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P01298

- PAHO_HUMAN

UniProt

P01298 - PAHO_HUMAN

Protein

Pancreatic prohormone

Gene

PPY

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions.
    The physiological role for the icosapeptide has not yet been elucidated.

    GO - Molecular functioni

    1. hormone activity Source: ProtInc
    2. receptor binding Source: ProtInc

    GO - Biological processi

    1. digestion Source: ProtInc
    2. protein secretion Source: ProtInc

    Keywords - Molecular functioni

    Hormone

    Enzyme and pathway databases

    ReactomeiREACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pancreatic prohormone
    Alternative name(s):
    Pancreatic polypeptide
    Short name:
    PP
    INN: Obinepitide
    Cleaved into the following 2 chains:
    Pancreatic hormone
    Short name:
    PH
    Gene namesi
    Name:PPY
    Synonyms:PNP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:9327. PPY.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Pharmaceutical usei

    Obinepitide is under clinical trial by 7TM Pharma to be used for the treatment of obesity. Obinepitide is derived from pancreatic hormone by having Gln-63.

    Organism-specific databases

    PharmGKBiPA33690.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Add
    BLAST
    Peptidei30 – 6536Pancreatic hormonePRO_0000025365Add
    BLAST
    Peptidei69 – 8820Pancreatic icosapeptidePRO_0000025366Add
    BLAST
    Propeptidei89 – 957PRO_0000025367

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei65 – 651Tyrosine amideBy similarity

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues

    Proteomic databases

    PaxDbiP01298.
    PRIDEiP01298.

    Expressioni

    Gene expression databases

    ArrayExpressiP01298.
    BgeeiP01298.
    CleanExiHS_PPY.
    GenevestigatoriP01298.

    Organism-specific databases

    HPAiCAB000069.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000225992.

    Structurei

    Secondary structure

    1
    95
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi43 – 475
    Helixi48 – 525
    Helixi53 – 608

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1TZ4NMR-A48-52[»]
    1TZ5NMR-A30-47[»]
    A53-65[»]
    ProteinModelPortaliP01298.
    SMRiP01298. Positions 30-65.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP01298.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NPY family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG45827.
    HOGENOMiHOG000252942.
    InParanoidiP01298.
    KOiK05234.
    PhylomeDBiP01298.
    TreeFamiTF332778.

    Family and domain databases

    InterProiIPR015480. Pancreatic_hormone.
    IPR001955. Pancreatic_hormone-like.
    IPR020392. Pancreatic_hormone-like_CS.
    [Graphical view]
    PANTHERiPTHR10533. PTHR10533. 1 hit.
    PTHR10533:SF2. PTHR10533:SF2. 1 hit.
    PfamiPF00159. Hormone_3. 1 hit.
    [Graphical view]
    PRINTSiPR00278. PANCHORMONE.
    ProDomiPD001267. Pancreatic_hormone-like. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00309. PAH. 1 hit.
    [Graphical view]
    PROSITEiPS00265. PANCREATIC_HORMONE_1. 1 hit.
    PS50276. PANCREATIC_HORMONE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P01298-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAARLCLSL LLLSTCVALL LQPLLGAQGA PLEPVYPGDN ATPEQMAQYA   50
    ADLRRYINML TRPRYGKRHK EDTLAFSEWG SPHAAVPREL SPLDL 95
    Length:95
    Mass (Da):10,445
    Last modified:July 21, 1986 - v1
    Checksum:i44F0265092F9C4A0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti86 – 861V → I in AAA60161. (PubMed:3753985)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti78 – 781E → G.
    Corresponds to variant rs7215698 [ dbSNP | Ensembl ].
    VAR_050615

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X00491 mRNA. Translation: CAA25161.1.
    M11726 Genomic DNA. Translation: AAA60156.1.
    M15788 mRNA. Translation: AAA60161.1.
    BC032225 mRNA. Translation: AAH32225.1.
    BC040033 mRNA. Translation: AAH40033.1.
    CCDSiCCDS11472.1.
    PIRiA92498. PCHU.
    RefSeqiNP_002713.1. NM_002722.3.
    UniGeneiHs.558368.
    Hs.744427.

