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P01520

- CA2_CONGE

UniProt

P01520 - CA2_CONGE

Protein

Alpha-conotoxin GII

Gene
N/A
Organism
Conus geographus (Geography cone) (Nubecula geographus)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.

    Keywords - Molecular functioni

    Acetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-conotoxin GII
    OrganismiConus geographus (Geography cone) (Nubecula geographus)
    Taxonomic identifieri6491 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

    Organism-specific databases

    ConoServeri24. GII.

    Subcellular locationi

    GO - Cellular componenti

    1. other organism postsynaptic membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Peptidei1 – 1313Alpha-conotoxin GIIPRO_0000044460Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi2 ↔ 7By similarity
    Disulfide bondi3 ↔ 13By similarity
    Modified residuei13 – 131Cysteine amide1 Publication

    Keywords - PTMi

    Amidation, Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom duct.

    Family & Domainsi

    Domaini

    The cysteine framework is I (CC-C-C). Alpha3/5 pattern.

    Sequence similaritiesi

    Belongs to the conotoxin A superfamily.Curated

    Family and domain databases

    InterProiIPR018072. Conotoxin_a-typ_CS.
    [Graphical view]
    PROSITEiPS60014. ALPHA_CONOTOXIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P01520-1 [UniParc]FASTAAdd to Basket

    « Hide

    ECCHPACGKH FSC                                           13
    Length:13
    Mass (Da):1,422
    Last modified:July 21, 1986 - v1
    Checksum:iDEEE831C39297EBD
    GO

    Sequence databases

    PIRiA01783. NTKN2G.

    Cross-referencesi

    Sequence databases

    PIRi A01783. NTKN2G.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    ConoServeri 24. GII.

    Family and domain databases

    InterProi IPR018072. Conotoxin_a-typ_CS.
    [Graphical view ]
    PROSITEi PS60014. ALPHA_CONOTOXIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Peptide toxins from Conus geographus venom."
      Gray W.R., Luque A., Olivera B.M., Barrett J., Cruz L.J.
      J. Biol. Chem. 256:4734-4740(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Tissue: Venom.

    Entry informationi

    Entry nameiCA2_CONGE
    AccessioniPrimary (citable) accession number: P01520
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3