Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P01552

- ETXB_STAAU

UniProt

P01552 - ETXB_STAAU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Enterotoxin type B

Gene

entB

Organism
Staphylococcus aureus
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death.

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Enterotoxin, Superantigen, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Enterotoxin type B
Alternative name(s):
SEB
Gene namesi
Name:entB
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei2140. Sta a SEB.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 27271 PublicationAdd
BLAST
Chaini28 – 266239Enterotoxin type BPRO_0000035606Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi120 ↔ 140

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

DIPiDIP-35541N.
IntActiP01552. 1 interaction.

Structurei

Secondary structure

1
266
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi33 – 364Combined sources
Helixi41 – 433Combined sources
Helixi49 – 524Combined sources
Helixi53 – 553Combined sources
Beta strandi60 – 667Combined sources
Beta strandi67 – 693Combined sources
Beta strandi75 – 784Combined sources
Turni83 – 853Combined sources
Beta strandi89 – 946Combined sources
Helixi98 – 1047Combined sources
Beta strandi107 – 1137Combined sources
Turni128 – 1314Combined sources
Beta strandi138 – 1425Combined sources
Beta strandi145 – 1484Combined sources
Turni149 – 1513Combined sources
Beta strandi152 – 16514Combined sources
Beta strandi168 – 18316Combined sources
Helixi184 – 19916Combined sources
Beta strandi204 – 2063Combined sources
Beta strandi208 – 21811Combined sources
Beta strandi221 – 2266Combined sources
Beta strandi231 – 2333Combined sources
Helixi237 – 2415Combined sources
Helixi242 – 2465Combined sources
Beta strandi249 – 2513Combined sources
Turni252 – 2543Combined sources
Beta strandi255 – 2639Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1D5MX-ray2.00C28-266[»]
1D5XX-ray2.45C28-266[»]
1D5ZX-ray2.00C28-266[»]
1D6EX-ray2.45C28-266[»]
1GOZX-ray2.00A/B28-266[»]
1SBBX-ray2.40B/D28-266[»]
1SE3X-ray2.30A28-266[»]
1SE4X-ray1.90A28-266[»]
1SEBX-ray2.70D/H29-262[»]
2SEBX-ray2.50D28-266[»]
3GP7X-ray1.90A/B28-266[»]
3R8BX-ray2.95A/C/E/G/I/K/M/O28-266[»]
3SEBX-ray1.48A28-265[»]
3W2DX-ray3.10A28-266[»]
4C56X-ray2.90C/I29-266[»]
ProteinModelPortaliP01552.
SMRiP01552. Positions 28-266.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01552.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.10.20.120. 1 hit.
InterProiIPR008992. Enterotoxin.
IPR006126. Staph/Strept_toxin_CS.
IPR006173. Staph_tox_OB.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
IPR006177. Toxin_bac.
[Graphical view]
PfamiPF02876. Stap_Strp_tox_C. 1 hit.
PF01123. Stap_Strp_toxin. 1 hit.
[Graphical view]
PRINTSiPR00279. BACTRLTOXIN.
PR01898. SAGSUPRFAMLY.
SUPFAMiSSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEiPS00277. STAPH_STREP_TOXIN_1. 1 hit.
PS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01552-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYKRLFISHV ILIFALILVI STPNVLAESQ PDPKPDELHK SSKFTGLMEN
60 70 80 90 100
MKVLYDDNHV SAINVKSIDQ FLYFDLIYSI KDTKLGNYDN VRVEFKNKDL
110 120 130 140 150
ADKYKDKYVD VFGANYYYQC YFSKKTNDIN SHQTDKRKTC MYGGVTEHNG
160 170 180 190 200
NQLDKYRSIT VRVFEDGKNL LSFDVQTNKK KVTAQELDYL TRHYLVKNKK
210 220 230 240 250
LYEFNNSPYE TGYIKFIENE NSFWYDMMPA PGDKFDQSKY LMMYNDNKMV
260
DSKDVKIEVY LTTKKK
Length:266
Mass (Da):31,436
Last modified:August 13, 1987 - v1
Checksum:iB6D417F61CF018B0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti56 – 583DDN → NND AA sequence (PubMed:5470821)Curated
Sequence conflicti69 – 779DQFLYFDLI → NEFFDLIYL AA sequence (PubMed:5470821)Curated
Sequence conflicti118 – 1181Missing AA sequence (PubMed:5470821)Curated
Sequence conflicti128 – 1303DIN → NID AA sequence (PubMed:5470821)Curated
Sequence conflicti133 – 1353QTD → ENT AA sequence (PubMed:5470821)Curated
Sequence conflicti149 – 1502NG → GN AA sequence (PubMed:5470821)Curated
Sequence conflicti156 – 1561Y → YY AA sequence (PubMed:5470821)Curated
Sequence conflicti185 – 1862QE → EQ AA sequence (PubMed:5470821)Curated
Sequence conflicti233 – 2331D → N AA sequence (PubMed:5470821)Curated
Sequence conflicti246 – 2472DN → ND AA sequence (PubMed:5470821)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11118 Genomic DNA. Translation: AAA88550.1.
PIRiS27360. ENSAB6.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11118 Genomic DNA. Translation: AAA88550.1 .
PIRi S27360. ENSAB6.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1D5M X-ray 2.00 C 28-266 [» ]
1D5X X-ray 2.45 C 28-266 [» ]
1D5Z X-ray 2.00 C 28-266 [» ]
1D6E X-ray 2.45 C 28-266 [» ]
1GOZ X-ray 2.00 A/B 28-266 [» ]
1SBB X-ray 2.40 B/D 28-266 [» ]
1SE3 X-ray 2.30 A 28-266 [» ]
1SE4 X-ray 1.90 A 28-266 [» ]
1SEB X-ray 2.70 D/H 29-262 [» ]
2SEB X-ray 2.50 D 28-266 [» ]
3GP7 X-ray 1.90 A/B 28-266 [» ]
3R8B X-ray 2.95 A/C/E/G/I/K/M/O 28-266 [» ]
3SEB X-ray 1.48 A 28-265 [» ]
3W2D X-ray 3.10 A 28-266 [» ]
4C56 X-ray 2.90 C/I 29-266 [» ]
ProteinModelPortali P01552.
SMRi P01552. Positions 28-266.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-35541N.
IntActi P01552. 1 interaction.

