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Protein

Pancreatic prohormone

Gene

PPY

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.
The physiological role for the icosapeptide has not yet been elucidated.

GO - Molecular functioni

  • G-protein coupled receptor binding Source: GO_Central
  • hormone activity Source: ProtInc
  • neuropeptide hormone activity Source: GO_Central
  • receptor binding Source: ProtInc

GO - Biological processi

  • cell-cell signaling Source: GO_Central
  • digestion Source: ProtInc
  • feeding behavior Source: GO_Central
  • neuropeptide signaling pathway Source: GO_Central
  • protein secretion Source: ProtInc
  • regulation of appetite Source: GO_Central

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-HSA-375276. Peptide ligand-binding receptors.
R-HSA-418594. G alpha (i) signalling events.
SIGNORiP01298.

Names & Taxonomyi

Protein namesi
Recommended name:
Pancreatic prohormone
Alternative name(s):
Pancreatic polypeptide
Short name:
PP
INN: Obinepitide
Cleaved into the following 2 chains:
Pancreatic hormone
Short name:
PH
Gene namesi
Name:PPY
Synonyms:PNP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108849.7.
HGNCiHGNC:9327. PPY.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Pharmaceutical usei

Obinepitide is under clinical trial by 7TM Pharma to be used for the treatment of obesity. Obinepitide is derived from pancreatic hormone by having Gln-63.

Organism-specific databases

DisGeNETi5539.
OpenTargetsiENSG00000108849.
PharmGKBiPA33690.

Polymorphism and mutation databases

BioMutaiPPY.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Add BLAST29
PeptideiPRO_000002536530 – 65Pancreatic hormoneAdd BLAST36
PeptideiPRO_000002536669 – 88Pancreatic icosapeptideAdd BLAST20
PropeptideiPRO_000002536789 – 957

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei65Tyrosine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP01298.
PeptideAtlasiP01298.
PRIDEiP01298.

PTM databases

SwissPalmiP01298.

Expressioni

Gene expression databases

BgeeiENSG00000108849.
CleanExiHS_PPY.
ExpressionAtlasiP01298. baseline and differential.
GenevisibleiP01298. HS.

Organism-specific databases

HPAiCAB016735.
HPA032122.

Interactioni

GO - Molecular functioni

  • G-protein coupled receptor binding Source: GO_Central
  • hormone activity Source: ProtInc
  • neuropeptide hormone activity Source: GO_Central
  • receptor binding Source: ProtInc

Protein-protein interaction databases

BioGridi111531. 2 interactors.
IntActiP01298. 1 interactor.
STRINGi9606.ENSP00000225992.

Structurei

Secondary structure

195
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi43 – 60Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TZ4NMR-A48-52[»]
1TZ5NMR-A30-47[»]
A53-65[»]
ProteinModelPortaliP01298.
SMRiP01298.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01298.

Family & Domainsi

Sequence similaritiesi

Belongs to the NPY family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J7V9. Eukaryota.
ENOG41115N2. LUCA.
GeneTreeiENSGT00530000064295.
HOGENOMiHOG000252942.
InParanoidiP01298.
KOiK05234.
PhylomeDBiP01298.
TreeFamiTF332778.

Family and domain databases

CDDicd00126. PAH. 1 hit.
InterProiView protein in InterPro
IPR015480. Pancreatic_hormone.
IPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
PANTHERiPTHR10533. PTHR10533. 1 hit.
PTHR10533:SF2. PTHR10533:SF2. 1 hit.
PfamiView protein in Pfam
PF00159. Hormone_3. 1 hit.
PRINTSiPR00278. PANCHORMONE.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001267. Pancreatic_hormone-like. 1 hit.
SMARTiView protein in SMART
SM00309. PAH. 1 hit.
PROSITEiView protein in PROSITE
PS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P01298-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAARLCLSL LLLSTCVALL LQPLLGAQGA PLEPVYPGDN ATPEQMAQYA
60 70 80 90
ADLRRYINML TRPRYGKRHK EDTLAFSEWG SPHAAVPREL SPLDL
Length:95
Mass (Da):10,445
Last modified:July 21, 1986 - v1
Checksum:i44F0265092F9C4A0
GO
Isoform 2 (identifier: P01298-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     62-62: R → RPRCVPQLGR...HSACPCCLFP

Note: No experimental confirmation available. Derived from EST data.Curated
Show »
Length:178
Mass (Da):18,786
Checksum:iF847D6246E7F608C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti86V → I in AAA60161 (PubMed:3753985).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05061578E → G. Corresponds to variant dbSNP:rs7215698Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05785262R → RPRCVPQLGREIPAPGTLGP LHIPGHTLSPAPAPAPSRPA LGKTGHLCSTGLDQCALGKM VPTGRYETGGLAPGHSACPC CLFP in isoform 2. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00491 mRNA. Translation: CAA25161.1.
M11726 Genomic DNA. Translation: AAA60156.1.
M15788 mRNA. Translation: AAA60161.1.
AC007993 Genomic DNA. No translation available.
BC032225 mRNA. Translation: AAH32225.1.
BC040033 mRNA. Translation: AAH40033.1.
BP385720 mRNA. No translation available.
CCDSiCCDS11472.1. [P01298-1]
PIRiA92498. PCHU.
RefSeqiNP_002713.1. NM_002722.4. [P01298-1]
UniGeneiHs.558368.
Hs.744427.

Genome annotation databases

EnsembliENST00000225992; ENSP00000225992; ENSG00000108849. [P01298-1]
ENST00000591228; ENSP00000466009; ENSG00000108849. [P01298-1]
GeneIDi5539.
KEGGihsa:5539.
UCSCiuc002iep.4. human. [P01298-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPAHO_HUMAN
AccessioniPrimary (citable) accession number: P01298
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 25, 2017
This is version 172 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families