P01316 (INS_ELEMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Insulin

Cleaved into the following 2 chains:

1. Insulin B chain
2. Insulin A chain

Gene names

Name:

INS

Organism

Elephas maximus (Indian elephant)

Taxonomic identifier

9783 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Afrotheria › Proboscidea › Elephantidae › Elephas

Protein attributes

Sequence length	51 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
Subunit structure	Heterodimer of a B chain and an A chain linked by two disulfide bonds.
Subcellular location	Secreted.
Miscellaneous	The species of elephant is not given, but it is most probably the indian elephant (Elephas maximus).
Sequence similarities	Belongs to the insulin family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Cellular component	Secreted
Molecular function	Hormone
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	glucose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	hormone activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Peptide	1 – 30	30	Insulin B chain		PRO_0000015807
	Peptide	31 – 51	21	Insulin A chain		PRO_0000015808
Amino acid modifications
	Disulfide bond	7 ↔ 37		Interchain (between B and A chains)
	Disulfide bond	19 ↔ 50		Interchain (between B and A chains)
	Disulfide bond	36 ↔ 41
Experimental info
	Non-adjacent residues	30 – 31	2

Sequences

	Sequence		Length	Mass (Da)
	P01316 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 9007B50CDB457D6D	FASTA	51	5,752
	10 20 30 40 50 FVNQHLCGSH LVEALYLVCG ERGFFYTPKT GIVEQCCTGV CSLYQLENYC N

References

[1]	"Species variation in the amino acid sequence of insulin." Smith L.F. Am. J. Med. 40:662-666(1966) [PubMed: 5949593] [Abstract] Cited for: PROTEIN SEQUENCE.
+	Additional computationally mapped references.

Cross-references

3D structure databases
ProteinModelPortal	P01316.
SMR	P01316. Positions 1-30.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG006137.
Family and domain databases
InterPro	IPR004825. Insulin. IPR016179. Insulin-like. IPR022353. Insulin_CS. IPR022352. Insulin_family. [Graphical view]
Gene3D	G3DSA:1.10.100.10. Ins/IGF/relaxin. 1 hit.
Pfam	PF00049. Insulin. 2 hits. [Graphical view]
PRINTS	PR00277. INSULIN. PR00276. INSULINFAMLY.
SMART	SM00078. IlGF. 1 hit. [Graphical view]
SUPFAM	SSF56994. Insulin-like. 1 hit.
PROSITE	PS00262. INSULIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

INS_ELEMA

Accession

Primary (citable) accession number: P01316

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	August 10, 2010
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program