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Protein

Insulin

Gene

INS

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin
Cleaved into the following 2 chains:
Gene namesi
Name:INS
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 18

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
PeptideiPRO_000001577725 – 54Insulin B chainAdd BLAST30
PropeptideiPRO_000001577857 – 87C peptideAdd BLAST31
PeptideiPRO_000001577990 – 110Insulin A chainAdd BLAST21

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 96Interchain (between B and A chains)By similarity
Disulfide bondi43 ↔ 109Interchain (between B and A chains)By similarity
Disulfide bondi95 ↔ 100By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP01321.

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.By similarity

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000040273.

Structurei

3D structure databases

ProteinModelPortaliP01321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZ9B. Eukaryota.
ENOG41115QQ. LUCA.
GeneTreeiENSGT00390000015440.
HOGENOMiHOG000261669.
HOVERGENiHBG006137.
InParanoidiP01321.
KOiK04526.
OMAiGFFYSPK.

Family and domain databases

Gene3Di1.10.100.10. 2 hits.
InterProiIPR004825. Insulin.
IPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR00277. INSULIN.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01321-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALWMRLLPL LALLALWAPA PTRAFVNQHL CGSHLVEALY LVCGERGFFY
60 70 80 90 100
TPKARREVED LQVRDVELAG APGEGGLQPL ALEGALQKRG IVEQCCTSIC
110
SLYQLENYCN
Length:110
Mass (Da):12,190
Last modified:July 21, 1986 - v1
Checksum:iA574791864A4FB98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00179 Genomic DNA. Translation: CAA23475.1.
PIRiA92413. IPDG.
RefSeqiNP_001123565.1. NM_001130093.1.
UniGeneiCfa.18796.

Genome annotation databases

EnsembliENSCAFT00000016041; ENSCAFP00000014836; ENSCAFG00000010092.
GeneIDi483665.
KEGGicfa:483665.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00179 Genomic DNA. Translation: CAA23475.1.
PIRiA92413. IPDG.
RefSeqiNP_001123565.1. NM_001130093.1.
UniGeneiCfa.18796.

3D structure databases

ProteinModelPortaliP01321.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000040273.

Proteomic databases

PaxDbiP01321.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000016041; ENSCAFP00000014836; ENSCAFG00000010092.
GeneIDi483665.
KEGGicfa:483665.

Organism-specific databases

CTDi3630.

Phylogenomic databases

eggNOGiENOG410IZ9B. Eukaryota.
ENOG41115QQ. LUCA.
GeneTreeiENSGT00390000015440.
HOGENOMiHOG000261669.
HOVERGENiHBG006137.
InParanoidiP01321.
KOiK04526.
OMAiGFFYSPK.

Family and domain databases

Gene3Di1.10.100.10. 2 hits.
InterProiIPR004825. Insulin.
IPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR00277. INSULIN.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiINS_CANLF
AccessioniPrimary (citable) accession number: P01321
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 5, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.