Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P01533

- TXA1_ANESU

UniProt

P01533 - TXA1_ANESU

Protein

Neurotoxin-1

Gene
N/A
Organism
Anemonia sulcata (Mediterranean snakelocks sea anemone) (Anemonia viridis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds specifically to the sodium channel (Nav), thereby delaying its inactivation during signal transduction. Thus it strongly stimulates mammalian cardiac muscle contraction.

    GO - Biological processi

    1. regulation of signal transduction Source: InterPro

    Keywords - Molecular functioni

    Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neurotoxin-1
    Alternative name(s):
    As1
    Toxin ATX-I
    OrganismiAnemonia sulcata (Mediterranean snakelocks sea anemone) (Anemonia viridis)
    Taxonomic identifieri6108 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaNynantheaeActiniidaeAnemonia

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. nematocyst Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nematocyst, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4646Neurotoxin-1PRO_0000221512Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi4 ↔ 43
    Disulfide bondi6 ↔ 34
    Disulfide bondi27 ↔ 44

    Keywords - PTMi

    Disulfide bond

    Structurei

    Secondary structure

    1
    46
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi3 – 53
    Beta strandi16 – 2510
    Beta strandi32 – 343
    Beta strandi37 – 459

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1ATXNMR-A1-46[»]
    ProteinModelPortaliP01533.
    SMRiP01533. Positions 1-46.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP01533.

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di2.20.20.10. 1 hit.
    InterProiIPR000693. Anenome_toxin.
    IPR023355. Myo_neuro_toxin.
    [Graphical view]
    PfamiPF00706. Toxin_4. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001905. Anenome_toxin. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P01533-1 [UniParc]FASTAAdd to Basket

    « Hide

    GAACLCKSDG PNTRGNSMSG TIWVFGCPSG WNNCEGRAII GYCCKQ       46
    Length:46
    Mass (Da):4,814
    Last modified:July 21, 1986 - v1
    Checksum:i862C1E21FDA5432D
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti3 – 31A → P in about 20% of the molecules.

    Sequence databases

    PIRiA01796. TZAZ1.

    Cross-referencesi

    Sequence databases

    PIRi A01796. TZAZ1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1ATX NMR - A 1-46 [» ]
    ProteinModelPortali P01533.
    SMRi P01533. Positions 1-46.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P01533.

    Family and domain databases

    Gene3Di 2.20.20.10. 1 hit.
    InterProi IPR000693. Anenome_toxin.
    IPR023355. Myo_neuro_toxin.
    [Graphical view ]
    Pfami PF00706. Toxin_4. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001905. Anenome_toxin. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Amino-acid sequence of toxin I from Anemonia sulcata."
      Wunderer G., Eulitz M.
      Eur. J. Biochem. 89:11-17(1978) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Tissue: Nematoblast.
    2. "The secondary structure of the toxin ATX Ia from Anemonia sulcata in aqueous solution determined on the basis of complete sequence-specific 1H-NMR assignments."
      Widmer H., Wagner G., Schweitz H., Lazdunski M., Wuethrich K.
      Eur. J. Biochem. 171:177-192(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR, DISULFIDE BONDS.
    3. "Three-dimensional structure of the neurotoxin ATX Ia from Anemonia sulcata in aqueous solution determined by nuclear magnetic resonance spectroscopy."
      Widmer H., Billeter M., Wuethrich K.
      Proteins 6:357-371(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR, DISULFIDE BONDS.

    Entry informationi

    Entry nameiTXA1_ANESU
    AccessioniPrimary (citable) accession number: P01533
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3