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Protein

Enterotoxin type B

Gene

entB

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Enterotoxin, Superantigen, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Enterotoxin type B
Alternative name(s):
SEB
Gene namesi
Name:entB
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei2140. Sta a SEB.

Chemistry databases

DrugBankiDB04465. Lactose.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 271 PublicationAdd BLAST27
ChainiPRO_000003560628 – 266Enterotoxin type BAdd BLAST239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi120 ↔ 140

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

DIPiDIP-35541N.
IntActiP01552. 1 interactor.
STRINGi93062.SACOL0907.

Structurei

Secondary structure

1266
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi33 – 36Combined sources4
Helixi41 – 43Combined sources3
Helixi49 – 52Combined sources4
Helixi53 – 55Combined sources3
Beta strandi60 – 66Combined sources7
Beta strandi67 – 69Combined sources3
Beta strandi75 – 78Combined sources4
Turni83 – 85Combined sources3
Beta strandi89 – 94Combined sources6
Helixi98 – 104Combined sources7
Beta strandi107 – 113Combined sources7
Turni128 – 131Combined sources4
Beta strandi138 – 142Combined sources5
Beta strandi145 – 148Combined sources4
Turni149 – 151Combined sources3
Beta strandi152 – 165Combined sources14
Beta strandi168 – 183Combined sources16
Helixi184 – 199Combined sources16
Beta strandi204 – 206Combined sources3
Beta strandi208 – 218Combined sources11
Beta strandi221 – 226Combined sources6
Beta strandi231 – 233Combined sources3
Helixi237 – 241Combined sources5
Helixi242 – 246Combined sources5
Beta strandi249 – 251Combined sources3
Turni252 – 254Combined sources3
Beta strandi255 – 263Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D5MX-ray2.00C28-266[»]
1D5XX-ray2.45C28-266[»]
1D5ZX-ray2.00C28-266[»]
1D6EX-ray2.45C28-266[»]
1GOZX-ray2.00A/B28-266[»]
1SBBX-ray2.40B/D28-266[»]
1SE3X-ray2.30A28-266[»]
1SE4X-ray1.90A28-266[»]
1SEBX-ray2.70D/H29-262[»]
2SEBX-ray2.50D28-266[»]
3GP7X-ray1.90A/B28-266[»]
3R8BX-ray2.95A/C/E/G/I/K/M/O28-266[»]
3SEBX-ray1.48A28-265[»]
3W2DX-ray3.10A28-266[»]
4C56X-ray2.90C/I29-266[»]
4RGMX-ray2.69A/S28-266[»]
4RGNX-ray2.70A/S28-266[»]
4RGOX-ray1.80S28-266[»]
ProteinModelPortaliP01552.
SMRiP01552.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01552.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.10.20.120. 1 hit.
InterProiIPR008992. Enterotoxin.
IPR006126. Staph/Strept_toxin_CS.
IPR006173. Staph_tox_OB.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
IPR006177. Toxin_bac.
[Graphical view]
PfamiPF02876. Stap_Strp_tox_C. 1 hit.
PF01123. Stap_Strp_toxin. 1 hit.
[Graphical view]
PRINTSiPR00279. BACTRLTOXIN.
PR01898. SAGSUPRFAMLY.
SUPFAMiSSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEiPS00277. STAPH_STREP_TOXIN_1. 1 hit.
PS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01552-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKRLFISHV ILIFALILVI STPNVLAESQ PDPKPDELHK SSKFTGLMEN
60 70 80 90 100
MKVLYDDNHV SAINVKSIDQ FLYFDLIYSI KDTKLGNYDN VRVEFKNKDL
110 120 130 140 150
ADKYKDKYVD VFGANYYYQC YFSKKTNDIN SHQTDKRKTC MYGGVTEHNG
160 170 180 190 200
NQLDKYRSIT VRVFEDGKNL LSFDVQTNKK KVTAQELDYL TRHYLVKNKK
210 220 230 240 250
LYEFNNSPYE TGYIKFIENE NSFWYDMMPA PGDKFDQSKY LMMYNDNKMV
260
DSKDVKIEVY LTTKKK
Length:266
Mass (Da):31,436
Last modified:August 13, 1987 - v1
Checksum:iB6D417F61CF018B0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56 – 58DDN → NND AA sequence (PubMed:5470821).Curated3
Sequence conflicti69 – 77DQFLYFDLI → NEFFDLIYL AA sequence (PubMed:5470821).Curated9
Sequence conflicti118Missing AA sequence (PubMed:5470821).Curated1
Sequence conflicti128 – 130DIN → NID AA sequence (PubMed:5470821).Curated3
Sequence conflicti133 – 135QTD → ENT AA sequence (PubMed:5470821).Curated3
Sequence conflicti149 – 150NG → GN AA sequence (PubMed:5470821).Curated2
Sequence conflicti156Y → YY AA sequence (PubMed:5470821).Curated1
Sequence conflicti185 – 186QE → EQ AA sequence (PubMed:5470821).Curated2
Sequence conflicti233D → N AA sequence (PubMed:5470821).Curated1
Sequence conflicti246 – 247DN → ND AA sequence (PubMed:5470821).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11118 Genomic DNA. Translation: AAA88550.1.
PIRiS27360. ENSAB6.
RefSeqiWP_000278085.1. NZ_LSBE01000008.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11118 Genomic DNA. Translation: AAA88550.1.
PIRiS27360. ENSAB6.
RefSeqiWP_000278085.1. NZ_LSBE01000008.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D5MX-ray2.00C28-266[»]
1D5XX-ray2.45C28-266[»]
1D5ZX-ray2.00C28-266[»]
1D6EX-ray2.45C28-266[»]
1GOZX-ray2.00A/B28-266[»]
1SBBX-ray2.40B/D28-266[»]
1SE3X-ray2.30A28-266[»]
1SE4X-ray1.90A28-266[»]
1SEBX-ray2.70D/H29-262[»]
2SEBX-ray2.50D28-266[»]
3GP7X-ray1.90A/B28-266[»]
3R8BX-ray2.95A/C/E/G/I/K/M/O28-266[»]
3SEBX-ray1.48A28-265[»]
3W2DX-ray3.10A28-266[»]
4C56X-ray2.90C/I29-266[»]
4RGMX-ray2.69A/S28-266[»]
4RGNX-ray2.70A/S28-266[»]
4RGOX-ray1.80S28-266[»]
ProteinModelPortaliP01552.
SMRiP01552.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-35541N.
IntActiP01552. 1 interactor.
STRINGi93062.SACOL0907.

Chemistry databases

DrugBankiDB04465. Lactose.

Protein family/group databases

Allergomei2140. Sta a SEB.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP01552.
PROiP01552.

Family and domain databases

Gene3Di3.10.20.120. 1 hit.
InterProiIPR008992. Enterotoxin.
IPR006126. Staph/Strept_toxin_CS.
IPR006173. Staph_tox_OB.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
IPR006177. Toxin_bac.
[Graphical view]
PfamiPF02876. Stap_Strp_tox_C. 1 hit.
PF01123. Stap_Strp_toxin. 1 hit.
[Graphical view]
PRINTSiPR00279. BACTRLTOXIN.
PR01898. SAGSUPRFAMLY.
SUPFAMiSSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEiPS00277. STAPH_STREP_TOXIN_1. 1 hit.
PS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiETXB_STAAU
AccessioniPrimary (citable) accession number: P01552
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 13, 1987
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.