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P01552

- ETXB_STAAU

UniProt

P01552 - ETXB_STAAU

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Protein
Enterotoxin type B
Gene
entB
Organism
Staphylococcus aureus
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death.

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Enterotoxin, Superantigen, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Enterotoxin type B
Alternative name(s):
SEB
Gene namesi
Name:entB
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei2140. Sta a SEB.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 27271 Publication
Add
BLAST
Chaini28 – 266239Enterotoxin type B
PRO_0000035606Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi120 ↔ 140

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

DIPiDIP-35541N.
IntActiP01552. 1 interaction.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi33 – 364
Helixi41 – 433
Helixi49 – 524
Helixi53 – 553
Beta strandi60 – 667
Beta strandi67 – 693
Beta strandi75 – 784
Turni83 – 853
Beta strandi89 – 946
Helixi98 – 1047
Beta strandi107 – 1137
Turni128 – 1314
Beta strandi138 – 1425
Beta strandi145 – 1484
Turni149 – 1513
Beta strandi152 – 16514
Beta strandi168 – 18316
Helixi184 – 19916
Beta strandi204 – 2063
Beta strandi208 – 21811
Beta strandi221 – 2266
Beta strandi231 – 2333
Helixi237 – 2415
Helixi242 – 2465
Beta strandi249 – 2513
Turni252 – 2543
Beta strandi255 – 2639

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1D5MX-ray2.00C28-266[»]
1D5XX-ray2.45C28-266[»]
1D5ZX-ray2.00C28-266[»]
1D6EX-ray2.45C28-266[»]
1GOZX-ray2.00A/B28-266[»]
1SBBX-ray2.40B/D28-266[»]
1SE3X-ray2.30A28-266[»]
1SE4X-ray1.90A28-266[»]
1SEBX-ray2.70D/H29-262[»]
2SEBX-ray2.50D28-266[»]
3GP7X-ray1.90A/B28-266[»]
3R8BX-ray2.95A/C/E/G/I/K/M/O28-266[»]
3SEBX-ray1.48A28-265[»]
3W2DX-ray3.10A28-266[»]
ProteinModelPortaliP01552.
SMRiP01552. Positions 28-266.

Miscellaneous databases

EvolutionaryTraceiP01552.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.10.20.120. 1 hit.
InterProiIPR008992. Enterotoxin.
IPR006126. Staph/Strept_toxin_CS.
IPR006173. Staph_tox_OB.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
IPR006177. Toxin_bac.
[Graphical view]
PfamiPF02876. Stap_Strp_tox_C. 1 hit.
PF01123. Stap_Strp_toxin. 1 hit.
[Graphical view]
PRINTSiPR00279. BACTRLTOXIN.
PR01898. SAGSUPRFAMLY.
SUPFAMiSSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEiPS00277. STAPH_STREP_TOXIN_1. 1 hit.
PS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01552-1 [UniParc]FASTAAdd to Basket

« Hide

MYKRLFISHV ILIFALILVI STPNVLAESQ PDPKPDELHK SSKFTGLMEN    50
MKVLYDDNHV SAINVKSIDQ FLYFDLIYSI KDTKLGNYDN VRVEFKNKDL 100
ADKYKDKYVD VFGANYYYQC YFSKKTNDIN SHQTDKRKTC MYGGVTEHNG 150
NQLDKYRSIT VRVFEDGKNL LSFDVQTNKK KVTAQELDYL TRHYLVKNKK 200
LYEFNNSPYE TGYIKFIENE NSFWYDMMPA PGDKFDQSKY LMMYNDNKMV 250
DSKDVKIEVY LTTKKK 266
Length:266
Mass (Da):31,436
Last modified:August 13, 1987 - v1
Checksum:iB6D417F61CF018B0
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti56 – 583DDN → NND AA sequence 1 Publication
Sequence conflicti69 – 779DQFLYFDLI → NEFFDLIYL AA sequence 1 Publication
Sequence conflicti118 – 1181Missing AA sequence 1 Publication
Sequence conflicti128 – 1303DIN → NID AA sequence 1 Publication
Sequence conflicti133 – 1353QTD → ENT AA sequence 1 Publication
Sequence conflicti149 – 1502NG → GN AA sequence 1 Publication
Sequence conflicti156 – 1561Y → YY AA sequence 1 Publication
Sequence conflicti185 – 1862QE → EQ AA sequence 1 Publication
Sequence conflicti233 – 2331D → N AA sequence 1 Publication
Sequence conflicti246 – 2472DN → ND AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M11118 Genomic DNA. Translation: AAA88550.1.
PIRiS27360. ENSAB6.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M11118 Genomic DNA. Translation: AAA88550.1 .
PIRi S27360. ENSAB6.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1D5M X-ray 2.00 C 28-266 [» ]
1D5X X-ray 2.45 C 28-266 [» ]
1D5Z X-ray 2.00 C 28-266 [» ]
1D6E X-ray 2.45 C 28-266 [» ]
1GOZ X-ray 2.00 A/B 28-266 [» ]
1SBB X-ray 2.40 B/D 28-266 [» ]
1SE3 X-ray 2.30 A 28-266 [» ]
1SE4 X-ray 1.90 A 28-266 [» ]
1SEB X-ray 2.70 D/H 29-262 [» ]
2SEB X-ray 2.50 D 28-266 [» ]
3GP7 X-ray 1.90 A/B 28-266 [» ]
3R8B X-ray 2.95 A/C/E/G/I/K/M/O 28-266 [» ]
3SEB X-ray 1.48 A 28-265 [» ]
3W2D X-ray 3.10 A 28-266 [» ]
ProteinModelPortali P01552.
SMRi P01552. Positions 28-266.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-35541N.
IntActi P01552. 1 interaction.

