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P01441

- CX2_NAJOX

UniProt

P01441 - CX2_NAJOX

Protein

Cytotoxin 2

Gene
N/A
Organism
Naja oxiana (Central Asian cobra) (Oxus cobra)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    This three-finger cytotoxin is a basic protein that interacts and penetrates into the cell membrane, with the tips of all the three loops. Cytotoxins which have a Pro-30 (P-type) interacts with membrane stronger that those which have a 'Ser-28' (S-type). CTII interacts with membrane stronger than CTI.3 Publications

    GO - Biological processi

    1. cytolysis Source: UniProtKB-KW
    2. modification of morphology or physiology of other organism Source: InterPro

    Keywords - Molecular functioni

    Cardiotoxin, Toxin

    Keywords - Biological processi

    Cytolysis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytotoxin 2
    Alternative name(s):
    Cytotoxin II
    Short name:
    CTII
    OrganismiNaja oxiana (Central Asian cobra) (Oxus cobra)
    Taxonomic identifieri8657 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeElapinaeNaja

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6060Cytotoxin 2PRO_0000093517Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi3 ↔ 21
    Disulfide bondi14 ↔ 38
    Disulfide bondi42 ↔ 53
    Disulfide bondi54 ↔ 59

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Structurei

    Secondary structure

    1
    60
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi2 – 43
    Beta strandi11 – 133
    Beta strandi20 – 267
    Beta strandi33 – 419
    Beta strandi47 – 5610

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1CB9NMR-A1-60[»]
    1CCQNMR-A1-60[»]
    1FFJNMR-A1-60[»]
    ProteinModelPortaliP01441.
    SMRiP01441. Positions 1-60.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP01441.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOVERGENiHBG006553.

    Family and domain databases

    InterProiIPR003572. Cytotoxin.
    IPR003571. Snake_toxin.
    IPR018354. Snake_toxin_BS.
    [Graphical view]
    PfamiPF00087. Toxin_1. 1 hit.
    [Graphical view]
    PRINTSiPR00282. CYTOTOXIN.
    PROSITEiPS00272. SNAKE_TOXIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P01441-1 [UniParc]FASTAAdd to Basket

    « Hide

    LKCKKLVPLF SKTCPAGKNL CYKMFMVAAP HVPVKRGCID VCPKSSLLVK   50
    YVCCNTDKCN 60
    Length:60
    Mass (Da):6,636
    Last modified:July 21, 1986 - v1
    Checksum:i3512FDB5EED2C5F7
    GO

    Sequence databases

    PIRiA01709. H3NJ2R.

    Cross-referencesi

    Sequence databases

    PIRi A01709. H3NJ2R.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1CB9 NMR - A 1-60 [» ]
    1CCQ NMR - A 1-60 [» ]
    1FFJ NMR - A 1-60 [» ]
    ProteinModelPortali P01441.
    SMRi P01441. Positions 1-60.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG006553.

    Miscellaneous databases

    EvolutionaryTracei P01441.

    Family and domain databases

    InterProi IPR003572. Cytotoxin.
    IPR003571. Snake_toxin.
    IPR018354. Snake_toxin_BS.
    [Graphical view ]
    Pfami PF00087. Toxin_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00282. CYTOTOXIN.
    PROSITEi PS00272. SNAKE_TOXIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The isolation and sequence determination of a cytotoxin from the venom of the Middle-Asian cobra Naja naja oxiana."
      Grishin E.V., Sukhikh A.P., Adamovich T.B., Ovchinnikov Y.A., Yukelson L.Y.
      FEBS Lett. 48:179-183(1974) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
      Tissue: Venom.
    2. "ESR study of the interaction of cytotoxin II with model membranes."
      Dubinnyi M.A., Dubovskii P.V., Utkin Y.N., Simonova T.N., Barsukov L.I., Arseniev A.S.
      Bioorg. Khim. 27:102-113(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    3. "Interaction of the P-type cardiotoxin with phospholipid membranes."
      Dubovskii P.V., Lesovoy D.M., Dubinnyi M.A., Utkin Y.N., Arseniev A.S.
      Eur. J. Biochem. 270:2038-2046(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH PHOSPHOLIPID MEMBRANES.
    4. "Interaction of three-finger toxins with phospholipid membranes: comparison of S- and P-type cytotoxins."
      Dubovskii P.V., Lesovoy D.M., Dubinnyi M.A., Konshina A.G., Utkin Y.N., Efremov R.G., Arseniev A.S.
      Biochem. J. 387:807-815(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, APPARTENANCE TO P-TYPE CYTOTOXINS.
    5. "Two forms of cytotoxin II (cardiotoxin) from Naja naja oxiana in aqueous solution: spatial structures with tightly bound water molecules."
      Dementieva D.V., Bocharov E.V., Arseniev A.S.
      Eur. J. Biochem. 263:152-162(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR, DISULFIDE BONDS.
    6. Cited for: STRUCTURE BY NMR, DISULFIDE BONDS.

    Entry informationi

    Entry nameiCX2_NAJOX
    AccessioniPrimary (citable) accession number: P01441
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3