P01553 (ENTC1_STAAU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Enterotoxin type C-1

Alternative name(s):
SEC1

Gene names

Name:

entC1

Organism

Staphylococcus aureus

Taxonomic identifier

1280 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus

Protein attributes

Sequence length	266 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death.
Subcellular location	Secreted.
Sequence similarities	Belongs to the staphylococcal/streptococcal toxin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Enterotoxin Superantigen Toxin
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 27	27	Ref.2
	Chain	28 – 266	239	Enterotoxin type C-1 Ref.2		PRO_0000035607
Amino acid modifications
	Disulfide bond	120 ↔ 137		Ref.2
Experimental info
	Sequence conflict	177	1	D → N AA sequence Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P01553 [UniParc]. Last modified January 1, 1990. Version 2. Checksum: 3A7AB59A8986853B	FASTA	266	30,546
	10 20 30 40 50 60 MNKSRFISCV ILIFALILVL FTPNVLAESQ PDPTPDELHK ASKFTGLMEN MKVLYDDHYV 70 80 90 100 110 120 SATKVKSVDK FLAHDLIYNI SDKKLKNYDK VKTELLNEGL AKKYKDEVVD VYGSNYYVNC 130 140 150 160 170 180 YFSSKDNVGK VTGGKTCMYG GITKHEGNHF DNGNLQNVLI RVYENKRNTI SFEVQTDKKS 190 200 210 220 230 240 VTAQELDIKA RNFLINKKNL YEFNSSPYET GYIKFIENNG NTFWYDMMPA PGDKFDQSKY 250 260 LMMYNDNKTV DSKSVKIEVH LTTKNG

References

[1]	"Nucleotide sequence of the staphylococcal enterotoxin C1 gene and relatedness to other pyrogenic toxins." Bohach G.A., Schlievert P.M. Mol. Gen. Genet. 209:15-20(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The complete amino acid sequence of staphylococcal enterotoxin C1." Schmidt J.J., Spero L. J. Biol. Chem. 258:6300-6306(1983) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 28-266.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X05815 Genomic DNA. Translation: CAA29260.1.
PIR	ENSAC1. S06356.
3D structure databases
ProteinModelPortal	P01553.
SMR	P01553. Positions 28-264.
ModBase	Search...
Protein family/group databases
Allergome	2141. Sta a SEC.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.10.20.120. 1 hit.
InterPro	IPR008992. Enterotoxin_bac. IPR006126. Staph/Strept_toxin_CS. IPR006173. Staph_tox_OB. IPR016091. SuperAg_toxin_C. IPR013307. Superantigen_bac. IPR006123. Toxin_b-grasp_Staph/Strep. IPR006177. Toxin_bac. [Graphical view]
Pfam	PF02876. Stap_Strp_tox_C. 1 hit. PF01123. Stap_Strp_toxin. 1 hit. [Graphical view]
PRINTS	PR00279. BACTRLTOXIN. PR01898. SAGSUPRFAMLY.
SUPFAM	SSF50203. Bact_endotox. 1 hit. SSF54334. Stap/Strep_toxin. 1 hit.
PROSITE	PS00277. STAPH_STREP_TOXIN_1. 1 hit. PS00278. STAPH_STREP_TOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ENTC1_STAAU

Accession

Primary (citable) accession number: P01553

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	January 1, 1990
Last modified:	May 1, 2013
This is version 76 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program