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Protein

Gastrin

Gene

GAST

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-CFA-416476. G alpha (q) signalling events.
R-CFA-881907. Gastrin-CREB signalling pathway via PKC and MAPK.

Names & Taxonomyi

Protein namesi
Recommended name:
Gastrin
Cleaved into the following 2 chains:
Alternative name(s):
Gastrin-34
Short name:
G34
Gene namesi
Name:GAST
Synonyms:GAS
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 9

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000001061322 – 581 PublicationAdd BLAST37
PeptideiPRO_000001061459 – 92Big gastrinAdd BLAST34
PeptideiPRO_000001061576 – 92GastrinAdd BLAST17
PropeptideiPRO_000001061696 – 1049

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei59Pyrrolidone carboxylic acid1 Publication1
Modified residuei76Pyrrolidone carboxylic acid1 Publication1
Modified residuei87Sulfotyrosine1 Publication1
Modified residuei92Phenylalanine amide1 Publication1
Modified residuei96Phosphoserine1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Phosphoprotein, Pyrrolidone carboxylic acid, Sulfation

Proteomic databases

PaxDbiP01353.

PTM databases

iPTMnetiP01353.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000023420.

Family & Domainsi

Sequence similaritiesi

Belongs to the gastrin/cholecystokinin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1ZA. Eukaryota.
ENOG4111D7Y. LUCA.
GeneTreeiENSGT00390000014792.
HOGENOMiHOG000073533.
HOVERGENiHBG097593.
InParanoidiP01353.
KOiK13768.
OMAiKKQGPWM.
OrthoDBiEOG091G147Z.
TreeFamiTF336994.

Family and domain databases

InterProiIPR001651. Gastrin.
IPR013152. Gastrin/cholecystokinin_CS.
[Graphical view]
PfamiPF00918. Gastrin. 1 hit.
[Graphical view]
PROSITEiPS00259. GASTRIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01353-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRLCVYVLI LALALATFSE ASWKPRSRLQ DAPSGPGANR GLEPHGLDQL
60 70 80 90 100
GPASHHRRQL GLQGPPQLVA DLSKKQGPWM EEEEAAYGWM DFGRRSAEEG

DQRP
Length:104
Mass (Da):11,519
Last modified:July 15, 1998 - v3
Checksum:i73BF72A18DFE78CA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti83 – 85EEA → AEE AA sequence (PubMed:5799207).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti85A → T.1

Sequence databases

PIRiB61053. GMDG.
RefSeqiXP_003435286.1. XM_003435238.3.

Genome annotation databases

EnsembliENSCAFT00000025228; ENSCAFP00000023420; ENSCAFG00000015924.
GeneIDi100685087.
KEGGicfa:100685087.

Cross-referencesi

Sequence databases

PIRiB61053. GMDG.
RefSeqiXP_003435286.1. XM_003435238.3.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000023420.

PTM databases

iPTMnetiP01353.

Proteomic databases

PaxDbiP01353.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000025228; ENSCAFP00000023420; ENSCAFG00000015924.
GeneIDi100685087.
KEGGicfa:100685087.

Organism-specific databases

CTDi2520.

Phylogenomic databases

eggNOGiENOG410J1ZA. Eukaryota.
ENOG4111D7Y. LUCA.
GeneTreeiENSGT00390000014792.
HOGENOMiHOG000073533.
HOVERGENiHBG097593.
InParanoidiP01353.
KOiK13768.
OMAiKKQGPWM.
OrthoDBiEOG091G147Z.
TreeFamiTF336994.

Enzyme and pathway databases

ReactomeiR-CFA-416476. G alpha (q) signalling events.
R-CFA-881907. Gastrin-CREB signalling pathway via PKC and MAPK.

Family and domain databases

InterProiIPR001651. Gastrin.
IPR013152. Gastrin/cholecystokinin_CS.
[Graphical view]
PfamiPF00918. Gastrin. 1 hit.
[Graphical view]
PROSITEiPS00259. GASTRIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGAST_CANLF
AccessioniPrimary (citable) accession number: P01353
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 15, 1998
Last modified: September 7, 2016
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.