Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cholecystokinin

Gene

CCK

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.

GO - Molecular functioni

  • neuropeptide hormone activity Source: UniProtKB

GO - Biological processi

  • axonogenesis Source: UniProtKB
  • eating behavior Source: UniProtKB
  • neuron migration Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-SSC-375276. Peptide ligand-binding receptors.
R-SSC-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Cholecystokinin
Short name:
CCK
Cleaved into the following 10 chains:
Cholecystokinin-58
Short name:
CCK58
Alternative name(s):
(1-49)-CCK58
Cholecystokinin-39
Short name:
CCK39
Cholecystokinin-33
Short name:
CCK33
Cholecystokinin-25
Short name:
CCK25
Cholecystokinin-18
Short name:
CCK18
Cholecystokinin-12
Short name:
CCK12
Cholecystokinin-8
Short name:
CCK8
Cholecystokinin-7
Short name:
CCK7
Cholecystokinin-5
Short name:
CCK5
Gene namesi
Name:CCK
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 13

Subcellular locationi

GO - Cellular componenti

  • axon Source: UniProtKB
  • extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020CuratedAdd
BLAST
Chaini21 – 11494CholecystokininPRO_0000010558Add
BLAST
Peptidei45 – 10258Cholecystokinin-58PRO_0000010559Add
BLAST
Peptidei46 – 9449Cholecystokinin-58 desnonopeptideBy similarityPRO_0000306314Add
BLAST
Peptidei64 – 10239Cholecystokinin-39PRO_0000010560Add
BLAST
Peptidei70 – 10233Cholecystokinin-33PRO_0000010561Add
BLAST
Peptidei79 – 10325Cholecystokinin-25By similarityPRO_0000306315Add
BLAST
Peptidei86 – 10318Cholecystokinin-18By similarityPRO_0000306316Add
BLAST
Peptidei91 – 10212Cholecystokinin-12PRO_0000010562Add
BLAST
Peptidei95 – 1028Cholecystokinin-8PRO_0000010563
Peptidei97 – 1037Cholecystokinin-7By similarityPRO_0000306317
Peptidei99 – 1035Cholecystokinin-5By similarityPRO_0000306318
Propeptidei106 – 1149PRO_0000010564

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei96 – 961Sulfotyrosine2 Publications
Modified residuei102 – 1021Phenylalanine amide1 Publication
Modified residuei110 – 1101Sulfotyrosine1 Publication
Modified residuei112 – 1121Sulfotyrosine1 Publication

Post-translational modificationi

The precursor is cleaved by proteases to produce a number of active cholecystokinins. Brain contains CCK-octapeptide (CCK8) and several CCK-desoctapeptides; whereas pig gut contains intact CCK33, CCK39, and CCK58 as well as CCK-octapeptide and the CCK-desoctapeptides. Distribution differences are due to tissue-specific post-translational processing events.

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Sulfation

Proteomic databases

PaxDbiP01356.

Expressioni

Tissue specificityi

Synthesized in both cerebral cortex and duodenal mucosa.

Gene expression databases

BgeeiENSSSCG00000011277.
GenevisibleiP01356. SS.

Interactioni

Subunit structurei

Binds to CCK-A receptors in the pancreas and CCK-B receptors in the brain.By similarity

GO - Molecular functioni

  • neuropeptide hormone activity Source: UniProtKB

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000012023.

Chemistry

BindingDBiP01356.

Family & Domainsi

Sequence similaritiesi

Belongs to the gastrin/cholecystokinin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXQ9. Eukaryota.
ENOG411211F. LUCA.
GeneTreeiENSGT00390000003571.
HOGENOMiHOG000073533.
HOVERGENiHBG005806.
InParanoidiP01356.
KOiK05226.
OMAiDGEPRAH.
OrthoDBiEOG091G11B3.
TreeFamiTF333419.

Family and domain databases

InterProiIPR015499. CCK-like.
IPR001651. Gastrin.
IPR013152. Gastrin/cholecystokinin_CS.
[Graphical view]
PANTHERiPTHR10786. PTHR10786. 1 hit.
PfamiPF00918. Gastrin. 1 hit.
[Graphical view]
PROSITEiPS00259. GASTRIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01356-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGGLCLCVL MAVLAAGTLA QPVPPADSAV PGAQEEEAHR RQLRAVQKVD
60 70 80 90 100
GESRAHLGAL LARYIQQARK APSGRVSMIK NLQSLDPSHR ISDRDYMGWM
110
DFGRRSAEEY EYTS
Length:114
Mass (Da):12,526
Last modified:October 23, 1986 - v1
Checksum:i8F8C05DF29B0E6EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01940 mRNA. Translation: AAA31014.1.
PIRiA05084. GMPGCP.
RefSeqiNP_999402.1. NM_214237.2.
UniGeneiSsc.717.

Genome annotation databases

EnsembliENSSSCT00000012346; ENSSSCP00000012023; ENSSSCG00000011277.
GeneIDi397468.
KEGGissc:397468.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01940 mRNA. Translation: AAA31014.1.
PIRiA05084. GMPGCP.
RefSeqiNP_999402.1. NM_214237.2.
UniGeneiSsc.717.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000012023.

Chemistry

BindingDBiP01356.

Proteomic databases

PaxDbiP01356.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000012346; ENSSSCP00000012023; ENSSSCG00000011277.
GeneIDi397468.
KEGGissc:397468.

Organism-specific databases

CTDi885.

Phylogenomic databases

eggNOGiENOG410IXQ9. Eukaryota.
ENOG411211F. LUCA.
GeneTreeiENSGT00390000003571.
HOGENOMiHOG000073533.
HOVERGENiHBG005806.
InParanoidiP01356.
KOiK05226.
OMAiDGEPRAH.
OrthoDBiEOG091G11B3.
TreeFamiTF333419.

Enzyme and pathway databases

ReactomeiR-SSC-375276. Peptide ligand-binding receptors.
R-SSC-416476. G alpha (q) signalling events.

Gene expression databases

BgeeiENSSSCG00000011277.
GenevisibleiP01356. SS.

Family and domain databases

InterProiIPR015499. CCK-like.
IPR001651. Gastrin.
IPR013152. Gastrin/cholecystokinin_CS.
[Graphical view]
PANTHERiPTHR10786. PTHR10786. 1 hit.
PfamiPF00918. Gastrin. 1 hit.
[Graphical view]
PROSITEiPS00259. GASTRIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCKN_PIG
AccessioniPrimary (citable) accession number: P01356
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 23, 1986
Last modified: September 7, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.