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P01479 (SCX1_ANDAU) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neurotoxin-1''
Alternative name(s):
AaH I''
Short name=AaHI''
Neurotoxin I''

Cleaved into the following chain:

  1. Neurotoxin-1/1'
    Alternative name(s):
    AaH I/AaH I'
    Short name=AaHI/AaHI'
    Neurotoxin I/I'
OrganismAndroctonus australis (Sahara scorpion)
Taxonomic identifier6858 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeAndroctonus

Protein attributes

Sequence length83 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. Is active against mammals and binds with high affinity rat brain synaptosomes.

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Sequence similarities

Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Alpha subfamily.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionIon channel impairing toxin
Neurotoxin
Toxin
Voltage-gated sodium channel impairing toxin
   PTMDisulfide bond
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processdefense response

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionion channel inhibitor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Ref.3 Ref.4
Chain20 – 8364Neurotoxin-1''
PRO_0000035217
Chain20 – 8263Neurotoxin-1/1'
PRO_0000035218
Propeptide831Removed by a carboxypeptidase (in neurotoxin-1/1')
PRO_0000035219

Amino acid modifications

Disulfide bond31 ↔ 81 By similarity
Disulfide bond35 ↔ 53 By similarity
Disulfide bond39 ↔ 63 By similarity
Disulfide bond43 ↔ 65 By similarity

Natural variations

Natural variant361V → I in neurotoxin-1'.

Sequences

Sequence LengthMass (Da)Tools
P01479 [UniParc].

Last modified July 1, 1993. Version 3.
Checksum: 7B6F72F3CB98D1C6

FASTA839,061
        10         20         30         40         50         60 
MNYLVMISLA LLLMIGVESK RDGYIVYPNN CVYHCVPPCD GLCKKNGGSS GSCSFLVPSG 

        70         80 
LACWCKDLPD NVPIKDTSRK CTR 

« Hide

References

[1]"Precursors of Androctonus australis scorpion neurotoxins. Structures of precursors, processing outcomes, and expression of a functional recombinant toxin II."
Bougis P.E., Rochat H., Smith L.A.
J. Biol. Chem. 264:19259-19265(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (AAH I AND AAH I').
Strain: Hector.
[2]"Promoter structure and intron-exon organization of a scorpion alpha-toxin gene."
Delabre M.-L., Pasero P., Marilley M., Bougis P.E.
Biochemistry 34:6729-6736(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (AAH I').
Strain: Hector.
[3]"The amino acid sequence of neurotoxin I of Androctonus australis hector."
Rochat H., Rochat C., Miranda F., Lissitzky S., Edman P.
Eur. J. Biochem. 17:262-266(1970) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 20-82 (AAH I).
Strain: Hector.
Tissue: Venom.
[4]"Purification and amino acid sequence of toxin I' from the venom of the North African scorpion Androctonus australis hector."
Martin M.-F., Rochat H.
Toxicon 22:695-703(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 20-83 (AAH I'').
Strain: Hector.
Tissue: Venom.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M27701 mRNA. Translation: AAA29946.1.
M27702 mRNA. Translation: AAA29947.1.
X76135 Genomic DNA. Translation: CAA53740.1.
PIRNTSRIA. A34444.
NTSRI2. B34444.

3D structure databases

ProteinModelPortalP01479.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.30.30.10. 1 hit.
InterProIPR003614. Scorpion_toxin-like.
IPR018218. Scorpion_toxinL.
IPR002061. Scorpion_toxinL/defensin.
[Graphical view]
PfamPF00537. Toxin_3. 1 hit.
[Graphical view]
PRINTSPR00285. SCORPNTOXIN.
SMARTSM00505. Knot1. 1 hit.
[Graphical view]
SUPFAMSSF57095. SSF57095. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSCX1_ANDAU
AccessionPrimary (citable) accession number: P01479
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 1, 1993
Last modified: March 19, 2014
This is version 91 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families