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Protein

Promotilin

Gene

MLN

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionHormone

Names & Taxonomyi

Protein namesi
Recommended name:
Promotilin
Cleaved into the following 2 chains:
Gene namesi
Name:MLN
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
ChainiPRO_000034217326 – 119PromotilinAdd BLAST94
PeptideiPRO_000001918826 – 47MotilinAdd BLAST22
PeptideiPRO_000001918950 – 119Motilin-associated peptideAdd BLAST70

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiP01307.
PRIDEiP01307.

Expressioni

Gene expression databases

GenevisibleiP01307. SS.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000001650.

Structurei

3D structure databases

SMRiP01307.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the motilin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J17F. Eukaryota.
ENOG411197B. LUCA.
HOGENOMiHOG000108883.
HOVERGENiHBG003618.
InParanoidiP01307.
KOiK05265.
OrthoDBiEOG091G0X9Z.
TreeFamiTF336217.

Family and domain databases

InterProiView protein in InterPro
IPR006737. Motilin_assoc.
IPR006738. Motilin_ghrelin.
IPR015662. Promotilin.
PANTHERiPTHR14156. PTHR14156. 1 hit.
PfamiView protein in Pfam
PF04643. Motilin_assoc. 1 hit.
PF04644. Motilin_ghrelin. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01307-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSRKAVVVL LVVHAAAMLA SHTEAFVPIF TYGELQRMQE KERNKGQKKS
60 70 80 90 100
LSVQQASEEL GPLDPSEPTK EEERVVIKLL APVDIGIRMD SRQLEKYRAT
110
LERLLGQAPQ STQNQNAAK
Length:119
Mass (Da):13,296
Last modified:August 1, 1992 - v2
Checksum:i6E31A1038E142671
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29I → S in AAA31088 (PubMed:2456453).Curated1
Sequence conflicti29I → S in ABG23101 (Ref. 3) Curated1
Sequence conflicti103R → G in ABC94729 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31219 mRNA. Translation: AAA31088.1.
DQ355970 mRNA. Translation: ABC94729.1.
DQ663494 Genomic DNA. Translation: ABG23101.1.
PIRiA40932. MSPG.
RefSeqiNP_999400.1. NM_214235.1.
XP_013833249.1. XM_013977795.1.
XP_013833250.1. XM_013977796.1.
UniGeneiSsc.714.

Genome annotation databases

GeneIDi397466.
KEGGissc:397466.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMOTI_PIG
AccessioniPrimary (citable) accession number: P01307
Secondary accession number(s): A5X8W5, Q2I0F9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 1, 1992
Last modified: May 10, 2017
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families