    Genome annotation databases

    EnsembliENST00000225992; ENSP00000225992; ENSG00000108849.
    ENST00000591228; ENSP00000466009; ENSG00000108849.
    GeneIDi5539.
    KEGGihsa:5539.
    UCSCiuc002iep.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X00491 mRNA. Translation: CAA25161.1 .
    M11726 Genomic DNA. Translation: AAA60156.1 .
    M15788 mRNA. Translation: AAA60161.1 .
    BC032225 mRNA. Translation: AAH32225.1 .
    BC040033 mRNA. Translation: AAH40033.1 .
    CCDSi CCDS11472.1.
    PIRi A92498. PCHU.
    RefSeqi NP_002713.1. NM_002722.3.
    UniGenei Hs.558368.
    Hs.744427.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1TZ4 NMR - A 48-52 [» ]
    1TZ5 NMR - A 30-47 [» ]
    A 53-65 [» ]
    ProteinModelPortali P01298.
    SMRi P01298. Positions 30-65.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000225992.

    Proteomic databases

    PaxDbi P01298.
    PRIDEi P01298.

    Protocols and materials databases

    DNASUi 5539.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000225992 ; ENSP00000225992 ; ENSG00000108849 .
    ENST00000591228 ; ENSP00000466009 ; ENSG00000108849 .
    GeneIDi 5539.
    KEGGi hsa:5539.
    UCSCi uc002iep.3. human.

    Organism-specific databases

    CTDi 5539.
    GeneCardsi GC17M042028.
    H-InvDB HIX0039051.
    HGNCi HGNC:9327. PPY.
    HPAi CAB000069.
    MIMi 167780. gene.
    neXtProti NX_P01298.
    PharmGKBi PA33690.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45827.
    HOGENOMi HOG000252942.
    InParanoidi P01298.
    KOi K05234.
    PhylomeDBi P01298.
    TreeFami TF332778.

    Enzyme and pathway databases

    Reactomei REACT_14819. Peptide ligand-binding receptors.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    ChiTaRSi PPY. human.
    EvolutionaryTracei P01298.
    GenomeRNAii 5539.
    NextBioi 21458.
    PROi P01298.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P01298.
    Bgeei P01298.
    CleanExi HS_PPY.
    Genevestigatori P01298.

    Family and domain databases

    InterProi IPR015480. Pancreatic_hormone.
    IPR001955. Pancreatic_hormone-like.
    IPR020392. Pancreatic_hormone-like_CS.
    [Graphical view ]
    PANTHERi PTHR10533. PTHR10533. 1 hit.
    PTHR10533:SF2. PTHR10533:SF2. 1 hit.
    Pfami PF00159. Hormone_3. 1 hit.
    [Graphical view ]
    PRINTSi PR00278. PANCHORMONE.
    ProDomi PD001267. Pancreatic_hormone-like. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00309. PAH. 1 hit.
    [Graphical view ]
    PROSITEi PS00265. PANCREATIC_HORMONE_1. 1 hit.
    PS50276. PANCREATIC_HORMONE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A cDNA encoding a small common precursor for human pancreatic polypeptide and pancreatic icosapeptide."
      Boel E., Schwartz T.W., Norris K.E., Fiil N.P.
      EMBO J. 3:909-912(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEOLYTIC PROCESSING.
      Tissue: Pancreas.
    2. "Exons of the human pancreatic polypeptide gene define functional domains of the precursor."
      Leiter A.B., Montminy M.R., Jamieson E., Goodman R.H.
      J. Biol. Chem. 260:13013-13017(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Structure of a precursor to human pancreatic polypeptide."
      Leiter A.B., Keutmann H.T., Goodman R.H.
      J. Biol. Chem. 259:14702-14705(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pancreatic tumor.
    4. "Genes encoding pancreatic polypeptide and neuropeptide Y are on human chromosomes 17 and 7."
      Takeuchi T., Gumucio D.L., Yamada T., Meisler M.H., Minth C.D., Dixon J.E., Eddy R.E., Shows T.B.
      J. Clin. Invest. 77:1038-1041(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreas and Spleen.
    6. "Human pancreatic icosapeptide: isolation, sequence, and immunocytochemical localization of the COOH-terminal fragment of the pancreatic polypeptide precursor."
      Schwartz T.W., Hansen H.F., Haakanson R., Sundler F., Tager H.S.
      Proc. Natl. Acad. Sci. U.S.A. 81:708-712(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 69-88.
    7. "Strongly altered receptor binding properties in PP and NPY chimeras are accompanied by changes in structure and membrane binding."
      Lerch M., Kamimori H., Folkers G., Aguilar M.-I., Beck-Sickinger A.G., Zerbe O.
      Biochemistry 44:9255-9264(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 30-54.

    Entry informationi

    Entry nameiPAHO_HUMAN
    AccessioniPrimary (citable) accession number: P01298
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 145 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3