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P01502

- MEL_APIDO

UniProt

P01502 - MEL_APIDO

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Protein
Melittin
Gene
MELT
Organism
Apis dorsata (Giant honeybee)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Main toxin of bee venom with strong hemolytic activity. Integrates into cell membranes and has multiple effects, probably, as a result of its interaction with negatively charged phospholipids. It inhibits well known transport pumps such as the Na+-K+-ATPase and the H+-K+-ATPase. Increases the permeability of cell membranes to ions, particularly Na+ and indirectly Ca2+, because of the Na+-Ca2+-exchange.

GO - Molecular functioni

  1. protein kinase inhibitor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. hemolysis in other organism Source: UniProtKB-KW
  2. ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Toxin

Keywords - Biological processi

Cytolysis, Hemolysis, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Melittin
Gene namesi
Name:MELT
OrganismiApis dorsata (Giant honeybee)
Taxonomic identifieri7462 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataApoideaApidaeApis

Subcellular locationi

Secreted. Target cell membrane
Note: Forms a transmembrane alpha-helix in the target cell membrane. Forms a membrane channel in the prey.

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. other organism cell membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted, Target cell membrane, Target membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei1 – 2626Melittin
PRO_0000044531Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei26 – 261Glutamic acid 1-amide1 Publication

Keywords - PTMi

Amidation

Miscellaneous databases

PMAP-CutDBP01502.

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Monomer and homotetramer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP01502.
SMRiP01502. Positions 1-26.

Family & Domainsi

Sequence similaritiesi

Belongs to the melittin family.

Keywords - Domaini

Transmembrane

Family and domain databases

InterProiIPR002116. Melittin/Api_allergen.
[Graphical view]
PfamiPF01372. Melittin. 1 hit.
[Graphical view]
ProDomiPD014636. Melittin/Api_allergen. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

P01502-1 [UniParc]FASTAAdd to Basket

« Hide

GIGAILKVLS TGLPALISWI KRKRQE                             26
Length:26
Mass (Da):2,848
Last modified:July 21, 1986 - v1
Checksum:iF1DA8F92514EF01C
GO

Sequence databases

PIRiA01763. MEHBCD.

Cross-referencesi

Web resourcesi

Protein Spotlight

Why Pooh luvvs hunny - Issue 12 of July 2001

Sequence databases

PIRi A01763. MEHBCD.

3D structure databases

ProteinModelPortali P01502.
SMRi P01502. Positions 1-26.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

PMAP-CutDB P01502.

Family and domain databases

InterProi IPR002116. Melittin/Api_allergen.
[Graphical view ]
Pfami PF01372. Melittin. 1 hit.
[Graphical view ]
ProDomi PD014636. Melittin/Api_allergen. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. "The structure of Apis dorsata melittin: phylogenetic relationships between honeybees as deduced from sequence data."
    Kreil G.
    FEBS Lett. 54:100-102(1975) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, AMIDATION AT GLU-26.

Entry informationi

Entry nameiMEL_APIDO
AccessioniPrimary (citable) accession number: P01502
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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