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Protein

Apamin

Gene
N/A
Organism
Apis mellifera (Honeybee)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Neurotoxin that blocks voltage-independent calcium-activated potassium channels (KCNN1=SK1, KCNN2=SK2, KCNN3=SK3).

GO - Molecular functioni

Keywordsi

Molecular functionCalcium-activated potassium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Apamin
OrganismiApis mellifera (Honeybee)
Taxonomic identifieri7460 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaHymenopteraApocritaAculeataApoideaApidaeApis
Proteomesi
  • UP000005203 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 272 PublicationsAdd BLAST27
PeptideiPRO_000001861128 – 45ApaminAdd BLAST18

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 38
Disulfide bondi30 ↔ 42
Modified residuei45Histidine amide1 Publication1

Keywords - PTMi

Amidation, Disulfide bond

Proteomic databases

PaxDbiP01500.

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

ProteinModelPortaliP01500.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni40 – 41Essential for toxin activity2

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000033980.

Family and domain databases

InterProiView protein in InterPro
IPR035361. Bee_toxin.
PfamiView protein in Pfam
PF17454. Bee_toxin. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD026566. PD026566. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01500-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
MISMLRCIYL FLSVILITSY FVTPVMPCNC KAPETALCAR RCQQHG
Length:46
Mass (Da):5,223
Last modified:October 1, 1996 - v2
Checksum:i92694A07501AEE33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S78458 mRNA. Translation: AAB34402.1.
PIRiA56710. AMHB.
RefSeqiNP_001011612.1. NM_001011612.1.
UniGeneiAme.1216.

Genome annotation databases

EnsemblMetazoaiGB40697-RA; GB40697-PA; GB40697.
GeneIDi406135.
KEGGiame:406135.

Similar proteinsi

Entry informationi

Entry nameiAPAM_APIME
AccessioniPrimary (citable) accession number: P01500
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 1, 1996
Last modified: November 22, 2017
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome