Reviewed, UniProtKB/Swiss-Prot P01505 (BMN_BOMVA)

Names and origin

Protein names	Recommended name:     Bombinin
Organism	Bombina variegata (Yellow-bellied toad)
Taxonomic identifier	8348 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Archeobatrachia › Bombinatoridae › Bombina

Protein attributes

Sequence length	24 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Has antimicrobial and hemolytic activities.
Subcellular location	Secreted.
Tissue specificity	Expressed by the skin glands.
Sequence similarities	Belongs to the bombinin family.

Ontologies

Keywords
Biological process	Cytolysis Hemolysis
Cellular component	Secreted
Molecular function	Amphibian defense peptide Antibiotic Antimicrobial
PTM	Amidation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	cytolysis Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW hemolysis by symbiont of host erythrocytes Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 24	24	Bombinin		PRO_0000043500
Amino acid modifications
	Modified residue	24	1	Asparagine amide

Sequences

	Sequence		Length	Mass (Da)
	P01505-1 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: ACC0FCE3B7402E85	FASTA	24	2,294
	10 20 GIGALSAKGA LKGLAKGLAZ HFAN

References

[1]	"Isolation and structural resolution of a haemolytically active polypeptide from the immune secretion of a European toad." Csordas A., Michl H. Monatsh. Chem. 101:182-189(1970) Cited for: PROTEIN SEQUENCE. Tissue: Skin secretion.

Cross-references

Sequence databases
PIR	BMTD. A01766.
3D structure databases
ModBase	Search...
Phylogenomic databases
HOVERGEN	P01505.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

BMN_BOMVA

Accession

Primary (citable) accession number: P01505

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	June 16, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)