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Protein

Long neurotoxin 1

Gene
N/A
Organism
Naja anchietae (Anchieta's cobra) (Naja haje anchietae)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Long neurotoxin 1
Alternative name(s):
Toxin III
OrganismiNaja anchietae (Anchieta's cobra) (Naja haje anchietae)
Taxonomic identifieri263737 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeElapinaeNaja

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Toxic dosei

LD50 is 0.067 mg/kg by subcutaneous injection.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000935431 – 72Long neurotoxin 1Add BLAST72

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi3 ↔ 21By similarity
Disulfide bondi14 ↔ 42By similarity
Disulfide bondi27 ↔ 31By similarity
Disulfide bondi46 ↔ 57By similarity
Disulfide bondi58 ↔ 63By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

TopDownProteomicsiP01389.

Expressioni

Tissue specificityi

Expressed by the venom gland.Curated

Structurei

3D structure databases

ProteinModelPortaliP01389.
SMRiP01389.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG006553.

Family and domain databases

CDDicd00206. snake_toxin. 1 hit.
InterProiView protein in InterPro
IPR003571. Snake_3FTx.
IPR018354. Snake_toxin_con_site.
IPR035076. Toxin/TOLIP.
PfamiView protein in Pfam
PF00087. Toxin_TOLIP. 1 hit.
PROSITEiView protein in PROSITE
PS00272. SNAKE_TOXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

P01389-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
IRCFITPDVT SQACPDGQNI CYTKTWCDNF CGMRGKRVDL GCAATCPTVK
60 70
PGVDIKCCST DNCNPFPTRE RS
Length:72
Mass (Da):7,911
Last modified:July 21, 1986 - v1
Checksum:i3DE0C49D59E91086
GO

Sequence databases

PIRiA01660. N2NJ1A.

Similar proteinsi

Entry informationi

Entry namei3L21_NAJAC
AccessioniPrimary (citable) accession number: P01389
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 22, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families