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P01502 (MEL_APIDO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Melittin
Gene names
Name:MELT
OrganismApis dorsata (Giant honeybee)
Taxonomic identifier7462 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataApoideaApidaeApis

Protein attributes

Sequence length26 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Main toxin of bee venom with strong hemolytic activity. Integrates into cell membranes and has multiple effects, probably, as a result of its interaction with negatively charged phospholipids. It inhibits well known transport pumps such as the Na+-K+-ATPase and the H+-K+-ATPase. Increases the permeability of cell membranes to ions, particularly Na+ and indirectly Ca2+, because of the Na+-Ca2+-exchange.

Subunit structure

Monomer and homotetramer By similarity.

Subcellular location

Secreted. Target cell membrane. Note: Forms a transmembrane alpha-helix in the target cell membrane. Forms a membrane channel in the prey.

Tissue specificity

Expressed by the venom gland.

Sequence similarities

Belongs to the melittin family.

Ontologies

Keywords
   Biological processCytolysis
Hemolysis
Ion transport
Transport
   Cellular componentMembrane
Secreted
Target cell membrane
Target membrane
   DomainTransmembrane
   Molecular functionToxin
   PTMAmidation
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processhemolysis in other organism

Inferred from electronic annotation. Source: UniProtKB-KW

ion transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

other organism cell membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotein kinase inhibitor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Peptide1 – 2626Melittin
PRO_0000044531

Amino acid modifications

Modified residue261Glutamic acid 1-amide Ref.1

Sequences

Sequence LengthMass (Da)Tools
P01502 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: F1DA8F92514EF01C

FASTA262,848
        10         20 
GIGAILKVLS TGLPALISWI KRKRQE 

« Hide

References

[1]"The structure of Apis dorsata melittin: phylogenetic relationships between honeybees as deduced from sequence data."
Kreil G.
FEBS Lett. 54:100-102(1975) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, AMIDATION AT GLU-26.

Web resources

Protein Spotlight

Why Pooh luvvs hunny - Issue 12 of July 2001

Cross-references

Sequence databases

PIRMEHBCD. A01763.

3D structure databases

ProteinModelPortalP01502.
SMRP01502. Positions 1-26.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR002116. Melittin/Api_allergen.
[Graphical view]
PfamPF01372. Melittin. 1 hit.
[Graphical view]
ProDomPD014636. Melittin/Api_allergen. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other

PMAP-CutDBP01502.

Entry information

Entry nameMEL_APIDO
AccessionPrimary (citable) accession number: P01502
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries