Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytotoxin 2

Gene
N/A
Organism
Naja oxiana (Central Asian cobra) (Oxus cobra)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This three-finger cytotoxin is a basic protein that interacts and penetrates into the cell membrane, with the tips of all the three loops. Cytotoxins which have a Pro-30 (P-type) interacts with membrane stronger that those which have a 'Ser-28' (S-type). CTII interacts with membrane stronger than CTI.3 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cardiotoxin, Toxin

Keywords - Biological processi

Cytolysis

Names & Taxonomyi

Protein namesi
Recommended name:
Cytotoxin 2
Alternative name(s):
Cytotoxin II
Short name:
CTII
OrganismiNaja oxiana (Central Asian cobra) (Oxus cobra)
Taxonomic identifieri8657 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeElapinaeNaja

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted, Target cell membrane, Target membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6060Cytotoxin 2PRO_0000093517Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi3 ↔ 212 Publications
Disulfide bondi14 ↔ 382 Publications
Disulfide bondi42 ↔ 532 Publications
Disulfide bondi54 ↔ 592 Publications

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.Curated

Interactioni

Subunit structurei

Monomer in solution; Homodimer and oligomer in the presence of negatively charged lipids forming a pore with a size ranging between 20 and 30 Angstroms.By similarity

Structurei

Secondary structure

1
60
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 43Combined sources
Beta strandi11 – 133Combined sources
Beta strandi20 – 267Combined sources
Beta strandi33 – 419Combined sources
Beta strandi47 – 5610Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1CB9NMR-A1-60[»]
1CCQNMR-A1-60[»]
1FFJNMR-A1-60[»]
ProteinModelPortaliP01441.
SMRiP01441. Positions 1-60.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01441.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG006553.

Family and domain databases

CDDicd00206. snake_toxin. 1 hit.
InterProiIPR003572. Cytotoxin.
IPR003571. Snake_3FTx.
IPR018354. Snake_toxin_con_site.
[Graphical view]
PRINTSiPR00282. CYTOTOXIN.
PROSITEiPS00272. SNAKE_TOXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01441-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LKCKKLVPLF SKTCPAGKNL CYKMFMVAAP HVPVKRGCID VCPKSSLLVK
60
YVCCNTDKCN
Length:60
Mass (Da):6,636
Last modified:July 21, 1986 - v1
Checksum:i3512FDB5EED2C5F7
GO

Sequence databases

PIRiA01709. H3NJ2R.

Cross-referencesi

Sequence databases

PIRiA01709. H3NJ2R.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1CB9NMR-A1-60[»]
1CCQNMR-A1-60[»]
1FFJNMR-A1-60[»]
ProteinModelPortaliP01441.
SMRiP01441. Positions 1-60.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG006553.

Miscellaneous databases

EvolutionaryTraceiP01441.

Family and domain databases

CDDicd00206. snake_toxin. 1 hit.
InterProiIPR003572. Cytotoxin.
IPR003571. Snake_3FTx.
IPR018354. Snake_toxin_con_site.
[Graphical view]
PRINTSiPR00282. CYTOTOXIN.
PROSITEiPS00272. SNAKE_TOXIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei3SA2_NAJOX
AccessioniPrimary (citable) accession number: P01441
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 7, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.