Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Purothionin A-1

Gene

THI1.3

Organism
Triticum aestivum (Wheat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Thionins are small plant proteins which are toxic to animal cells. They seem to exert their toxic effect at the level of the cell membrane. Their precise function is not known.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Toxin

Keywords - Biological processi

Plant defense

Protein family/group databases

TCDBi1.C.44.1.1. the plant thionine (pt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Purothionin A-1
Alternative name(s):
Beta-purothionin
Purothionin A-I
Cleaved into the following 2 chains:
Gene namesi
Name:THI1.3
OrganismiTriticum aestivum (Wheat)
Taxonomic identifieri4565 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaeTriticodaeTriticeaeTriticinaeTriticum
Proteomesi
  • UP000019116 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei9834. Tri a 37.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 27273 PublicationsAdd
BLAST
Chaini28 – 7245Purothionin A-1PRO_0000034130Add
BLAST
Chaini73 – 13664Acidic proteinPRO_0000034131Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 66
Disulfide bondi31 ↔ 58
Disulfide bondi39 ↔ 56
Disulfide bondi43 ↔ 52

Keywords - PTMi

Disulfide bond

Structurei

Secondary structure

1
136
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi29 – 335Combined sources
Helixi34 – 4310Combined sources
Turni44 – 463Combined sources
Helixi49 – 557Combined sources
Beta strandi58 – 603Combined sources
Beta strandi62 – 654Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BHPX-ray1.70A28-72[»]
ProteinModelPortaliP01543.
SMRiP01543. Positions 28-72.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01543.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.30.1350.10. 1 hit.
InterProiIPR001010. Thionin.
[Graphical view]
PfamiPF00321. Thionin. 1 hit.
[Graphical view]
PRINTSiPR00287. THIONIN.
SUPFAMiSSF57429. SSF57429. 1 hit.
PROSITEiPS00271. THIONIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01543-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSKGLKGVM VCLLILGLVL EQVQVEGKSC CKSTLGRNCY NLCRARGAQK
60 70 80 90 100
LCANVCRCKL TSGLSCPKDF PKLVLESNSD EPDTMEYCNL GCRSSLCDYI
110 120 130
VNAAADDEEM KLYVEQCGDA CVNFCNADAG LTSLDA
Length:136
Mass (Da):14,625
Last modified:July 15, 1998 - v2
Checksum:iA855C815519EDA24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004018 mRNA. Translation: AAB71137.1.
UniGeneiTa.1308.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004018 mRNA. Translation: AAB71137.1.
UniGeneiTa.1308.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BHPX-ray1.70A28-72[»]
ProteinModelPortaliP01543.
SMRiP01543. Positions 28-72.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei9834. Tri a 37.
TCDBi1.C.44.1.1. the plant thionine (pt) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP01543.

Family and domain databases

Gene3Di3.30.1350.10. 1 hit.
InterProiIPR001010. Thionin.
[Graphical view]
PfamiPF00321. Thionin. 1 hit.
[Graphical view]
PRINTSiPR00287. THIONIN.
SUPFAMiSSF57429. SSF57429. 1 hit.
PROSITEiPS00271. THIONIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTHNB_WHEAT
AccessioniPrimary (citable) accession number: P01543
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 15, 1998
Last modified: February 17, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.