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Protein

Prorelaxin 1

Gene

Rln1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals.

GO - Molecular functioni

  • hormone activity Source: RGD
  • receptor binding Source: RGD

GO - Biological processi

  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: MGI
  • developmental growth Source: RGD
  • mammary gland morphogenesis Source: RGD
  • negative regulation of apoptotic process Source: CACAO
  • nipple development Source: RGD
  • prostate gland growth Source: RGD
  • regulation of apoptotic process Source: RGD
  • regulation of body fluid levels Source: RGD
  • regulation of cell proliferation Source: CACAO
  • regulation of nitric oxide mediated signal transduction Source: MGI
  • spermatogenesis Source: RGD

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-RNO-418555. G alpha (s) signalling events.
R-RNO-444821. Relaxin receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Prorelaxin 1
Cleaved into the following 2 chains:
Gene namesi
Name:Rln1
Synonyms:Rln
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3579. Rln1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
PeptideiPRO_000001611623 – 57Relaxin B chainAdd BLAST35
PropeptideiPRO_000001611758 – 158Connecting peptideAdd BLAST101
PeptideiPRO_0000016118163 – 186Relaxin A chainAdd BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 173Interchain (between B and A chains)By similarity
Disulfide bondi48 ↔ 186Interchain (between B and A chains)By similarity
Modified residuei163Pyrrolidone carboxylic acid1 Publication1
Disulfide bondi172 ↔ 177By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP01347.

Expressioni

Gene expression databases

BgeeiENSRNOG00000060867.
GenevisibleiP01347. RN.

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

GO - Molecular functioni

  • hormone activity Source: RGD
  • receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021315.

Structurei

3D structure databases

SMRiP01347.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1BP. Eukaryota.
ENOG411169Y. LUCA.
GeneTreeiENSGT00510000048834.
HOGENOMiHOG000236342.
HOVERGENiHBG003234.
InParanoidiP01347.
KOiK21998.
OMAiIKACGRE.
OrthoDBiEOG091G0SV7.
PhylomeDBiP01347.
TreeFamiTF333404.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR016179. Insulin-like.
IPR036438. Insulin-like_sf.
IPR022353. Insulin_CS.
IPR022421. Relaxin.
PfamiView protein in Pfam
PF00049. Insulin. 1 hit.
PRINTSiPR02004. RELAXIN.
SMARTiView protein in SMART
SM00078. IlGF. 1 hit.
SUPFAMiSSF56994. SSF56994. 2 hits.
PROSITEiView protein in PROSITE
PS00262. INSULIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01347-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRLLLQLL GFWLFLSQPC RARVSEEWMD QVIQVCGRGY ARAWIEVCGA
60 70 80 90 100
SVGRLALSQE EPAPLARQAT AEVVPSFINK DAEPFDMTLK CLPNLSEERK
110 120 130 140 150
AALSEGRAPF PELQQHAPAL SDSVVSLEGF KKTFHNQLGE AEDGGPPELK
160 170 180
YLGSDAQSRK KRQSGALLSE QCCHIGCTRR SIAKLC
Length:186
Mass (Da):20,489
Last modified:July 21, 1986 - v1
Checksum:i08BAEC79BCF0E80F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00780 mRNA. Translation: AAA42029.1.
V01264 mRNA. Translation: CAA24578.1.
AY240029 Genomic DNA. Translation: AAP41739.1.
PIRiA01614. RXRT.
RefSeqiNP_038199.1. NM_013413.1.
UniGeneiRn.9830.

Genome annotation databases

EnsembliENSRNOT00000088193; ENSRNOP00000072430; ENSRNOG00000060867.
GeneIDi25616.
KEGGirno:25616.
UCSCiRGD:3579. rat.

Similar proteinsi

Entry informationi

Entry nameiREL1_RAT
AccessioniPrimary (citable) accession number: P01347
Secondary accession number(s): Q78N50
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 22, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families