P01483 (SCX2_BUTOC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Neurotoxin Bot2 Alternative name(s): Bot II Short name=BotII Neurotoxin II
Organism	Buthus occitanus tunetanus (Common European scorpion)
Taxonomic identifier	6871 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Buthus › Buthus occitanus

Protein attributes

Sequence length	65 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to sodium channels (Nav) and inhibits the inactivation of the activated channels, thereby blocking neuronal transmission.
Subcellular location	Secreted.
Tissue specificity	Expressed by the venom gland.
Sequence similarities	Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Alpha subfamily.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Ion channel impairing toxin Neurotoxin Sodium channel inhibitor Toxin
PTM	Amidation Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	defense response Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sodium channel inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 65	65	Neurotoxin Bot2		PRO_0000066733
Amino acid modifications
	Modified residue	65	1	Phenylalanine amide
	Disulfide bond	12 ↔ 63
	Disulfide bond	16 ↔ 36
	Disulfide bond	22 ↔ 46
	Disulfide bond	26 ↔ 48

Sequences

	Sequence		Length	Mass (Da)
	P01483 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 52CC2836B2763B9A	FASTA	65	7,354
	10 20 30 40 50 60 GRDAYIAQPE NCVYECAKNS YCNDLCTKNG AKSGYCQWLG RWGNACYCID LPDKVPIRIE GKCHF

References

[1]	"Neurotoxins from the venoms of two scorpions: Buthus occitanus tunetanus and Buthus occitanus mardochei." Vargas O., Gregoire J., Martin M.-F., Bechis G., Rochat H. Toxicon 20:79-79(1982) Cited for: PROTEIN SEQUENCE. Tissue: Venom.

Cross-references

Sequence databases
PIR	NTSR2B. A01743.
3D structure databases
ProteinModelPortal	P01483.
SMR	P01483. Positions 2-64.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.30.30.10. 1 hit.
InterPro	IPR003614. Scorpion_toxin-like. IPR018218. Scorpion_toxinL. IPR002061. Scorpion_toxinL/defesin. [Graphical view]
Pfam	PF00537. Toxin_3. 1 hit. [Graphical view]
PRINTS	PR00285. SCORPNTOXIN.
SMART	SM00505. Knot1. 1 hit. [Graphical view]
SUPFAM	SSF57095. SSF57095. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SCX2_BUTOC

Accession

Primary (citable) accession number: P01483

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	May 1, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Animal Toxin Annotation Program