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Protein

Interferon alpha-1/13

Gene

IFNA1

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense

Enzyme and pathway databases

BioCyciZFISH:ENSG00000147885-MONOMER.
ReactomeiR-HSA-909733. Interferon alpha/beta signaling.
R-HSA-912694. Regulation of IFNA signaling.
R-HSA-933541. TRAF6 mediated IRF7 activation.
R-HSA-983231. Factors involved in megakaryocyte development and platelet production.
SignaLinkiP01562.
SIGNORiP01562.

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-1/13
Short name:
IFN-alpha-1/13
Alternative name(s):
Interferon alpha-D
Short name:
LeIF D
Gene namesi
Name:IFNA1
AND
Name:IFNA13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:5417. IFNA1.
HGNC:5419. IFNA13.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3439.
3447.
OpenTargetsiENSG00000197919.
PharmGKBiPA29658.

Polymorphism and mutation databases

BioMutaiIFNA1.
DMDMi124455.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 232 PublicationsAdd BLAST23
ChainiPRO_000001635924 – 189Interferon alpha-1/13Add BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 122By similarity
Disulfide bondi52 ↔ 1621 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP01562.
MaxQBiP01562.
PaxDbiP01562.
PeptideAtlasiP01562.
PRIDEiP01562.

PTM databases

iPTMnetiP01562.
PhosphoSitePlusiP01562.

Expressioni

Gene expression databases

BgeeiENSG00000197919.
CleanExiHS_IFNA1.
HS_IFNA13.
ExpressionAtlasiP01562. baseline and differential.
GenevisibleiP01562. HS.

Organism-specific databases

HPAiHPA047557.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109662. 8 interactors.
109670. 7 interactors.
DIPiDIP-6020N.
IntActiP01562. 1 interactor.
STRINGi9606.ENSP00000276927.

Structurei

Secondary structure

1189
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi35 – 43Combined sources9
Helixi49 – 51Combined sources3
Turni53 – 55Combined sources3
Helixi63 – 66Combined sources4
Helixi77 – 91Combined sources15
Helixi94 – 99Combined sources6
Helixi102 – 122Combined sources21
Helixi137 – 156Combined sources20
Turni157 – 159Combined sources3
Helixi161 – 178Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3UX9X-ray2.80A/C24-189[»]
ProteinModelPortaliP01562.
SMRiP01562.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IR8X. Eukaryota.
ENOG4110Q1A. LUCA.
GeneTreeiENSGT00760000119150.
HOVERGENiHBG052086.
InParanoidiP01562.
KOiK05414.
OMAiYFERITI.
PhylomeDBiP01562.
TreeFamiTF336177.

Family and domain databases

CDDicd00095. IFab. 1 hit.
Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01562-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPFALLMV LVVLSCKSSC SLGCDLPETH SLDNRRTLML LAQMSRISPS
60 70 80 90 100
SCLMDRHDFG FPQEEFDGNQ FQKAPAISVL HELIQQIFNL FTTKDSSAAW
110 120 130 140 150
DEDLLDKFCT ELYQQLNDLE ACVMQEERVG ETPLMNADSI LAVKKYFRRI
160 170 180
TLYLTEKKYS PCAWEVVRAE IMRSLSLSTN LQERLRRKE
Length:189
Mass (Da):21,725
Last modified:July 21, 1986 - v1
Checksum:iF32F9CB969606B69
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti116L → P in AAL35223 (Ref. 14) Curated1
Sequence conflicti172M → V in AAL35223 (Ref. 14) Curated1

Polymorphismi

Two forms exist; alpha-1a (shown here) and alpha-1b (PubMed:11032395).1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02450810V → A.3 PublicationsCorresponds to variant rs1758567dbSNPEnsembl.1
Natural variantiVAR_013000137A → V in alpha-1B. 1 PublicationCorresponds to variant rs2230050dbSNPEnsembl.1
Natural variantiVAR_025173163A → G.1 PublicationCorresponds to variant rs33965070dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00537 mRNA. Translation: CAA23798.1.
J00210 Genomic DNA. Translation: AAB59403.1.
V00538 mRNA. Translation: CAA23799.1.
X00803 Genomic DNA. Translation: CAA25381.1.
X75934 Genomic DNA. Translation: CAA53538.1.
AB445100 Genomic DNA. Translation: BAI99735.1.
DQ185447 Genomic DNA. Translation: ABA03167.1.
AL353732 Genomic DNA. Translation: CAH72904.1.
AL353732 Genomic DNA. Translation: CAH72911.1.
CH471071 Genomic DNA. Translation: EAW58609.1.
BC069427 mRNA. Translation: AAH69427.1.
BC074928 mRNA. Translation: AAH74928.1.
BC074929 mRNA. Translation: AAH74929.1.
BC093988 mRNA. Translation: AAH93988.1.
BC112002 mRNA. Translation: AAI12003.1.
BC112300 mRNA. Translation: AAI12301.1.
BC112302 mRNA. Translation: AAI12303.1.
M29884 Genomic DNA. Translation: AAA52714.1.
AF439447 Genomic DNA. Translation: AAL35223.1.
CCDSiCCDS6508.1.
PIRiC23285. IVHUA1.
F42753.
H42753.
RefSeqiNP_008831.3. NM_006900.3.
NP_076918.1. NM_024013.2.
UniGeneiHs.37026.
Hs.533471.

