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Protein

Insulin

Gene

INS

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.

Caution

X's at positions 31-32 and 64-65 represent paired basic residues assumed by homology to be present in the precursor molecule.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone
Biological processCarbohydrate metabolism, Glucose metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin
Cleaved into the following 2 chains:
Gene namesi
Name:INS
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000158161 – 30Insulin B chainAdd BLAST30
PropeptideiPRO_000001581733 – 63C peptideAdd BLAST31
PeptideiPRO_000001581866 – 86Insulin A chainAdd BLAST21

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi7 ↔ 72Interchain (between B and A chains)By similarity
Disulfide bondi19 ↔ 85Interchain (between B and A chains)By similarity
Disulfide bondi71 ↔ 76By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP01310
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.Curated

Phylogenomic databases

HOGENOMiHOG000261669
HOVERGENiHBG006137
InParanoidiP01310

Family and domain databases

InterProiView protein in InterPro
IPR004825 Insulin
IPR016179 Insulin-like
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
IPR022352 Insulin_family
PfamiView protein in Pfam
PF00049 Insulin, 1 hit
PRINTSiPR00277 INSULIN
PR00276 INSULINFAMLY
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 1 hit
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01310-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
FVNQHLCGSH LVEALYLVCG ERGFFYTPKA XXEAEDPQVG EVELGGGPGL
60 70 80
GGLQPLALAG PQQXXGIVEQ CCTGICSLYQ LENYCN
Length:86
Mass (Da):9,147
Last modified:July 21, 1986 - v1
Checksum:iA3E1E822711BDB46
GO

Sequence databases

PIRiA01580 IPHO

Similar proteinsi

Entry informationi

Entry nameiINS_HORSE
AccessioniPrimary (citable) accession number: P01310
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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