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P01303

- NPY_HUMAN

UniProt

P01303 - NPY_HUMAN

Protein

Pro-neuropeptide Y

Gene

NPY

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.

    GO - Molecular functioni

    1. calcium channel regulator activity Source: ProtInc
    2. G-protein coupled receptor activity Source: ProtInc
    3. neuropeptide hormone activity Source: ProtInc
    4. receptor binding Source: ProtInc

    GO - Biological processi

    1. adult feeding behavior Source: HGNC
    2. behavior Source: ProtInc
    3. blood circulation Source: ProtInc
    4. calcium ion transport Source: ProtInc
    5. cell proliferation Source: ProtInc
    6. cellular component movement Source: ProtInc
    7. central nervous system neuron development Source: DFLAT
    8. cerebral cortex development Source: DFLAT
    9. digestion Source: ProtInc
    10. feeding behavior Source: ProtInc
    11. G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
    12. neuron projection development Source: DFLAT
    13. neuropeptide signaling pathway Source: UniProtKB-KW
    14. positive regulation of appetite Source: HGNC
    15. regulation of blood pressure Source: Ensembl
    16. synaptic transmission Source: ProtInc

    Keywords - Molecular functioni

    Neuropeptide

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pro-neuropeptide Y
    Cleaved into the following 2 chains:
    Alternative name(s):
    Neuropeptide tyrosine
    Short name:
    NPY
    Gene namesi
    Name:NPY
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:7955. NPY.

    Subcellular locationi

    GO - Cellular componenti

    1. cell Source: ProtInc
    2. extracellular region Source: Reactome
    3. extracellular space Source: HGNC

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA255.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 28281 PublicationAdd
    BLAST
    Peptidei29 – 6436Neuropeptide YPRO_0000025321Add
    BLAST
    Peptidei68 – 9730C-flanking peptide of NPYPRO_0000025322Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei64 – 641Tyrosine amide1 Publication

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues

    Proteomic databases

    PaxDbiP01303.
    PRIDEiP01303.

    PTM databases

    PhosphoSiteiP01303.

    Miscellaneous databases

    PMAP-CutDBP01303.

    Expressioni

    Tissue specificityi

    One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.

    Gene expression databases

    ArrayExpressiP01303.
    BgeeiP01303.
    CleanExiHS_NPY.
    GenevestigatoriP01303.

    Organism-specific databases

    HPAiCAB016733.
    CAB034368.
    HPA044572.

    Interactioni

    Protein-protein interaction databases

    BioGridi110914. 7 interactions.
    IntActiP01303. 10 interactions.
    MINTiMINT-7900013.
    STRINGi9606.ENSP00000242152.

    Structurei

    Secondary structure

    1
    97
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi31 – 333
    Helixi41 – 444
    Helixi53 – 6311

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1QFANMR-A52-64[»]
    1RONNMR-A29-64[»]
    ProteinModelPortaliP01303.
    SMRiP01303. Positions 29-64.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP01303.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NPY family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG45909.
    HOGENOMiHOG000252942.
    HOVERGENiHBG006485.
    InParanoidiP01303.
    KOiK05232.
    OMAiFEDPSMW.
    OrthoDBiEOG7WDN4S.
    PhylomeDBiP01303.
    TreeFamiTF332778.

    Family and domain databases

    InterProiIPR001955. Pancreatic_hormone-like.
    IPR020392. Pancreatic_hormone-like_CS.
    [Graphical view]
    PANTHERiPTHR10533. PTHR10533. 1 hit.
    PfamiPF00159. Hormone_3. 1 hit.
    [Graphical view]
    PRINTSiPR00278. PANCHORMONE.
    ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00309. PAH. 1 hit.
    [Graphical view]
    PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
    PS50276. PANCREATIC_HORMONE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01303-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLGNKRLGLS GLTLALSLLV CLGALAEAYP SKPDNPGEDA PAEDMARYYS   50
    ALRHYINLIT RQRYGKRSSP ETLISDLLMR ESTENVPRTR LEDPAMW 97
    Length:97
    Mass (Da):10,851
    Last modified:July 21, 1986 - v1
    Checksum:i832CF124321718F2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti53 – 531R → G in AAA59945. (PubMed:2427515)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti7 – 71L → P.
    Corresponds to variant rs16139 [ dbSNP | Ensembl ].
    VAR_014598
    Natural varianti22 – 221L → M.
    Corresponds to variant rs5571 [ dbSNP | Ensembl ].
    VAR_014599

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K01911 mRNA. Translation: AAA59944.1.
    M14298, M14296, M14297 Genomic DNA. Translation: AAA59945.1.
    M15789 mRNA. Translation: AAA59946.1.
    AC004485 Genomic DNA. Translation: AAQ96843.1.
    BC029497 mRNA. Translation: AAH29497.1.
    CCDSiCCDS5387.1.
    PIRiA25198. NYHUY.
    RefSeqiNP_000896.1. NM_000905.3.
    UniGeneiHs.1832.

    Genome annotation databases

    EnsembliENST00000242152; ENSP00000242152; ENSG00000122585.
    ENST00000405982; ENSP00000385282; ENSG00000122585.
    ENST00000407573; ENSP00000384364; ENSG00000122585.
    GeneIDi4852.
    KEGGihsa:4852.
    UCSCiuc003sww.2. human.

