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Protein

Gastrin

Gene

GAST

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.

GO - Molecular functioni

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: GO_Central
  • response to food Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-BTA-416476. G alpha (q) signalling events.
R-BTA-881907. Gastrin-CREB signalling pathway via PKC and MAPK.

Names & Taxonomyi

Protein namesi
Recommended name:
Gastrin
Cleaved into the following 2 chains:
Alternative name(s):
Gastrin-34
Short name:
G34
Gene namesi
Name:GAST
Synonyms:GAS
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
PropeptideiPRO_000001060922 – 58Add BLAST37
PeptideiPRO_000001061059 – 92Big gastrinAdd BLAST34
PeptideiPRO_000001061176 – 92Gastrin1 PublicationAdd BLAST17
PropeptideiPRO_000001061296 – 1049

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei59Pyrrolidone carboxylic acid1 Publication1
Modified residuei76Pyrrolidone carboxylic acid1 Publication1
Modified residuei87Sulfotyrosine1 Publication1
Modified residuei92Phenylalanine amide1 Publication1
Modified residuei96PhosphoserineBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Phosphoprotein, Pyrrolidone carboxylic acid, Sulfation

Proteomic databases

PaxDbiP01352.
PRIDEiP01352.

Expressioni

Gene expression databases

BgeeiENSBTAG00000017663.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023489.

Family & Domainsi

Sequence similaritiesi

Belongs to the gastrin/cholecystokinin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1ZA. Eukaryota.
ENOG4111D7Y. LUCA.
GeneTreeiENSGT00390000014792.
HOGENOMiHOG000073533.
HOVERGENiHBG097593.
InParanoidiP01352.
KOiK13768.
OMAiKKQGPWM.
OrthoDBiEOG091G147Z.
TreeFamiTF336994.

Family and domain databases

InterProiIPR001651. Gastrin.
IPR013152. Gastrin/cholecystokinin_CS.
[Graphical view]
PfamiPF00918. Gastrin. 1 hit.
[Graphical view]
PROSITEiPS00259. GASTRIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01352-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRLCAHVLI LVLALAAFCE ASWKPHSHLQ DAPVAPGANR GQEPLRMNRL
60 70 80 90 100
GPASNPRRQL GLQDPPHMVA DLSKKQGPWV EEEEAAYGWM DFGRRSAEEG

DQHP
Length:104
Mass (Da):11,573
Last modified:November 1, 1991 - v2
Checksum:i54D03BF200F299F2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32A → L in AAA30537 (PubMed:2608050).Curated1
Sequence conflicti37G → R in AAA30537 (PubMed:2608050).Curated1
Sequence conflicti48N → T in AAA30537 (PubMed:2608050).Curated1
Sequence conflicti74K → N in AAA30537 (PubMed:2608050).Curated1
Sequence conflicti81E → G in AAA30537 (PubMed:2608050).Curated1
Sequence conflicti96S → M in AAA30537 (PubMed:2608050).Curated1
Sequence conflicti99E → G in AAA30537 (PubMed:2608050).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31657 Genomic DNA. Translation: AAA30537.1.
X16581 mRNA. Translation: CAA34598.1.
PIRiS14400. GMBO.
RefSeqiNP_776340.1. NM_173915.2.
UniGeneiBt.312.

Genome annotation databases

EnsembliENSBTAT00000023489; ENSBTAP00000023489; ENSBTAG00000017663.
GeneIDi280800.
KEGGibta:280800.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31657 Genomic DNA. Translation: AAA30537.1.
X16581 mRNA. Translation: CAA34598.1.
PIRiS14400. GMBO.
RefSeqiNP_776340.1. NM_173915.2.
UniGeneiBt.312.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023489.

Proteomic databases

PaxDbiP01352.
PRIDEiP01352.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000023489; ENSBTAP00000023489; ENSBTAG00000017663.
GeneIDi280800.
KEGGibta:280800.

Organism-specific databases

CTDi2520.

Phylogenomic databases

eggNOGiENOG410J1ZA. Eukaryota.
ENOG4111D7Y. LUCA.
GeneTreeiENSGT00390000014792.
HOGENOMiHOG000073533.
HOVERGENiHBG097593.
InParanoidiP01352.
KOiK13768.
OMAiKKQGPWM.
OrthoDBiEOG091G147Z.
TreeFamiTF336994.

Enzyme and pathway databases

ReactomeiR-BTA-416476. G alpha (q) signalling events.
R-BTA-881907. Gastrin-CREB signalling pathway via PKC and MAPK.

Gene expression databases

BgeeiENSBTAG00000017663.

Family and domain databases

InterProiIPR001651. Gastrin.
IPR013152. Gastrin/cholecystokinin_CS.
[Graphical view]
PfamiPF00918. Gastrin. 1 hit.
[Graphical view]
PROSITEiPS00259. GASTRIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGAST_BOVIN
AccessioniPrimary (citable) accession number: P01352
Secondary accession number(s): Q28114
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1991
Last modified: September 7, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.