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P01374

- TNFB_HUMAN

UniProt

P01374 - TNFB_HUMAN

Protein

Lymphotoxin-alpha

Gene

LTA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 165 (01 Oct 2014)
      Sequence version 2 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.

    GO - Molecular functioni

    1. receptor binding Source: ProtInc

    GO - Biological processi

    1. apoptotic process Source: ProtInc
    2. cell-cell signaling Source: ProtInc
    3. defense response to Gram-positive bacterium Source: Ensembl
    4. humoral immune response Source: Ensembl
    5. lymph node development Source: Ensembl
    6. negative regulation of fibroblast proliferation Source: Ensembl
    7. negative regulation of growth of symbiont in host Source: Ensembl
    8. positive regulation of apoptotic process Source: Ensembl
    9. positive regulation of chronic inflammatory response to antigenic stimulus Source: Ensembl
    10. positive regulation of humoral immune response mediated by circulating immunoglobulin Source: Ensembl
    11. positive regulation of interferon-gamma production Source: Ensembl
    12. response to drug Source: Ensembl
    13. response to hypoxia Source: Ensembl
    14. response to lipopolysaccharide Source: Ensembl
    15. response to nutrient Source: Ensembl
    16. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Cytokine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lymphotoxin-alpha
    Short name:
    LT-alpha
    Alternative name(s):
    TNF-beta
    Tumor necrosis factor ligand superfamily member 1
    Gene namesi
    Name:LTA
    Synonyms:TNFB, TNFSF1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:6709. LTA.

    Subcellular locationi

    Secreted. Membrane
    Note: The homotrimer is secreted. The heterotrimer is membrane-associated.

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW
    2. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Psoriatic arthritis (PSORAS) [MIM:607507]: An inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).1 Publication
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

    Organism-specific databases

    MIMi607507. phenotype.
    610988. phenotype.
    Orphaneti40050. Adult psoriatic arthritis.
    PharmGKBiPA30474.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3434Add
    BLAST
    Chaini35 – 205171Lymphotoxin-alphaPRO_0000034463Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi41 – 411O-linked (GalNAc...); partial1 Publication
    Glycosylationi96 – 961N-linked (GlcNAc...)1 PublicationCAR_000048

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiP01374.

    PTM databases

    UniCarbKBiP01374.

    Expressioni

    Gene expression databases

    ArrayExpressiP01374.
    BgeeiP01374.
    CleanExiHS_LTA.
    GenevestigatoriP01374.

    Organism-specific databases

    HPAiHPA007729.

    Interactioni

    Subunit structurei

    Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits.

    Protein-protein interaction databases

    BioGridi110227. 7 interactions.
    DIPiDIP-2910N.
    DIP-6228N.
    IntActiP01374. 3 interactions.
    MINTiMINT-365276.
    STRINGi9606.ENSP00000372793.

    Structurei

    Secondary structure

    1
    205
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi64 – 696
    Turni71 – 733
    Beta strandi74 – 763
    Beta strandi87 – 893
    Beta strandi93 – 953
    Beta strandi98 – 1003
    Beta strandi103 – 11715
    Helixi122 – 1254
    Beta strandi129 – 13810
    Beta strandi142 – 1443
    Beta strandi146 – 15510
    Beta strandi163 – 17513
    Beta strandi180 – 1867
    Helixi188 – 1903
    Turni195 – 1973
    Beta strandi198 – 2047

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1TNRX-ray2.85A62-205[»]
    4MXVX-ray3.20A/B/D62-205[»]
    4MXWX-ray3.60A/X62-205[»]
    ProteinModelPortaliP01374.
    SMRiP01374. Positions 62-205.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP01374.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tumor necrosis factor family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG41746.
    HOGENOMiHOG000048729.
    HOVERGENiHBG012516.
    InParanoidiP01374.
    KOiK05468.
    OMAiYTLLTHE.
    OrthoDBiEOG7V4B0Q.
    PhylomeDBiP01374.
    TreeFamiTF332169.

