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Protein

Prorelaxin

Gene

RLN

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals.

GO - Molecular functioni

GO - Biological processi

  • blastocyst growth Source: CACAO
  • flagellated sperm motility Source: CACAO
  • oocyte maturation Source: CACAO
  • positive regulation of acrosome reaction Source: CACAO
  • positive regulation of epithelial cell proliferation Source: CACAO
  • positive regulation of glucose import Source: CACAO

Keywordsi

Molecular functionHormone

Names & Taxonomyi

Protein namesi
Recommended name:
Prorelaxin
Cleaved into the following 2 chains:
Gene namesi
Name:RLN
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
PeptideiPRO_000001611225 – 56Relaxin B chain1 PublicationAdd BLAST32
PropeptideiPRO_000001611357 – 154Connecting peptideAdd BLAST98
PropeptideiPRO_0000016114159 – 1601 Publication2
PeptideiPRO_0000016115161 – 182Relaxin A chain1 PublicationAdd BLAST22

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25Pyrrolidone carboxylic acid2 Publications1
Disulfide bondi34 ↔ 169Interchain (between B and A chains)1 Publication
Disulfide bondi46 ↔ 182Interchain (between B and A chains)1 Publication
Disulfide bondi168 ↔ 1731 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP01348
PRIDEiP01348

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

GO - Molecular functioni

Protein-protein interaction databases

IntActiP01348, 1 interactor
MINTiP01348
STRINGi9823.ENSSSCP00000005607

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RLXmodel-A161-182[»]
B25-50[»]
2RLXmodel-A161-182[»]
B25-50[»]
3RLXmodel-A161-182[»]
B25-50[»]
4RLXmodel-A161-182[»]
B25-50[»]
SMRiP01348
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1BP Eukaryota
ENOG411169Y LUCA
HOGENOMiHOG000236342
HOVERGENiHBG003234
InParanoidiP01348
KOiK21998

Family and domain databases

InterProiView protein in InterPro
IPR016179 Insulin-like
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
IPR022421 Relaxin
PfamiView protein in Pfam
PF00049 Insulin, 1 hit
PRINTSiPR02004 RELAXIN
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 2 hits
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01348-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRLFSYLLG VWLLLSQLPR EIPGQSTNDF IKACGRELVR LWVEICGSVS
60 70 80 90 100
WGRTALSLEE PQLETGPPAE TMPSSITKDA EILKMMLEFV PNLPQELKAT
110 120 130 140 150
LSERQPSLRE LQQSASKDSN LNFEEFKKII LNRQNEAEDK SLLELKNLGL
160 170 180
DKHSRKKRLF RMTLSEKCCQ VGCIRKDIAR LC
Length:182
Mass (Da):20,818
Last modified:November 1, 1988 - v1
Checksum:i20736EB089F13AB4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47G → GVWS AA sequence (PubMed:851452).Curated1
Sequence conflicti51 – 54WGRT → TWGR AA sequence (PubMed:876374).Curated4
Sequence conflicti116S → L in AAA31115 (PubMed:2442155).Curated1
Sequence conflicti170Q → E AA sequence (PubMed:938497).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01088 mRNA Translation: AAA31114.1
J02792 Genomic DNA Translation: AAA31115.1
PIRiA90934 RXPG
RefSeqiNP_999037.1, NM_213872.1
UniGeneiSsc.162
Ssc.82485

Genome annotation databases

GeneIDi396891
KEGGissc:396891

Similar proteinsi

Entry informationi

Entry nameiRELX_PIG
AccessioniPrimary (citable) accession number: P01348
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1988
Last modified: March 28, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health