Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P01298 (PAHO_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 142. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pancreatic prohormone
Alternative name(s):
Pancreatic polypeptide
Short name=PP
INN=Obinepitide

Cleaved into the following 2 chains:

  1. Pancreatic hormone
    Short name=PH
  2. Pancreatic icosapeptide
    Short name=PI
Gene names
Name:PPY
Synonyms:PNP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length95 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.

The physiological role for the icosapeptide has not yet been elucidated.

Subcellular location

Secreted.

Pharmaceutical use

Obinepitide is under clinical trial by 7TM Pharma to be used for the treatment of obesity. Obinepitide is derived from pancreatic hormone by having Gln-63.

Sequence similarities

Belongs to the NPY family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionHormone
   PTMAmidation
Cleavage on pair of basic residues
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Pharmaceutical
Reference proteome
Gene Ontology (GO)
   Biological_processdigestion

Traceable author statement Ref.1. Source: ProtInc

protein secretion

Traceable author statement Ref.2. Source: ProtInc

   Cellular_componentextracellular region

Traceable author statement. Source: Reactome

   Molecular_functionhormone activity

Traceable author statement Ref.2. Source: ProtInc

receptor binding

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929
Peptide30 – 6536Pancreatic hormone
PRO_0000025365
Peptide69 – 8820Pancreatic icosapeptide Ref.6
PRO_0000025366
Propeptide89 – 957
PRO_0000025367

Amino acid modifications

Modified residue651Tyrosine amide By similarity

Natural variations

Natural variant781E → G.
Corresponds to variant rs7215698 [ dbSNP | Ensembl ].
VAR_050615

Experimental info

Sequence conflict861V → I in AAA60161. Ref.4

Secondary structure

..... 95
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P01298 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 44F0265092F9C4A0

FASTA9510,445
        10         20         30         40         50         60 
MAAARLCLSL LLLSTCVALL LQPLLGAQGA PLEPVYPGDN ATPEQMAQYA ADLRRYINML 

        70         80         90 
TRPRYGKRHK EDTLAFSEWG SPHAAVPREL SPLDL 

« Hide

References

« Hide 'large scale' references
[1]"A cDNA encoding a small common precursor for human pancreatic polypeptide and pancreatic icosapeptide."
Boel E., Schwartz T.W., Norris K.E., Fiil N.P.
EMBO J. 3:909-912(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEOLYTIC PROCESSING.
Tissue: Pancreas.
[2]"Exons of the human pancreatic polypeptide gene define functional domains of the precursor."
Leiter A.B., Montminy M.R., Jamieson E., Goodman R.H.
J. Biol. Chem. 260:13013-13017(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Structure of a precursor to human pancreatic polypeptide."
Leiter A.B., Keutmann H.T., Goodman R.H.
J. Biol. Chem. 259:14702-14705(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pancreatic tumor.
[4]"Genes encoding pancreatic polypeptide and neuropeptide Y are on human chromosomes 17 and 7."
Takeuchi T., Gumucio D.L., Yamada T., Meisler M.H., Minth C.D., Dixon J.E., Eddy R.E., Shows T.B.
J. Clin. Invest. 77:1038-1041(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pancreas and Spleen.
[6]"Human pancreatic icosapeptide: isolation, sequence, and immunocytochemical localization of the COOH-terminal fragment of the pancreatic polypeptide precursor."
Schwartz T.W., Hansen H.F., Haakanson R., Sundler F., Tager H.S.
Proc. Natl. Acad. Sci. U.S.A. 81:708-712(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 69-88.
[7]"Strongly altered receptor binding properties in PP and NPY chimeras are accompanied by changes in structure and membrane binding."
Lerch M., Kamimori H., Folkers G., Aguilar M.-I., Beck-Sickinger A.G., Zerbe O.
Biochemistry 44:9255-9264(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 30-54.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X00491 mRNA. Translation: CAA25161.1.
M11726 Genomic DNA. Translation: AAA60156.1.
M15788 mRNA. Translation: AAA60161.1.
BC032225 mRNA. Translation: AAH32225.1.
BC040033 mRNA. Translation: AAH40033.1.
PIRPCHU. A92498.
RefSeqNP_002713.1. NM_002722.3.
UniGeneHs.558368.
Hs.744427.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1TZ4NMR-A48-52[»]
1TZ5NMR-A30-65[»]
ProteinModelPortalP01298.
SMRP01298. Positions 30-65.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000225992.

Proteomic databases

PaxDbP01298.
PRIDEP01298.

Protocols and materials databases

DNASU5539.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000225992; ENSP00000225992; ENSG00000108849.
ENST00000591228; ENSP00000466009; ENSG00000108849.
GeneID5539.
KEGGhsa:5539.
UCSCuc002iep.3. human.

Organism-specific databases

CTD5539.
GeneCardsGC17M042028.
H-InvDBHIX0039051.
HGNCHGNC:9327. PPY.
HPACAB000069.
MIM167780. gene.
neXtProtNX_P01298.
PharmGKBPA33690.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45827.
HOGENOMHOG000252942.
InParanoidP01298.
KOK05234.
PhylomeDBP01298.
TreeFamTF332778.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP01298.
BgeeP01298.
CleanExHS_PPY.
GenevestigatorP01298.

Family and domain databases

InterProIPR015480. Pancreatic_hormone.
IPR001955. Pancreatic_hormone-like.
IPR020392. Pancreatic_hormone-like_CS.
[Graphical view]
PANTHERPTHR10533. PTHR10533. 1 hit.
PTHR10533:SF2. PTHR10533:SF2. 1 hit.
PfamPF00159. Hormone_3. 1 hit.
[Graphical view]
PRINTSPR00278. PANCHORMONE.
ProDomPD001267. Pancreatic_hormone-like. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00309. PAH. 1 hit.
[Graphical view]
PROSITEPS00265. PANCREATIC_HORMONE_1. 1 hit.
PS50276. PANCREATIC_HORMONE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPPY. human.
EvolutionaryTraceP01298.
GenomeRNAi5539.
NextBio21458.
PROP01298.
SOURCESearch...

Entry information

Entry namePAHO_HUMAN
AccessionPrimary (citable) accession number: P01298
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 16, 2014
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM