P01505 (BMN_BOMVA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Bombinin
Organism	Bombina variegata (Yellow-bellied toad)
Taxonomic identifier	8348 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Bombinatoridae › Bombina

Protein attributes

Sequence length	24 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Has antimicrobial and hemolytic activities.
Subcellular location	Secreted.
Tissue specificity	Expressed by the skin glands.
Sequence similarities	Belongs to the bombinin family.
Caution	Residue 20 is assigned as E by similarity to other bombin sequences instead of Z (Glutamic acid or Gutamine) given in the original sequence by the authors.

Ontologies

Keywords
Biological process	Cytolysis Hemolysis
Cellular component	Secreted
Molecular function	Amphibian defense peptide Antibiotic Antimicrobial
PTM	Amidation
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	cytolysis Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW hemolysis in other organism Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 24	24	Bombinin		PRO_0000043500
Amino acid modifications
	Modified residue	24	1	Asparagine amide

Sequences

	Sequence		Length	Mass (Da)
	P01505 [UniParc]. Last modified September 22, 2009. Version 2. Checksum: ACC0FCE3A5D02E85	FASTA	24	2,295
	10 20 GIGALSAKGA LKGLAKGLAE HFAN

References

[1]	"Isolation and structural resolution of a haemolytically active polypeptide from the immune secretion of a European toad." Csordas A., Michl H. Monatsh. Chem. 101:182-189(1970) Cited for: PROTEIN SEQUENCE. Tissue: Skin secretion.

Cross-references

Sequence databases
PIR	BMTD. A01766.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

BMN_BOMVA

Accession

Primary (citable) accession number: P01505

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	September 22, 2009
Last modified:	July 11, 2012
This is version 48 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program