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Protein

Enterotoxin type C-1

Gene

entC1

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death.

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Enterotoxin, Superantigen, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Enterotoxin type C-1
Alternative name(s):
SEC1
Gene namesi
Name:entC1
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei2141. Sta a SEC.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 27271 PublicationAdd
BLAST
Chaini28 – 266239Enterotoxin type C-11 PublicationPRO_0000035607Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi120 ↔ 1371 Publication

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliP01553.
SMRiP01553. Positions 28-264.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.10.20.120. 1 hit.
InterProiIPR008992. Enterotoxin.
IPR006126. Staph/Strept_toxin_CS.
IPR006173. Staph_tox_OB.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
IPR006177. Toxin_bac.
[Graphical view]
PfamiPF02876. Stap_Strp_tox_C. 1 hit.
PF01123. Stap_Strp_toxin. 1 hit.
[Graphical view]
PRINTSiPR00279. BACTRLTOXIN.
PR01898. SAGSUPRFAMLY.
SUPFAMiSSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEiPS00277. STAPH_STREP_TOXIN_1. 1 hit.
PS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01553-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKSRFISCV ILIFALILVL FTPNVLAESQ PDPTPDELHK ASKFTGLMEN
60 70 80 90 100
MKVLYDDHYV SATKVKSVDK FLAHDLIYNI SDKKLKNYDK VKTELLNEGL
110 120 130 140 150
AKKYKDEVVD VYGSNYYVNC YFSSKDNVGK VTGGKTCMYG GITKHEGNHF
160 170 180 190 200
DNGNLQNVLI RVYENKRNTI SFEVQTDKKS VTAQELDIKA RNFLINKKNL
210 220 230 240 250
YEFNSSPYET GYIKFIENNG NTFWYDMMPA PGDKFDQSKY LMMYNDNKTV
260
DSKSVKIEVH LTTKNG
Length:266
Mass (Da):30,546
Last modified:January 1, 1990 - v2
Checksum:i3A7AB59A8986853B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti177 – 1771D → N AA sequence (PubMed:6189824).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05815 Genomic DNA. Translation: CAA29260.1.
PIRiS06356. ENSAC1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05815 Genomic DNA. Translation: CAA29260.1.
PIRiS06356. ENSAC1.

3D structure databases

ProteinModelPortaliP01553.
SMRiP01553. Positions 28-264.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei2141. Sta a SEC.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

PROiP01553.

Family and domain databases

Gene3Di3.10.20.120. 1 hit.
InterProiIPR008992. Enterotoxin.
IPR006126. Staph/Strept_toxin_CS.
IPR006173. Staph_tox_OB.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
IPR006177. Toxin_bac.
[Graphical view]
PfamiPF02876. Stap_Strp_tox_C. 1 hit.
PF01123. Stap_Strp_toxin. 1 hit.
[Graphical view]
PRINTSiPR00279. BACTRLTOXIN.
PR01898. SAGSUPRFAMLY.
SUPFAMiSSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEiPS00277. STAPH_STREP_TOXIN_1. 1 hit.
PS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence of the staphylococcal enterotoxin C1 gene and relatedness to other pyrogenic toxins."
    Bohach G.A., Schlievert P.M.
    Mol. Gen. Genet. 209:15-20(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The complete amino acid sequence of staphylococcal enterotoxin C1."
    Schmidt J.J., Spero L.
    J. Biol. Chem. 258:6300-6306(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 28-266.

Entry informationi

Entry nameiENTC1_STAAU
AccessioniPrimary (citable) accession number: P01553
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 1, 1990
Last modified: January 7, 2015
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.