    Family and domain databases

    Gene3Di2.60.120.40. 1 hit.
    InterProiIPR006053. TNF.
    IPR002960. TNF_beta.
    IPR021184. TNF_CS.
    IPR006052. TNF_dom.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view]
    PfamiPF00229. TNF. 1 hit.
    [Graphical view]
    PRINTSiPR01234. TNECROSISFCT.
    PR01236. TNFBETA.
    SMARTiSM00207. TNF. 1 hit.
    [Graphical view]
    SUPFAMiSSF49842. SSF49842. 1 hit.
    PROSITEiPS00251. TNF_1. 1 hit.
    PS50049. TNF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01374-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTPPERLFLP RVCGTTLHLL LLGLLLVLLP GAQGLPGVGL TPSAAQTARQ    50
    HPKMHLAHST LKPAAHLIGD PSKQNSLLWR ANTDRAFLQD GFSLSNNSLL 100
    VPTSGIYFVY SQVVFSGKAY SPKATSSPLY LAHEVQLFSS QYPFHVPLLS 150
    SQKMVYPGLQ EPWLHSMYHG AAFQLTQGDQ LSTHTDGIPH LVLSPSTVFF 200
    GAFAL 205
    Length:205
    Mass (Da):22,297
    Last modified:July 1, 1989 - v2
    Checksum:i1BBD5E7D496A3A82
    GO

    Polymorphismi

    A polymorphism in LTA accounts, in part, for susceptibility to leprosy linked to chromosome 6p21.3 (LPRS4) [MIMi:610988].

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti13 – 131C → R.3 Publications
    Corresponds to variant rs2229094 [ dbSNP | Ensembl ].
    VAR_013023
    Natural varianti51 – 511H → P.2 Publications
    Corresponds to variant rs2229092 [ dbSNP | Ensembl ].
    VAR_013024
    Natural varianti60 – 601T → N in allele TNFB*2. 4 Publications
    Corresponds to variant rs1041981 [ dbSNP | Ensembl ].
    VAR_007511
    Natural varianti125 – 1251T → P in allele 8.1. 1 Publication
    VAR_007512

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X01393 mRNA. Translation: CAA25649.1.
    X02911 Genomic DNA. Translation: CAA26670.1.
    D00102 mRNA. Translation: BAA00064.1.
    M16441 Genomic DNA. Translation: AAA61199.1.
    D12614 mRNA. Translation: BAA02139.1.
    M55913 Genomic DNA. Translation: AAB59455.1.
    Z15026 Genomic DNA. Translation: CAA78746.1.
    Y14768 Genomic DNA. Translation: CAA75071.1.
    AF129756 Genomic DNA. Translation: AAD18092.1.
    BA000025 Genomic DNA. Translation: BAB63397.1.
    AY070490 Genomic DNA. Translation: AAL49956.1.
    AY216498 Genomic DNA. Translation: AAO21135.1.
    BC034729 mRNA. Translation: AAH34729.1.
    CCDSiCCDS4701.1.
    PIRiA92755. QWHUX.
    RefSeqiNP_000586.2. NM_000595.3.
    NP_001153212.1. NM_001159740.2.
    UniGeneiHs.36.

    Genome annotation databases

    EnsembliENST00000412851; ENSP00000412555; ENSG00000230279.
    ENST00000418386; ENSP00000413450; ENSG00000226979.
    ENST00000426845; ENSP00000402413; ENSG00000230279.
    ENST00000436519; ENSP00000395976; ENSG00000231408.
    ENST00000454550; ENSP00000416509; ENSG00000231408.
    ENST00000454783; ENSP00000403495; ENSG00000226979.
    GeneIDi4049.
    KEGGihsa:4049.
    UCSCiuc003nue.2. human.