Protein family/group databases

Allergomei 2140. Sta a SEB.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P01552.
PROi P01552.

Family and domain databases

Gene3Di 3.10.20.120. 1 hit.
InterProi IPR008992. Enterotoxin.
IPR006126. Staph/Strept_toxin_CS.
IPR006173. Staph_tox_OB.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
IPR006177. Toxin_bac.
[Graphical view ]
Pfami PF02876. Stap_Strp_tox_C. 1 hit.
PF01123. Stap_Strp_toxin. 1 hit.
[Graphical view ]
PRINTSi PR00279. BACTRLTOXIN.
PR01898. SAGSUPRFAMLY.
SUPFAMi SSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEi PS00277. STAPH_STREP_TOXIN_1. 1 hit.
PS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the enterotoxin B gene from Staphylococcus aureus."
    Jones C.L., Khan S.A.
    J. Bacteriol. 166:29-33(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Molecular cloning of staphylococcal enterotoxin B gene in Escherichia coli and Staphylococcus aureus."
    Ranelli D.M., Jones C.L., Johns M.B., Mussey G.J., Khan S.A.
    Proc. Natl. Acad. Sci. U.S.A. 82:5850-5854(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 40-91.
  3. "The primary structure of staphylococcal enterotoxin B. 3. The cyanogen bromide peptides of reduced and aminoethylated enterotoxin B, and the complete amino acid sequence."
    Huang I.-Y., Bergdoll M.S.
    J. Biol. Chem. 245:3518-3525(1970) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 28-266 (S-6).
  4. "Crystal structure of staphylococcal enterotoxin B, a superantigen."
    Swaminathan S., Furey W.F. Jr., Pletcher J., Sax M.
    Nature 359:801-806(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
  5. "Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen."
    Jardetzky T.S., Brown J.H., Gorga J.C., Stern L.J., Urban R.G., Chi Y.I., Stauffacher C., Strominger J.L., Wiley D.C.
    Nature 368:711-718(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF COMPLEX WITH MHC II.
  6. "Three-dimensional structure of the complex between a T cell receptor beta chain and the superantigen staphylococcal enterotoxin B."
    Li H., Llera A., Tsuchiya D., Leder L., Ysern X., Schlievert P.M., Karjalainen K., Mariuzza R.A.
    Immunity 9:807-816(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF COMPLEX WITH TCR.
  7. "Crystal structure of microbial superantigen staphylococcal enterotoxin B at 1.5-A resolution: implications for superantigen recognition by MHC class II molecules and T-cell receptors."
    Papageorgiou A.C., Tranter H.S., Acharya K.R.
    J. Mol. Biol. 277:61-79(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS).

Entry informationi

Entry nameiETXB_STAAU
AccessioniPrimary (citable) accession number: P01552
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 13, 1987
Last modified: November 26, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3