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Protein

Corticostatin-3

Gene
N/A
Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This peptide has antibiotic, anti-fungi and antiviral activity. It also inhibits corticotropin (ACTH) stimulated corticosterone production.

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin, Fungicide
Biological processAntiviral defense

Protein family/group databases

TCDBi1.C.19.1.2. the defensin (defensin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Corticostatin-3
Alternative name(s):
Antiadrenocorticotropin peptide III
Corticostatin III
Short name:
CS-III
Macrophage antibiotic peptide MCP-1
Short name:
NP-1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000000680920 – 623 PublicationsAdd BLAST43
PeptideiPRO_000000681063 – 95Corticostatin-3Add BLAST33

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi65 ↔ 93By similarity
Disulfide bondi67 ↔ 82By similarity
Disulfide bondi72 ↔ 92By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Gene expression databases

BgeeiENSOCUG00000003229.

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000002802.

Structurei

3D structure databases

SMRiP01376.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JFE2. Eukaryota.
ENOG4111A2R. LUCA.
GeneTreeiENSGT00730000111183.
HOGENOMiHOG000233351.
HOVERGENiHBG011703.
InParanoidiP01376.
KOiK05230.
OMAiSFTYCCT.
OrthoDBiEOG091G12GE.
TreeFamiTF338414.

Family and domain databases

InterProiView protein in InterPro
IPR006081. Alpha-defensin.
IPR016327. Alpha-defensin_pro.
IPR006080. Defensin_beta/alpha.
IPR002366. Defensin_propep.
PANTHERiPTHR11876. PTHR11876. 1 hit.
PfamiView protein in Pfam
PF00323. Defensin_1. 1 hit.
PF00879. Defensin_propep. 1 hit.
PIRSFiPIRSF001875. Alpha-defensin. 1 hit.
SMARTiView protein in SMART
SM00048. DEFSN. 1 hit.
PROSITEiView protein in PROSITE
PS00269. DEFENSIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01376-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTLALLAAI LLVALQAQAE HVSVSIDEVV DQQPPQAEDQ DVAIYVKEHE
60 70 80 90
SSALEALGVK AGVVCACRRA LCLPRERRAG FCRIRGRIHP LCCRR
Length:95
Mass (Da):10,460
Last modified:January 1, 1990 - v2
Checksum:i58593721BB6EF032
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M28883 mRNA. Translation: AAA31387.1.
M28072 Genomic DNA. Translation: AAA31388.1.
PIRiA45811. WTRBM1.
RefSeqiNP_001164486.1. NM_001171015.1.
UniGeneiOcu.6425.

Genome annotation databases

EnsembliENSOCUT00000003227; ENSOCUP00000002802; ENSOCUG00000003229.
GeneIDi100009115.
KEGGiocu:100009115.

Similar proteinsi

Entry informationi

Entry nameiDEF3_RABIT
AccessioniPrimary (citable) accession number: P01376
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 1, 1990
Last modified: August 30, 2017
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families