Genome annotation databases

EnsembliENST00000276927; ENSP00000276927; ENSG00000197919.
ENST00000449498; ENSP00000394494; ENSG00000233816.
GeneIDi3439.
3447.
KEGGihsa:3439.
hsa:3447.
UCSCiuc003zpd.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00537 mRNA. Translation: CAA23798.1.
J00210 Genomic DNA. Translation: AAB59403.1.
V00538 mRNA. Translation: CAA23799.1.
X00803 Genomic DNA. Translation: CAA25381.1.
X75934 Genomic DNA. Translation: CAA53538.1.
AB445100 Genomic DNA. Translation: BAI99735.1.
DQ185447 Genomic DNA. Translation: ABA03167.1.
AL353732 Genomic DNA. Translation: CAH72904.1.
AL353732 Genomic DNA. Translation: CAH72911.1.
CH471071 Genomic DNA. Translation: EAW58609.1.
BC069427 mRNA. Translation: AAH69427.1.
BC074928 mRNA. Translation: AAH74928.1.
BC074929 mRNA. Translation: AAH74929.1.
BC093988 mRNA. Translation: AAH93988.1.
BC112002 mRNA. Translation: AAI12003.1.
BC112300 mRNA. Translation: AAI12301.1.
BC112302 mRNA. Translation: AAI12303.1.
M29884 Genomic DNA. Translation: AAA52714.1.
AF439447 Genomic DNA. Translation: AAL35223.1.
CCDSiCCDS6508.1.
PIRiC23285. IVHUA1.
F42753.
H42753.
RefSeqiNP_008831.3. NM_006900.3.
NP_076918.1. NM_024013.2.
UniGeneiHs.37026.
Hs.533471.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3UX9X-ray2.80A/C24-189[»]
ProteinModelPortaliP01562.
SMRiP01562.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109662. 8 interactors.
109670. 7 interactors.
DIPiDIP-6020N.
IntActiP01562. 1 interactor.
STRINGi9606.ENSP00000276927.

PTM databases

iPTMnetiP01562.
PhosphoSitePlusiP01562.

Polymorphism and mutation databases

BioMutaiIFNA1.
DMDMi124455.

Proteomic databases

EPDiP01562.
MaxQBiP01562.
PaxDbiP01562.
PeptideAtlasiP01562.
PRIDEiP01562.

Protocols and materials databases

DNASUi3439.
3447.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276927; ENSP00000276927; ENSG00000197919.
ENST00000449498; ENSP00000394494; ENSG00000233816.
GeneIDi3439.
3447.
KEGGihsa:3439.
hsa:3447.
UCSCiuc003zpd.2. human.

Organism-specific databases

CTDi3439.
3447.
DisGeNETi3439.
3447.
GeneCardsiIFNA1.
IFNA13.
HGNCiHGNC:5417. IFNA1.
HGNC:5419. IFNA13.
HPAiHPA047557.
MIMi147578. gene.
147660. gene.
neXtProtiNX_P01562.
OpenTargetsiENSG00000197919.
PharmGKBiPA29658.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IR8X. Eukaryota.
ENOG4110Q1A. LUCA.
GeneTreeiENSGT00760000119150.
HOVERGENiHBG052086.
InParanoidiP01562.
KOiK05414.
OMAiYFERITI.
PhylomeDBiP01562.
TreeFamiTF336177.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000147885-MONOMER.
ReactomeiR-HSA-909733. Interferon alpha/beta signaling.
R-HSA-912694. Regulation of IFNA signaling.
R-HSA-933541. TRAF6 mediated IRF7 activation.
R-HSA-983231. Factors involved in megakaryocyte development and platelet production.
SignaLinkiP01562.
SIGNORiP01562.

Miscellaneous databases

GeneWikiiIFNA13.
Interferon,_alpha_1.
PROiP01562.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197919.
CleanExiHS_IFNA1.
HS_IFNA13.
ExpressionAtlasiP01562. baseline and differential.
GenevisibleiP01562. HS.

Family and domain databases

CDDicd00095. IFab. 1 hit.
Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR000471. Interferon_alpha/beta/delta.
[Graphical view]
PANTHERiPTHR11691. PTHR11691. 1 hit.
PfamiPF00143. Interferon. 1 hit.
[Graphical view]
PRINTSiPR00266. INTERFERONAB.
SMARTiSM00076. IFabd. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00252. INTERFERON_A_B_D. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIFNA1_HUMAN
AccessioniPrimary (citable) accession number: P01562
Secondary accession number(s): D4Q9M8
, Q14605, Q2M1L8, Q52LB8, Q5VYQ2, Q7M4Q1, Q8WZ68, Q9UMJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 30, 2016
This is version 172 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Interferons alpha-1 and alpha-13 have identical protein sequences.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.