Protein family/group databases

Allergomei 2140. Sta a SEB.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P01552.
PROi P01552.

Family and domain databases

Gene3Di 3.10.20.120. 1 hit.
InterProi IPR008992. Enterotoxin.
IPR006126. Staph/Strept_toxin_CS.
IPR006173. Staph_tox_OB.
IPR016091. SuperAg_toxin_C.
IPR013307. Superantigen_bac.
IPR006123. Toxin_b-grasp_Staph/Strep.
IPR006177. Toxin_bac.
[Graphical view ]
Pfami PF02876. Stap_Strp_tox_C. 1 hit.
PF01123. Stap_Strp_toxin. 1 hit.
[Graphical view ]
PRINTSi PR00279. BACTRLTOXIN.
PR01898. SAGSUPRFAMLY.
SUPFAMi SSF50203. SSF50203. 1 hit.
SSF54334. SSF54334. 1 hit.
PROSITEi PS00277. STAPH_STREP_TOXIN_1. 1 hit.
PS00278. STAPH_STREP_TOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the enterotoxin B gene from Staphylococcus aureus."
    Jones C.L., Khan S.A.
    J. Bacteriol. 166:29-33(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Molecular cloning of staphylococcal enterotoxin B gene in Escherichia coli and Staphylococcus aureus."
    Ranelli D.M., Jones C.L., Johns M.B., Mussey G.J., Khan S.A.
    Proc. Natl. Acad. Sci. U.S.A. 82:5850-5854(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 40-91.
  3. "The primary structure of staphylococcal enterotoxin B. 3. The cyanogen bromide peptides of reduced and aminoethylated enterotoxin B, and the complete amino acid sequence."
    Huang I.-Y., Bergdoll M.S.
    J. Biol. Chem. 245:3518-3525(1970) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 28-266 (S-6).
  4. "Crystal structure of staphylococcal enterotoxin B, a superantigen."
    Swaminathan S., Furey W.F. Jr., Pletcher J., Sax M.
    Nature 359:801-806(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
  5. "Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen."
    Jardetzky T.S., Brown J.H., Gorga J.C., Stern L.J., Urban R.G., Chi Y.I., Stauffacher C., Strominger J.L., Wiley D.C.
    Nature 368:711-718(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF COMPLEX WITH MHC II.
  6. "Three-dimensional structure of the complex between a T cell receptor beta chain and the superantigen staphylococcal enterotoxin B."
    Li H., Llera A., Tsuchiya D., Leder L., Ysern X., Schlievert P.M., Karjalainen K., Mariuzza R.A.
    Immunity 9:807-816(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF COMPLEX WITH TCR.
  7. "Crystal structure of microbial superantigen staphylococcal enterotoxin B at 1.5-A resolution: implications for superantigen recognition by MHC class II molecules and T-cell receptors."
    Papageorgiou A.C., Tranter H.S., Acharya K.R.
    J. Mol. Biol. 277:61-79(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS).

Entry informationi

Entry nameiETXB_STAAU
AccessioniPrimary (citable) accession number: P01552
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 13, 1987
Last modified: September 3, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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