P01498 (SCXP_ANDMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Neurotoxin P2
Organism	Androctonus mauretanicus mauretanicus (Scorpion)
Taxonomic identifier	6860 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Androctonus › Androctonus mauritanicus

Protein attributes

Sequence length	35 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Blocks small-conductance chloride channels By similarity.
Subcellular location	Secreted.
Tissue specificity	Expressed by the venom gland.
Domain	The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin By similarity.
Sequence similarities	Belongs to the short scorpion toxin superfamily. Chloride channel inhibitor family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Knottin
Molecular function	Chloride channel inhibitor Ion channel impairing toxin Neurotoxin Toxin
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	chloride channel inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 35	35	Neurotoxin P2		PRO_0000044934
Amino acid modifications
	Disulfide bond	1 ↔ 18		By similarity
	Disulfide bond	4 ↔ 25		By similarity
	Disulfide bond	15 ↔ 30		By similarity
	Disulfide bond	19 ↔ 32		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P01498 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 213E69262289EB5A	FASTA	35	3,673
	10 20 30 CGPCFTTDPY TESKCATCCG GRGKCVGPQC LCNRI

References

[1]	"Characterization of ten proteins from the venom of the Moroccan scorpion Androctonus mauretanicus mauretanicus, six of which are toxic to the mouse." Rosso J.-P., Rochat H. Toxicon 23:113-125(1985) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Venom.

Cross-references

Sequence databases
PIR	NTSRPM. A01758.
3D structure databases
ProteinModelPortal	P01498.
SMR	P01498. Positions 1-33.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR003614. Scorpion_toxin-like. IPR007958. Scorpion_toxinS_Cl_inh. [Graphical view]
Pfam	PF05294. Toxin_5. 1 hit. [Graphical view]
SUPFAM	SSF57095. SSF57095. 1 hit.
PROSITE	PS51200. SHORT_SCORPION_CHLORIDE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SCXP_ANDMA

Accession

Primary (citable) accession number: P01498

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	May 1, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Animal Toxin Annotation Program