true1986-07-212023-02-22107NA11_ANESUAmino-acid sequence of toxin I from Anemonia sulcata.Wunderer G.Eulitz M.doi:10.1111/j.1432-1033.1978.tb20890.x1978Eur. J. Biochem.8911-17PROTEIN SEQUENCENematoblastAnemonia sulcata toxins modify activation and inactivation of Na+ currents in a crayfish neurone.Hartung K.Rathmayer W.doi:10.1007/bf005854061985Pflugers Arch.404119-125FUNCTIONDevelopment of a rational nomenclature for naming peptide and protein toxins from sea anemones.Oliveira J.S.Fuentes-Silva D.King G.F.doi:10.1016/j.toxicon.2012.05.0202012Toxicon60539-550NOMENCLATUREThe secondary structure of the toxin ATX Ia from Anemonia sulcata in aqueous solution determined on the basis of complete sequence-specific 1H-NMR assignments.Widmer H.Wagner G.Schweitz H.Lazdunski M.Wuethrich K.doi:10.1111/j.1432-1033.1988.tb13774.x1988Eur. J. Biochem.171177-192STRUCTURE BY NMRDISULFIDE BONDSThree-dimensional structure of the neurotoxin ATX Ia from Anemonia sulcata in aqueous solution determined by nuclear magnetic resonance spectroscopy.Widmer H.Billeter M.Wuethrich K.doi:10.1002/prot.3400604031989Proteins6357-371STRUCTURE BY NMRDISULFIDE BONDSTZAZ1A=1-46Anthopleurin-AAnenome_toxinMyo_ane_neurotoxin_sfToxin_4Anenome_toxinDefensin-likeDelta-actitoxin-Avd1aDelta-AITX-Avd1aAs1Delta-actitoxin-Avd1bDelta-AITX-Avd1bToxin ATX-IATX IToxin-1Binds specifically to voltage-gated sodium channels (Nav) and delays their inactivation during signal transduction (when tested on the soma membrane of a crustacean neuron). Has also been observed to affect the activation of the sodium current.Negative results: does not have effect on potassium or calcium currents with concentrations up to 5 uM (PubMed:2409523). Is inactive at excitable membranes of frog (PubMed:2409523).Belongs to the sea anemone sodium channel inhibitory toxin family. Type I subfamily.Opinions are divided on whether Anemonia viridis (Forsskal, 1775) and Anemonia sulcata (Pennant, 1777) are separate species.Delta-actitoxin-Avd1a48141464436342744In about 20% of the molecules.P3516253237451986-07-211481475d142ab8f972b1c9754ee738b95e639GAACLCKSDGPNTRGNSMSGTIWVFGCPSGWNNCEGRAIIGYCCKQtruetruetruetruetruetruetruetrue