Insulin-like growth factor IA precursor

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Sequences

References

Web resources

Cross-references

Entry information

Molecule processing

Regions

Amino acid modifications

Natural variations

Secondary structure

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3D structure databases

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Reviewed, UniProtKB/Swiss-Prot P01343 (IGF1A_HUMAN)

Last modified June 16, 2009. Version 116. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Protein names

Recommended name:
    Insulin-like growth factor IA
      Short name=IGF-IA
Alternative name(s):
    Somatomedin-C
    Mechano growth factor
      Short name=MGF

Gene names

Name:	IGF1
Synonyms:	IBP1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Sequence length	153 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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Function	The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity.
Subcellular location	Secreted.
Involvement in disease	Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
Sequence similarities	Belongs to the insulin family.

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Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Deafness
Domain	Signal
Molecular function	Growth factor
PTM	Disulfide bond
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Biological process	DNA replication Traceable author statement. Source: ProtInc Ras protein signal transduction Traceable author statement. Source: ProtInc cell motion Traceable author statement. Source: ProtInc glycolate metabolic process Traceable author statement. Source: ProtInc muscle organ development Traceable author statement. Source: ProtInc positive regulation of cell proliferation Inferred from direct assay. Source: UniProtKB proteoglycan biosynthetic process Inferred from direct assay. Source: UniProtKB regulation of steroid hormone receptor signaling pathway Inferred from direct assay. Source: MGI sensory perception of sound Inferred from electronic annotation. Source: UniProtKB-KW skeletal system development Traceable author statement. Source: ProtInc
Cellular component	extracellular region Non-traceable author statement. Source: UniProtKB platelet alpha granule lumen Inferred from Experiment. Source: Reactome
Molecular function	growth factor activity Inferred from electronic annotation. Source: UniProtKB-KW hormone activity Traceable author statement. Source: ProtInc insulin-like growth factor receptor binding Traceable author statement. Source: ProtInc
Complete GO annotation...

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Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Signal peptide

1 – 21

Potential

Propeptide

22 – 48

Ref.9

PRO_0000015660

Chain

49 – 118

Insulin-like growth factor IA

PRO_0000015661

Propeptide

119 – 153

E peptide

PRO_0000015662

Region

Region

Region

Region

Disulfide bond

Disulfide bond

Disulfide bond

Natural variant

115

A → T: dbSNP rs17884626.

VAR_050006

153

Helix Strand Turn

Details...

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Sequence

Length

Mass (Da)

Tools

Isoform IGF-IA [UniParc].

Last modified August 13, 1987. Version 1.
Checksum: C6ECD92DCA9B37BC
Show »

FASTA

153

17,026

        10         20         30         40         50         60 
MGKISSLPTQ LFKCCFCDFL KVKMHTMSSS HLFYLALCLL TFTSSATAGP ETLCGAELVD 

        70         80         90        100        110        120 
ALQFVCGDRG FYFNKPTGYG SSSRRAPQTG IVDECCFRSC DLRRLEMYCA PLKPAKSARS 

       130        140        150 
VRAQRHTDMP KTQKEVHLKN ASRGSAGNKN YRM

« Hide

Isoform IGF-IB.

See P05019.

FASTA

–

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[1]	"Organization and sequence of the human insulin-like growth factor I gene. Alternative RNA processing produces two insulin-like growth factor I precursor peptides." Rotwein P., Pollock K.M., Didier D.K., Krivi G.G. J. Biol. Chem. 261:4828-4832(1986) [PubMed: 2937782] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Sequence of cDNA encoding human insulin-like growth factor I precursor." Jansen M., van Schaik F.M.A., Ricker A.T., Bullock B., Woods D.E., Gabbay K.H., Nussbaum A.L., Sussenbach J.S., van den Brande J.L. Nature 306:609-611(1983) [PubMed: 6358902] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Complete characterization of the human IGF-I nucleotide sequence isolated from a newly constructed adult liver cDNA library." le Bouc Y., Dreyer D., Jaeger F., Binoux M., Sondermeyer P. FEBS Lett. 196:108-112(1986) [PubMed: 2935423] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Organization of the human genes for insulin-like growth factors I and II." de Pagter-Holthuizen P., van Schaik F.M.A., Verduijn G.M., van Ommen G.J.B., Bouma B.N., Jansen M., Sussenbach J.S. FEBS Lett. 195:179-184(1986) [PubMed: 3002851] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"Complete nucleotide sequence of the high molecular weight human IGF-I mRNA." Steenbergh P.H., Koonen-Reemst A.M.C.B., Cleutjens C.B.J.M., Sussenbach J.S. Biochem. Biophys. Res. Commun. 175:507-514(1991) [PubMed: 2018498] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[6]	"Characterization of two cDNAs encoding insulin-like growth factor 1 (IGF-1) in the human fetal brain." Sandberg-Nordqvist A.-C., Staehlbom P.-A., Lake M., Sara V.R. Brain Res. Mol. Brain Res. 12:275-277(1992) [PubMed: 1372070] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[7]	NIEHS SNPs program Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[8]	"Insulin-like growth factor II precursor gene organization in relation to insulin gene family." Dull T.J., Gray A., Hayflick J.S., Ullrich A. Nature 310:777-781(1984) [PubMed: 6382022] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-50 AND 119-153.
[9]	"The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin." Rinderknecht E., Humbel R.E. J. Biol. Chem. 253:2769-2776(1978) [PubMed: 632300] [Abstract] Cited for: PROTEIN SEQUENCE OF 49-118.
[10]	"Tertiary structures, receptor binding, and antigenicity of insulinlike growth factors." Blundell T.L., Bedarkar S., Humbel R.E. Fed. Proc. 42:2592-2597(1983) [PubMed: 6189745] [Abstract] Cited for: 3D-STRUCTURE MODELING.
[11]	"Solution structure of human insulin-like growth factor 1: a nuclear magnetic resonance and restrained molecular dynamics study." Cooke R.M., Harvey T.S., Campbell I.D. Biochemistry 30:5484-5491(1991) [PubMed: 2036417] [Abstract] Cited for: STRUCTURE BY NMR.
[12]	"1H-NMR assignment and secondary structure of human insulin-like growth factor-I (IGF-I) in solution." Sato A., Nishimura S., Ohkubo T., Kyogoku Y., Koyama S., Kobayashi M., Yasuda T., Kobayashi Y. J. Biochem. 111:529-536(1992) [PubMed: 1319992] [Abstract] Cited for: STRUCTURE BY NMR.
[13]	"Location of disulphide bonds in human insulin-like growth factors (IGFs) synthesized by recombinant DNA technology." Raschdorf F., Dahinden R., Maerki W., Richter W.J., Merryweather J.P. Biomed. Environ. Mass Spectrom. 16:3-8(1988) [PubMed: 3242681] [Abstract] Cited for: DISULFIDE BONDS.
[14]	"Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene." Woods K.A., Camacho-Hubner C., Savage M.O., Clark A.J. N. Engl. J. Med. 335:1363-1367(1996) [PubMed: 8857020] [Abstract] Cited for: INVOLVEMENT IN IGF1 DEFICIENCY.
+	Additional computationally mapped references.

