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P01303 (NPY_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 150. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pro-neuropeptide Y

Cleaved into the following 2 chains:

  1. Neuropeptide Y
    Alternative name(s):
    Neuropeptide tyrosine
    Short name=NPY
  2. C-flanking peptide of NPY
    Short name=CPON
Gene names
Name:NPY
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length97 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.

Subcellular location

Secreted.

Tissue specificity

One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.

Sequence similarities

Belongs to the NPY family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionNeuropeptide
   PTMAmidation
Cleavage on pair of basic residues
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

Traceable author statement PubMed 8132547. Source: ProtInc

adult feeding behavior

Inferred from sequence or structural similarity. Source: HGNC

behavior

Traceable author statement PubMed 9845072. Source: ProtInc

blood circulation

Non-traceable author statement PubMed 8421707. Source: ProtInc

calcium ion transport

Traceable author statement PubMed 8132547. Source: ProtInc

cell proliferation

Traceable author statement PubMed 10488139. Source: ProtInc

cellular component movement

Traceable author statement PubMed 10488139. Source: ProtInc

central nervous system neuron development

Inferred from expression pattern PubMed 20846339. Source: DFLAT

cerebral cortex development

Inferred from expression pattern PubMed 9067840. Source: DFLAT

digestion

Non-traceable author statement PubMed 8421707. Source: ProtInc

feeding behavior

Traceable author statement PubMed 10698177. Source: ProtInc

neuron projection development

Inferred from expression pattern PubMed 20846339. Source: DFLAT

neuropeptide signaling pathway

Inferred from electronic annotation. Source: UniProtKB-KW

positive regulation of appetite

Inferred from sequence or structural similarity. Source: HGNC

regulation of blood pressure

Inferred from electronic annotation. Source: Ensembl

synaptic transmission

Traceable author statement PubMed 10557353. Source: ProtInc

   Cellular_componentcell

Traceable author statement PubMed 2444979. Source: ProtInc

extracellular region

Traceable author statement. Source: Reactome

extracellular space

Inferred from sequence or structural similarity. Source: HGNC

   Molecular_functionG-protein coupled receptor activity

Traceable author statement PubMed 1321422. Source: ProtInc

calcium channel regulator activity

Traceable author statement PubMed 8132547. Source: ProtInc

neuropeptide hormone activity

Traceable author statement Ref.2. Source: ProtInc

receptor binding

Traceable author statement PubMed 10698177PubMed 8132547. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Ref.1
Peptide29 – 6436Neuropeptide Y
PRO_0000025321
Peptide68 – 9730C-flanking peptide of NPY
PRO_0000025322

Amino acid modifications

Modified residue641Tyrosine amide

Natural variations

Natural variant71L → P.
Corresponds to variant rs16139 [ dbSNP | Ensembl ].
VAR_014598
Natural variant221L → M.
Corresponds to variant rs5571 [ dbSNP | Ensembl ].
VAR_014599

Experimental info

Sequence conflict531R → G in AAA59945. Ref.2

Secondary structure

....... 97
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P01303 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 832CF124321718F2

FASTA9710,851
        10         20         30         40         50         60 
MLGNKRLGLS GLTLALSLLV CLGALAEAYP SKPDNPGEDA PAEDMARYYS ALRHYINLIT 

        70         80         90 
RQRYGKRSSP ETLISDLLMR ESTENVPRTR LEDPAMW 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, characterization, and DNA sequence of a human cDNA encoding neuropeptide tyrosine."
Minth C.D., Bloom S.R., Polak J.M., Dixon J.E.
Proc. Natl. Acad. Sci. U.S.A. 81:4577-4581(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Characterization, sequence, and expression of the cloned human neuropeptide Y gene."
Minth C.D., Andrews P.C., Dixon J.E.
J. Biol. Chem. 261:11974-11979(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Genes encoding pancreatic polypeptide and neuropeptide Y are on human chromosomes 17 and 7."
Takeuchi T., Gumucio D.L., Yamada T., Meisler M.H., Minth C.D., Dixon J.E., Eddy R.E., Shows T.B.
J. Clin. Invest. 77:1038-1041(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[6]"Presence of the predicted C-flanking peptide of neuropeptide Y (CPON) in tissue extracts."
Allen J.M., Polak J.M., Bloom S.R.
Neuropeptides 6:95-100(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION OF CPON.
[7]"Solution conformation of human neuropeptide Y by 1H nuclear magnetic resonance and restrained molecular dynamics."
Darbon H., Bernassau J.-M., Deleuze C., Chenu J., Roussel A., Cambillau C.
Eur. J. Biochem. 209:765-771(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 29-64.
[8]"Solution structure of human neuropeptide Y."
Monks S.A., Karagianis G., Howlett G.J., Norton R.S.
J. Biomol. NMR 8:379-390(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 29-64.
[9]"Helical structure and self-association in a 13 residue neuropeptide Y Y2 receptor agonist: relationship to biological activity."
Barnham K.J., Catalfamo F., Pallaghy P.K., Howlett G.J., Norton R.S.
Biochim. Biophys. Acta 1435:127-137(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 52-64.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
K01911 mRNA. Translation: AAA59944.1.
M14298, M14296, M14297 Genomic DNA. Translation: AAA59945.1.
M15789 mRNA. Translation: AAA59946.1.
AC004485 Genomic DNA. Translation: AAQ96843.1.
BC029497 mRNA. Translation: AAH29497.1.
PIRNYHUY. A25198.
RefSeqNP_000896.1. NM_000905.3.
UniGeneHs.1832.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1QFANMR-A52-64[»]
1RONNMR-A29-64[»]
ProteinModelPortalP01303.
SMRP01303. Positions 29-64.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110914. 7 interactions.
IntActP01303. 10 interactions.
MINTMINT-7900013.
STRING9606.ENSP00000242152.

Chemistry

BindingDBP01303.

PTM databases

PhosphoSiteP01303.

Polymorphism databases

DMDM128117.

Proteomic databases

PaxDbP01303.
PRIDEP01303.

Protocols and materials databases

DNASU4852.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000242152; ENSP00000242152; ENSG00000122585.
ENST00000405982; ENSP00000385282; ENSG00000122585.
ENST00000407573; ENSP00000384364; ENSG00000122585.
GeneID4852.
KEGGhsa:4852.
UCSCuc003sww.2. human.

Organism-specific databases

CTD4852.
GeneCardsGC07P024290.
HGNCHGNC:7955. NPY.
HPACAB016733.
CAB034368.
HPA044572.
MIM162640. gene.
neXtProtNX_P01303.
PharmGKBPA255.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45909.
HOGENOMHOG000252942.
HOVERGENHBG006485.
InParanoidP01303.
KOK05232.
OMAFEDPSMW.
OrthoDBEOG7WDN4S.
PhylomeDBP01303.
TreeFamTF332778.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP01303.
BgeeP01303.
CleanExHS_NPY.
GenevestigatorP01303.

Family and domain databases

InterProIPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PANTHERPTHR10533. PTHR10533. 1 hit.
PfamPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSPR00278. PANCHORMONE.
ProDomPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00309. PAH. 1 hit.
[Graphical view]
PROSITEPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSNPY. human.
EvolutionaryTraceP01303.
GeneWikiNeuropeptide_Y.
GenomeRNAi4852.
NextBio18688.
PMAP-CutDBP01303.
PROP01303.
SOURCESearch...

Entry information

Entry nameNPY_HUMAN
AccessionPrimary (citable) accession number: P01303
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 150 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM