Pancreatic prohormone precursor - Homo sapiens (Human)

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P01298 (PAHO_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 134. History...

Clusters with 100%, 90%, 50% identity |

Documents (6) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Pancreatic prohormone

Alternative name(s):
Pancreatic polypeptide
Short name=PP
INN=Obinepitide

Cleaved into the following 2 chains:

Pancreatic hormone
Short name=PH
Pancreatic icosapeptide
Short name=PI

Gene names

Name:	PPY
Synonyms:	PNP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	95 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions. The physiological role for the icosapeptide has not yet been elucidated.
Subcellular location	Secreted.
Pharmaceutical use	Obinepitide is under clinical trial by 7TM Pharma to be used for the treatment of obesity. Obinepitide is derived from pancreatic hormone by having Gln-63.
Sequence similarities	Belongs to the NPY family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Molecular function	Hormone
PTM	Amidation Cleavage on pair of basic residues
Technical term	3D-structure Complete proteome Direct protein sequencing Pharmaceutical Reference proteome
Gene Ontology (GO)
Biological_process	digestion Traceable author statement Ref.1. Source: ProtInc protein secretion Traceable author statement Ref.2. Source: ProtInc
Cellular_component	extracellular region Traceable author statement. Source: Reactome
Molecular_function	hormone activity Traceable author statement Ref.2. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 29

Peptide

30 – 65

Pancreatic hormone

PRO_0000025365

Peptide

69 – 88

Pancreatic icosapeptide Ref.6

PRO_0000025366

Propeptide

89 – 95

PRO_0000025367

Amino acid modifications

Modified residue

Tyrosine amide By similarity

Natural variations

Natural variant

E → G.
Corresponds to variant rs7215698 [ dbSNP | Ensembl ].

VAR_050615

Experimental info

Sequence conflict

V → I in AAA60161. Ref.4

Secondary structure

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P01298 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 44F0265092F9C4A0
Show »

FASTA

10,445

        10         20         30         40         50         60 
MAAARLCLSL LLLSTCVALL LQPLLGAQGA PLEPVYPGDN ATPEQMAQYA ADLRRYINML 

        70         80         90 
TRPRYGKRHK EDTLAFSEWG SPHAAVPREL SPLDL

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A cDNA encoding a small common precursor for human pancreatic polypeptide and pancreatic icosapeptide." Boel E., Schwartz T.W., Norris K.E., Fiil N.P. EMBO J. 3:909-912(1984) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEOLYTIC PROCESSING. Tissue: Pancreas.
[2]	"Exons of the human pancreatic polypeptide gene define functional domains of the precursor." Leiter A.B., Montminy M.R., Jamieson E., Goodman R.H. J. Biol. Chem. 260:13013-13017(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Structure of a precursor to human pancreatic polypeptide." Leiter A.B., Keutmann H.T., Goodman R.H. J. Biol. Chem. 259:14702-14705(1984) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pancreatic tumor.
[4]	"Genes encoding pancreatic polypeptide and neuropeptide Y are on human chromosomes 17 and 7." Takeuchi T., Gumucio D.L., Yamada T., Meisler M.H., Minth C.D., Dixon J.E., Eddy R.E., Shows T.B. J. Clin. Invest. 77:1038-1041(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas and Spleen.
[6]	"Human pancreatic icosapeptide: isolation, sequence, and immunocytochemical localization of the COOH-terminal fragment of the pancreatic polypeptide precursor." Schwartz T.W., Hansen H.F., Haakanson R., Sundler F., Tager H.S. Proc. Natl. Acad. Sci. U.S.A. 81:708-712(1984) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 69-88.
[7]	"Strongly altered receptor binding properties in PP and NPY chimeras are accompanied by changes in structure and membrane binding." Lerch M., Kamimori H., Folkers G., Aguilar M.-I., Beck-Sickinger A.G., Zerbe O. Biochemistry 44:9255-9264(2005) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR OF 30-54.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X00491 mRNA. Translation: CAA25161.1.
M11726 Genomic DNA. Translation: AAA60156.1.
M15788 mRNA. Translation: AAA60161.1.
BC032225 mRNA. Translation: AAH32225.1.
BC040033 mRNA. Translation: AAH40033.1.

IPI

IPI00000982.

PIR

PCHU. A92498.

RefSeq

NP_002713.1. NM_002722.3.

UniGene

Hs.558368.
Hs.741723.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1TZ4	NMR	-	A	48-52	[»]
1TZ5	NMR	-	A	30-65	[»]

ProteinModelPortal

P01298.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000225992.

Polymorphism databases

DMDM

129567.

Proteomic databases

PaxDb

P01298.

PRIDE

P01298.

Protocols and materials databases

DNASU

5539.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000225992; ENSP00000225992; ENSG00000108849.
ENST00000591228; ENSP00000466009; ENSG00000108849.

GeneID

5539.

KEGG

hsa:5539.

UCSC

uc002iep.3. human.

Organism-specific databases

CTD

5539.

GeneCards

GC17M042028.

H-InvDB

HIX0039051.

HGNC

HGNC:9327. PPY.

HPA

CAB000069.

MIM

167780. gene.

neXtProt

NX_P01298.

PharmGKB

PA33690.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG45827.

HOGENOM

HOG000252942.

InParanoid

P01298.

K05234.

OMA

TLGFLEW.

OrthoDB

EOG4X3H32.

PhylomeDB

P01298.

Enzyme and pathway databases

Reactome

REACT_111102. Signal Transduction.

Gene expression databases

Bgee

P01298.

CleanEx

HS_PPY.

Genevestigator

P01298.

GermOnline

ENSG00000108849. Homo sapiens.

Family and domain databases

InterPro

IPR015480. Pancreatic_hormone.
IPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]

PANTHER

PTHR10533. PTHR10533. 1 hit.
PTHR10533:SF2. PTHR10533:SF2. 1 hit.

Pfam

PF00159. Hormone_3. 1 hit.
[Graphical view]

PRINTS

PR00278. PANCHORMONE.

ProDom

PD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SMART

SM00309. PAH. 1 hit.
[Graphical view]

PROSITE

PS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

PPY. human.

EvolutionaryTrace

P01298.

GenomeRNAi

5539.

NextBio

21458.

SOURCE

Search...

Entry information

Entry name

PAHO_HUMAN

Accession

Primary (citable) accession number: P01298

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	May 1, 2013
This is version 134 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Cleaved into the following 2 chains:

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Amino acid modifications

Natural variations

Experimental info

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents