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P01441

- CX2_NAJOX

UniProt

P01441 - CX2_NAJOX

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Protein

Cytotoxin 2

Gene
N/A
Organism
Naja oxiana (Central Asian cobra) (Oxus cobra)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

This three-finger cytotoxin is a basic protein that interacts and penetrates into the cell membrane, with the tips of all the three loops. Cytotoxins which have a Pro-30 (P-type) interacts with membrane stronger that those which have a 'Ser-28' (S-type). CTII interacts with membrane stronger than CTI.3 Publications

GO - Biological processi

  1. cytolysis Source: UniProtKB-KW
  2. modification of morphology or physiology of other organism Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Cardiotoxin, Toxin

Keywords - Biological processi

Cytolysis

Names & Taxonomyi

Protein namesi
Recommended name:
Cytotoxin 2
Alternative name(s):
Cytotoxin II
Short name:
CTII
OrganismiNaja oxiana (Central Asian cobra) (Oxus cobra)
Taxonomic identifieri8657 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeElapinaeNaja

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6060Cytotoxin 2PRO_0000093517Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi3 ↔ 21
Disulfide bondi14 ↔ 38
Disulfide bondi42 ↔ 53
Disulfide bondi54 ↔ 59

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

Secondary structure

1
60
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 43
Beta strandi11 – 133
Beta strandi20 – 267
Beta strandi33 – 419
Beta strandi47 – 5610

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1CB9NMR-A1-60[»]
1CCQNMR-A1-60[»]
1FFJNMR-A1-60[»]
ProteinModelPortaliP01441.
SMRiP01441. Positions 1-60.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01441.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG006553.

Family and domain databases

InterProiIPR003572. Cytotoxin.
IPR003571. Snake_toxin.
IPR018354. Snake_toxin_BS.
[Graphical view]
PfamiPF00087. Toxin_1. 1 hit.
[Graphical view]
PRINTSiPR00282. CYTOTOXIN.
PROSITEiPS00272. SNAKE_TOXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P01441-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
LKCKKLVPLF SKTCPAGKNL CYKMFMVAAP HVPVKRGCID VCPKSSLLVK
60
YVCCNTDKCN
Length:60
Mass (Da):6,636
Last modified:July 21, 1986 - v1
Checksum:i3512FDB5EED2C5F7
GO

Sequence databases

PIRiA01709. H3NJ2R.

Cross-referencesi

Sequence databases

PIRi A01709. H3NJ2R.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1CB9 NMR - A 1-60 [» ]
1CCQ NMR - A 1-60 [» ]
1FFJ NMR - A 1-60 [» ]
ProteinModelPortali P01441.
SMRi P01441. Positions 1-60.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG006553.

Miscellaneous databases

EvolutionaryTracei P01441.

Family and domain databases

InterProi IPR003572. Cytotoxin.
IPR003571. Snake_toxin.
IPR018354. Snake_toxin_BS.
[Graphical view ]
Pfami PF00087. Toxin_1. 1 hit.
[Graphical view ]
PRINTSi PR00282. CYTOTOXIN.
PROSITEi PS00272. SNAKE_TOXIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The isolation and sequence determination of a cytotoxin from the venom of the Middle-Asian cobra Naja naja oxiana."
    Grishin E.V., Sukhikh A.P., Adamovich T.B., Ovchinnikov Y.A., Yukelson L.Y.
    FEBS Lett. 48:179-183(1974) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Tissue: Venom.
  2. "ESR study of the interaction of cytotoxin II with model membranes."
    Dubinnyi M.A., Dubovskii P.V., Utkin Y.N., Simonova T.N., Barsukov L.I., Arseniev A.S.
    Bioorg. Khim. 27:102-113(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  3. "Interaction of the P-type cardiotoxin with phospholipid membranes."
    Dubovskii P.V., Lesovoy D.M., Dubinnyi M.A., Utkin Y.N., Arseniev A.S.
    Eur. J. Biochem. 270:2038-2046(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PHOSPHOLIPID MEMBRANES.
  4. "Interaction of three-finger toxins with phospholipid membranes: comparison of S- and P-type cytotoxins."
    Dubovskii P.V., Lesovoy D.M., Dubinnyi M.A., Konshina A.G., Utkin Y.N., Efremov R.G., Arseniev A.S.
    Biochem. J. 387:807-815(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, APPARTENANCE TO P-TYPE CYTOTOXINS.
  5. "Two forms of cytotoxin II (cardiotoxin) from Naja naja oxiana in aqueous solution: spatial structures with tightly bound water molecules."
    Dementieva D.V., Bocharov E.V., Arseniev A.S.
    Eur. J. Biochem. 263:152-162(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR, DISULFIDE BONDS.
  6. Cited for: STRUCTURE BY NMR, DISULFIDE BONDS.

Entry informationi

Entry nameiCX2_NAJOX
AccessioniPrimary (citable) accession number: P01441
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3