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Protein

Corticostatin-3

Gene
N/A
Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This peptide has antibiotic, anti-fungi and antiviral activity. It also inhibits corticotropin (ACTH) stimulated corticosterone production.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin, Fungicide

Keywords - Biological processi

Antiviral defense

Protein family/group databases

TCDBi1.C.19.1.2. the defensin (defensin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Corticostatin-3
Alternative name(s):
Antiadrenocorticotropin peptide III
Corticostatin III
Short name:
CS-III
Macrophage antibiotic peptide MCP-1
Short name:
NP-1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Propeptidei20 – 62433 PublicationsPRO_0000006809Add
BLAST
Peptidei63 – 9533Corticostatin-3PRO_0000006810Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi65 ↔ 93By similarity
Disulfide bondi67 ↔ 82By similarity
Disulfide bondi72 ↔ 92By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000002802.

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JFE2. Eukaryota.
ENOG4111A2R. LUCA.
GeneTreeiENSGT00730000111183.
HOGENOMiHOG000233351.
HOVERGENiHBG011703.
InParanoidiP01376.
KOiK05230.
OMAiSFTYCCT.
OrthoDBiEOG091G12GE.
TreeFamiTF338414.

Family and domain databases

InterProiIPR006081. Alpha-defensin.
IPR016327. Alpha-defensin_pro.
IPR006080. Defensin_beta/alpha.
IPR002366. Defensin_propep.
[Graphical view]
PANTHERiPTHR11876. PTHR11876. 1 hit.
PfamiPF00323. Defensin_1. 1 hit.
PF00879. Defensin_propep. 1 hit.
[Graphical view]
PIRSFiPIRSF001875. Alpha-defensin. 1 hit.
SMARTiSM00048. DEFSN. 1 hit.
[Graphical view]
PROSITEiPS00269. DEFENSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01376-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTLALLAAI LLVALQAQAE HVSVSIDEVV DQQPPQAEDQ DVAIYVKEHE
60 70 80 90
SSALEALGVK AGVVCACRRA LCLPRERRAG FCRIRGRIHP LCCRR
Length:95
Mass (Da):10,460
Last modified:January 1, 1990 - v2
Checksum:i58593721BB6EF032
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28883 mRNA. Translation: AAA31387.1.
M28072 Genomic DNA. Translation: AAA31388.1.
PIRiA45811. WTRBM1.
RefSeqiNP_001164486.1. NM_001171015.1.
UniGeneiOcu.6425.

Genome annotation databases

EnsembliENSOCUT00000003227; ENSOCUP00000002802; ENSOCUG00000003229.
GeneIDi100009115.
KEGGiocu:100009115.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28883 mRNA. Translation: AAA31387.1.
M28072 Genomic DNA. Translation: AAA31388.1.
PIRiA45811. WTRBM1.
RefSeqiNP_001164486.1. NM_001171015.1.
UniGeneiOcu.6425.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000002802.

Protein family/group databases

TCDBi1.C.19.1.2. the defensin (defensin) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOCUT00000003227; ENSOCUP00000002802; ENSOCUG00000003229.
GeneIDi100009115.
KEGGiocu:100009115.

Organism-specific databases

CTDi178982.

Phylogenomic databases

eggNOGiENOG410JFE2. Eukaryota.
ENOG4111A2R. LUCA.
GeneTreeiENSGT00730000111183.
HOGENOMiHOG000233351.
HOVERGENiHBG011703.
InParanoidiP01376.
KOiK05230.
OMAiSFTYCCT.
OrthoDBiEOG091G12GE.
TreeFamiTF338414.

Family and domain databases

InterProiIPR006081. Alpha-defensin.
IPR016327. Alpha-defensin_pro.
IPR006080. Defensin_beta/alpha.
IPR002366. Defensin_propep.
[Graphical view]
PANTHERiPTHR11876. PTHR11876. 1 hit.
PfamiPF00323. Defensin_1. 1 hit.
PF00879. Defensin_propep. 1 hit.
[Graphical view]
PIRSFiPIRSF001875. Alpha-defensin. 1 hit.
SMARTiSM00048. DEFSN. 1 hit.
[Graphical view]
PROSITEiPS00269. DEFENSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDEF3_RABIT
AccessioniPrimary (citable) accession number: P01376
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 1, 1990
Last modified: September 7, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.