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P01552 (ETXB_STAAU) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Enterotoxin type B
Alternative name(s):
SEB
Gene names
Name:entB
OrganismStaphylococcus aureus
Taxonomic identifier1280 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death.

Subcellular location

Secreted.

Sequence similarities

Belongs to the staphylococcal/streptococcal toxin family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionEnterotoxin
Superantigen
Toxin
   PTMDisulfide bond
   Technical term3D-structure
Direct protein sequencing
Gene Ontology (GO)
   Biological_processpathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Ref.3
Chain28 – 266239Enterotoxin type B
PRO_0000035606

Amino acid modifications

Disulfide bond120 ↔ 140

Experimental info

Sequence conflict56 – 583DDN → NND AA sequence Ref.3
Sequence conflict69 – 779DQFLYFDLI → NEFFDLIYL AA sequence Ref.3
Sequence conflict1181Missing AA sequence Ref.3
Sequence conflict128 – 1303DIN → NID AA sequence Ref.3
Sequence conflict133 – 1353QTD → ENT AA sequence Ref.3
Sequence conflict149 – 1502NG → GN AA sequence Ref.3
Sequence conflict1561Y → YY AA sequence Ref.3
Sequence conflict185 – 1862QE → EQ AA sequence Ref.3
Sequence conflict2331D → N AA sequence Ref.3
Sequence conflict246 – 2472DN → ND AA sequence Ref.3

Secondary structure

............................................... 266
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P01552 [UniParc].

Last modified August 13, 1987. Version 1.
Checksum: B6D417F61CF018B0

FASTA26631,436
        10         20         30         40         50         60 
MYKRLFISHV ILIFALILVI STPNVLAESQ PDPKPDELHK SSKFTGLMEN MKVLYDDNHV 

        70         80         90        100        110        120 
SAINVKSIDQ FLYFDLIYSI KDTKLGNYDN VRVEFKNKDL ADKYKDKYVD VFGANYYYQC 

       130        140        150        160        170        180 
YFSKKTNDIN SHQTDKRKTC MYGGVTEHNG NQLDKYRSIT VRVFEDGKNL LSFDVQTNKK 

       190        200        210        220        230        240 
KVTAQELDYL TRHYLVKNKK LYEFNNSPYE TGYIKFIENE NSFWYDMMPA PGDKFDQSKY 

       250        260 
LMMYNDNKMV DSKDVKIEVY LTTKKK 

« Hide

References

[1]"Nucleotide sequence of the enterotoxin B gene from Staphylococcus aureus."
Jones C.L., Khan S.A.
J. Bacteriol. 166:29-33(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Molecular cloning of staphylococcal enterotoxin B gene in Escherichia coli and Staphylococcus aureus."
Ranelli D.M., Jones C.L., Johns M.B., Mussey G.J., Khan S.A.
Proc. Natl. Acad. Sci. U.S.A. 82:5850-5854(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 40-91.
[3]"The primary structure of staphylococcal enterotoxin B. 3. The cyanogen bromide peptides of reduced and aminoethylated enterotoxin B, and the complete amino acid sequence."
Huang I.-Y., Bergdoll M.S.
J. Biol. Chem. 245:3518-3525(1970) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 28-266 (S-6).
[4]"Crystal structure of staphylococcal enterotoxin B, a superantigen."
Swaminathan S., Furey W.F. Jr., Pletcher J., Sax M.
Nature 359:801-806(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
[5]"Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen."
Jardetzky T.S., Brown J.H., Gorga J.C., Stern L.J., Urban R.G., Chi Y.I., Stauffacher C., Strominger J.L., Wiley D.C.
Nature 368:711-718(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF COMPLEX WITH MHC II.
[6]"Three-dimensional structure of the complex between a T cell receptor beta chain and the superantigen staphylococcal enterotoxin B."
Li H., Llera A., Tsuchiya D., Leder L., Ysern X., Schlievert P.M., Karjalainen K., Mariuzza R.A.
Immunity 9:807-816(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF COMPLEX WITH TCR.
[7]"Crystal structure of microbial superantigen staphylococcal enterotoxin B at 1.5-A resolution: implications for superantigen recognition by MHC class II molecules and T-cell receptors."
Papageorgiou A.C., Tranter H.S., Acharya K.R.
J. Mol. Biol. 277:61-79(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M11118 Genomic DNA. Translation: AAA88550.1.
PIRENSAB6. S27360.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1D5MX-ray2.00C28-266[»]
1D5XX-ray2.45C28-266[»]
1D5ZX-ray2.00C28-266[»]
1D6EX-ray2.45C28-266[»]
1GOZX-ray2.00A/B28-266[»]
1SBBX-ray2.40B/D28-266[»]
1SE3X-ray2.30A28-266[»]
1SE4X-ray1.90A28-266[»]
1SEBX-ray2.70D/H29-262[»]
2SEBX-ray2.50D28-266[»]
3GP7X-ray1.90A/B28-266[»]
3R8BX-ray2.95A/C/E/G/I/K/M/O28-266[»]
3SEBX-ray1.48A28-265[»]
3W2DX-ray3.10A28-266[»]
ProteinModelPortalP01552.
SMRP01552. Positions 28-266.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-35541N.
IntActP01552. 1 interaction.

Protein family/group databases

Allergome2140. Sta a SEB.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.10.20.120. 1 hit.
InterProIPR008992. Enterotoxin_bac.
IPR006126. Staph/Strept_toxin_CS.
IPR006173. Staph_tox_OB.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
IPR006177. Toxin_bac.
[Graphical view]
PfamPF02876. Stap_Strp_tox_C. 1 hit.
PF01123. Stap_Strp_toxin. 1 hit.
[Graphical view]
PRINTSPR00279. BACTRLTOXIN.
PR01898. SAGSUPRFAMLY.
SUPFAMSSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEPS00277. STAPH_STREP_TOXIN_1. 1 hit.
PS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP01552.
PROP01552.

Entry information

Entry nameETXB_STAAU
AccessionPrimary (citable) accession number: P01552
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 13, 1987
Last modified: March 19, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references