Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cecropin-A

Gene
N/A
Organism
Hyalophora cecropia (Cecropia moth)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial
Biological processImmunity, Innate immunity

Protein family/group databases

TCDBi1.C.17.1.1. the cecropin (cecropin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cecropin-A
Alternative name(s):
Cecropin-C
OrganismiHyalophora cecropia (Cecropia moth)
Taxonomic identifieri7123 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaLepidopteraGlossataDitrysiaBombycoideaSaturniidaeSaturniinaeAttaciniHyalophora

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Add BLAST22
PropeptideiPRO_000000485923 – 26Removed by a dipeptidylpeptidase1 Publication4
ChainiPRO_000000486027 – 63Cecropin-AAdd BLAST37

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei63Lysine amide1 Publication1

Post-translational modificationi

A protein with the same sequence as cecropin A, but lacking the carboxyl blocking group, has been isolated and called cecropin C.1 Publication

Keywords - PTMi

Amidation

Structurei

Secondary structure

164
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi29 – 33Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D9JNMR-A27-34[»]
1D9LNMR-A27-34[»]
1D9MNMR-A27-34[»]
1D9ONMR-A27-34[»]
1D9PNMR-A27-34[»]
1F0DNMR-A27-34[»]
1F0ENMR-A27-34[»]
1F0FNMR-A27-34[»]
1F0GNMR-A27-34[»]
1F0HNMR-A27-34[»]
SMRiP01507.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01507.

Family & Domainsi

Sequence similaritiesi

Belongs to the cecropin family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR000875. Cecropin.
PfamiView protein in Pfam
PF00272. Cecropin. 1 hit.
PROSITEiView protein in PROSITE
PS00268. CECROPIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01507-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFSRIFFFV FACLTALAMV NAAPEPKWKL FKKIEKVGQN IRDGIIKAGP
60
AVAVVGQATQ IAKG
Length:64
Mass (Da):6,952
Last modified:April 1, 1988 - v1
Checksum:i0B3AEA15C32DB3A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06672 mRNA. Translation: CAA29871.1.
M63845 Genomic DNA. Translation: AAA29185.1.
PIRiA40420. CKWKA.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06672 mRNA. Translation: CAA29871.1.
M63845 Genomic DNA. Translation: AAA29185.1.
PIRiA40420. CKWKA.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D9JNMR-A27-34[»]
1D9LNMR-A27-34[»]
1D9MNMR-A27-34[»]
1D9ONMR-A27-34[»]
1D9PNMR-A27-34[»]
1F0DNMR-A27-34[»]
1F0ENMR-A27-34[»]
1F0FNMR-A27-34[»]
1F0GNMR-A27-34[»]
1F0HNMR-A27-34[»]
SMRiP01507.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi1.C.17.1.1. the cecropin (cecropin) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP01507.

Family and domain databases

InterProiView protein in InterPro
IPR000875. Cecropin.
PfamiView protein in Pfam
PF00272. Cecropin. 1 hit.
PROSITEiView protein in PROSITE
PS00268. CECROPIN. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCECA_HYACE
AccessioniPrimary (citable) accession number: P01507
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 1, 1988
Last modified: April 12, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.