Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P01504

- MEL_APIFL

UniProt

P01504 - MEL_APIFL

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Melittin

Gene

MELT

Organism
Apis florea (Dwarf honeybee)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Main toxin of bee venom with strong hemolytic activity. Integrates into cell membranes and has multiple effects, probably, as a result of its interaction with negatively charged phospholipids. It inhibits well known transport pumps such as the Na+-K+-ATPase and the H+-K+-ATPase. Increases the permeability of cell membranes to ions, particularly Na+ and indirectly Ca2+, because of the Na+-Ca2+-exchange.

GO - Molecular functioni

  1. protein kinase inhibitor activity Source: InterPro

GO - Biological processi

  1. hemolysis in other organism Source: UniProtKB-KW
  2. ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Toxin

Keywords - Biological processi

Cytolysis, Hemolysis, Ion transport, Transport

Protein family/group databases

TCDBi1.C.18.1.2. the melittin (melittin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Melittin
Gene namesi
Name:MELT
OrganismiApis florea (Dwarf honeybee)
Taxonomic identifieri7463 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataApoideaApidaeApis

Subcellular locationi

Secreted. Target cell membrane By similarity
Note: Forms a transmembrane alpha-helix in the target cell membrane. Forms a membrane channel in the prey By similarity.By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. other organism cell membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted, Target cell membrane, Target membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 2626MelittinPRO_0000044532Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei26 – 261Glutamine amide1 Publication

Keywords - PTMi

Amidation

Miscellaneous databases

PMAP-CutDBP01504.

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Monomer and homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP01504.
SMRiP01504. Positions 1-26.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the melittin family.Curated

Keywords - Domaini

Transmembrane

Family and domain databases

InterProiIPR002116. Melittin/Api_allergen.
[Graphical view]
PfamiPF01372. Melittin. 1 hit.
[Graphical view]
ProDomiPD014636. Melittin/Api_allergen. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P01504-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20
GIGAILKVLA TGLPTLISWI KNKRKQ
Length:26
Mass (Da):2,819
Last modified:July 21, 1986 - v1
Checksum:iF20E8F82400EF01C
GO

Sequence databases

PIRiA01765. MEHBCF.

Cross-referencesi

Web resourcesi

Protein Spotlight

Why Pooh luvvs hunny - Issue 12 of July 2001

Sequence databases

PIRi A01765. MEHBCF.

3D structure databases

ProteinModelPortali P01504.
SMRi P01504. Positions 1-26.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

TCDBi 1.C.18.1.2. the melittin (melittin) family.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

PMAP-CutDB P01504.

Family and domain databases

InterProi IPR002116. Melittin/Api_allergen.
[Graphical view ]
Pfami PF01372. Melittin. 1 hit.
[Graphical view ]
ProDomi PD014636. Melittin/Api_allergen. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. "Structure of melittin isolated from two species of honey bees."
    Kreil G.
    FEBS Lett. 33:241-244(1973)
    Cited for: PROTEIN SEQUENCE, AMIDATION AT GLN-26.

Entry informationi

Entry nameiMEL_APIFL
AccessioniPrimary (citable) accession number: P01504
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3