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Protein

Trefoil factor 2

Gene

TFF2

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains.

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Trefoil factor 2
Alternative name(s):
Pancreatic spasmolytic polypeptide
Short name:
PSP
Spasmolytic polypeptide
Short name:
SP
Gene namesi
Name:TFF2
Synonyms:SML1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei‹1 – 21›211 PublicationAdd
BLAST
Chaini22 – 127106Trefoil factor 2PRO_0000023462Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei22 – 221Pyrrolidone carboxylic acid
Disulfide bondi27 ↔ 125
Disulfide bondi29 ↔ 56
Disulfide bondi40 ↔ 55
Disulfide bondi50 ↔ 67
Disulfide bondi79 ↔ 105
Disulfide bondi89 ↔ 104
Disulfide bondi99 ↔ 116

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP01359.

Expressioni

Tissue specificityi

Found in pancreas.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000025323.

Structurei

Secondary structure

1
127
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi26 – 305Combined sources
Helixi34 – 363Combined sources
Helixi47 – 526Combined sources
Beta strandi61 – 644Combined sources
Beta strandi66 – 683Combined sources
Beta strandi74 – 763Combined sources
Helixi77 – 793Combined sources
Helixi83 – 853Combined sources
Helixi96 – 1016Combined sources
Beta strandi110 – 1134Combined sources
Beta strandi115 – 1173Combined sources
Helixi122 – 1243Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PCPNMR-A23-127[»]
1POSX-ray2.60A/B23-127[»]
1PSPX-ray2.50A/B23-127[»]
2PSPX-ray1.95A/B23-127[»]
ProteinModelPortaliP01359.
SMRiP01359. Positions 22-127.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01359.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 7145P-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini77 – 12044P-type 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 P-type (trefoil) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IZEH. Eukaryota.
ENOG410Y3PX. LUCA.
HOVERGENiHBG004363.
InParanoidiP01359.

Family and domain databases

CDDicd00111. Trefoil. 2 hits.
Gene3Di4.10.110.10. 2 hits.
InterProiIPR017994. P_trefoil_chordata.
IPR017957. P_trefoil_CS.
IPR000519. P_trefoil_dom.
[Graphical view]
PfamiPF00088. Trefoil. 2 hits.
[Graphical view]
PRINTSiPR00680. PTREFOIL.
SMARTiSM00018. PD. 2 hits.
[Graphical view]
SUPFAMiSSF57492. SSF57492. 2 hits.
PROSITEiPS00025. P_TREFOIL_1. 2 hits.
PS51448. P_TREFOIL_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01359-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
EPQRPAPGHP PPAGAVCLTG AQKPAACRCS RQDPKNRVNC GFPGITSDQC
60 70 80 90 100
FTSGCCFDSQ VPGVPWCFKP LPAQESEECV MEVSARKNCG YPGISPEDCA
110 120
RRNCCFSDTI PEVPWCFFPM SVEDCHY
Length:127
Mass (Da):13,834
Last modified:October 1, 1994 - v4
Checksum:iF9012134CE13CF5C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Sequence conflicti82 – 821E → Q AA sequence (PubMed:2857575).Curated
Sequence conflicti101 – 1011R → A AA sequence (PubMed:2857575).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51696 mRNA. Translation: CAA35993.1.
PIRiS12373. JOPGP.
UniGeneiSsc.650.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51696 mRNA. Translation: CAA35993.1.
PIRiS12373. JOPGP.
UniGeneiSsc.650.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1PCPNMR-A23-127[»]
1POSX-ray2.60A/B23-127[»]
1PSPX-ray2.50A/B23-127[»]
2PSPX-ray1.95A/B23-127[»]
ProteinModelPortaliP01359.
SMRiP01359. Positions 22-127.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000025323.

Proteomic databases

PaxDbiP01359.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410IZEH. Eukaryota.
ENOG410Y3PX. LUCA.
HOVERGENiHBG004363.
InParanoidiP01359.

Miscellaneous databases

EvolutionaryTraceiP01359.

Family and domain databases

CDDicd00111. Trefoil. 2 hits.
Gene3Di4.10.110.10. 2 hits.
InterProiIPR017994. P_trefoil_chordata.
IPR017957. P_trefoil_CS.
IPR000519. P_trefoil_dom.
[Graphical view]
PfamiPF00088. Trefoil. 2 hits.
[Graphical view]
PRINTSiPR00680. PTREFOIL.
SMARTiSM00018. PD. 2 hits.
[Graphical view]
SUPFAMiSSF57492. SSF57492. 2 hits.
PROSITEiPS00025. P_TREFOIL_1. 2 hits.
PS51448. P_TREFOIL_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTFF2_PIG
AccessioniPrimary (citable) accession number: P01359
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 1, 1994
Last modified: September 7, 2016
This is version 107 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.