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Protein

Cecropin-B

Gene
N/A
Organism
Hyalophora cecropia (Cecropia moth)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Keywords - Biological processi

Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Cecropin-B
Alternative name(s):
Immune protein P9
OrganismiHyalophora cecropia (Cecropia moth)
Taxonomic identifieri7123 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaBombycoideaSaturniidaeSaturniinaeAttaciniHyalophora

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Add
BLAST
Propeptidei23 – 264Removed by a dipeptidylpeptidase1 PublicationPRO_0000004861
Chaini27 – 6135Cecropin-BPRO_0000004862Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei61 – 611Leucine amide1 Publication

Keywords - PTMi

Amidation

Family & Domainsi

Sequence similaritiesi

Belongs to the cecropin family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR000875. Cecropin.
[Graphical view]
PfamiPF00272. Cecropin. 1 hit.
[Graphical view]
PROSITEiPS00268. CECROPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01508-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFSRIFFFV FALVLALSTV SAAPEPKWKV FKKIEKMGRN IRNGIVKAGP
60
AIAVLGEAKA LG
Length:62
Mass (Da):6,750
Last modified:August 13, 1987 - v1
Checksum:i65E309CB2983BD61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10309 mRNA. Translation: AAA29184.1.
M34924 mRNA. Translation: AAA29187.1.
X07404 Genomic DNA. Translation: CAA30306.1.
PIRiS02606. CKWKB.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10309 mRNA. Translation: AAA29184.1.
M34924 mRNA. Translation: AAA29187.1.
X07404 Genomic DNA. Translation: CAA30306.1.
PIRiS02606. CKWKB.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR000875. Cecropin.
[Graphical view]
PfamiPF00272. Cecropin. 1 hit.
[Graphical view]
PROSITEiPS00268. CECROPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCECB_HYACE
AccessioniPrimary (citable) accession number: P01508
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 13, 1987
Last modified: January 7, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.