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Protein

Purothionin A-1

Gene

THI1.3

Organism
Triticum aestivum (Wheat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Thionins are small plant proteins which are toxic to animal cells. They seem to exert their toxic effect at the level of the cell membrane. Their precise function is not known.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionToxin
Biological processPlant defense

Protein family/group databases

TCDBi1.C.44.1.1. the plant thionine (pt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Purothionin A-1
Alternative name(s):
Beta-purothionin
Purothionin A-I
Cleaved into the following 2 chains:
Gene namesi
Name:THI1.3
OrganismiTriticum aestivum (Wheat)
Taxonomic identifieri4565 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaeTriticodaeTriticeaeTriticinaeTriticum
Proteomesi
  • UP000019116 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei9834. Tri a 37.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 273 PublicationsAdd BLAST27
ChainiPRO_000003413028 – 72Purothionin A-1Add BLAST45
ChainiPRO_000003413173 – 136Acidic proteinAdd BLAST64

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 66
Disulfide bondi31 ↔ 58
Disulfide bondi39 ↔ 56
Disulfide bondi43 ↔ 52

Keywords - PTMi

Disulfide bond

Expressioni

Gene expression databases

ExpressionAtlasiP01543. baseline.

Structurei

Secondary structure

1136
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi29 – 33Combined sources5
Helixi34 – 43Combined sources10
Turni44 – 46Combined sources3
Helixi49 – 55Combined sources7
Beta strandi58 – 60Combined sources3
Beta strandi62 – 65Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BHPX-ray1.70A28-72[»]
ProteinModelPortaliP01543.
SMRiP01543.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01543.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.30.1350.10. 1 hit.
InterProiView protein in InterPro
IPR001010. Thionin.
IPR036391. Thionin-like_sf.
PANTHERiPTHR33920. PTHR33920. 1 hit.
PfamiView protein in Pfam
PF00321. Thionin. 1 hit.
PRINTSiPR00287. THIONIN.
SUPFAMiSSF57429. SSF57429. 1 hit.
PROSITEiView protein in PROSITE
PS00271. THIONIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01543-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSKGLKGVM VCLLILGLVL EQVQVEGKSC CKSTLGRNCY NLCRARGAQK
60 70 80 90 100
LCANVCRCKL TSGLSCPKDF PKLVLESNSD EPDTMEYCNL GCRSSLCDYI
110 120 130
VNAAADDEEM KLYVEQCGDA CVNFCNADAG LTSLDA
Length:136
Mass (Da):14,625
Last modified:July 15, 1998 - v2
Checksum:iA855C815519EDA24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF004018 mRNA. Translation: AAB71137.1.
UniGeneiTa.1308.

Similar proteinsi

Entry informationi

Entry nameiTHNB_WHEAT
AccessioniPrimary (citable) accession number: P01543
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 15, 1998
Last modified: November 22, 2017
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families