P01303 (NPY_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pro-neuropeptide Y

Cleaved into the following 2 chains:

1. Neuropeptide Y
   Alternative name(s):
   Neuropeptide tyrosine
   Short name=NPY
2. C-flanking peptide of NPY
   Short name=CPON

Gene names

Name:

NPY

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	97 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.
Subcellular location	Secreted.
Tissue specificity	One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.
Sequence similarities	Belongs to the NPY family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Neuropeptide
PTM	Amidation Cleavage on pair of basic residues
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Traceable author statement PubMed 8132547. Source: ProtInc adult feeding behavior Inferred from sequence or structural similarity. Source: HGNC blood circulation Non-traceable author statement PubMed 8421707. Source: ProtInc calcium ion transport Traceable author statement PubMed 8132547. Source: ProtInc cell proliferation Traceable author statement PubMed 10488139. Source: ProtInc cellular component movement Traceable author statement PubMed 10488139. Source: ProtInc central nervous system neuron development Inferred from expression pattern PubMed 20846339. Source: DFLAT cerebral cortex development Inferred from expression pattern PubMed 9067840. Source: DFLAT digestion Non-traceable author statement PubMed 8421707. Source: ProtInc neuron projection development Inferred from expression pattern PubMed 20846339. Source: DFLAT neuropeptide signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of appetite Inferred from sequence or structural similarity. Source: HGNC regulation of blood pressure Inferred from electronic annotation. Source: Compara synaptic transmission Traceable author statement PubMed 10557353. Source: ProtInc
Cellular_component	cell Traceable author statement PubMed 2444979. Source: ProtInc extracellular space Inferred from sequence or structural similarity. Source: HGNC
Molecular_function	G-protein coupled receptor activity Traceable author statement PubMed 1321422. Source: ProtInc calcium channel regulator activity Traceable author statement PubMed 8132547. Source: ProtInc neuropeptide hormone activity Traceable author statement Ref.2. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 28

28

Ref.1

Peptide

29 – 64

36

Neuropeptide Y

PRO_0000025321

Peptide

68 – 97

30

C-flanking peptide of NPY

PRO_0000025322

Amino acid modifications

Modified residue

64

1

Tyrosine amide

Natural variations

Natural variant

7

1

L → P.
Corresponds to variant rs16139 [ dbSNP | Ensembl ].

VAR_014598

Natural variant

22

1

L → M.
Corresponds to variant rs5571 [ dbSNP | Ensembl ].

VAR_014599

Experimental info

Sequence conflict

53

1

R → G in AAA59945. Ref.2

Secondary structure

1

.

.

.

.

.

.

.

97

Helix Strand Turn

Details...

Beta strand

31 – 33

3

Helix

41 – 44

4

Helix

53 – 63

11

Sequences

	Sequence		Length	Mass (Da)
	P01303 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 832CF124321718F2	FASTA	97	10,851
	10 20 30 40 50 60 MLGNKRLGLS GLTLALSLLV CLGALAEAYP SKPDNPGEDA PAEDMARYYS ALRHYINLIT 70 80 90 RQRYGKRSSP ETLISDLLMR ESTENVPRTR LEDPAMW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, characterization, and DNA sequence of a human cDNA encoding neuropeptide tyrosine." Minth C.D., Bloom S.R., Polak J.M., Dixon J.E. Proc. Natl. Acad. Sci. U.S.A. 81:4577-4581(1984) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Characterization, sequence, and expression of the cloned human neuropeptide Y gene." Minth C.D., Andrews P.C., Dixon J.E. J. Biol. Chem. 261:11974-11979(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Genes encoding pancreatic polypeptide and neuropeptide Y are on human chromosomes 17 and 7." Takeuchi T., Gumucio D.L., Yamada T., Meisler M.H., Minth C.D., Dixon J.E., Eddy R.E., Shows T.B. J. Clin. Invest. 77:1038-1041(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[6]	"Presence of the predicted C-flanking peptide of neuropeptide Y (CPON) in tissue extracts." Allen J.M., Polak J.M., Bloom S.R. Neuropeptides 6:95-100(1985) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION OF CPON.
[7]	"Solution conformation of human neuropeptide Y by 1H nuclear magnetic resonance and restrained molecular dynamics." Darbon H., Bernassau J.-M., Deleuze C., Chenu J., Roussel A., Cambillau C. Eur. J. Biochem. 209:765-771(1992) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR OF 29-64.
[8]	"Solution structure of human neuropeptide Y." Monks S.A., Karagianis G., Howlett G.J., Norton R.S. J. Biomol. NMR 8:379-390(1996) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR OF 29-64.
[9]	"Helical structure and self-association in a 13 residue neuropeptide Y Y2 receptor agonist: relationship to biological activity." Barnham K.J., Catalfamo F., Pallaghy P.K., Howlett G.J., Norton R.S. Biochim. Biophys. Acta 1435:127-137(1999) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR OF 52-64.
+	Additional computationally mapped references.

