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Protein

Prorelaxin 1

Gene

Rln1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals.

GO - Molecular functioni

  • hormone activity Source: RGD

GO - Biological processi

  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: MGI
  • negative regulation of apoptotic process Source: CACAO
  • regulation of body fluid levels Source: RGD
  • regulation of cell proliferation Source: CACAO
  • regulation of nitric oxide mediated signal transduction Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-RNO-418555. G alpha (s) signalling events.
R-RNO-444821. Relaxin receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Prorelaxin 1
Cleaved into the following 2 chains:
Gene namesi
Name:Rln1
Synonyms:Rln
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi3579. Rln1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22221 PublicationAdd
BLAST
Peptidei23 – 5735Relaxin B chainPRO_0000016116Add
BLAST
Propeptidei58 – 158101Connecting peptidePRO_0000016117Add
BLAST
Peptidei163 – 18624Relaxin A chainPRO_0000016118Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 173Interchain (between B and A chains)By similarity
Disulfide bondi48 ↔ 186Interchain (between B and A chains)By similarity
Modified residuei163 – 1631Pyrrolidone carboxylic acid1 Publication
Disulfide bondi172 ↔ 177By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP01347.

Expressioni

Gene expression databases

GenevisibleiP01347. RN.

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

GO - Molecular functioni

  • hormone activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021315.

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1BP. Eukaryota.
ENOG411169Y. LUCA.
GeneTreeiENSGT00510000048834.
HOGENOMiHOG000236342.
HOVERGENiHBG003234.
InParanoidiP01347.
KOiK05255.
OMAiDKHSRKK.
OrthoDBiEOG7QZGC5.
PhylomeDBiP01347.
TreeFamiTF333404.

Family and domain databases

InterProiIPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022421. Relaxin.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR02004. RELAXIN.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 2 hits.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01347-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRLLLQLL GFWLFLSQPC RARVSEEWMD QVIQVCGRGY ARAWIEVCGA
60 70 80 90 100
SVGRLALSQE EPAPLARQAT AEVVPSFINK DAEPFDMTLK CLPNLSEERK
110 120 130 140 150
AALSEGRAPF PELQQHAPAL SDSVVSLEGF KKTFHNQLGE AEDGGPPELK
160 170 180
YLGSDAQSRK KRQSGALLSE QCCHIGCTRR SIAKLC
Length:186
Mass (Da):20,489
Last modified:July 21, 1986 - v1
Checksum:i08BAEC79BCF0E80F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00780 mRNA. Translation: AAA42029.1.
V01264 mRNA. Translation: CAA24578.1.
AY240029 Genomic DNA. Translation: AAP41739.1.
PIRiA01614. RXRT.
RefSeqiNP_038199.1. NM_013413.1.
UniGeneiRn.9830.

Genome annotation databases

EnsembliENSRNOT00000088193; ENSRNOP00000072430; ENSRNOG00000060867.
GeneIDi25616.
KEGGirno:25616.
UCSCiRGD:3579. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00780 mRNA. Translation: AAA42029.1.
V01264 mRNA. Translation: CAA24578.1.
AY240029 Genomic DNA. Translation: AAP41739.1.
PIRiA01614. RXRT.
RefSeqiNP_038199.1. NM_013413.1.
UniGeneiRn.9830.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021315.

Proteomic databases

PaxDbiP01347.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000088193; ENSRNOP00000072430; ENSRNOG00000060867.
GeneIDi25616.
KEGGirno:25616.
UCSCiRGD:3579. rat.

Organism-specific databases

CTDi6013.
RGDi3579. Rln1.

Phylogenomic databases

eggNOGiENOG410J1BP. Eukaryota.
ENOG411169Y. LUCA.
GeneTreeiENSGT00510000048834.
HOGENOMiHOG000236342.
HOVERGENiHBG003234.
InParanoidiP01347.
KOiK05255.
OMAiDKHSRKK.
OrthoDBiEOG7QZGC5.
PhylomeDBiP01347.
TreeFamiTF333404.

Enzyme and pathway databases

ReactomeiR-RNO-418555. G alpha (s) signalling events.
R-RNO-444821. Relaxin receptors.

Miscellaneous databases

NextBioi607371.
PROiP01347.

Gene expression databases

GenevisibleiP01347. RN.

Family and domain databases

InterProiIPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022421. Relaxin.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR02004. RELAXIN.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 2 hits.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and characterization of cDNA sequences coding for rat relaxin."
    Hudson P., Haley J., Cronk M., Shine J., Niall H.
    Nature 291:127-131(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning, characterization, and expression of the rat relaxin gene."
    Soloff M.S., Gal S., Hoare S., Peters C.A., Hunzicker-Dunn M., Anderson G.D., Wood T.G.
    Gene 323:149-155(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Limited sequence homology between porcine and rat relaxins: implications for physiological studies."
    John M.J., Borjesson B.W., Walsh J.R., Niall H.D.
    Endocrinology 108:726-729(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 23-57 AND 163-186, PYROGLUTAMATE FORMATION AT GLN-163.

Entry informationi

Entry nameiREL1_RAT
AccessioniPrimary (citable) accession number: P01347
Secondary accession number(s): Q78N50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 11, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.