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Protein

Pro-neuropeptide Y

Gene

NPY

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.

GO - Molecular functioni

GO - Biological processi

  • adult feeding behavior Source: HGNC
  • cell-cell signaling Source: GO_Central
  • digestion Source: GO_Central
  • feeding behavior Source: GO_Central
  • negative regulation of somatostatin secretion Source: AgBase
  • neuropeptide signaling pathway Source: GO_Central
  • positive regulation of appetite Source: HGNC
  • positive regulation of somatostatin secretion Source: AgBase
  • regulation of appetite Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Enzyme and pathway databases

ReactomeiR-SSC-375276. Peptide ligand-binding receptors.
R-SSC-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-neuropeptide Y
Cleaved into the following 2 chains:
Alternative name(s):
Neuropeptide tyrosine
Short name:
NPY
Gene namesi
Name:NPY
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei‹1 – 9›91 Publication
Peptidei10 – 4536Neuropeptide YPRO_0000025327Add
BLAST
Peptidei49 – ›76›28C-flanking peptide of NPYPRO_0000025328Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei45 – 451Tyrosine amide1 Publication
Modified residuei64 – 641PhosphothreonineBy similarity

Post-translational modificationi

The neuropeptide Y form is cleaved at Pro-11 by the prolyl endopeptidase FAP (seprase) activity (in vitro).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei11 – 122Cleavage; by FAPBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Phosphoprotein

Proteomic databases

PaxDbiP01304.

Expressioni

Tissue specificityi

One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.

Gene expression databases

GenevisibleiP01304. SS.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000017708.

Structurei

Secondary structure

1
76
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni22 – 254Combined sources
Helixi26 – 4419Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1F8PNMR-A10-45[»]
1FVNNMR-A10-45[»]
1ICYNMR-A10-45[»]
1TZ4NMR-A10-27[»]
A33-45[»]
1TZ5NMR-A28-32[»]
ProteinModelPortaliP01304.
SMRiP01304. Positions 10-45.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01304.

Family & Domainsi

Sequence similaritiesi

Belongs to the NPY family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0KC. Eukaryota.
ENOG41128I2. LUCA.
InParanoidiP01304.

Family and domain databases

InterProiIPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PANTHERiPTHR10533. PTHR10533. 1 hit.
PfamiPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSiPR00278. PANCHORMONE.
ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00309. PAH. 1 hit.
[Graphical view]
PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01304-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VCLCALAEAY PSKPDNPGED APAEDLARYY SALRHYINLI TRQRYGKRSS
60 70
PETLISDLLM REGTENVPRT RLEDPS
Length:76
Mass (Da):8,596
Last modified:May 16, 2003 - v2
Checksum:i84E40EC2A4F94B2C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei76 – 761

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF264083 mRNA. Translation: AAF72538.1.
PIRiA01573. NYPGY.
UniGeneiSsc.15981.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF264083 mRNA. Translation: AAF72538.1.
PIRiA01573. NYPGY.
UniGeneiSsc.15981.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1F8PNMR-A10-45[»]
1FVNNMR-A10-45[»]
1ICYNMR-A10-45[»]
1TZ4NMR-A10-27[»]
A33-45[»]
1TZ5NMR-A28-32[»]
ProteinModelPortaliP01304.
SMRiP01304. Positions 10-45.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000017708.

Proteomic databases

PaxDbiP01304.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410J0KC. Eukaryota.
ENOG41128I2. LUCA.
InParanoidiP01304.

Enzyme and pathway databases

ReactomeiR-SSC-375276. Peptide ligand-binding receptors.
R-SSC-418594. G alpha (i) signalling events.

Miscellaneous databases

EvolutionaryTraceiP01304.

Gene expression databases

GenevisibleiP01304. SS.

Family and domain databases

InterProiIPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PANTHERiPTHR10533. PTHR10533. 1 hit.
PfamiPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSiPR00278. PANCHORMONE.
ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00309. PAH. 1 hit.
[Graphical view]
PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Matteri R.L.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hypothalamus.
  2. "Neuropeptide Y: complete amino acid sequence of the brain peptide."
    Tatemoto K.
    Proc. Natl. Acad. Sci. U.S.A. 79:5485-5489(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 10-45, AMIDATION AT TYR-45.
  3. "Sequence-specific 1H NMR assignment and secondary structure of neuropeptide Y in aqueous solution."
    Saudek V., Pelton J.T.
    Biochemistry 29:4509-4515(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 10-45.
  4. Cited for: STRUCTURE BY NMR OF 10-45.

Entry informationi

Entry nameiNPY_PIG
AccessioniPrimary (citable) accession number: P01304
Secondary accession number(s): Q9N0M5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: May 16, 2003
Last modified: February 17, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.