Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P01520 (CA2_CONGE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 24, 2013. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha-conotoxin GII
OrganismConus geographus (Geography cone) (Nubecula geographus)
Taxonomic identifier6491 [NCBI]
Taxonomic lineageEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Protein attributes

Sequence length13 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom duct.

Domain

The cysteine framework is I (CC-C-C).

Sequence similarities

Belongs to the conotoxin A superfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide1 – 1313Alpha-conotoxin GII
PRO_0000044460

Amino acid modifications

Modified residue131Cysteine amide Ref.1
Disulfide bond2 ↔ 7 By similarity
Disulfide bond3 ↔ 13 By similarity

Sequences

Sequence LengthMass (Da)Tools
P01520 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: DEEE831C39297EBD

FASTA131,422
        10 
ECCHPACGKH FSC 

« Hide

References

[1]"Peptide toxins from Conus geographus venom."
Gray W.R., Luque A., Olivera B.M., Barrett J., Cruz L.J.
J. Biol. Chem. 256:4734-4740(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Venom.

Cross-references

Sequence databases

PIRNTKN2G. A01783.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

ConoServer24. GII.

Family and domain databases

InterProIPR018072. Conotoxin_a-typ_CS.
[Graphical view]
PROSITEPS60014. ALPHA_CONOTOXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCA2_CONGE
AccessionPrimary (citable) accession number: P01520
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: July 24, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families