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Protein

Insulin

Gene

INS

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.

GO - Molecular functioni

  • hormone activity Source: AgBase
  • identical protein binding Source: IntAct
  • insulin-like growth factor receptor binding Source: AgBase
  • insulin receptor binding Source: Ensembl
  • protease binding Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionHormone
Biological processCarbohydrate metabolism, Glucose metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin
Cleaved into the following 2 chains:
Gene namesi
Name:INS
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei2122 Sus s Insulin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
PeptideiPRO_000001587925 – 54Insulin B chainAdd BLAST30
PropeptideiPRO_000001588057 – 85C peptideAdd BLAST29
PeptideiPRO_000001588188 – 108Insulin A chainAdd BLAST21

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 94Interchain (between B and A chains)Combined sources3 Publications
Disulfide bondi43 ↔ 107Interchain (between B and A chains)Combined sources3 Publications
Disulfide bondi93 ↔ 98Combined sources3 Publications

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP01315

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-8437944,EBI-8437944

GO - Molecular functioni

  • hormone activity Source: AgBase
  • identical protein binding Source: IntAct
  • insulin-like growth factor receptor binding Source: AgBase
  • insulin receptor binding Source: Ensembl
  • protease binding Source: Ensembl

Protein-protein interaction databases

IntActiP01315, 1 interactor
MINTiP01315
STRINGi9823.ENSSSCP00000025428

Structurei

Secondary structure

1108
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi33 – 43Combined sources11
Helixi44 – 46Combined sources3
Beta strandi48 – 50Combined sources3
Helixi89 – 95Combined sources7
Helixi100 – 103Combined sources4
Helixi104 – 106Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B17X-ray1.70A88-108[»]
B25-54[»]
1B18X-ray1.80A88-108[»]
B25-54[»]
1B19X-ray1.80A88-108[»]
B25-54[»]
1B2AX-ray1.70A88-108[»]
B25-54[»]
1B2BX-ray1.80A88-108[»]
B25-54[»]
1B2CX-ray1.80A88-108[»]
B25-54[»]
1B2DX-ray1.70A88-108[»]
B25-54[»]
1B2EX-ray1.90A88-108[»]
B25-54[»]
1B2FX-ray1.90A88-108[»]
B25-54[»]
1B2GX-ray1.80A88-108[»]
B25-54[»]
1DEIX-ray1.60A/C88-108[»]
B/D25-47[»]
1IZAX-ray2.50A/C88-108[»]
B/D25-53[»]
1IZBX-ray2.00A/C88-108[»]
B/D25-53[»]
1M5AX-ray1.20A/C88-108[»]
B/D25-54[»]
1MPJX-ray2.30A/C88-108[»]
B/D25-54[»]
1SDBX-ray1.65A88-108[»]
B27-49[»]
1WAVX-ray2.50A/C/E/G/I/K88-108[»]
B/D/F/H/J/L25-54[»]
1ZEIX-ray1.90A/B/C/D/E/F25-54[»]
A/B/C/D/E/F88-108[»]
1ZNIX-ray1.50A/C88-108[»]
B/D25-54[»]
2EFAneutron diffraction2.70A88-108[»]
B25-54[»]
2G4MX-ray1.80A88-108[»]
B25-54[»]
2TCIX-ray1.80A/C88-108[»]
B/D25-54[»]
2ZPPneutron diffraction2.50A88-108[»]
B25-54[»]
3FHPneutron diffraction2.00A/C88-108[»]
B/D25-54[»]
3GKYX-ray1.80A/C88-108[»]
B/D25-54[»]
3INSX-ray1.50A/C88-108[»]
B/D25-54[»]
3MTHX-ray1.90A/C88-108[»]
B/D25-54[»]
3RTOX-ray1.80A/C88-108[»]
B/D25-54[»]
3T2AX-ray2.10A88-108[»]
B25-54[»]
4A7EX-ray1.86A88-108[»]
B25-54[»]
4INSX-ray1.50A/C88-108[»]
B/D25-54[»]
5D52X-ray1.80A88-108[»]
B25-54[»]
5D53X-ray1.50A88-108[»]
B25-54[»]
5D54X-ray1.50A88-108[»]
B25-54[»]
5D5EX-ray2.41A88-108[»]
B25-54[»]
5FB6X-ray1.90A88-108[»]
B25-54[»]
5LISX-ray2.29A88-108[»]
B25-54[»]
6INSX-ray2.00E/F25-108[»]
7INSX-ray2.00A/C/E88-108[»]
B/D/F25-54[»]
9INSX-ray1.70A88-108[»]
B25-54[»]
ProteinModelPortaliP01315
SMRiP01315
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01315

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0XC Eukaryota
ENOG4111VJB LUCA
GeneTreeiENSGT00390000015440
HOVERGENiHBG006137
InParanoidiP01315
KOiK04526

Family and domain databases

InterProiView protein in InterPro
IPR004825 Insulin
IPR016179 Insulin-like
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
IPR022352 Insulin_family
PfamiView protein in Pfam
PF00049 Insulin, 1 hit
PRINTSiPR00277 INSULIN
PR00276 INSULINFAMLY
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 1 hit
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01315-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALWTRLLPL LALLALWAPA PAQAFVNQHL CGSHLVEALY LVCGERGFFY
60 70 80 90 100
TPKARREAEN PQAGAVELGG GLGGLQALAL EGPPQKRGIV EQCCTSICSL

YQLENYCN
Length:108
Mass (Da):11,672
Last modified:December 1, 2000 - v2
Checksum:iCB4491B429858EBE
GO

Sequence cautioni

The sequence AAC77920 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064555 mRNA Translation: AAC77920.1 Different initiation.
AY044828 Genomic DNA Translation: AAL69550.1
AY242098 Genomic DNA Translation: AAQ00952.1
AY242099 Genomic DNA Translation: AAQ00954.1
AY242100 Genomic DNA Translation: AAQ00957.1
AY242101 Genomic DNA Translation: AAQ00960.1
AY242102 Genomic DNA Translation: AAQ00963.1
AY242103 Genomic DNA Translation: AAQ00966.1
AY242104 Genomic DNA Translation: AAQ00969.1
AY242105 Genomic DNA Translation: AAQ00972.1
AY242106 Genomic DNA Translation: AAQ00975.1
AY242107 Genomic DNA Translation: AAQ00978.1
AY242108 Genomic DNA Translation: AAQ00981.1
AY242109 Genomic DNA Translation: AAQ00983.1
AY242110 Genomic DNA Translation: AAQ00985.1
AY242111 Genomic DNA Translation: AAQ00987.1
AY242112 Genomic DNA Translation: AAQ00990.1
PIRiA01583 IPPG
RefSeqiNP_001103242.1, NM_001109772.1
UniGeneiSsc.583

Genome annotation databases

EnsembliENSSSCT00000064136; ENSSSCP00000044635; ENSSSCG00000033740
GeneIDi397415
KEGGissc:397415

Similar proteinsi

Entry informationi

Entry nameiINS_PIG
AccessioniPrimary (citable) accession number: P01315
Secondary accession number(s): Q9TSJ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: December 1, 2000
Last modified: May 23, 2018
This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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