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Protein

Prorelaxin

Gene

RLN

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals.

GO - Biological processi

  • blastocyst growth Source: CACAO
  • oocyte maturation Source: CACAO
  • positive regulation of acrosome reaction Source: CACAO
  • positive regulation of epithelial cell proliferation Source: CACAO
  • positive regulation of glucose import Source: CACAO
  • sperm motility Source: CACAO
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Prorelaxin
Cleaved into the following 2 chains:
Gene namesi
Name:RLN
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 24241 PublicationAdd
BLAST
Peptidei25 – 5632Relaxin B chain1 PublicationPRO_0000016112Add
BLAST
Propeptidei57 – 15498Connecting peptidePRO_0000016113Add
BLAST
Propeptidei159 – 16021 PublicationPRO_0000016114
Peptidei161 – 18222Relaxin A chain1 PublicationPRO_0000016115Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei25 – 251Pyrrolidone carboxylic acid2 Publications
Disulfide bondi34 ↔ 169Interchain (between B and A chains)1 Publication
Disulfide bondi46 ↔ 182Interchain (between B and A chains)1 Publication
Disulfide bondi168 ↔ 1731 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP01348.
PRIDEiP01348.

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

Protein-protein interaction databases

MINTiMINT-231177.
STRINGi9823.ENSSSCP00000005607.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RLXmodel-A161-182[»]
B25-50[»]
2RLXmodel-A161-182[»]
B25-50[»]
3RLXmodel-A161-182[»]
B25-50[»]
4RLXmodel-A161-182[»]
B25-50[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1BP. Eukaryota.
ENOG411169Y. LUCA.
HOGENOMiHOG000236342.
HOVERGENiHBG003234.
InParanoidiP01348.
KOiK05255.

Family and domain databases

InterProiIPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022421. Relaxin.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR02004. RELAXIN.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 2 hits.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01348-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRLFSYLLG VWLLLSQLPR EIPGQSTNDF IKACGRELVR LWVEICGSVS
60 70 80 90 100
WGRTALSLEE PQLETGPPAE TMPSSITKDA EILKMMLEFV PNLPQELKAT
110 120 130 140 150
LSERQPSLRE LQQSASKDSN LNFEEFKKII LNRQNEAEDK SLLELKNLGL
160 170 180
DKHSRKKRLF RMTLSEKCCQ VGCIRKDIAR LC
Length:182
Mass (Da):20,818
Last modified:November 1, 1988 - v1
Checksum:i20736EB089F13AB4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti47 – 471G → GVWS AA sequence (PubMed:851452).Curated
Sequence conflicti51 – 544WGRT → TWGR AA sequence (PubMed:876374).Curated
Sequence conflicti116 – 1161S → L in AAA31115 (PubMed:2442155).Curated
Sequence conflicti170 – 1701Q → E AA sequence (PubMed:938497).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01088 mRNA. Translation: AAA31114.1.
J02792 Genomic DNA. Translation: AAA31115.1.
PIRiA90934. RXPG.
RefSeqiNP_999037.1. NM_213872.1.
UniGeneiSsc.162.
Ssc.82485.

Genome annotation databases

GeneIDi396891.
KEGGissc:396891.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01088 mRNA. Translation: AAA31114.1.
J02792 Genomic DNA. Translation: AAA31115.1.
PIRiA90934. RXPG.
RefSeqiNP_999037.1. NM_213872.1.
UniGeneiSsc.162.
Ssc.82485.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RLXmodel-A161-182[»]
B25-50[»]
2RLXmodel-A161-182[»]
B25-50[»]
3RLXmodel-A161-182[»]
B25-50[»]
4RLXmodel-A161-182[»]
B25-50[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-231177.
STRINGi9823.ENSSSCP00000005607.

Proteomic databases

PaxDbiP01348.
PRIDEiP01348.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396891.
KEGGissc:396891.

Organism-specific databases

CTDi6019.

Phylogenomic databases

eggNOGiENOG410J1BP. Eukaryota.
ENOG411169Y. LUCA.
HOGENOMiHOG000236342.
HOVERGENiHBG003234.
InParanoidiP01348.
KOiK05255.

Family and domain databases

InterProiIPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022421. Relaxin.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR02004. RELAXIN.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 2 hits.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRELX_PIG
AccessioniPrimary (citable) accession number: P01348
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1988
Last modified: May 11, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.