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P01479

- SCX1_ANDAU

UniProt

P01479 - SCX1_ANDAU

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Protein

Neurotoxin-1''

Gene
N/A
Organism
Androctonus australis (Sahara scorpion)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. Is active against mammals and binds with high affinity rat brain synaptosomes.

GO - Molecular functioni

  1. ion channel inhibitor activity Source: InterPro

GO - Biological processi

  1. defense response Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotoxin-1''
Alternative name(s):
AaH I''
Short name:
AaHI''
Neurotoxin I''
Cleaved into the following chain:
Alternative name(s):
AaH I/AaH I'
Short name:
AaHI/AaHI'
Neurotoxin I/I'
OrganismiAndroctonus australis (Sahara scorpion)
Taxonomic identifieri6858 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeAndroctonus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19192 PublicationsAdd
BLAST
Chaini20 – 8364Neurotoxin-1''PRO_0000035217Add
BLAST
Chaini20 – 8263Neurotoxin-1/1'PRO_0000035218Add
BLAST
Propeptidei83 – 831Removed by a carboxypeptidase (in neurotoxin-1/1')PRO_0000035219

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 81By similarity
Disulfide bondi35 ↔ 53By similarity
Disulfide bondi39 ↔ 63By similarity
Disulfide bondi43 ↔ 65By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

ProteinModelPortaliP01479.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.30.30.10. 1 hit.
InterProiIPR003614. Scorpion_toxin-like.
IPR018218. Scorpion_toxinL.
IPR002061. Scorpion_toxinL/defensin.
[Graphical view]
PfamiPF00537. Toxin_3. 1 hit.
[Graphical view]
PRINTSiPR00285. SCORPNTOXIN.
SMARTiSM00505. Knot1. 1 hit.
[Graphical view]
SUPFAMiSSF57095. SSF57095. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01479-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNYLVMISLA LLLMIGVESK RDGYIVYPNN CVYHCVPPCD GLCKKNGGSS
60 70 80
GSCSFLVPSG LACWCKDLPD NVPIKDTSRK CTR
Length:83
Mass (Da):9,061
Last modified:July 1, 1993 - v3
Checksum:i7B6F72F3CB98D1C6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti36 – 361V → I in neurotoxin-1'.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M27701 mRNA. Translation: AAA29946.1.
M27702 mRNA. Translation: AAA29947.1.
X76135 Genomic DNA. Translation: CAA53740.1.
PIRiA34444. NTSRIA.
B34444. NTSRI2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M27701 mRNA. Translation: AAA29946.1 .
M27702 mRNA. Translation: AAA29947.1 .
X76135 Genomic DNA. Translation: CAA53740.1 .
PIRi A34444. NTSRIA.
B34444. NTSRI2.

3D structure databases

ProteinModelPortali P01479.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.30.30.10. 1 hit.
InterProi IPR003614. Scorpion_toxin-like.
IPR018218. Scorpion_toxinL.
IPR002061. Scorpion_toxinL/defensin.
[Graphical view ]
Pfami PF00537. Toxin_3. 1 hit.
[Graphical view ]
PRINTSi PR00285. SCORPNTOXIN.
SMARTi SM00505. Knot1. 1 hit.
[Graphical view ]
SUPFAMi SSF57095. SSF57095. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Precursors of Androctonus australis scorpion neurotoxins. Structures of precursors, processing outcomes, and expression of a functional recombinant toxin II."
    Bougis P.E., Rochat H., Smith L.A.
    J. Biol. Chem. 264:19259-19265(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (AAH I AND AAH I').
    Strain: Hector.
  2. "Promoter structure and intron-exon organization of a scorpion alpha-toxin gene."
    Delabre M.-L., Pasero P., Marilley M., Bougis P.E.
    Biochemistry 34:6729-6736(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (AAH I').
    Strain: Hector.
  3. "The amino acid sequence of neurotoxin I of Androctonus australis hector."
    Rochat H., Rochat C., Miranda F., Lissitzky S., Edman P.
    Eur. J. Biochem. 17:262-266(1970) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-82 (AAH I).
    Strain: Hector.
    Tissue: Venom.
  4. "Purification and amino acid sequence of toxin I' from the venom of the North African scorpion Androctonus australis hector."
    Martin M.-F., Rochat H.
    Toxicon 22:695-703(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 20-83 (AAH I'').
    Strain: Hector.
    Tissue: Venom.

Entry informationi

Entry nameiSCX1_ANDAU
AccessioniPrimary (citable) accession number: P01479
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 1, 1993
Last modified: October 29, 2014
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3