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Protein

Actinoxanthin

Gene

axnA

Organism
Streptomyces globisporus
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds non-covalently to a chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore binds to DNA as a weak intercalator and causes single- and double-strand breaks.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Actinoxanthin
Short name:
AXN
Gene namesi
Name:axnA
OrganismiStreptomyces globisporus
Taxonomic identifieri1908 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 331 PublicationAdd BLAST33
ChainiPRO_000001945834 – 143ActinoxanthinAdd BLAST110

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi69 ↔ 781 Publication
Disulfide bondi119 ↔ 1241 Publication

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

1143
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi36 – 40Combined sources5
Beta strandi50 – 55Combined sources6
Beta strandi62 – 69Combined sources8
Turni80 – 82Combined sources3
Beta strandi85 – 87Combined sources3
Beta strandi95 – 99Combined sources5
Beta strandi102 – 107Combined sources6
Beta strandi113 – 118Combined sources6
Turni119 – 121Combined sources3
Beta strandi125 – 129Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ACXX-ray2.00A34-143[»]
ProteinModelPortaliP01551.
SMRiP01551.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01551.

Family & Domainsi

Sequence similaritiesi

Belongs to the neocarzinostatin family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.60.40.230. 1 hit.
InterProiIPR027273. Neocarzinostatin-like.
IPR002186. Neocarzinostatin_fam.
[Graphical view]
PfamiPF00960. Neocarzinostat. 1 hit.
[Graphical view]
PRINTSiPR01885. MACROMOMYCIN.
ProDomiPD012709. NCS-type_chromop. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF49319. SSF49319. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01551-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLRHMSRRA SRFGVVAVAS IGLAAAAQSV AFAAPAFSVS PASGLSDGQS
60 70 80 90 100
VSVSVSGAAA GETYYIAQCA PVGGQDACNP ATATSFTTDA SGAASFSFVV
110 120 130 140
RKSYAGSTPE GTPVGSVDCA TDACNLGAGN SGLDLGHVAL TFG
Length:143
Mass (Da):13,887
Last modified:February 1, 1995 - v2
Checksum:i2CB2E57FA5DC2F2C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54 – 55Missing AA sequence (PubMed:994323).Curated2
Sequence conflicti100Missing AA sequence (PubMed:994323).Curated1
Sequence conflicti107S → E AA sequence (PubMed:994323).Curated1
Sequence conflicti110E → S AA sequence (PubMed:994323).Curated1
Sequence conflicti134D → N AA sequence (PubMed:994323).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11457 Genomic DNA. Translation: BAA02014.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D11457 Genomic DNA. Translation: BAA02014.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ACXX-ray2.00A34-143[»]
ProteinModelPortaliP01551.
SMRiP01551.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP01551.

Family and domain databases

Gene3Di2.60.40.230. 1 hit.
InterProiIPR027273. Neocarzinostatin-like.
IPR002186. Neocarzinostatin_fam.
[Graphical view]
PfamiPF00960. Neocarzinostat. 1 hit.
[Graphical view]
PRINTSiPR01885. MACROMOMYCIN.
ProDomiPD012709. NCS-type_chromop. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF49319. SSF49319. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiATXA_STRGL
AccessioniPrimary (citable) accession number: P01551
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 1995
Last modified: November 2, 2016
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.