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Protein

Delta-hexatoxin-Ar1a

Gene
N/A
Organism
Atrax robustus (Sydney funnel-web spider)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits tetrodotoxin-sensitive voltage-gated sodium channels (Nav) by binding to site 3. It slows the inactivation, causes a prolongation of action potential duration resulting in repetitive firing in autonomic and motor nerve fibers. Does not depolarize the resting potential. Does not affect tetrodotoxin-resistant sodium channels. This lethal neurotoxin is active on both insect and mammalian voltage-gated sodium channels.4 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-hexatoxin-Ar1a
Short name:
Delta-HXTX-Ar1a
Alternative name(s):
Delta-atracotoxin-Ar1a
Short name:
Delta-AcTx-Ar1
Short name:
Delta-AcTx-Ar1a
Robustoxin
Short name:
RBX
OrganismiAtrax robustus (Sydney funnel-web spider)
Taxonomic identifieri6903 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeMygalomorphaeHexathelidaeAtrax

Organism-specific databases

ArachnoServeriAS000305. delta-hexatoxin-Ar1a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000876531 – 42Delta-hexatoxin-Ar1aAdd BLAST42

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi1 ↔ 15
Disulfide bondi8 ↔ 20
Disulfide bondi14 ↔ 31
Disulfide bondi16 ↔ 42

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

Secondary structure

142
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi19 – 21Combined sources3
Beta strandi30 – 33Combined sources4
Turni37 – 39Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QDPNMR-A1-42[»]
ProteinModelPortaliP01478.
SMRiP01478.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01478.

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

Sequence similaritiesi

Belongs to the delta-atracotoxin family.Curated

Keywords - Domaini

Knottin

Family and domain databases

InterProiIPR008017. Atracotoxin_delta.
[Graphical view]
PfamiPF05353. Atracotoxin. 1 hit.
[Graphical view]
ProDomiPD026455. Atracotoxin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS60018. DELTA_ACTX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01478-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40 
CAKKRNWCGK NEDCCCPMKC IYAWYNQQGS CQTTITGLFK KC
Length:42
Mass (Da):4,857
Last modified:July 21, 1986 - v1
Checksum:i093CF5D89540E284
GO

Mass spectrometryi

Molecular mass is 4848.7 Da from positions 1 - 42. Determined by ESI. 1 Publication

Sequence databases

PIRiA01738. NTIIRF.

Cross-referencesi

Sequence databases

PIRiA01738. NTIIRF.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QDPNMR-A1-42[»]
ProteinModelPortaliP01478.
SMRiP01478.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ArachnoServeriAS000305. delta-hexatoxin-Ar1a.

Miscellaneous databases

EvolutionaryTraceiP01478.

Family and domain databases

InterProiIPR008017. Atracotoxin_delta.
[Graphical view]
PfamiPF05353. Atracotoxin. 1 hit.
[Graphical view]
ProDomiPD026455. Atracotoxin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS60018. DELTA_ACTX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTXDT1_ATRRO
AccessioniPrimary (citable) accession number: P01478
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Miscellaneous

In this species, the venom of the male is lethal rather than that of the female.

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.