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Protein

Melittin

Gene

MELT

Organism
Apis dorsata (Giant honeybee)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Main toxin of bee venom with strong hemolytic activity. Integrates into cell membranes and has multiple effects, probably, as a result of its interaction with negatively charged phospholipids. It inhibits well known transport pumps such as the Na+-K+-ATPase and the H+-K+-ATPase. Increases the permeability of cell membranes to ions, particularly Na+ and indirectly Ca2+, because of the Na+-Ca2+-exchange.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionToxin
Biological processCytolysis, Hemolysis, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Melittin
Gene namesi
Name:MELT
OrganismiApis dorsata (Giant honeybee)
Taxonomic identifieri7462 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaHymenopteraApocritaAculeataApoideaApidaeApis

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Secreted, Target cell membrane, Target membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000445311 – 26MelittinAdd BLAST26

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei26Glutamic acid 1-amide1 Publication1

Keywords - PTMi

Amidation

Miscellaneous databases

PMAP-CutDBiP01502.

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Monomer and homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP01502.
SMRiP01502.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the melittin family.Curated

Keywords - Domaini

Transmembrane

Family and domain databases

InterProiView protein in InterPro
IPR002116. Melittin/Api_allergen.
PfamiView protein in Pfam
PF01372. Melittin. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD014636. Melittin/Api_allergen. 1 hit.

Sequencei

Sequence statusi: Complete.

P01502-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
GIGAILKVLS TGLPALISWI KRKRQE
Length:26
Mass (Da):2,848
Last modified:July 21, 1986 - v1
Checksum:iF1DA8F92514EF01C
GO

Sequence databases

PIRiA01763. MEHBCD.

Similar proteinsi

Entry informationi

Entry nameiMEL_APIDO
AccessioniPrimary (citable) accession number: P01502
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 27, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families