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Protein

Myotoxin

Gene
N/A
Organism
Crotalus oreganus helleri (Southern pacific rattlesnake) (Crotalus viridis helleri)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cationic peptide that possesses multiple functions. It acts as a cell-penetrating peptide (CPP), and as a potent voltage-gated potassium channel (Kv) inhibitor. It exhibits antimicrobial activities, hind limb paralysis, and severe muscle necrosis by a non-enzymatic mechanism (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionAntimicrobial, Ion channel impairing toxin, Myotoxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Myotoxin
Alternative name(s):
Crotamine-4
Toxic peptide C
OrganismiCrotalus oreganus helleri (Southern pacific rattlesnake) (Crotalus viridis helleri)
Taxonomic identifieri8741 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeCrotalinaeCrotalus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Toxic dosei

LD50 is 1.96 mg/kg by intravenous injection.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000022156923 – 70MyotoxinAdd BLAST48

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 58PROSITE-ProRule annotation
Disulfide bondi33 ↔ 52PROSITE-ProRule annotation
Disulfide bondi40 ↔ 59PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

SMRiP01477.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the crotamine-myotoxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG006434.

Family and domain databases

Gene3Di2.20.20.10. 1 hit.
InterProiView protein in InterPro
IPR023355. Myo_neuro_toxin.
IPR000881. Myotoxin.
PfamiView protein in Pfam
PF00819. Myotoxins. 1 hit.
PRINTSiPR00283. MYOTOXIN.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005972. Myotoxin. 1 hit.
PROSITEiView protein in PROSITE
PS00459. MYOTOXINS_1. 1 hit.
PS51345. MYOTOXINS_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01477-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILYLLFAF LFLAFLSEPG NAYKRCHKKG GHCFPKTVIC LPPSSDFGKM
60 70
DCRWKWKCCK KGSVNNAISI
Length:70
Mass (Da):7,989
Last modified:November 13, 2013 - v2
Checksum:i06B32AE06B0989F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JF895769 mRNA. Translation: AEU60012.1.
GAKQ01000002 mRNA. Translation: JAA97967.1.
GAKQ01000001 mRNA. Translation: JAA97968.1.
GAKR01000001 mRNA. Translation: JAA97984.1.
GAKS01000002 mRNA. Translation: JAA98014.1.
GAKS01000001 mRNA. Translation: JAA98015.1.
GALC01000001 mRNA. Translation: JAA98041.1.
PIRiA01737. CXRSCH.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMYXC_CROOH
AccessioniPrimary (citable) accession number: P01477
Secondary accession number(s): G9DCI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 13, 2013
Last modified: May 10, 2017
This is version 73 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families