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Protein

Insulin-2

Gene

Ins2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone
Biological processCarbohydrate metabolism, Glucose metabolism

Enzyme and pathway databases

ReactomeiR-RNO-264876 Insulin processing
R-RNO-422085 Synthesis, secretion, and deacylation of Ghrelin
R-RNO-6807878 COPI-mediated anterograde transport
R-RNO-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-RNO-74713 IRS activation
R-RNO-74749 Signal attenuation
R-RNO-74751 Insulin receptor signalling cascade
R-RNO-74752 Signaling by Insulin receptor
R-RNO-77387 Insulin receptor recycling

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-2
Cleaved into the following 2 chains:
Gene namesi
Name:Ins2
Synonyms:Ins-2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi2916 Ins2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
PeptideiPRO_000001589825 – 54Insulin-2 B chain1 PublicationAdd BLAST30
PropeptideiPRO_000001589957 – 87C peptideAdd BLAST31
PeptideiPRO_000001590090 – 110Insulin-2 A chain1 PublicationAdd BLAST21

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 96Interchain (between B and A chains)By similarity
Disulfide bondi43 ↔ 109Interchain (between B and A chains)By similarity
Disulfide bondi95 ↔ 1001 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP01323
PRIDEiP01323

PTM databases

PhosphoSitePlusiP01323

Miscellaneous databases

PMAP-CutDBiP01323

Expressioni

Gene expression databases

BgeeiENSRNOG00000020405
GenevisibleiP01323 RN

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi246665, 1 interactor
STRINGi10116.ENSRNOP00000027656

Structurei

3D structure databases

ProteinModelPortaliP01323
SMRiP01323
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0XC Eukaryota
ENOG4111VJB LUCA
GeneTreeiENSGT00390000015440
HOGENOMiHOG000261669
HOVERGENiHBG006137
InParanoidiP01323
KOiK04526
OMAiDPQVGQV
OrthoDBiEOG091G0H56
PhylomeDBiP01323
TreeFamiTF332820

Family and domain databases

InterProiView protein in InterPro
IPR004825 Insulin
IPR016179 Insulin-like
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
IPR022352 Insulin_family
PfamiView protein in Pfam
PF00049 Insulin, 1 hit
PRINTSiPR00277 INSULIN
PR00276 INSULINFAMLY
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 1 hit
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01323-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALWIRFLPL LALLILWEPR PAQAFVKQHL CGSHLVEALY LVCGERGFFY
60 70 80 90 100
TPMSRREVED PQVAQLELGG GPGAGDLQTL ALEVARQKRG IVDQCCTSIC
110
SLYQLENYCN
Length:110
Mass (Da):12,339
Last modified:July 21, 1986 - v1
Checksum:i3A626DA98C86F3CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V01243 Genomic DNA Translation: CAA24560.1
J00748 Genomic DNA Translation: AAA41443.1
M25585, M25583 Genomic DNA Translation: AAA41440.1
PIRiB90789 IPRT2
RefSeqiNP_062003.1, NM_019130.2
UniGeneiRn.989

Genome annotation databases

EnsembliENSRNOT00000027656; ENSRNOP00000027656; ENSRNOG00000020405
GeneIDi24506
KEGGirno:24506

Similar proteinsi

Entry informationi

Entry nameiINS2_RAT
AccessioniPrimary (citable) accession number: P01323
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 25, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health