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P01533 (TXA1_ANESU) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neurotoxin-1
Alternative name(s):
As1
Toxin ATX-I
OrganismAnemonia sulcata (Mediterranean snakelocks sea anemone) (Anemonia viridis)
Taxonomic identifier6108 [NCBI]
Taxonomic lineageEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaNynantheaeActiniidaeAnemonia

Protein attributes

Sequence length46 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds specifically to the sodium channel (Nav), thereby delaying its inactivation during signal transduction. Thus it strongly stimulates mammalian cardiac muscle contraction.

Subcellular location

Secreted. Nematocyst.

Sequence similarities

Belongs to the sea anemone sodium channel inhibitory toxin family. Type I subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4646Neurotoxin-1
PRO_0000221512

Amino acid modifications

Disulfide bond4 ↔ 43 Ref.2 Ref.3
Disulfide bond6 ↔ 34 Ref.2 Ref.3
Disulfide bond27 ↔ 44 Ref.2 Ref.3

Natural variations

Natural variant31A → P in about 20% of the molecules.

Secondary structure

......... 46
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P01533 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 862C1E21FDA5432D

FASTA464,814
        10         20         30         40 
GAACLCKSDG PNTRGNSMSG TIWVFGCPSG WNNCEGRAII GYCCKQ 

« Hide

References

[1]"Amino-acid sequence of toxin I from Anemonia sulcata."
Wunderer G., Eulitz M.
Eur. J. Biochem. 89:11-17(1978) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Nematoblast.
[2]"The secondary structure of the toxin ATX Ia from Anemonia sulcata in aqueous solution determined on the basis of complete sequence-specific 1H-NMR assignments."
Widmer H., Wagner G., Schweitz H., Lazdunski M., Wuethrich K.
Eur. J. Biochem. 171:177-192(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR, DISULFIDE BONDS.
[3]"Three-dimensional structure of the neurotoxin ATX Ia from Anemonia sulcata in aqueous solution determined by nuclear magnetic resonance spectroscopy."
Widmer H., Billeter M., Wuethrich K.
Proteins 6:357-371(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR, DISULFIDE BONDS.

Cross-references

Sequence databases

PIRTZAZ1. A01796.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1ATXNMR-A1-46[»]
ProteinModelPortalP01533.
SMRP01533. Positions 1-46.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.20.20.10. 1 hit.
InterProIPR000693. Anenome_toxin.
IPR023355. Myo_neuro_toxin.
[Graphical view]
PfamPF00706. Toxin_4. 1 hit.
[Graphical view]
PIRSFPIRSF001905. Anenome_toxin. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceP01533.

Entry information

Entry nameTXA1_ANESU
AccessionPrimary (citable) accession number: P01533
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 16, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references