Reviewed,
UniProtKB/Swiss-Prot P01562 (IFNA1_HUMAN)
Last modified
July 22, 2008.
Version 94.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Interferon alpha-1/13 Alternative name(s): Interferon alpha-D Short name(s)=LeIF D | |||||
| Gene names |
| |||||
| Organism | Homo sapiens (Human) | |||||
| Taxonomic identifier | 9606 [NCBI] | |||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 189 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. |
| Subcellular location | |
| Polymorphism | Two forms exist; alpha-1a (shown here) and alpha-1b. |
| Miscellaneous | Interferons alpha-1 and alpha-13 have identical protein sequences. |
| Sequence similarities | Belongs to the alpha/beta interferon family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Antiviral defense |
| Cellular component | Secreted |
| Coding sequence diversity | Polymorphism |
| Domain | Signal |
| Molecular function | Cytokine |
| Technical term | Direct protein sequencing |
Gene Ontology (GO) | |
| Molecular function | interferon-alpha/beta receptor binding Ref.5 Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | ||||||
Molecule processing | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 23 | 23 | ||||||||
| Chain | 24 – 189 | 166 | Interferon alpha-1/13 | |||||||
Amino acid modifications | ||||||||||
| Disulfide bond | 24 ↔ 122 | By similarity | ||||||||
| Disulfide bond | 52 ↔ 162 | By similarity | ||||||||
Natural variations | ||||||||||
| Natural variant | 10 | 1 | V → A: dbSNP rs1758567. | |||||||
| Natural variant | 137 | 1 | A → V in alpha-1B. dbSNP rs2230050. | |||||||
| Natural variant | 163 | 1 | A → G | |||||||
Experimental info | ||||||||||
| Sequence conflict | 116 | 1 | L → P in AAL35223. Ref.12 | |||||||
| Sequence conflict | 172 | 1 | M → V in AAL35223. Ref.12 | |||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The nucleotide sequence of a cloned human leukocyte interferon cDNA." Mantei N., Schwarzstein M., Streuli M., Panem S., Nagata S., Weissmann C. Gene 10:1-10(1980) [PubMed: 6157600] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Human leukocyte and fibroblast interferons are structurally related." Taniguchi T., Mantei N., Schwarzstein M., Nagata S., Muramatsu M., Weissmann C. Nature 285:547-549(1980) [PubMed: 6157095] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "The structure of eight distinct cloned human leukocyte interferon cDNAs." Goeddel D.V., Leung D.W., Dull T.J., Gross M., Lawn R.M., McCandliss R., Seeburg P.H., Ullrich A., Yelverton E., Gray P.W. Nature 290:20-26(1981) [PubMed: 6163083] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [4] | "Two non-allelic human interferon alpha genes with identical coding regions." Todokoro K., Kioussis D., Weissmann C. EMBO J. 3:1809-1812(1984) [PubMed: 6479148] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [5] | "Structural relationship of human interferon alpha genes and pseudogenes." Henco K., Brosius J., Fujisawa A., Fujisawa J., Haynes J.R., Hochstadt J., Kovacic T., Pasek M., Schamboeck A., Schmid J., Todokoro K., Waelchli M., Nagata S., Weissmann C. J. Mol. Biol. 185:227-260(1985) [PubMed: 4057246] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [6] | "Two distinct families of human and bovine interferon-alpha genes are coordinately expressed and encode functional polypeptides." Capon D.J., Shepard H.M., Goeddel D.V. Mol. Cell. Biol. 5:768-779(1985) [PubMed: 2985969] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. |
| [7] | Rostoks N. Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ALA-10. |
| [8] | "NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)." Livingston R.J., Rieder M.J., Shaffer T., Bertucci C., Baier C.N., Rajkumar N., Willa H.T., Daniels M., Downing T.K., Stanaway I.B., Nguyen C.P., Gildersleeve H., Cassidy C.M., Johnson E.J., Swanson J.E., McFarland I., Yool B., Park C., Nickerson D.A. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ALA-10; VAL-137 AND GLY-163. |