    Polymorphism databases

    DMDMi135940.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Lymphotoxin entry

    Atlas of Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPs
    SeattleSNPs
    SHMPD

    The Singapore human mutation and polymorphism database

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X01393 mRNA. Translation: CAA25649.1 .
    X02911 Genomic DNA. Translation: CAA26670.1 .
    D00102 mRNA. Translation: BAA00064.1 .
    M16441 Genomic DNA. Translation: AAA61199.1 .
    D12614 mRNA. Translation: BAA02139.1 .
    M55913 Genomic DNA. Translation: AAB59455.1 .
    Z15026 Genomic DNA. Translation: CAA78746.1 .
    Y14768 Genomic DNA. Translation: CAA75071.1 .
    AF129756 Genomic DNA. Translation: AAD18092.1 .
    BA000025 Genomic DNA. Translation: BAB63397.1 .
    AY070490 Genomic DNA. Translation: AAL49956.1 .
    AY216498 Genomic DNA. Translation: AAO21135.1 .
    BC034729 mRNA. Translation: AAH34729.1 .
    CCDSi CCDS4701.1.
    PIRi A92755. QWHUX.
    RefSeqi NP_000586.2. NM_000595.3.
    NP_001153212.1. NM_001159740.2.
    UniGenei Hs.36.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1TNR X-ray 2.85 A 62-205 [» ]
    4MXV X-ray 3.20 A/B/D 62-205 [» ]
    4MXW X-ray 3.60 A/X 62-205 [» ]
    ProteinModelPortali P01374.
    SMRi P01374. Positions 62-205.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110227. 7 interactions.
    DIPi DIP-2910N.
    DIP-6228N.
    IntActi P01374. 3 interactions.
    MINTi MINT-365276.
    STRINGi 9606.ENSP00000372793.

    Chemistry

    BindingDBi P01374.
    ChEMBLi CHEMBL2059.
    DrugBanki DB00005. Etanercept.

    PTM databases

    UniCarbKBi P01374.

    Polymorphism databases

    DMDMi 135940.

    Proteomic databases

    PRIDEi P01374.

    Protocols and materials databases

    DNASUi 4049.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000412851 ; ENSP00000412555 ; ENSG00000230279 .
    ENST00000418386 ; ENSP00000413450 ; ENSG00000226979 .
    ENST00000426845 ; ENSP00000402413 ; ENSG00000230279 .
    ENST00000436519 ; ENSP00000395976 ; ENSG00000231408 .
    ENST00000454550 ; ENSP00000416509 ; ENSG00000231408 .
    ENST00000454783 ; ENSP00000403495 ; ENSG00000226979 .
    GeneIDi 4049.
    KEGGi hsa:4049.
    UCSCi uc003nue.2. human.

    Organism-specific databases

    CTDi 4049.
    GeneCardsi GC06P031541.
    GC06Pl31579.
    GC06Po31529.
    HGNCi HGNC:6709. LTA.
    HPAi HPA007729.
    MIMi 153440. gene.
    607507. phenotype.
    610988. phenotype.
    neXtProti NX_P01374.
    Orphaneti 40050. Adult psoriatic arthritis.
    PharmGKBi PA30474.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41746.
    HOGENOMi HOG000048729.
    HOVERGENi HBG012516.
    InParanoidi P01374.
    KOi K05468.
    OMAi YTLLTHE.
    OrthoDBi EOG7V4B0Q.
    PhylomeDBi P01374.
    TreeFami TF332169.

    Miscellaneous databases

    EvolutionaryTracei P01374.
    GeneWikii Lymphotoxin_alpha.
    GenomeRNAii 4049.
    NextBioi 15860.
    PROi P01374.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P01374.
    Bgeei P01374.
    CleanExi HS_LTA.
    Genevestigatori P01374.