    Polymorphism databases

    DMDMi128117.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Neuropeptide Y entry

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    K01911 mRNA. Translation: AAA59944.1 .
    M14298 , M14296 , M14297 Genomic DNA. Translation: AAA59945.1 .
    M15789 mRNA. Translation: AAA59946.1 .
    AC004485 Genomic DNA. Translation: AAQ96843.1 .
    BC029497 mRNA. Translation: AAH29497.1 .
    CCDSi CCDS5387.1.
    PIRi A25198. NYHUY.
    RefSeqi NP_000896.1. NM_000905.3.
    UniGenei Hs.1832.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1QFA NMR - A 52-64 [» ]
    1RON NMR - A 29-64 [» ]
    ProteinModelPortali P01303.
    SMRi P01303. Positions 29-64.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110914. 7 interactions.
    IntActi P01303. 10 interactions.
    MINTi MINT-7900013.
    STRINGi 9606.ENSP00000242152.

    Chemistry

    BindingDBi P01303.

    PTM databases

    PhosphoSitei P01303.

    Polymorphism databases

    DMDMi 128117.

    Proteomic databases

    PaxDbi P01303.
    PRIDEi P01303.

    Protocols and materials databases

    DNASUi 4852.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000242152 ; ENSP00000242152 ; ENSG00000122585 .
    ENST00000405982 ; ENSP00000385282 ; ENSG00000122585 .
    ENST00000407573 ; ENSP00000384364 ; ENSG00000122585 .
    GeneIDi 4852.
    KEGGi hsa:4852.
    UCSCi uc003sww.2. human.

    Organism-specific databases

    CTDi 4852.
    GeneCardsi GC07P024290.
    HGNCi HGNC:7955. NPY.
    HPAi CAB016733.
    CAB034368.
    HPA044572.
    MIMi 162640. gene.
    neXtProti NX_P01303.
    PharmGKBi PA255.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45909.
    HOGENOMi HOG000252942.
    HOVERGENi HBG006485.
    InParanoidi P01303.
    KOi K05232.
    OMAi FEDPSMW.
    OrthoDBi EOG7WDN4S.
    PhylomeDBi P01303.
    TreeFami TF332778.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    ChiTaRSi NPY. human.
    EvolutionaryTracei P01303.
    GeneWikii Neuropeptide_Y.
    GenomeRNAii 4852.
    NextBioi 18688.
    PMAP-CutDB P01303.
    PROi P01303.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P01303.
    Bgeei P01303.
    CleanExi HS_NPY.
    Genevestigatori P01303.

    Family and domain databases

    InterProi IPR001955. Pancreatic_hormone-like.
    IPR020392. Pancreatic_hormone-like_CS.
    [Graphical view ]
    PANTHERi PTHR10533. PTHR10533. 1 hit.
    Pfami PF00159. Hormone_3. 1 hit.
    [Graphical view ]
    PRINTSi PR00278. PANCHORMONE.
    ProDomi PD001267. Pancreatic_hormone-like. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00309. PAH. 1 hit.
    [Graphical view ]
    PROSITEi PS00265. PANCREATIC_HORMONE_1. 1 hit.
    PS50276. PANCREATIC_HORMONE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, characterization, and DNA sequence of a human cDNA encoding neuropeptide tyrosine."
      Minth C.D., Bloom S.R., Polak J.M., Dixon J.E.
      Proc. Natl. Acad. Sci. U.S.A. 81:4577-4581(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], AMIDATION AT TYR-64.
    2. "Characterization, sequence, and expression of the cloned human neuropeptide Y gene."
      Minth C.D., Andrews P.C., Dixon J.E.
      J. Biol. Chem. 261:11974-11979(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Genes encoding pancreatic polypeptide and neuropeptide Y are on human chromosomes 17 and 7."
      Takeuchi T., Gumucio D.L., Yamada T., Meisler M.H., Minth C.D., Dixon J.E., Eddy R.E., Shows T.B.
      J. Clin. Invest. 77:1038-1041(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. "Presence of the predicted C-flanking peptide of neuropeptide Y (CPON) in tissue extracts."
      Allen J.M., Polak J.M., Bloom S.R.
      Neuropeptides 6:95-100(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION OF CPON.
    7. "Solution conformation of human neuropeptide Y by 1H nuclear magnetic resonance and restrained molecular dynamics."
      Darbon H., Bernassau J.-M., Deleuze C., Chenu J., Roussel A., Cambillau C.
      Eur. J. Biochem. 209:765-771(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 29-64.
    8. Cited for: STRUCTURE BY NMR OF 29-64.
    9. "Helical structure and self-association in a 13 residue neuropeptide Y Y2 receptor agonist: relationship to biological activity."
      Barnham K.J., Catalfamo F., Pallaghy P.K., Howlett G.J., Norton R.S.
      Biochim. Biophys. Acta 1435:127-137(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 52-64.

    Entry informationi

    Entry nameiNPY_HUMAN
    AccessioniPrimary (citable) accession number: P01303
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 154 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3