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Alpha-conotoxin MI

Conus magus (Magus cone) (Magician's cone snail)
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli


Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. Blocks mammalian nAChR composed of alpha-1/delta subunits with high potency and alpha-1/gamma with a low potency.1 Publication

GO - Molecular functioni


Molecular functionAcetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-conotoxin MI
Short name:
Short name:
Alternative name(s):
OrganismiConus magus (Magus cone) (Magician's cone snail)
Taxonomic identifieri6492 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConusPionoconus

Organism-specific databases

ConoServeri23. MI.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti


Pathology & Biotechi


Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2R → A: 4-fold loss of activity. 1 Publication1
Mutagenesisi5H → A: 3-fold loss of activity. 1 Publication1
Mutagenesisi6P → A: 73-fold loss of activity. 1 Publication1
Mutagenesisi10K → A: 9-fold loss of activity. 1 Publication1
Mutagenesisi11N → A: 3-fold loss of activity. 1 Publication1
Mutagenesisi12Y → A: 8500-fold loss of activity. 1 Publication1
Mutagenesisi12Y → H: 33-fold loss of activity. 1 Publication1
Mutagenesisi12Y → M: 48-fold loss of activity. 1 Publication1
Mutagenesisi12Y → W: 5-fold loss of activity. 1 Publication1
Mutagenesisi13S → A: No loss of activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000444611 – 14Alpha-conotoxin MIAdd BLAST14

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi3 ↔ 81 Publication
Disulfide bondi4 ↔ 141 Publication
Modified residuei14Cysteine amide1 Publication1

Post-translational modificationi

Amidated; synthetic peptide with a C-terminus free is 6-fold less active than the amidated peptide.

Keywords - PTMi

Amidation, Disulfide bond


Tissue specificityi

Expressed by the venom duct.

Family & Domainsi


The cysteine framework is I (CC-C-C). Alpha3/5 pattern.

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Family and domain databases

InterProiView protein in InterPro
IPR018072. Conotoxin_a-typ_CS.
PROSITEiView protein in PROSITE
PS60014. ALPHA_CONOTOXIN. 1 hit.


Sequence statusi: Complete.

Mass (Da):1,499
Last modified:July 21, 1986 - v1

Sequence databases

PIRiA01784. NTKN1M.

Similar proteinsi

Entry informationi

Entry nameiCA1_CONMA
AccessioniPrimary (citable) accession number: P01521
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: January 31, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program


Keywords - Technical termi

Direct protein sequencing