    Family and domain databases

    Gene3Di 2.60.120.40. 1 hit.
    InterProi IPR006053. TNF.
    IPR002960. TNF_beta.
    IPR021184. TNF_CS.
    IPR006052. TNF_dom.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view ]
    Pfami PF00229. TNF. 1 hit.
    [Graphical view ]
    PRINTSi PR01234. TNECROSISFCT.
    PR01236. TNFBETA.
    SMARTi SM00207. TNF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49842. SSF49842. 1 hit.
    PROSITEi PS00251. TNF_1. 1 hit.
    PS50049. TNF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Tandem arrangement of genes coding for tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) in the human genome."
      Nedospasov S.A., Shakhov A.N., Turetskaya R.L., Mett V.A., Azizov M.M., Georgiev G.P., Korobko V.G., Dobrynin V.N., Filippov S.A., Bystrov N.S., Boldyreva E.F., Chuvpilo S.A., Chumakov A.M., Shingarova L.N., Ovchinnikov Y.A.
      Cold Spring Harb. Symp. Quant. Biol. 51:611-624(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Cloning and expression of human lymphotoxin mRNA derived from a human T cell hybridoma."
      Kobayashi Y., Miyamoto D., Asada M., Obinata M., Osawa T.
      J. Biochem. 100:727-733(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity."
      Gray P.W., Aggarwal B.B., Benton C.V., Bringman T.S., Henzel W.J., Jarrett J.A., Leung D.W., Moffat B., Ng P., Svedersky L.P., Palladino M.A., Nedwin G.E.
      Nature 312:721-724(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. "Nucleotide sequence of a cDNA encoding human tumor necrosis factor beta from B lymphoblastoid cell RPMI 1788."
      Matsuyama N., Okawa N., Tsukii Y., Endo T., Kaji A.
      FEBS Lett. 302:141-144(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    6. "Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment."
      Iris F.J.M., Bougueleret L., Prieur S., Caterina D., Primas G., Perrot V., Jurka J., Rodriguez-Tome P., Claverie J.-M., Dausset J., Cohen D.
      Nat. Genet. 3:137-145(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    7. "A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC."
      Neville M.J., Campbell R.D.
      J. Immunol. 162:4745-4754(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    8. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
      Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
      Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
      Shiina S., Tamiya G., Oka A., Inoko H.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. SeattleSNPs variation discovery resource
      Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-13; PRO-51 AND ASN-60.
    11. NIEHS SNPs program
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-13; PRO-51 AND ASN-60.
    12. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-13.
      Tissue: Lymph.
    13. "Natural human tumor necrosis factor beta (lymphotoxin). Variable O-glycosylation at Thr7, proteolytic processing, and allelic variation."
      Voigt C.G., Maurer-Fogy I., Adolf G.R.
      FEBS Lett. 314:85-88(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE, GLYCOSYLATION AT THR-41 AND ASN-96, VARIANT ASN-60.
    14. "The structure of human lymphotoxin (tumor necrosis factor-beta) at 1.9-A resolution."
      Eck M.J., Ultsch M., Rinderknecht E., de Vos A.M., Sprang S.R.
      J. Biol. Chem. 267:2119-2122(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).
    15. "Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation."
      Banner D.W., D'Arcy A., Janes W., Gentz R., Schoenfeld H.-J., Broger C., Loetscher H., Lesslauer W.
      Cell 73:431-445(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS) OF 61-205 OF COMPLEX WITH TNFR1.
    16. "Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production."
      Messer G., Spengler U., Jung M.C., Honold G., Bloemer K., Pape G.R., Riethmueller G., Weiss E.H.
      J. Exp. Med. 173:209-219(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT ASN-60.
    17. Cited for: VARIANT PRO-125.
    18. "Cytokine gene polymorphisms: association with psoriatic arthritis susceptibility and severity."
      Balding J., Kane D., Livingstone W., Mynett-Johnson L., Bresnihan B., Smith O., FitzGerald O.
      Arthritis Rheum. 48:1408-1413(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN PSORIATIC ARTHRITIS SUSCEPTIBILITY.
    19. "Stepwise replication identifies a low-producing lymphotoxin-alpha allele as a major risk factor for early-onset leprosy."
      Alcaies A., Alter A., Antoni G., Orlova M., Nguyen V.T., Singh M., Vanderborght P.R., Katoch K., Mira M.T., Vu H.T., Ngyuen T.H., Nguyen N.B., Moraes M., Mehra N., Schurr E., Abel L.
      Nat. Genet. 39:517-522(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN LPRS4.

    Entry informationi

    Entry nameiTNFB_HUMAN
    AccessioniPrimary (citable) accession number: P01374
    Secondary accession number(s): Q8N4C3, Q9UKS8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 165 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3