Web resources

Wikipedia

Neuropeptide Y entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

K01911 mRNA. Translation: AAA59944.1.
M14298, M14296, M14297 Genomic DNA. Translation: AAA59945.1.
M15789 mRNA. Translation: AAA59946.1.
AC004485 Genomic DNA. Translation: AAQ96843.1.
BC029497 mRNA. Translation: AAH29497.1.

IPI

IPI00001506.

PIR

NYHUY. A25198.

RefSeq

NP_000896.1. NM_000905.3.

UniGene

Hs.1832.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1QFA	NMR	-	A	52-64	[»]
1RON	NMR	-	A	29-64	[»]

ProteinModelPortal

P01303.

ModBase

Search...

Protein-protein interaction databases

IntAct

P01303. 4 interactions.

STRING

9606.ENSP00000242152.

PTM databases

PhosphoSite

P01303.

Polymorphism databases

DMDM

128117.

Proteomic databases

PaxDb

P01303.

PRIDE

P01303.

Protocols and materials databases

DNASU

4852.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000242152; ENSP00000242152; ENSG00000122585.
ENST00000405982; ENSP00000385282; ENSG00000122585.
ENST00000407573; ENSP00000384364; ENSG00000122585.

GeneID

4852.

KEGG

hsa:4852.

UCSC

uc003sww.2. human.

Organism-specific databases

CTD

4852.

GeneCards

GC07P024290.

HGNC

HGNC:7955. NPY.

MIM

162640. gene.

neXtProt

NX_P01303.

PharmGKB

PA255.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG45909.

HOGENOM

HOG000252942.

HOVERGEN

HBG006485.

InParanoid

P01303.

KO

K05232.

OMA

RFEDPSM.

OrthoDB

EOG4PVP19.

PhylomeDB

P01303.

Enzyme and pathway databases

Reactome

REACT_111102. Signal Transduction.

Gene expression databases

ArrayExpress

P01303.

Bgee

P01303.

CleanEx

HS_NPY.

Genevestigator

P01303.

GermOnline

ENSG00000122585. Homo sapiens.

Family and domain databases

InterPro

IPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]

PANTHER

PTHR10533. PTHR10533. 1 hit.

Pfam

PF00159. Hormone_3. 1 hit.
[Graphical view]

PRINTS

PR00278. PANCHORMONE.

ProDom

PD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SMART

SM00309. PAH. 1 hit.
[Graphical view]

PROSITE

PS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

P01303.

ChiTaRS

NPY. human.

EvolutionaryTrace

P01303.

GenomeRNAi

4852.

NextBio

18688.

PMAP-CutDB

P01303.

SOURCE

Search...

Entry information

Entry name

NPY_HUMAN

Accession

Primary (citable) accession number: P01303

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	May 1, 2013
This is version 141 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.