| [9] | "DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. Dunham I.Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [10] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-10. Tissue: Cerebellum. |
| [11] | "Formation of genes coding for hybrid proteins by recombination between related, cloned genes in E. coli." Weber H., Weissmann C. Nucleic Acids Res. 11:5661-5669(1983) [PubMed: 6310510] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-189. |
| [12] | Chen H.H., Yu X.B. Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-189. Tissue: Leukocyte. |
| [13] | "Purification and characterization of multiple components of human lymphoblastoid interferon-alpha." Zoon K.C., Miller D., Bekisz J., zur Nedden D., Enterline J.C., Nguyen N.Y., Hu R.-Q. J. Biol. Chem. 267:15210-15216(1992) [PubMed: 1634550] [Abstract] Cited for: PROTEIN SEQUENCE OF 24-59, FUNCTION. |
| [14] | "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes." Nyman T.A., Toeloe H., Parkkinen J., Kalkkinen N. Biochem. J. 329:295-302(1998) [PubMed: 9425112] [Abstract] Cited for: PROTEIN SEQUENCE OF 24-58. |
| [15] | "IFN-alpha-1a gene is the major variant in the North American population." Hussain M., Ni D., Gill D., Liao M.-J. J. Interferon Cytokine Res. 20:763-768(2000) [PubMed: 11032395] [Abstract] Cited for: POLYMORPHISM. |
Cross-references
Sequence databases | |
|---|---|
| V00537 mRNA. Translation: CAA23798.1. J00210 Genomic DNA. Translation: AAB59403.1. V00538 mRNA. Translation: CAA23799.1. X00803 Genomic DNA. Translation: CAA25381.1. X75934 Genomic DNA. Translation: CAA53538.1. DQ185447 Genomic DNA. Translation: ABA03167.1. AL353732 Genomic DNA. Translation: CAH72904.1. AL353732 Genomic DNA. Translation: CAH72911.1. BC069427 mRNA. Translation: AAH69427.1. BC074928 mRNA. Translation: AAH74928.1. BC074929 mRNA. Translation: AAH74929.1. BC093988 mRNA. Translation: AAH93988.1. BC112002 mRNA. Translation: AAI12003.1. BC112300 mRNA. Translation: AAI12301.1. BC112302 mRNA. Translation: AAI12303.1. M29884 Genomic DNA. Translation: AAA52714.1. AF439447 Genomic DNA. Translation: AAL35223.1. | |
| PIR | IVHUA1. C23285. F42753. H42753. |
| RefSeq | NP_076918.1. |
| UniGene | Hs.37026 Hs.533471 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1ITF based on UniProtKB P01563. |
| SMR | P01562. Positions 24-189. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:6020N. |
Polymorphism databases | |
| NIEHS-SNPs | Search... |
Genome annotation databases | |
| Ensembl | ENSG00000197919. Homo sapiens. [Contig view] |
| GeneID | 3439. |
| KEGG | hsa:3439. |
Organism-specific databases | |
| H-InvDB | HIX0034868. |
| HGNC | HGNC:5417. IFNA1. HGNC:5419. IFNA13. |
| MIM | 147578. gene. 147660. gene. |
| PharmGKB | PA29656. |
| GenAtlas | Search... |
| GeneCards | Search... |
| GeneLynx | Search... |
Phylogenomic databases | |
| HOGENOM | P01562. |
| HOVERGEN | P01562. |
Gene expression databases | |
| CleanEx | HS_IFNA1. HS_IFNA13. |
| GermOnline | ENSG00000197919. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR012351. 4_helix_cytokine_core. IPR015589. IFNa. IPR000471. Interferon_abd. [Graphical view] |
| Gene3D | G3DSA:1.20.1250.10. 4_helix_cytokine_core. 1 hit. |
| PANTHER | PTHR11691:SF9. IFNa. 1 hit. PTHR11691. Interferon_abd. 1 hit. |
| Pfam | PF00143. Interferon. 1 hit. [Graphical view] |
| PRINTS | PR00266. INTERFERONAB. |
| ProDom | PD000550. Interferon_abd. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00076. IFabd. 1 hit. [Graphical view] |
| PROSITE | PS00252. INTERFERON_A_B_D. 1 hit. [Graphical view] |
| BLOCKS | Search... |
Other Resources | |
| SOURCE | Search... |
| ProtoNet | Search... |
Entry information
| Entry name | IFNA1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P01562 Secondary accession number(s): Q14605 Q9UMJ3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 9 Human chromosome 9: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |

Clusters with


