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P01352 (GAST_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gastrin

Cleaved into the following 2 chains:

  1. Big gastrin
    Alternative name(s):
    Gastrin-34
    Short name=G34
  2. Gastrin
Gene names
Name:GAST
Synonyms:GAS
OrganismBos taurus (Bovine)
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length104 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.

Subcellular location

Secreted.

Sequence similarities

Belongs to the gastrin/cholecystokinin family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionHormone
   PTMAmidation
Cleavage on pair of basic residues
Phosphoprotein
Pyrrolidone carboxylic acid
Sulfation
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionhormone activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121
Propeptide22 – 5837
PRO_0000010609
Peptide59 – 9234Big gastrin
PRO_0000010610
Peptide76 – 9217Gastrin Ref.2 Ref.3
PRO_0000010611
Propeptide96 – 1049
PRO_0000010612

Amino acid modifications

Modified residue591Pyrrolidone carboxylic acid
Modified residue761Pyrrolidone carboxylic acid Ref.3
Modified residue871Sulfotyrosine Ref.3
Modified residue921Phenylalanine amide Ref.3
Modified residue961Phosphoserine By similarity

Experimental info

Sequence conflict321A → L in AAA30537. Ref.1
Sequence conflict371G → R in AAA30537. Ref.1
Sequence conflict481N → T in AAA30537. Ref.1
Sequence conflict741K → N in AAA30537. Ref.1
Sequence conflict811E → G in AAA30537. Ref.1
Sequence conflict961S → M in AAA30537. Ref.1
Sequence conflict991E → G in AAA30537. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P01352 [UniParc].

Last modified November 1, 1991. Version 2.
Checksum: 54D03BF200F299F2

FASTA10411,573
        10         20         30         40         50         60 
MQRLCAHVLI LVLALAAFCE ASWKPHSHLQ DAPVAPGANR GQEPLRMNRL GPASNPRRQL 

        70         80         90        100 
GLQDPPHMVA DLSKKQGPWV EEEEAAYGWM DFGRRSAEEG DQHP 

« Hide

References

[1]"Cloning and sequencing of the bovine gastrin gene."
Lund T., Olsen J., Rehfeld J.F.
Mol. Endocrinol. 3:1585-1588(1989) [PubMed: 2608050] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Liver.
[2]"Bovine and feline gastrin cDNA sequences and the amino acid and nucleotide sequence homologies among mammalian species."
Kim S.J., Uhm K.N., Kang Y.K., Yoo O.J.
DNA Seq. 1:181-187(1991) [PubMed: 1773057] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[3]"Isolation, structure and synthesis of ovine and bovine gastrins."
Agarwal K.L., Beacham J., Bentley P.H., Gregory R.A., Kenner G.W., Sheppard R.C., Tracy H.J.
Nature 219:614-615(1968) [PubMed: 5665711] [Abstract]
Cited for: PROTEIN SEQUENCE OF 76-92.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M31657 Genomic DNA. Translation: AAA30537.1.
X16581 mRNA. Translation: CAA34598.1.
IPIIPI00694911.
PIRGMBO. S14400.
RefSeqNP_776340.1. NM_173915.2.
UniGeneBt.312.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGP01352.

Proteomic databases

PRIDEP01352.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000023489; ENSBTAP00000023489; ENSBTAG00000017663.
GeneID280800.
KEGGbta:280800.

Organism-specific databases

CTD2520.

Phylogenomic databases

eggNOGmaNOG20875.
GeneTreeENSGT00390000014792.
HOVERGENHBG097593.
InParanoidP01352.
OrthoDBEOG4CG09S.

Family and domain databases

InterProIPR001651. Gastrin.
IPR013152. Gastrin/cholecystokinin_CS.
[Graphical view]
KOK13768.
PfamPF00918. Gastrin. 1 hit.
[Graphical view]
SMARTSM00029. GASTRIN. 1 hit.
[Graphical view]
PROSITEPS00259. GASTRIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGAST_BOVIN
AccessionPrimary (citable) accession number: P01352
Secondary accession number(s): Q28114
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1991
Last modified: November 16, 2011
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families