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Protein

Pro-neuropeptide Y

Gene

NPY

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.

GO - Molecular functioni

  • calcium channel regulator activity Source: ProtInc
  • G-protein coupled receptor activity Source: ProtInc
  • G-protein coupled receptor binding Source: GO_Central
  • neuropeptide hormone activity Source: ProtInc
  • receptor binding Source: ProtInc

GO - Biological processi

  • adult feeding behavior Source: HGNC
  • antibacterial humoral response Source: UniProtKB
  • antifungal humoral response Source: UniProtKB
  • behavior Source: ProtInc
  • blood circulation Source: ProtInc
  • calcium ion transport Source: ProtInc
  • cell proliferation Source: ProtInc
  • central nervous system neuron development Source: DFLAT
  • cerebral cortex development Source: DFLAT
  • chemical synaptic transmission Source: ProtInc
  • defense response to Gram-negative bacterium Source: UniProtKB
  • defense response to Gram-positive bacterium Source: UniProtKB
  • digestion Source: GO_Central
  • feeding behavior Source: ProtInc
  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
  • innate immune response Source: UniProtKB
  • movement of cell or subcellular component Source: ProtInc
  • neuron projection development Source: DFLAT
  • neuropeptide signaling pathway Source: GO_Central
  • positive regulation of appetite Source: HGNC
  • regulation of appetite Source: GO_Central
  • regulation of blood pressure Source: Ensembl
  • response to yeast Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Enzyme and pathway databases

BioCyciZFISH:ENSG00000122585-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.
SIGNORiP01303.

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-neuropeptide Y
Cleaved into the following 2 chains:
Alternative name(s):
Neuropeptide tyrosine
Short name:
NPY
Gene namesi
Name:NPY
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:7955. NPY.

Subcellular locationi

GO - Cellular componenti

  • cell Source: ProtInc
  • extracellular region Source: Reactome
  • extracellular space Source: HGNC
  • Golgi apparatus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi4852.
OpenTargetsiENSG00000122585.
PharmGKBiPA255.

Polymorphism and mutation databases

BioMutaiNPY.
DMDMi128117.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 281 PublicationAdd BLAST28
PeptideiPRO_000002532129 – 64Neuropeptide YAdd BLAST36
PeptideiPRO_000002532268 – 97C-flanking peptide of NPYAdd BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei64Tyrosine amide1 Publication1
Modified residuei83PhosphothreonineCombined sources1

Post-translational modificationi

The neuropeptide Y form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei30 – 31Cleavage; by FAP1 Publication2

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Phosphoprotein

Proteomic databases

PaxDbiP01303.
PeptideAtlasiP01303.
PRIDEiP01303.

PTM databases

iPTMnetiP01303.
PhosphoSitePlusiP01303.

Miscellaneous databases

PMAP-CutDBP01303.

Expressioni

Tissue specificityi

One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.

Gene expression databases

BgeeiENSG00000122585.
CleanExiHS_NPY.
ExpressionAtlasiP01303. baseline and differential.
GenevisibleiP01303. HS.

Organism-specific databases

HPAiCAB016733.
CAB034368.
HPA044572.
HPA056798.

Interactioni

GO - Molecular functioni

  • G-protein coupled receptor binding Source: GO_Central
  • neuropeptide hormone activity Source: ProtInc
  • receptor binding Source: ProtInc

Protein-protein interaction databases

BioGridi110914. 7 interactors.
IntActiP01303. 10 interactors.
MINTiMINT-7900013.
STRINGi9606.ENSP00000242152.

Chemistry databases

BindingDBiP01303.

Structurei

Secondary structure

197
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi31 – 33Combined sources3
Helixi41 – 44Combined sources4
Helixi53 – 63Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QFANMR-A52-64[»]
1RONNMR-A29-64[»]
ProteinModelPortaliP01303.
SMRiP01303.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01303.

Family & Domainsi

Sequence similaritiesi

Belongs to the NPY family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0KC. Eukaryota.
ENOG41128I2. LUCA.
GeneTreeiENSGT00390000010775.
HOGENOMiHOG000252942.
HOVERGENiHBG006485.
InParanoidiP01303.
KOiK05232.
OMAiFEDPSMW.
OrthoDBiEOG091G0ZRE.
PhylomeDBiP01303.
TreeFamiTF332778.

