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Protein

Long neurotoxin 1

Gene
N/A
Organism
Ophiophagus hannah (King cobra) (Naja hannah)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Long neurotoxin 1
Alternative name(s):
Neurotoxin A
OrganismiOphiophagus hannah (King cobra) (Naja hannah)
Taxonomic identifieri8665 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeElapinaeOphiophagus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Toxic dosei

LD50 is 0.3 mg/kg by subcutaneous injection.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000935561 – 73Long neurotoxin 1Add BLAST73

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi3 ↔ 21By similarity
Disulfide bondi14 ↔ 42By similarity
Disulfide bondi27 ↔ 31By similarity
Disulfide bondi46 ↔ 57By similarity
Disulfide bondi58 ↔ 63By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

TopDownProteomicsiP01387.

Expressioni

Tissue specificityi

Expressed by the venom gland.Curated

Structurei

3D structure databases

ProteinModelPortaliP01387.
SMRiP01387.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG006553.

Family and domain databases

CDDicd00206. snake_toxin. 1 hit.
InterProiView protein in InterPro
IPR003571. Snake_3FTx.
IPR018354. Snake_toxin_con_site.
IPR035076. Toxin/TOLIP.
PfamiView protein in Pfam
PF00087. Toxin_TOLIP. 1 hit.
PROSITEiView protein in PROSITE
PS00272. SNAKE_TOXIN. 1 hit.

Sequencei

Sequence statusi: Complete.

P01387-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
TKCYVTPDVK SETCPAGQDI CYTETWCDAW CTSRGKRVDL GCAATCPIVK
60 70
PGVEIKCCST DNCNPFPTWR KRP
Length:73
Mass (Da):8,106
Last modified:July 21, 1986 - v1
Checksum:i1AC17E91E16C54F7
GO

Sequence databases

PIRiA01658. N2OH1.

Similar proteinsi

Entry informationi

Entry namei3L21_OPHHA
AccessioniPrimary (citable) accession number: P01387
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 22, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families