEEFDGNQ FQKAPAISVL HELIQQIFNL FTTKDSSAAW DEDLLDKFCT ELYQQLNDLE 130 140 150 160 170 180 ACVMQEERVG ETPLMNADSI LAVKKYFRRI TLYLTEKKYS PCAWEVVRAE IMRSLSLSTN LQERLRRKE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of a cloned human leukocyte interferon cDNA." Mantei N., Schwarzstein M., Streuli M., Panem S., Nagata S., Weissmann C. Gene 10:1-10(1980) [PubMed: 6157600] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Human leukocyte and fibroblast interferons are structurally related." Taniguchi T., Mantei N., Schwarzstein M., Nagata S., Muramatsu M., Weissmann C. Nature 285:547-549(1980) [PubMed: 6157095] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The structure of eight distinct cloned human leukocyte interferon cDNAs." Goeddel D.V., Leung D.W., Dull T.J., Gross M., Lawn R.M., McCandliss R., Seeburg P.H., Ullrich A., Yelverton E., Gray P.W. Nature 290:20-26(1981) [PubMed: 6163083] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Two non-allelic human interferon alpha genes with identical coding regions." Todokoro K., Kioussis D., Weissmann C. EMBO J. 3:1809-1812(1984) [PubMed: 6479148] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"Structural relationship of human interferon alpha genes and pseudogenes." Henco K., Brosius J., Fujisawa A., Fujisawa J., Haynes J.R., Hochstadt J., Kovacic T., Pasek M., Schamboeck A., Schmid J., Todokoro K., Waelchli M., Nagata S., Weissmann C. J. Mol. Biol. 185:227-260(1985) [PubMed: 4057246] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]	"Two distinct families of human and bovine interferon-alpha genes are coordinately expressed and encode functional polypeptides." Capon D.J., Shepard H.M., Goeddel D.V. Mol. Cell. Biol. 5:768-779(1985) [PubMed: 2985969] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[7]	Rostoks N. Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-10.
[8]	"NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)." Livingston R.J., Rieder M.J., Shaffer T., Bertucci C., Baier C.N., Rajkumar N., Willa H.T., Daniels M., Downing T.K., Stanaway I.B., Nguyen C.P., Gildersleeve H., Cassidy C.M., Johnson E.J., Swanson J.E., McFarland I., Yool B., Park C., Nickerson D.A. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-10; VAL-137 AND GLY-163.
[9]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-10. Tissue: Cerebellum.
[11]	"Formation of genes coding for hybrid proteins by recombination between related, cloned genes in E. coli." Weber H., Weissmann C. Nucleic Acids Res. 11:5661-5669(1983) [PubMed: 6310510] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-189.
[12]	Chen H.H., Yu X.B. Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-189. Tissue: Leukocyte.
[13]	"Purification and characterization of multiple components of human lymphoblastoid interferon-alpha." Zoon K.C., Miller D., Bekisz J., zur Nedden D., Enterline J.C., Nguyen N.Y., Hu R.-Q. J. Biol. Chem. 267:15210-15216(1992) [PubMed: 1634550] [Abstract] Cited for: PROTEIN SEQUENCE OF 24-59, FUNCTION.
[14]	"Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes." Nyman T.A., Toeloe H., Parkkinen J., Kalkkinen N. Biochem. J. 329:295-302(1998) [PubMed: 9425112] [Abstract] Cited for: PROTEIN SEQUENCE OF 24-58.
[15]	"IFN-alpha-1a gene is the major variant in the North American population." Hussain M., Ni D., Gill D., Liao M.-J. J. Interferon Cytokine Res. 20:763-768(2000) [PubMed: 11032395] [Abstract] Cited for: POLYMORPHISM.

Cross-references

Sequence databases
EMBLGenBankDDBJ	V00537 mRNA. Translation: CAA23798.1. J00210 Genomic DNA. Translation: AAB59403.1. V00538 mRNA. Translation: CAA23799.1. X00803 Genomic DNA. Translation: CAA25381.1. X75934 Genomic DNA. Translation: CAA53538.1. DQ185447 Genomic DNA. Translation: ABA03167.1. AL353732 Genomic DNA. Translation: CAH72904.1. AL353732 Genomic DNA. Translation: CAH72911.1. BC069427 mRNA. Translation: AAH69427.1. BC074928 mRNA. Translation: AAH74928.1. BC074929 mRNA. Translation: AAH74929.1. BC093988 mRNA. Translation: AAH93988.1. BC112002 mRNA. Translation: AAI12003.1. BC112300 mRNA. Translation: AAI12301.1. BC112302 mRNA. Translation: AAI12303.1. M29884 Genomic DNA. Translation: AAA52714.1. AF439447 Genomic DNA. Translation: AAL35223.1.
PIR	IVHUA1. C23285. F42753. H42753.
RefSeq	NP_076918.1.
UniGene	Hs.37026 Hs.533471
3D structure databases
HSSP	HSSP built from PDB template 1ITF based on UniProtKB P01563.
SMR	P01562. Positions 24-189.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:6020N.
Polymorphism databases
NIEHS-SNPs	Search...
Genome annotation databases
Ensembl	ENSG00000197919. Homo sapiens. [Contig view]
GeneID	3439.
KEGG	hsa:3439.
Organism-specific databases
H-InvDB	HIX0034868.
HGNC	HGNC:5417. IFNA1. HGNC:5419. IFNA13.
MIM	147578. gene. 147660. gene.
PharmGKB	PA29656.
GenAtlas	Search...
GeneCards	Search...
GeneLynx	Search...
Phylogenomic databases
HOGENOM	P01562.
HOVERGEN	P01562.
Gene expression databases
CleanEx	HS_IFNA1. HS_IFNA13.
GermOnline	ENSG00000197919. Homo sapiens.
Family and domain databases
InterPro	IPR012351. 4_helix_cytokine_core. IPR015589. IFNa. IPR000471. Interferon_abd. [Graphical view]
Gene3D	G3DSA:1.20.1250.10. 4_helix_cytokine_core. 1 hit.
PANTHER	PTHR11691:SF9. IFNa. 1 hit. PTHR11691. Interferon_abd. 1 hit.
Pfam	PF00143. Interferon. 1 hit. [Graphical view]
PRINTS	PR00266. INTERFERONAB.
ProDom	PD000550. Interferon_abd. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00076. IFabd. 1 hit. [Graphical view]
PROSITE	PS00252. INTERFERON_A_B_D. 1 hit. [Graphical view]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

IFNA1_HUMAN

Accession

Primary (citable) accession number: P01562
Secondary accession number(s): Q14605 , Q2M1L8, Q52LB8, Q5VYQ2, Q7M4Q1, Q8WZ68, Q9UMJ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	July 22, 2008
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)