Reviewed,
UniProtKB/Swiss-Prot P01303 (NPY_HUMAN)
Last modified
June 16, 2009.
Version 106.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Neuropeptide Y Cleaved into the following 2 chains: 1- Recommended name: Neuropeptide Y Alternative name(s): Neuropeptide tyrosine Short name=NPY 2- Recommended name: C-flanking peptide of NPY Short name=CPON | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 97 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. |
| Subcellular location | |
| Tissue specificity | One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla. |
| Sequence similarities | Belongs to the NPY family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||
Molecule processing | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 28 | 28 | Ref.1 | ||||||||||||
| Peptide | 29 – 64 | 36 | Neuropeptide Y | PRO_0000025321 | |||||||||||
| Peptide | 68 – 97 | 30 | C-flanking peptide of NPY | PRO_0000025322 | |||||||||||
Amino acid modifications | |||||||||||||||
| Modified residue | 64 | 1 | Tyrosine amide | ||||||||||||
Natural variations | |||||||||||||||
| Natural variant | 7 | 1 | L → P: dbSNP rs16139. | VAR_014598 | |||||||||||
| Natural variant | 22 | 1 | L → M: dbSNP rs5571. | VAR_014599 | |||||||||||
Experimental info | |||||||||||||||
| Sequence conflict | 53 | 1 | R → G in AAA59945. Ref.2 | ||||||||||||
Secondary structure | |||||||||||||||
Helix Strand Turn | |||||||||||||||
| Beta strand | 31 – 33 | 3 | |||||||||||||
| Helix | 41 – 44 | 4 | |||||||||||||
| Helix | 46 – 63 | 18 | |||||||||||||
Sequences
References
| « Hide 'large scale' references | |
| [1] | "Cloning, characterization, and DNA sequence of a human cDNA encoding neuropeptide tyrosine." Minth C.D., Bloom S.R., Polak J.M., Dixon J.E. Proc. Natl. Acad. Sci. U.S.A. 81:4577-4581(1984) [PubMed: 6589611] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Characterization, sequence, and expression of the cloned human neuropeptide Y gene." Minth C.D., Andrews P.C., Dixon J.E. J. Biol. Chem. 261:11974-11979(1986) [PubMed: 2427515] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "Genes encoding pancreatic polypeptide and neuropeptide Y are on human chromosomes 17 and 7." Takeuchi T., Gumucio D.L., Yamada T., Meisler M.H., Minth C.D., Dixon J.E., Eddy R.E., Shows T.B. J. Clin. Invest. 77:1038-1041(1986) [PubMed: 3753985] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [4] | "The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. Wilson R.K.Nature 424:157-164(2003) [PubMed: 12853948] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [6] | "Presence of the predicted C-flanking peptide of neuropeptide Y (CPON) in tissue extracts." Allen J.M., Polak J.M., Bloom S.R. Neuropeptides 6:95-100(1985) [PubMed: 3839058] [Abstract] Cited for: IDENTIFICATION OF CPON. |
| [7] | "Solution conformation of human neuropeptide Y by 1H nuclear magnetic resonance and restrained molecular dynamics." Darbon H., Bernassau J.-M., Deleuze C., Chenu J., Roussel A., Cambillau C. Eur. J. Biochem. 209:765-771(1992) [PubMed: 1425680] [Abstract] Cited for: STRUCTURE BY NMR OF 29-64. |
| [8] | "Solution structure of human neuropeptide Y." Monks S.A., Karagianis G., Howlett G.J., Norton R.S. J. Biomol. NMR 8:379-390(1996) [PubMed: 9008359] [Abstract] Cited for: STRUCTURE BY NMR OF 29-64. |
| [9] | "Helical structure and self-association in a 13 residue neuropeptide Y Y2 receptor agonist: relationship to biological activity." Barnham K.J., Catalfamo F., Pallaghy P.K., Howlett G.J., Norton R.S. Biochim. Biophys. Acta 1435:127-137(1999) [PubMed: 10561544] [Abstract] Cited for: STRUCTURE BY NMR OF 52-64. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| K01911 mRNA. Translation: AAA59944.1. M14298, M14296, M14297 Genomic DNA. Translation: AAA59945.1. M15789 mRNA. Translation: AAA59946.1. AC004485 Genomic DNA. Translation: AAQ96843.1. BC029497 mRNA. Translation: AAH29497.1. | |||||||||||||||||||
| IPI | IPI00001506. | ||||||||||||||||||
| PIR | NYHUY. A25198. | ||||||||||||||||||
| RefSeq | NP_000896.1. | ||||||||||||||||||
| UniGene | Hs.1832 | ||||||||||||||||||
3D structure databases | |||||||||||||||||||
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| ModBase | Search... | ||||||||||||||||||
Proteomic databases | |||||||||||||||||||
| PRIDE | P01303. | ||||||||||||||||||
Genome annotation databases | |||||||||||||||||||
| Ensembl | ENSG00000122585. Homo sapiens. [Contig view] | ||||||||||||||||||
| GeneID | 4852. | ||||||||||||||||||
| KEGG | hsa:4852. | ||||||||||||||||||
Organism-specific databases | |||||||||||||||||||
| GeneCards | GC07P024290. | ||||||||||||||||||
| H-InvDB | HIX0006525. | ||||||||||||||||||
| HGNC | HGNC:7955. NPY. | ||||||||||||||||||
| MIM | 162640. gene. | ||||||||||||||||||
| PharmGKB | PA255. | ||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||
| HOVERGEN | P01303. | ||||||||||||||||||
| OMA | P01303. ESTENIP. | ||||||||||||||||||
Gene expression databases | |||||||||||||||||||
| ArrayExpress | P01303. | ||||||||||||||||||
| Bgee | P01303. | ||||||||||||||||||
| CleanEx | HS_NPY. | ||||||||||||||||||
| GermOnline | ENSG00000122585. Homo sapiens. | ||||||||||||||||||
Family and domain databases | |||||||||||||||||||
| InterPro | IPR001955. Pancreatic_hormone. [Graphical view] | ||||||||||||||||||
| PANTHER | PTHR10533. Pancreatic_hormone. 1 hit. | ||||||||||||||||||
| Pfam | PF00159. Hormone_3. 1 hit. [Graphical view] | ||||||||||||||||||
| PRINTS | PR00278. PANCHORMONE. | ||||||||||||||||||
| ProDom | PD001267. Pancreatic_hormn. 1 hit. [Graphical view] [Entries sharing at least one domain] | ||||||||||||||||||
| SMART | SM00309. PAH. 1 hit. [Graphical view] | ||||||||||||||||||
| PROSITE | PS00265. PANCREATIC_HORMONE_1. 1 hit. PS50276. PANCREATIC_HORMONE_2. 1 hit. [Graphical view] | ||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||
Other Resources | |||||||||||||||||||
| NextBio | 18688. | ||||||||||||||||||
| PMAP-CutDB | P01303. | ||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||
Entry information
| Entry name | NPY_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P01303 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 7 Human chromosome 7: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


