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Protein

Apamin

Gene
N/A
Organism
Apis mellifera (Honeybee)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Neurotoxin that blocks voltage-independent calcium-activated potassium channels (KCNN1=SK1, KCNN2=SK2, KCNN3=SK3).

Keywords - Molecular functioni

Calcium-activated potassium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Apamin
OrganismiApis mellifera (Honeybee)
Taxonomic identifieri7460 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataApoideaApidaeApis
Proteomesi
  • UP000005203 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 27272 PublicationsAdd
BLAST
Peptidei28 – 4518ApaminPRO_0000018611Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi28 ↔ 38
Disulfide bondi30 ↔ 42
Modified residuei45 – 451Histidine amide

Keywords - PTMi

Amidation, Disulfide bond

Proteomic databases

PaxDbiP01500.

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Protein-protein interaction databases

STRINGi7460.GB18161-PA.

Structurei

3D structure databases

ProteinModelPortaliP01500.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni40 – 412Essential for toxin activity

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000033980.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01500-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
MISMLRCIYL FLSVILITSY FVTPVMPCNC KAPETALCAR RCQQHG
Length:46
Mass (Da):5,223
Last modified:October 1, 1996 - v2
Checksum:i92694A07501AEE33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S78458 mRNA. Translation: AAB34402.1.
PIRiA56710. AMHB.
RefSeqiNP_001011612.1. NM_001011612.1.
UniGeneiAme.1216.

Genome annotation databases

EnsemblMetazoaiGB40697-RA; GB40697-PA; GB40697.
GeneIDi406135.
KEGGiame:406135.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S78458 mRNA. Translation: AAB34402.1.
PIRiA56710. AMHB.
RefSeqiNP_001011612.1. NM_001011612.1.
UniGeneiAme.1216.

3D structure databases

ProteinModelPortaliP01500.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7460.GB18161-PA.

Proteomic databases

PaxDbiP01500.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiGB40697-RA; GB40697-PA; GB40697.
GeneIDi406135.
KEGGiame:406135.

Organism-specific databases

CTDi406135.

Phylogenomic databases

HOGENOMiHOG000033980.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiAPAM_APIME
AccessioniPrimary (citable) accession number: P01500
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 1, 1996
Last modified: November 11, 2015
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.