Family and domain databases

CDDicd00126. PAH. 1 hit.
InterProiIPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PANTHERiPTHR10533. PTHR10533. 1 hit.
PfamiPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSiPR00278. PANCHORMONE.
ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00309. PAH. 1 hit.
[Graphical view]
PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01303-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGNKRLGLS GLTLALSLLV CLGALAEAYP SKPDNPGEDA PAEDMARYYS
60 70 80 90
ALRHYINLIT RQRYGKRSSP ETLISDLLMR ESTENVPRTR LEDPAMW
Length:97
Mass (Da):10,851
Last modified:July 21, 1986 - v1
Checksum:i832CF124321718F2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53R → G in AAA59945 (PubMed:2427515).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0145987L → P.Corresponds to variant rs16139dbSNPEnsembl.1
Natural variantiVAR_01459922L → M.Corresponds to variant rs5571dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01911 mRNA. Translation: AAA59944.1.
M14298, M14296, M14297 Genomic DNA. Translation: AAA59945.1.
M15789 mRNA. Translation: AAA59946.1.
AC004485 Genomic DNA. Translation: AAQ96843.1.
BC029497 mRNA. Translation: AAH29497.1.
CCDSiCCDS5387.1.
PIRiA25198. NYHUY.
RefSeqiNP_000896.1. NM_000905.3.
UniGeneiHs.1832.

Genome annotation databases

EnsembliENST00000242152; ENSP00000242152; ENSG00000122585.
ENST00000405982; ENSP00000385282; ENSG00000122585.
ENST00000407573; ENSP00000384364; ENSG00000122585.
GeneIDi4852.
KEGGihsa:4852.
UCSCiuc003sww.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Neuropeptide Y entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01911 mRNA. Translation: AAA59944.1.
M14298, M14296, M14297 Genomic DNA. Translation: AAA59945.1.
M15789 mRNA. Translation: AAA59946.1.
AC004485 Genomic DNA. Translation: AAQ96843.1.
BC029497 mRNA. Translation: AAH29497.1.
CCDSiCCDS5387.1.
PIRiA25198. NYHUY.
RefSeqiNP_000896.1. NM_000905.3.
UniGeneiHs.1832.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QFANMR-A52-64[»]
1RONNMR-A29-64[»]
ProteinModelPortaliP01303.
SMRiP01303.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110914. 7 interactors.
IntActiP01303. 10 interactors.
MINTiMINT-7900013.
STRINGi9606.ENSP00000242152.

Chemistry databases

BindingDBiP01303.

PTM databases

iPTMnetiP01303.
PhosphoSitePlusiP01303.

Polymorphism and mutation databases

BioMutaiNPY.
DMDMi128117.

Proteomic databases

PaxDbiP01303.
PeptideAtlasiP01303.
PRIDEiP01303.

Protocols and materials databases

DNASUi4852.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000242152; ENSP00000242152; ENSG00000122585.
ENST00000405982; ENSP00000385282; ENSG00000122585.
ENST00000407573; ENSP00000384364; ENSG00000122585.
GeneIDi4852.
KEGGihsa:4852.
UCSCiuc003sww.3. human.

Organism-specific databases

CTDi4852.
DisGeNETi4852.
GeneCardsiNPY.
HGNCiHGNC:7955. NPY.
HPAiCAB016733.
CAB034368.
HPA044572.
HPA056798.
MIMi162640. gene.
neXtProtiNX_P01303.
OpenTargetsiENSG00000122585.
PharmGKBiPA255.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0KC. Eukaryota.
ENOG41128I2. LUCA.
GeneTreeiENSGT00390000010775.
HOGENOMiHOG000252942.
HOVERGENiHBG006485.
InParanoidiP01303.
KOiK05232.
OMAiFEDPSMW.
OrthoDBiEOG091G0ZRE.
PhylomeDBiP01303.
TreeFamiTF332778.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000122585-MONOMER.
ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.
SIGNORiP01303.

Miscellaneous databases

ChiTaRSiNPY. human.
EvolutionaryTraceiP01303.
GeneWikiiNeuropeptide_Y.
GenomeRNAii4852.
PMAP-CutDBP01303.
PROiP01303.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000122585.
CleanExiHS_NPY.
ExpressionAtlasiP01303. baseline and differential.
GenevisibleiP01303. HS.

Family and domain databases

CDDicd00126. PAH. 1 hit.
InterProiIPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PANTHERiPTHR10533. PTHR10533. 1 hit.
PfamiPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSiPR00278. PANCHORMONE.
ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00309. PAH. 1 hit.
[Graphical view]
PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNPY_HUMAN
AccessioniPrimary (citable) accession number: P01303
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 2, 2016
This is version 172 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.