Reviewed,
UniProtKB/Swiss-Prot P01352 (GAST_BOVIN)
Last modified
June 16, 2009.
Version 72.
History...
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50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Gastrin Cleaved into the following 2 chains: 1- Recommended name: Big gastrin Alternative name(s): Gastrin-34 Short name=G34 2- Recommended name: Gastrin | ||||
| Gene names |
| ||||
| Organism | Bos taurus (Bovine) | ||||
| Taxonomic identifier | 9913 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Protein attributes
| Sequence length | 104 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine. |
| Subcellular location | |
| Sequence similarities | Belongs to the gastrin/cholecystokinin family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Secreted |
| Domain | Signal |
| Molecular function | Hormone |
| PTM | Amidation Cleavage on pair of basic residues Phosphoprotein Pyrrolidone carboxylic acid Sulfation |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Cellular component | extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | hormone activity Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 21 | 21 | |||||||
| Propeptide | 22 – 58 | 37 | PRO_0000010609 | ||||||
| Peptide | 59 – 92 | 34 | Big gastrin | PRO_0000010610 | |||||
| Peptide | 76 – 92 | 17 | Gastrin Ref.2 | PRO_0000010611 | |||||
| Propeptide | 96 – 104 | 9 | PRO_0000010612 | ||||||
Amino acid modifications | |||||||||
| Modified residue | 59 | 1 | Pyrrolidone carboxylic acid | ||||||
| Modified residue | 76 | 1 | Pyrrolidone carboxylic acid Ref.3 | ||||||
| Modified residue | 87 | 1 | Sulfotyrosine Ref.3 | ||||||
| Modified residue | 92 | 1 | Phenylalanine amide Ref.3 | ||||||
| Modified residue | 96 | 1 | Phosphoserine By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 32 | 1 | A → L in AAA30537. Ref.1 | ||||||
| Sequence conflict | 37 | 1 | G → R in AAA30537. Ref.1 | ||||||
| Sequence conflict | 48 | 1 | N → T in AAA30537. Ref.1 | ||||||
| Sequence conflict | 74 | 1 | K → N in AAA30537. Ref.1 | ||||||
| Sequence conflict | 81 | 1 | E → G in AAA30537. Ref.1 | ||||||
| Sequence conflict | 96 | 1 | S → M in AAA30537. Ref.1 | ||||||
| Sequence conflict | 99 | 1 | E → G in AAA30537. Ref.1 | ||||||
Sequences
References
| [1] | "Cloning and sequencing of the bovine gastrin gene." Lund T., Olsen J., Rehfeld J.F. Mol. Endocrinol. 3:1585-1588(1989) [PubMed: 2608050] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Liver. |
| [2] | "Bovine and feline gastrin cDNA sequences and the amino acid and nucleotide sequence homologies among mammalian species." Kim S.J., Uhm K.N., Kang Y.K., Yoo O.J. DNA Seq. 1:181-187(1991) [PubMed: 1773057] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. |
| [3] | "Isolation, structure and synthesis of ovine and bovine gastrins." Agarwal K.L., Beacham J., Bentley P.H., Gregory R.A., Kenner G.W., Sheppard R.C., Tracy H.J. Nature 219:614-615(1968) [PubMed: 5665711] [Abstract] Cited for: PROTEIN SEQUENCE OF 76-92. |
Cross-references
Sequence databases | |
|---|---|
| M31657 Genomic DNA. Translation: AAA30537.1. X16581 mRNA. Translation: CAA34598.1. | |
| IPI | IPI00694911. |
| PIR | GMBO. S14400. |
| RefSeq | NP_776340.1. |
| UniGene | Bt.312 |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSBTAG00000017663. Bos taurus. [Contig view] |
| GeneID | 280800. |
| KEGG | bta:280800. |
Phylogenomic databases | |
| HOVERGEN | P01352. |
Family and domain databases | |
| InterPro | IPR001651. Gastrin. IPR013152. Gastrin/cholecystokinin_CS. [Graphical view] |
| Pfam | PF00918. Gastrin. 1 hit. [Graphical view] |
| SMART | SM00029. GASTRIN. 1 hit. [Graphical view] |
| PROSITE | PS00259. GASTRIN. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GAST_BOVIN | ||||||||
| Accession | Primary (citable) accession number: P01352 Secondary accession number(s): Q28114 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

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