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P01504

- MEL_APIFL

UniProt

P01504 - MEL_APIFL

Protein

Melittin

Gene

MELT

Organism
Apis florea (Dwarf honeybee)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Main toxin of bee venom with strong hemolytic activity. Integrates into cell membranes and has multiple effects, probably, as a result of its interaction with negatively charged phospholipids. It inhibits well known transport pumps such as the Na+-K+-ATPase and the H+-K+-ATPase. Increases the permeability of cell membranes to ions, particularly Na+ and indirectly Ca2+, because of the Na+-Ca2+-exchange.

    GO - Molecular functioni

    1. protein kinase inhibitor activity Source: InterPro

    GO - Biological processi

    1. hemolysis in other organism Source: UniProtKB-KW
    2. ion transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Toxin

    Keywords - Biological processi

    Cytolysis, Hemolysis, Ion transport, Transport

    Protein family/group databases

    TCDBi1.C.18.1.2. the melittin (melittin) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Melittin
    Gene namesi
    Name:MELT
    OrganismiApis florea (Dwarf honeybee)
    Taxonomic identifieri7463 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataApoideaApidaeApis

    Subcellular locationi

    Secreted. Target cell membrane By similarity
    Note: Forms a transmembrane alpha-helix in the target cell membrane. Forms a membrane channel in the prey By similarity.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. other organism cell membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Secreted, Target cell membrane, Target membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Peptidei1 – 2626MelittinPRO_0000044532Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei26 – 261Glutamine amide1 Publication

    Keywords - PTMi

    Amidation

    Miscellaneous databases

    PMAP-CutDBP01504.

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Interactioni

    Subunit structurei

    Monomer and homotetramer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP01504.
    SMRiP01504. Positions 1-26.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the melittin family.Curated

    Keywords - Domaini

    Transmembrane

    Family and domain databases

    InterProiIPR002116. Melittin/Api_allergen.
    [Graphical view]
    PfamiPF01372. Melittin. 1 hit.
    [Graphical view]
    ProDomiPD014636. Melittin/Api_allergen. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    P01504-1 [UniParc]FASTAAdd to Basket

    « Hide

    GIGAILKVLA TGLPTLISWI KNKRKQ                             26
    Length:26
    Mass (Da):2,819
    Last modified:July 21, 1986 - v1
    Checksum:iF20E8F82400EF01C
    GO

    Sequence databases

    PIRiA01765. MEHBCF.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Why Pooh luvvs hunny - Issue 12 of July 2001

    Sequence databases

    PIRi A01765. MEHBCF.

    3D structure databases

    ProteinModelPortali P01504.
    SMRi P01504. Positions 1-26.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    TCDBi 1.C.18.1.2. the melittin (melittin) family.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    PMAP-CutDB P01504.

    Family and domain databases

    InterProi IPR002116. Melittin/Api_allergen.
    [Graphical view ]
    Pfami PF01372. Melittin. 1 hit.
    [Graphical view ]
    ProDomi PD014636. Melittin/Api_allergen. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure of melittin isolated from two species of honey bees."
      Kreil G.
      FEBS Lett. 33:241-244(1973)
      Cited for: PROTEIN SEQUENCE, AMIDATION AT GLN-26.

    Entry informationi

    Entry nameiMEL_APIFL
    AccessioniPrimary (citable) accession number: P01504
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3