P01520 (CA2_CONGE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Alpha-conotoxin GII
Organism	Conus geographus (Geography cone) (Nubecula geographus)
Taxonomic identifier	6491 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Lophotrochozoa › Mollusca › Gastropoda › Caenogastropoda › Hypsogastropoda › Neogastropoda › Conoidea › Conidae › Conus

Protein attributes

Sequence length	13 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.
Subcellular location	Secreted.
Tissue specificity	Expressed by the venom duct.
Domain	The cysteine framework is I (CC-C-C).
Sequence similarities	Belongs to the conotoxin A superfamily.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Acetylcholine receptor inhibiting toxin Neurotoxin Postsynaptic neurotoxin Toxin
PTM	Amidation Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular_component	other organism postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	acetylcholine receptor inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 13	13	Alpha-conotoxin GII		PRO_0000044460
Amino acid modifications
	Modified residue	13	1	Cysteine amide Ref.1
	Disulfide bond	2 ↔ 7		By similarity
	Disulfide bond	3 ↔ 13		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P01520 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: DEEE831C39297EBD	FASTA	13	1,422
	10 ECCHPACGKH FSC

References

[1]	"Peptide toxins from Conus geographus venom." Gray W.R., Luque A., Olivera B.M., Barrett J., Cruz L.J. J. Biol. Chem. 256:4734-4740(1981) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Venom.

Cross-references

Sequence databases
PIR	NTKN2G. A01783.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
ConoServer	24. GII.
Family and domain databases
InterPro	IPR018072. Conotoxin_a-typ_CS. [Graphical view]
PROSITE	PS60014. ALPHA_CONOTOXIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CA2_CONGE

Accession

Primary (citable) accession number: P01520

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	May 1, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Animal Toxin Annotation Program