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Protein

Trefoil factor 2

Gene

TFF2

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Trefoil factor 2
Alternative name(s):
Pancreatic spasmolytic polypeptide
Short name:
PSP
Spasmolytic polypeptide
Short name:
SP
Gene namesi
Name:TFF2
Synonyms:SML1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei‹1 – 211 PublicationAdd BLAST›21
ChainiPRO_000002346222 – 127Trefoil factor 2Add BLAST106

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22Pyrrolidone carboxylic acid1
Disulfide bondi27 ↔ 125
Disulfide bondi29 ↔ 56
Disulfide bondi40 ↔ 55
Disulfide bondi50 ↔ 67
Disulfide bondi79 ↔ 105
Disulfide bondi89 ↔ 104
Disulfide bondi99 ↔ 116

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP01359.
PRIDEiP01359.

Expressioni

Tissue specificityi

Found in pancreas.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000025323.

Structurei

Secondary structure

1127
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi26 – 30Combined sources5
Helixi34 – 36Combined sources3
Helixi47 – 52Combined sources6
Beta strandi61 – 64Combined sources4
Beta strandi66 – 68Combined sources3
Beta strandi74 – 76Combined sources3
Helixi77 – 79Combined sources3
Helixi83 – 85Combined sources3
Helixi96 – 101Combined sources6
Beta strandi110 – 113Combined sources4
Beta strandi115 – 117Combined sources3
Helixi122 – 124Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PCPNMR-A23-127[»]
1POSX-ray2.60A/B23-127[»]
1PSPX-ray2.50A/B23-127[»]
2PSPX-ray1.95A/B23-127[»]
ProteinModelPortaliP01359.
SMRiP01359.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01359.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 71P-type 1PROSITE-ProRule annotationAdd BLAST45
Domaini77 – 120P-type 2PROSITE-ProRule annotationAdd BLAST44

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IZEH. Eukaryota.
ENOG410Y3PX. LUCA.
HOVERGENiHBG004363.
InParanoidiP01359.

Family and domain databases

CDDicd00111. Trefoil. 2 hits.
InterProiView protein in InterPro
IPR017994. P_trefoil_chordata.
IPR017957. P_trefoil_CS.
IPR000519. P_trefoil_dom.
PfamiView protein in Pfam
PF00088. Trefoil. 2 hits.
PRINTSiPR00680. PTREFOIL.
SMARTiView protein in SMART
SM00018. PD. 2 hits.
PROSITEiView protein in PROSITE
PS00025. P_TREFOIL_1. 2 hits.
PS51448. P_TREFOIL_2. 2 hits.

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01359-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
EPQRPAPGHP PPAGAVCLTG AQKPAACRCS RQDPKNRVNC GFPGITSDQC
60 70 80 90 100
FTSGCCFDSQ VPGVPWCFKP LPAQESEECV MEVSARKNCG YPGISPEDCA
110 120
RRNCCFSDTI PEVPWCFFPM SVEDCHY
Length:127
Mass (Da):13,834
Last modified:October 1, 1994 - v4
Checksum:iF9012134CE13CF5C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Sequence conflicti82E → Q AA sequence (PubMed:2857575).Curated1
Sequence conflicti101R → A AA sequence (PubMed:2857575).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51696 mRNA. Translation: CAA35993.1.
PIRiS12373. JOPGP.
UniGeneiSsc.650.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTFF2_PIG
AccessioniPrimary (citable) accession number: P01359
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 1, 1994
Last modified: May 10, 2017
This is version 112 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references