Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Insulin-like growth factor II

Gene

Igf2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF-II is influenced by placental lactogen. Also involved in tissue differentiation. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver.By similarity
Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.By similarity

Miscellaneous

The IGF2 locus is imprinted. Paternal inherited gene is expressed, while the maternal inherited gene is imprinted, hence silenced.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor, Hormone, Mitogen
Biological processCarbohydrate metabolism, Glucose metabolism, Osteogenesis

Enzyme and pathway databases

ReactomeiR-RNO-114608 Platelet degranulation
R-RNO-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-RNO-2428928 IRS-related events triggered by IGF1R
R-RNO-2428933 SHC-related events triggered by IGF1R
R-RNO-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor II
Short name:
IGF-II
Alternative name(s):
Multiplication-stimulating activity
Short name:
MSA
Multiplication-stimulating polypeptide
Cleaved into the following 2 chains:
Gene namesi
Name:Igf2
Synonyms:Igf-2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi2870 Igf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
ChainiPRO_000001572925 – 91Insulin-like growth factor IIAdd BLAST67
PropeptideiPRO_000001573092 – 180E peptideAdd BLAST89
PeptideiPRO_000037038093 – 126PreptinAdd BLAST34

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 71By similarity
Disulfide bondi45 ↔ 84By similarity
Disulfide bondi70 ↔ 75By similarity

Post-translational modificationi

Proteolytically processed by PCSK4, proIGF2 is cleaved at Arg-128 and Arg-92 to generate big-IGF2 and mature IGF2.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP01346
PRIDEiP01346

Expressioni

Gene expression databases

BgeeiENSRNOG00000020369
ExpressionAtlasiP01346 baseline
GenevisibleiP01346 RN

Interactioni

Subunit structurei

Interacts with MYORG; this interaction is required for IGF2 secretion.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP01346 1 interactor.
STRINGi10116.ENSRNOP00000047037

Structurei

3D structure databases

ProteinModelPortaliP01346
SMRiP01346
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 52BAdd BLAST28
Regioni53 – 64CAdd BLAST12
Regioni65 – 85AAdd BLAST21
Regioni86 – 91D6

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IY3P Eukaryota
ENOG4111KP2 LUCA
GeneTreeiENSGT00530000063856
HOGENOMiHOG000233362
HOVERGENiHBG006137
InParanoidiP01346
KOiK13769
PhylomeDBiP01346
TreeFamiTF332820

Family and domain databases

InterProiView protein in InterPro
IPR022334 IGF2
IPR013576 IGF2_C
IPR016179 Insulin-like
IPR022350 Insulin-like_growth_factor
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
IPR022352 Insulin_family
PfamiView protein in Pfam
PF08365 IGF2_C, 1 hit
PF00049 Insulin, 1 hit
PRINTSiPR02002 INSLNLIKEGF
PR02006 INSLNLIKEGF2
PR00276 INSULINFAMLY
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005188 IGF2_C, 1 hit
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 1 hit
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01346-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIPVGKSML VLLISLAFAL CCIAAYRPSE TLCGGELVDT LQFVCSDRGF
60 70 80 90 100
YFSRPSSRAN RRSRGIVEEC CFRSCDLALL ETYCATPAKS ERDVSTSQAV
110 120 130 140 150
LPDDFPRYPV GKFFKFDTWR QSAGRLRRGL PALLRARRGR MLAKELEAFR
160 170 180
EAKRHRPLIV LPPKDPAHGG ASSEMSSNHQ
Length:180
Mass (Da):20,086
Last modified:March 20, 1987 - v1
Checksum:iAF12B4EEC0DBCC34
GO

Sequence cautioni

The sequence CAA25427 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAA25429 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 8Missing (PubMed:3889836).Curated8
Sequence conflicti57S → G (PubMed:2438416).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00911 mRNA Translation: CAA25428.1
X00911 mRNA Translation: CAA25427.1 Different initiation.
X00911 mRNA Translation: CAA25429.1 Different initiation.
X02213 mRNA Translation: CAA26136.1
X13101 mRNA Translation: CAA31493.1
X14833 mRNA Translation: CAA32942.1
X14834 mRNA Translation: CAA32943.1
M13871, M13869, M13870 Genomic DNA Translation: AAB95624.1
M29880, M29879 Genomic DNA Translation: AAA41391.1
M30273 mRNA Translation: AAA41432.1
M31221 Genomic DNA Translation: AAA42046.1
PIRiA25350 IGRT2
RefSeqiNP_001177091.1, NM_001190162.1
NP_001177092.1, NM_001190163.1
NP_113699.2, NM_031511.2
XP_006230727.1, XM_006230665.2
UniGeneiRn.118681
Rn.224460

Genome annotation databases

EnsembliENSRNOT00000050760; ENSRNOP00000047037; ENSRNOG00000020369
ENSRNOT00000073850; ENSRNOP00000066983; ENSRNOG00000020369
ENSRNOT00000089171; ENSRNOP00000070557; ENSRNOG00000020369
GeneIDi24483
KEGGirno:24483
UCSCiRGD:2870 rat

Similar proteinsi

Entry informationi

Entry nameiIGF2_RAT
AccessioniPrimary (citable) accession number: P01346
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: March 20, 1987
Last modified: March 28, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome