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Protein

Cecropin-A

Gene
N/A
Organism
Hyalophora cecropia (Cecropia moth)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Keywords - Biological processi

Immunity, Innate immunity

Protein family/group databases

TCDBi1.C.17.1.1. the cecropin (cecropin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cecropin-A
Alternative name(s):
Cecropin-C
OrganismiHyalophora cecropia (Cecropia moth)
Taxonomic identifieri7123 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaBombycoideaSaturniidaeSaturniinaeAttaciniHyalophora

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Add BLAST22
PropeptideiPRO_000000485923 – 26Removed by a dipeptidylpeptidase1 Publication4
ChainiPRO_000000486027 – 63Cecropin-AAdd BLAST37

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei63Lysine amide1 Publication1

Post-translational modificationi

A protein with the same sequence as cecropin A, but lacking the carboxyl blocking group, has been isolated and called cecropin C.1 Publication

Keywords - PTMi

Amidation

Structurei

Secondary structure

164
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi29 – 33Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D9JNMR-A27-34[»]
1D9LNMR-A27-34[»]
1D9MNMR-A27-34[»]
1D9ONMR-A27-34[»]
1D9PNMR-A27-34[»]
1F0DNMR-A27-34[»]
1F0ENMR-A27-34[»]
1F0FNMR-A27-34[»]
1F0GNMR-A27-34[»]
1F0HNMR-A27-34[»]
SMRiP01507.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01507.

Family & Domainsi

Sequence similaritiesi

Belongs to the cecropin family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR000875. Cecropin.
[Graphical view]
PfamiPF00272. Cecropin. 1 hit.
[Graphical view]
PROSITEiPS00268. CECROPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01507-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFSRIFFFV FACLTALAMV NAAPEPKWKL FKKIEKVGQN IRDGIIKAGP
60
AVAVVGQATQ IAKG
Length:64
Mass (Da):6,952
Last modified:April 1, 1988 - v1
Checksum:i0B3AEA15C32DB3A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06672 mRNA. Translation: CAA29871.1.
M63845 Genomic DNA. Translation: AAA29185.1.
PIRiA40420. CKWKA.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06672 mRNA. Translation: CAA29871.1.
M63845 Genomic DNA. Translation: AAA29185.1.
PIRiA40420. CKWKA.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D9JNMR-A27-34[»]
1D9LNMR-A27-34[»]
1D9MNMR-A27-34[»]
1D9ONMR-A27-34[»]
1D9PNMR-A27-34[»]
1F0DNMR-A27-34[»]
1F0ENMR-A27-34[»]
1F0FNMR-A27-34[»]
1F0GNMR-A27-34[»]
1F0HNMR-A27-34[»]
SMRiP01507.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi1.C.17.1.1. the cecropin (cecropin) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP01507.

Family and domain databases

InterProiIPR000875. Cecropin.
[Graphical view]
PfamiPF00272. Cecropin. 1 hit.
[Graphical view]
PROSITEiPS00268. CECROPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCECA_HYACE
AccessioniPrimary (citable) accession number: P01507
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 1, 1988
Last modified: November 2, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.