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NIEHS-SNPs

SHMPD

The Singapore human mutation and polymorphism database

Wikipedia

Insulin-like growth factor 1 entry

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M14156

M14154 Genomic DNA. Translation: AAA52538.1.
X00173 mRNA. Translation: CAA24998.1.
M27544 mRNA. Translation: AAA52787.1.
X03420 Genomic DNA. Translation: CAA27152.1.
X03421 Genomic DNA. Translation: CAA27153.1.
X03422 Genomic DNA. Translation: CAA27154.1.
X57025 mRNA. Translation: CAA40342.1.
X56773 mRNA. Translation: CAA40092.1.
AY260957 Genomic DNA. Translation: AAO74829.1.
X03563 Genomic DNA. Translation: CAA27250.1. Sequence problems.

IPI

IPI00001610.

PIR

IGHU1. A92581.

RefSeq

NP_000609.1.

UniGene

Hs.160562

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1B9G	NMR	-	A	49-118	[»]
1GZR	X-ray	2.00	B	49-118	[»]
1GZY	X-ray	2.54	B	49-118	[»]
1GZZ	X-ray	2.30	B	49-118	[»]
1H02	X-ray	2.00	B	49-118	[»]
1H59	X-ray	2.10	A	49-118	[»]
1IMX	X-ray	1.82	A	49-118	[»]
1TGR	X-ray	1.42	A/B	49-110	[»]
2GF1	NMR	-	A	49-118	[»]
3GF1	NMR	-	A	49-118	[»]

ModBase

Search...

PhosphoSite

P01343.

PRIDE

P01343.

Ensembl

ENSG00000017427. Homo sapiens. [Contig view]

GeneID

3479.

KEGG

hsa:3479.

GeneCards

GC12M101292.

H-InvDB

HIX0036838.

HGNC

HGNC:5464. IGF1.

MIM

147440. gene.
608747. phenotype.

PharmGKB

PA29697.

GenAtlas

Search...

HOVERGEN

P01343.

OMA

P01343. GGPKKHP.

Pathway_Interaction_DB

ceramidepathway. Ceramide signaling pathway.
igf1_pathway. IGF1 pathway.
avb3_integrin_pathway. Integrins in angiogenesis.
er_nongenomic_pathway. Plasma membrane estrogen receptor signaling.

Reactome

REACT_604. Hemostasis.

ArrayExpress

P01343.

Bgee

P01343.

CleanEx

HS_IGF1.

GermOnline

ENSG00000017427. Homo sapiens.

InterPro

IPR004825. Ins/IGF/relaxin.
[Graphical view]

Gene3D

G3DSA:1.10.100.10. Ins/IGF/relaxin. 1 hit.

Pfam

PF00049. Insulin. 1 hit.
[Graphical view]

PRINTS

PR00277. INSULINB.

ProDom

PD001048. Bombyxin. 1 hit.
PD015667. Mollusc_ins. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SMART

SM00078. IlGF. 1 hit.
[Graphical view]

PROSITE

PS00262. INSULIN. 1 hit.
[Graphical view]

ProtoNet

Search...

NextBio

13678.

PMAP-CutDB

P01343.

SOURCE

Search...

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This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform IGF-IA (identifier: P01343-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform IGF-IB (identifier: P05019-1)

The sequence of this isoform can be found in the external entry P05019-1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Entry name

IGF1A_HUMAN

Accession

Primary (citable) accession number: P01343

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	August 13, 1987
Last modified:	June 16, 2009
This is version 116 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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